| Budget Amount *help |
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2013: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
|
|---|
| Outline of Final Research Achievements |
In mammals, digested substances taken from mouth were incorporated and metabolized at the intestine, and then were delivered to liver through hepatic portal vein. Liver plays crucial roles such as energy source accumulation and supply to whole body, detoxification and excretion by conjugation. Because, for drug development, it is necessary to investigate kinetics, metabolism, and toxicity of drugs in intestine and liver, many animal experiments and clinical studies have been carried out. So, we succeeded to establish ES/iPS-derived in vitro drug metabolism assay system closed to real intestine and liver, and these ES/iPS-derived intestine and liver tissues were cultured on our original fluidic devices. These results must be expected to be animal experiment alternatives.
|
