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Basic study of biofilm control by using bacterial signals

Research Project

Project/Area Number 25241020
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Modeling and technologies for environmental conservation and remediation
Research InstitutionUniversity of Tsukuba

Principal Investigator

NOMURA Nobuhiko  筑波大学, 生命環境系, 教授 (60292520)

Project Period (FY) 2013-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsバイオフィルム / 微生物間相互作用 / 細菌シグナル / クォーラムセンシング / 活性汚泥 / 窒素代謝 / 微生物相互作用 / 微生物制御 / 細胞外多糖 / バイオフィルムj / 細菌 / 硝化 / 脱窒 / 微生物 / 細菌間相互作用
Outline of Final Research Achievements

Promotion of issues regarding technology development for a sustainable supply of water is important. One pressing issue is the control of microorganisms in activated sludge which is required in waste water treatment. Microorganisms exist as multi-species biofilms, however, biofilm control is often based on engineering approaches, such as nutrients, pH, and oxygen supply, but these approaches are rapidly reaching their limit. Therefore, control technology and the theory of innovative multi-species biofilms is of vital importance. In light of this, we investigated cell-cell communications in activated sludge, and indicated that interactions between bacteria exist in activated sludge by using a new imaging technology.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (15 results)

All 2017 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (10 results) (of which Invited: 10 results)

  • [Journal Article] The <i>Pseudomonas</i> Quinolone Signal Inhibits Biofilm Development of <i>Streptococcus mutans</i>2015

    • Author(s)
      Inaba T, Oura H, Morinaga K, Toyofuku M, Nomura N
    • Journal Title

      Microbes and Environments

      Volume: 30 Issue: 2 Pages: 189-191

    • DOI

      10.1264/jsme2.ME14140

    • NAID

      130005077992

    • ISSN
      1342-6311, 1347-4405
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Pseudomonas aeruginosa Swarming Motility by 1-Naphthol and Other Bicyclic Compounds Bearing Hydroxyl Groups2015

    • Author(s)
      Oura H, Tashiro Y, Toyofuku M, Ueda K, Kiyokawa T, Ito S, Takahashi Y, Lee S, Nojiri H, Nakajima-Kambe T, Uchiyama H, Futamata H and Nomura N.
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 81(8) Issue: 8 Pages: 2808-2818

    • DOI

      10.1128/aem.04220-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aerobic Respiratory Enzymes, Cbb3-type Cytochrome Oxidases, Impact the Anaerobic Life of Pseudomonas aeruginosa2014

    • Author(s)
      Hamada, M., M. Toyofuku, T. Miyano, and N. Nomura
    • Journal Title

      J. Bacteriol

      Volume: 196 Issue: 22 Pages: 3881-3889

    • DOI

      10.1128/jb.01978-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1.2014

    • Author(s)
      Toyofuku M, Zhou S, Sawada I, Takaya N, Uchiyama H, Nomura N
    • Journal Title

      Environ Microbiol.

      Volume: 印刷中 Issue: 9 Pages: 2927-2938

    • DOI

      10.1111/1462-2920.12260

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional visualization of mixed species biofilm formation together with its substratum2013

    • Author(s)
      Inaba T, Ichihara T, Yawata Y, Toyofuku M, Uchiyama H, Nomura N
    • Journal Title

      Microbiol Immunol.

      Volume: 57 Issue: 8 Pages: 589-593

    • DOI

      10.1111/1348-0421.12064

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 細菌の細胞死とバイオフィルム ~One for All, All for One?~2017

    • Author(s)
      野村暢彦
    • Organizer
      アドバンスド・セミナー(大阪大学微生物病研究所)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 微生物制御3.0 ~微生物も群れて会話する~2017

    • Author(s)
      野村暢彦
    • Organizer
      平成29年度(第88回)広島醗酵会総会・公開講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 微生物制御3.02017

    • Author(s)
      野村暢彦
    • Organizer
      第31回日本バイオフィルム学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 微生物バイオフィルム制御の新展開2017

    • Author(s)
      野村暢彦
    • Organizer
      日本セラミックス協会秋季シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 集団微生物間ネットワークとバイオフィルム2017

    • Author(s)
      野村暢彦
    • Organizer
      第66回日本感染症学会東日本地方会学術集会 第64回日本化学療法学会東日本支部総会 合同学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 微生物制御3.0 ~集団微生物学のすすめ~2017

    • Author(s)
      野村暢彦
    • Organizer
      農芸化学100年シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 複合微生物系における細胞間シグナル伝達2017

    • Author(s)
      野村暢彦
    • Organizer
      JBA 発酵と代謝研究会 平成29年度第2回勉強会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 微生物細胞間シグナルの利用による革新的水処理技術への挑戦2014

    • Author(s)
      豊福雅典、稲葉知大、尾花望、野村暢彦
    • Organizer
      環境微生物系学会合同大会2014
    • Place of Presentation
      アクトシティ浜松(静岡・浜松)
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 微生物の城づくり ~微生物も会話し集団生活している~

    • Author(s)
      野村暢彦
    • Organizer
      第2回日本微生物学連盟フォーラム『微生物―知られざるミクロのエンジニア』
    • Place of Presentation
      東京大学駒場キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 微生物間コミュニケーションを利用したバイオフィルム制御技術の開発

    • Author(s)
      野村暢彦
    • Organizer
      藪田セミナー
    • Place of Presentation
      アクトシティ浜松コングレスセンター
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-10-24   Modified: 2023-03-23  

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