Oxidative stress-induced mutagenesis and carcinogenesis in DNA repair-deficient mice

• Project/Area Number: 25241012
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Kyushu University
• Principal Investigator: TSUZUKI Teruhisa 九州大学, 医学研究院, 教授 (40155429)
• Co-Investigator(Kenkyū-buntansha): 中津 可道 九州大学, 医学(系)研究科(研究院), 准教授 (00207820) ; 大野 みずき 九州大学, 医学(系)研究科(研究院), 助教 (70380524) ; 日高 真純 福岡歯科大学, 歯学部, 教授 (80238310)
• Research Collaborator: TAKANO Noriko 九州大学, 医学部, テクニカルスタッフ
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2013: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
• Keywords: 発がん / 酸化ストレス / 突然変異 / 細胞死 / DNA損傷 / DNA修復

Outline of Final Research Achievements

In order to identify the gene(s) commonly mutated during the process of oxidative stress-induced carcinogenesis, we performed genome-wide mutational analysis of the small intestinal tumors induced by oxidative stress in Mutyh gene deficient mice. We searched the commonly mutated gene(s) found in independent tumor tissues. Among three independent tumors, mutations resulting in amino acid substitution were detected in 105, 100, and 67 cases, respectively, with 6 genes in all 3 tumors, 9 genes in 2 of 3 tumors in common.
We also performed retrovirus-mediated gene-trap mutagenesis and isolated several clones exhibiting an increased resistance to the killing effect of DNA-damaging agents. By the analyses of the clones, we identified Mapo1 and Hmga as new genes involved in the induction of apoptosis triggered by DNA damage.

Research Products

• [Journal Article] Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway (2017)
  • Author(s): I. Egashira, F. Takahashi-Yanaga, R. Nishida, M. Arioka, K. Igawa, K. Tomooka, Y. Nakatsu, T. Tsuzuki, Y. Nakabeppu, T. Kitazono, T. Sasaguri,
  • Journal Title: Cancer Science Volume: 108 Issue: 1 Pages: 108-115
  • DOI: 10.1111/cas.13106
  • Peer Reviewed / Open Access
• [Journal Article] BUBR1 Insufficiency in Mice Increases their Sensitivity to Oxidative Stress (2016)
  • Author(s): D. Matsuda, T. Matsumoto, K. Honma, A. Ikawa-Yoshida, M. Onimaru, T. Furuyama, Y. Nakatsu, T. Tsuzuki, Y. Maehara
  • Journal Title: In Vivo Volume: 30 Issue: 6 Pages: 769-776
  • DOI: 10.21873/invivo.10993
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality (2016)
  • Author(s): A. Ikawa-Yoshida, T. Matsumoto, S. Okano, Y. Aoyagi, Y. Matsubara, T. Furuyama, Y. Nakatsu, T. Tsuzuki, M. Onimaru, T. Ohkusa, M. Nomura, Y. Maehara,
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 32399-32399
  • DOI: 10.1038/srep32399
  • Peer Reviewed / Open Access
• [Journal Article] Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (2016)
  • Author(s): Evans, M. D., Misty, V., Singh, R., Gackowski, D., Rozalski, R., Siomek, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Farmer, P. B., Oliski, R., Cooke, M. S.
  • Journal Title: Free Radic. Biol. Med. Volume: 99 Pages: 385-391
  • DOI: 10.1016/j.freeradbiomed.2016.08.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN couplex localization and promotes renal cancer progression (2016)
  • Author(s): Nagashima, K., Fukushima, H., Shimizu, K., Hidaka, M., Hasumi, H., Ikebe, T., Fukumoto, S., Okabe, K., Inuzuka, H.
  • Journal Title: Oncotarget Volume: 8 Issue: 6 Pages: 9947-9960
  • DOI: 10.18632/oncotarget.14221
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Function of high-mobility groupA proteins in the DNA damage signaling for the induction of apoptosis (2016)
  • Author(s): Fujikane, R., Komori, K., Sekiguchi, M., Hidaka, M.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 31714-31714
  • DOI: 10.1038/srep31714
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. (2015)
  • Author(s): Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T
  • Journal Title: J Pharmacol Sci Volume: 127 Issue: 4 Pages: 446-455
  • DOI: 10.1016/j.jphs.2015.03.005
  • Peer Reviewed / Open Access
• [Journal Article] BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice (2015)
  • Author(s): Kyuragi, R., Matsumoto, T., Harada, Y., Saito, S., Onimaru, M., Nakatsu, Y., Tsuzuki, T., Nomura, M., Yonemitsu, Y., Maehara, Y.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 35 Issue: 2 Pages: 341-347
  • DOI: 10.1161/atvbaha.114.304737
  • Peer Reviewed / Open Access
• [Journal Article] Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis (2014)
  • Author(s): J. Piao, Y. Nakatsu, M. Ohno, K. Taguchi, T. Tsuzuki
  • Journal Title: International Journal of Biological Sciences Volume: 10 Issue: 1 Pages: 73-79
  • DOI: 10.7150/ijbs.5750
  • Peer Reviewed / Open Access
• [Journal Article] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice. (2014)
  • Author(s): Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., and Sasaguri, T.
  • Journal Title: Biochem Pharmacol Volume: N/A Issue: 3 Pages: 340-348
  • DOI: 10.1016/j.bcp.2014.03.006
  • Peer Reviewed / Open Access
• [Journal Article] 8-oxoguanine causes spontaneous de novo germline mutations in mice. (2014)
  • Author(s): Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., and Nakabeppu, Y.
  • Journal Title: Sci Rep Volume: 4 Issue: 1 Pages: 4689-4689
  • DOI: 10.1038/srep04689
  • NAID: 120005703609
  • Peer Reviewed / Open Access
• [Journal Article] Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice (2014)
  • Author(s): Isoda T, Nakatsu Y, Yamauchi K, Piao J, Yao T, Honda H, Nakabeppu Y, Tsuzuki T
  • Journal Title: Int J Biol Sci Volume: 10 Issue: 8 Pages: 940-947
  • DOI: 10.7150/ijbs.9241
  • Peer Reviewed / Open Access
• [Presentation] Mutyh欠損マウスにおける酸化ストレスによる消化管腫瘍発生頻度上昇と特異的体細胞変異シグニチャーの解析 (2016)
  • Author(s): 鷹野典子、大野みずき、中津可道、中別府雄作、續輝久
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-12-02
• [Presentation] ヒト細胞由来ミスマッチ修復遺伝子変異体の作製とその解析 (2016)
  • Author(s): 林田元気、中津可道、日高京子、藤兼亮輔、日高真純、釣本敏樹、續輝久
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-12-02
• [Presentation] CRISPR/Cas9 を用いたDNAポリメラーゼδ R５０６H突然変異のMSH2-null HeLa MR 細胞への導入 (2016)
  • Author(s): 宋頴霞、日高京子、中津可道、織田信弥、林田元気、藤兼亮輔、日高真純、續輝久
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-12-02
• [Presentation] ミスマッチ修復依存のアポトーシス誘導に関わるクロマチンリモデラーの機能 (2016)
  • Author(s): 武石幸容、藤兼亮輔、高橋達郎、関口睦夫、日高真純
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-12-01
• [Presentation] ミスマッチ修復欠損マウスを用いた新規生殖細胞変異の検出 (2016)
  • Author(s): 大野みずき、鷹野典子、佐々木史子、中津可道、續輝久
  • Organizer: 日本環境変異原学会第45回大会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2016-11-17
• [Presentation] Development of assay systems to characterize the variants of mismatch repair factor MSH2 found in Lynch syndrome (2016)
  • Author(s): Hayashida, G., Nakatsu, Y., Hidaka, K., Fujikane, R., Hidaka, M., Tsurimoto, T., Tsuzuki, T.
  • Organizer: The 10th International 3R (Replication, Recombination and Repair) Symposium
  • Place of Presentation: 松江
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Function of high-mobility group A proteins in DNA damage signaling for the induction of apoptosis triggered by O6-methylguanine (2016)
  • Author(s): Fujikane, R., Komori, K., Sekiguchi, M., Hidaka, M.
  • Organizer: The 10th International 3R (Replication, Recombination and Repair) Symposium
  • Place of Presentation: 松江
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Characterization of mismatch repair factor MSH2 variants found in Lynch syndrome (2016)
  • Author(s): 林田元気、中津可道、日高京子、藤兼亮輔、日高真純、釣本敏樹、續輝久
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: 広島
  • Year and Date: 2016-10-27
• [Presentation] アルキル化剤によって引き起こされるアポトーシスに関わる新規因子の同定と解析 (2016)
  • Author(s): 藤兼亮輔、関口睦夫、日高真純
  • Organizer: 第23回日本歯科医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-23
• [Presentation] アポトーシス誘導過程に起こるクロマチン構造変化の解析 (2016)
  • Author(s): 武石幸容、藤兼亮輔、関口睦夫、日髙真純
  • Organizer: 第23回日本歯科医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-23
• [Presentation] 酸化ストレスによる消化管腫瘍発生頻度上昇と特異的体細胞変異シグニチャー： Mutyh欠損マウスを用いた解析 (2016)
  • Author(s): 大野みずき、鷹野典子、中津可道、中別府雄作、續輝久
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-07
• [Presentation] ヒト細胞を用いたミスマッチ修復因子MSH2の変異体の解析 (2016)
  • Author(s): 林田元気、中津可道、日高京子、藤兼亮輔、日高真純、續輝久
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-07
• [Presentation] A novel function of HMGA family proteins in the induction of apoptosis triggered by O6-methylguanine in DNA (2016)
  • Author(s): Fujikane, R., Takeishi, Y., Sekiguchi, M., Hidaka, M.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パイフィコ横浜
  • Year and Date: 2016-10-06
• [Presentation] CRISPR/Cas9を用いたヒト細胞のミスマッチ修復因子への変異導入 (2016)
  • Author(s): 林田元気、中津可道、日高京子、 藤兼亮輔、日高真純、釣本敏樹、 續輝久
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 三島
  • Year and Date: 2016-09-09
• [Presentation] ミスマッチDNA修復系が体細胞および生殖細胞ゲノムにおよぼす影響 (2016)
  • Author(s): 鷹野典子、大野みずき、 佐々木史子、中津可道、續輝久
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 三島
  • Year and Date: 2016-09-09
• [Presentation] 体細胞と生殖細胞のゲノム維持における酸化損傷DNAの修復機構の重要性 (2016)
  • Author(s): 大野みずき
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 三島
  • Year and Date: 2016-09-06
  • Invited
• [Presentation] O6メチルグアニンによりひき起こされるミスマッチ修復依存のアポトーシス誘導に関わる新規因子の同定 (2015)
  • Author(s): 藤兼亮輔、関口睦夫、日高真純
  • Organizer: 日本分子生物学会第38回年会・日本生化学会第88回大会合同大会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-12-01
• [Presentation] ミスマッチ修復に依存したアポトーシス誘導に関わるクロマチン動態の解析 (2015)
  • Author(s): 武石幸容、藤兼亮輔、関口睦夫、日高真純
  • Organizer: 日本分子生物学会第38回年会・日本生化学会第88回大会合同大会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-12-01
• [Presentation] Mutyh欠損マウスを用いた酸化ストレス誘発突然変異と発がんの解析 (2015)
  • Author(s): 鷹野典子、大野みずき、佐々木史子、山内一己、中別府雄作、中津可道、續輝久
  • Organizer: 日本分子生物学会第38回年会・日本生化学会第88回大会合同大会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-12-01
• [Presentation] Trp53欠損マウスにおける酸化ストレス誘発消化管がんの解析 (2015)
  • Author(s): 李賛、大野みずき、鷹野典子、佐々木史子、日高京子、中津可道、續輝久
  • Organizer: 日本環境変異原学会第44回大会
  • Place of Presentation: 福岡（九州大学コラボ・ステーションI・II）
  • Year and Date: 2015-11-27
• [Presentation] MUTYH欠損マウスを用いた酸化ストレス誘発消化管がんと体細胞突然変異の解析 (2015)
  • Author(s): 鷹野典子、大野みずき、佐々木史子、中別府雄作、日高京子、中津可道、續輝久
  • Organizer: 日本環境変異原学会第44回大会
  • Place of Presentation: 福岡（九州大学コラボ・ステーションI・II）
  • Year and Date: 2015-11-27
• [Presentation] 酸化ストレス誘発マウス小腸発がん実験から見えてきたこと (2015)
  • Author(s): 中津可道
  • Organizer: 日本環境変異原学会第44回大会 シンポジウム：酸化ストレスによる生物影響
  • Place of Presentation: 福岡（九州大学コラボ・ステーションI・II）
  • Year and Date: 2015-11-27
• [Presentation] 酸化ストレス誘発消化管発がんと突然変異の抑制におけるMUTYHの役割 (2015)
  • Author(s): 大野みずき、鷹野典子、中津可道、中別府雄作、續輝久
  • Organizer: 日本癌学会第74回学術総会
  • Place of Presentation: 名古屋（名古屋国際会議場）
  • Year and Date: 2015-10-08
• [Presentation] 酸化ストレス誘発消化管発がん：DNA修復遺伝子欠損マウスからの学び (2015)
  • Author(s): 續輝久
  • Organizer: 第42回日本毒性学会学術年会 シンポジウム 実験発がん研究の新基軸
  • Place of Presentation: 金沢（石川県立音楽堂）
  • Year and Date: 2015-06-29
  • Invited
• [Presentation] Oxidative Stress-induced Tumorigenesis: Lesson from the Experiments with DNA Repair-deficient Mice (2015)
  • Author(s): Teruhisa Tsuzuki, Mizuki Ohno, Noriko Takano, Kenichi Taguchi, Yusaku Nakabeppu, Yoshimichi Nakatsu
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto（京都国際会議場）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Mismatch Repair Deficient Mice Show Susceptibility to Oxidative Stress-induced Intestinal Carcinogenesis (2015)
  • Author(s): Yoshimich Nakatsu, Jingshu Piao, Takuya Hashizume, Mizuki Ohno, Kenichi Taguchi, Teruhisa Tsuzuki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto（京都国際会議場）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Oxidative stress-induced intestinal tumors in Mutyh-deficient mice treated with low doses of potassium bromate (2014)
  • Author(s): Teruhisa Tsuzuki, Mizuki Ohno, Noriko Takano, Kenichi Taguchi, Yusaku Nakabeppu, Yasunobu Aoki, Takehiko Nohmi, Yoshimichi Nakatsu
  • Organizer: 4th Asian Conference on Environmental Mutagen
  • Place of Presentation: Kolkata, India
  • Year and Date: 2014-12-10 – 2014-12-12
  • Invited
• [Presentation] Mutyh遺伝子欠損マウスにおける酸化ストレス誘発突然変異の解析 (2014)
  • Author(s): 鷹野典子、大野みずき、稲葉洋平、志村勉、欅田尚樹、中別府雄作、中津可道、續輝久
  • Organizer: 日本環境変異原学会第43回大会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] Mutyh遺伝子欠損マウスを用いた酸化ストレス誘発消化管がんの解析 (2014)
  • Author(s): 大野みずき、鷹野典子、佐々木史子、田口健一、中別府雄作、青木康展、能美健彦、中津可道、續輝久
  • Organizer: 日本環境変異原学会第43回大会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 非標的部位におけるミスマッチの配列変換（遺伝子修復）への影響 (2014)
  • Author(s): 西垣奈津希、池田彰弘、湯川誠也、守田由子、中津可道、續輝久、原島秀吉、紙谷浩之
  • Organizer: 日本分子生物学会第37回年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Mutyh遺伝子欠損マウスにおける酸化ストレス誘発突然変異の解析 (2014)
  • Author(s): 鷹野典子、大野みずき、稲葉洋平、志村勉、欅田尚樹、中別府雄作、中津可道、續輝久
  • Organizer: 日本分子生物学会第37回年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] 8-oxoguanine に起因するde novo germline mutation の解析 (2014)
  • Author(s): 大野みずき、福村龍太郎、権藤洋一、岩﨑裕貴、池村淑道、續輝久、中別府作
  • Organizer: 日本分子生物学会第37回年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25 – 2014-11-27
  • Invited
• [Presentation] Oxidative stress-induced intestinal tumors in Mutyh-deficient mice treated with low doses of potassium bromate (2014)
  • Author(s): Teruhisa Tsuzuki, Mizuki Ohno, Noriko Takan1, Kenichi Taguchi, Yusaku Nakabeppu, Yasunobu Aoki, Takehiko Nohmi, Yoshimichi Nakatsu
  • Organizer: 5th US-Japan DNA Repair Meeting
  • Place of Presentation: Tokushima
  • Year and Date: 2014-10-28 – 2014-10-31
  • Invited
• [Presentation] 酸化ストレス誘発突然変異と消化管がん解析 (2014)
  • Author(s): 大野みずき、鷹野典子、佐々木史子、橋詰拓弥、李賛、田口健一、中別府雄作、中津可道、續輝久
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] ミスマッチ修復欠損マウスにおける酸化ストレス誘発突然変異の解析 (2014)
  • Author(s): 橋詰拓弥、中津可道、大野みずき、佐々木史子、鷹野典子、續輝久
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] DNA修復欠損マウスを用いた発がん研究：低用量化学物質投与研究から見えること (2014)
  • Author(s): 續輝久
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-01 – 2014-10-03
  • Invited
• [Presentation] Oxidative stress-induced mutagenesis and tumorigenesis in the small intestine of Mutyh-deficient mice treated with low doses of potassium bromate (2014)
  • Author(s): Mizuki Ohno, Noriko Takano, Yoshimichi Nakatsu, Yusaku Nakabeppu, Teruhisa Tsuzuki
  • Organizer: 日本癌学会第73回学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Microsatellite instability is induced by DNA replication stress in association with massive induction of mutations (2014)
  • Author(s): Yuko Atsumi, Kotoe Katayama, Teppei Shimamura, Yoshimichi Nakats5, Mitsuko Masutani, Satoru Miyano, Hitoshi Nakagama, Teruhisa Tsuzuki, Ken-ichi Yoshioka
  • Organizer: 日本癌学会第73回学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3b and expressions of cyclin D1 and TCF7L2 (2014)
  • Author(s): Fumi Takahashi, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Toshiyuki Sasaguri
  • Organizer: 日本癌学会第73回学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] DNA酸化損傷修復欠損マウスの継代実験で捉えられた遺伝現象 (2014)
  • Author(s): 作見邦彦, 大野みずき, 福村龍太郎, 権藤洋一, 岩﨑裕貴, 池村淑道, 續輝久, 中別府雄作
  • Organizer: 日本遺伝学会第86回大会
  • Place of Presentation: 長浜
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] Mutyh欠損マウスにおける酸化ストレス誘発発がんおよび突然変異の解析 (2014)
  • Author(s): 鷹野典子, 大野みずき, 中別府雄作, 中津可道, 續輝久
  • Organizer: 日本遺伝学会第86回大会
  • Place of Presentation: 長浜
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] 8-Oxoguaninecauses spontaneous de novo germline mutations: a study from the mutator mouse lines
  • Author(s): 大野みずき、作見邦彦、福村龍太郎、権藤洋一、岩崎裕貴、池村淑道、續 輝久、中別府雄作
  • Organizer: SMBE Satellite Meeting / NIG International Symposium
  • Place of Presentation: 三島市
  • Invited
• [Presentation] 酸化DNA損傷と消化管がん
  • Author(s): 大野みずき、中津可道、中別府雄作、續 輝久
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] ミューテーターマウス家系を用いた生殖細胞突然変異の解析システム
  • Author(s): 大野みずき、作見邦彦、福村龍太郎、権藤洋一、岩崎裕貴、池村淑道、續 輝久、中別府雄作
  • Organizer: 日本環境変異原学会第42回大会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] 臭素酸カリウムがgpt deltaマウス小腸で誘導する突然変異の閾値と変異スペクトルの用量依存性変化
  • Author(s): 青木康展、松本みちよ、松本 理、増村健一、續 輝久、能美健彦
  • Organizer: 日本環境変異原学会第42回大会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestines of Mutyh-deficient mice: the effect of low-level exposure to KBrO3
  • Author(s): Teruhisa Tsuzuki
  • Organizer: 11th International Conference on Environmental Mutagens, Symposium: Mechanism underlying threshould for genotoxic carcinogenesis
  • Place of Presentation: Bourbon Cataratas Convention & Spa Resort; Foz do Iguassu, Brazil
  • Invited
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice: the effect of low-level exposure to KBrO3
  • Author(s): Teruhisa Tsuzuki, Mizuki Ohno, Yusaku Nakabeppu, Yoshimich Nakatsu
  • Organizer: 日本癌学会第72回学術総会, Symposium 21: Biological Effects of Ionizing Radiation and Genotoxic Chemotherapeutic Agents
  • Place of Presentation: パシフィコ横浜
• [Presentation] In vitro study for mutagenicity of purple rice hull extract using fibroblasts derived from rpsL-transgenic mouse
  • Author(s): Charatda Punvittayagul, Yoshimichi Nakatsu, Rawiwan Wongpoomchai, Mizuki Ohno, Teruhisa Tsuzuki
  • Organizer: 日本癌学会第72回学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析
  • Author(s): 大野みずき、作見邦彦、福村 太郎、権藤洋一、岩崎裕貴、池村淑道、續 輝久、中別府雄作
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 慶応義塾大学・日吉キャンパス（横浜市）
• [Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析 II
  • Author(s): 作見邦彦、大野みずき、福村 太郎、権藤洋一、岩崎裕貴、池村淑道、續 輝久、中別府雄作
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 慶応義塾大学・日吉キャンパス（横浜市）
• [Presentation] アポトーシス誘導過程のMAPO1の安定化はFLCNとAMPKにより制御される
  • Author(s): 日高真純、佐野しおり、坂上竜資、関口睦夫
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 慶応義塾大学・日吉キャンパス（横浜市）
• [Presentation] AARR Award (Medicine) Lecture, Prevention of Oxidative Tumorigenesis by DNA Repair Enzymes: Implication in Human Cancer
  • Author(s): Teruhisa Tsuzuki
  • Organizer: The 3rd Asian Congress of Radiation Research (ACRR 2013)
  • Place of Presentation: Beijing International Convention Center, Beijing, China
  • Invited
• [Book] Thresholds of Genotoxic Carcinogens; From Mechanisms to Regulation, Chapter 4: Possible mechanisms underlining genotoxic thresholds: DNA repair and translesion DNA synthesis (2016)
  • Author(s): Nohmi, T., Tsuzuki, T.
  • Total Pages: 210
  • Publisher: Academic Press
• [Book] 日本臨牀（増刊号）最新臨床大腸癌学 基礎研究から臨床応用へ (2015)
  • Author(s): 續輝久、大野みずき、中津可道
  • Total Pages: 715
  • Publisher: 株式会社 日本臨牀社