| Budget Amount *help |
¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2013: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Outline of Final Research Achievements |
Human ENaC (hENaC) is a candidate of salty taste receptor. High throughput screening of hENaC activation molecules was constructed. From about 4000 compounds, 4 molecules are extracted as a hENaC activation compound. Besides, a novel salty taste enhancer was synthesized by organic synthesis. We previously found free fatty acid suppresses the bitter taste and revealed the mechanism of bitterness suppression by fatty acid. Fatty acids interact directly with bitter substances through hydrogen bonds and hydrophobic interactions to form insoluble binary complexes that mask bitterness.
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