Development of the strategy for fundamental therapy of cancer using iPS derived Cancer Stem cell models
Project/Area Number |
25242045
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Okayama University |
Principal Investigator |
Seno Masaharu 岡山大学, 自然科学研究科, 教授 (90243493)
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Co-Investigator(Kenkyū-buntansha) |
笠井 智成 岡山大学, 自然科学研究科, 講師 (30530191)
工藤 孝幸 岡山大学, 自然科学研究科, 助教 (00346412)
水谷 昭文 岡山大学, 自然科学研究科, 助教 (50598331)
日沼 州司 千里金蘭大学, 生活科学部, 教授 (60550522)
加来田 博貴 岡山大学, 医歯(薬)学総合研究科, 准教授 (80362961)
村上 宏 岡山大学, 自然科学研究科, 准教授 (90260174)
浜田 博喜 岡山理科大学, 理学部, 教授 (10164914)
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Project Period (FY) |
2013-10-21 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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Keywords | 薬物送達システム / iPS細胞 / がん幹細胞 / 分子標的薬 / 抗がん剤 / 根本的治療 / 細胞死 / 制がん剤 / 根本治療 / VEGFR-2 阻害剤 |
Outline of Final Research Achievements |
For the purpose of the development of the fundamental therapeutic strategies to target cancer stem cells (CSCs), we have been taking advantage of iPS-derived CSCs (iPS-CSCs). In this project, we have proven the direct contribution of CSCs to tumor vasculature development, and have established a new model of pancreatic CSCs. In addition, we performed gene expression profiling of CSCs. These results should be valuable to identify new therapeutic target molecule(s) in CSCs and cancer niche. We also performed drug screening, tried to design new drug. Among the several approved anticancer drugs, we found a drug showing highly effective to iPS-CSCs.
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Report
(5 results)
Research Products
(50 results)
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[Journal Article] iPSC-derived cancer stem cells provide a model of tumor vasculature.2016
Author(s)
Prieto-Vila M, Yan T, Calle AS, Nair N, Hurley L, Kasai T, Kakuta H, Masuda J, Murakami H, Mizutani A, Seno M.
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Journal Title
Am J Cancer Res
Volume: 6
Pages: 1906-1921
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm).2016
Author(s)
Calle AS, Nair N, Oo AK, Prieto-Vila M, Koga M, Khayrani AC, Hussein M, Hurley L, Vaidyanath A, Seno A, Iwasaki Y, Calle M, Kasai T, Seno M
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Journal Title
Am J Cancer Res
Volume: 6
Pages: 2799-2815
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles2014
Author(s)
Yan T, Mizutani A, Chen L, Takaki M, Hiramoto Y, Matsuda S, Shigehiro T, Kasai T, Kudoh T, Murakami H, Masuda J, Hendrix MJ, Strizzi L, Salomon DS, Fu L, Seno M.
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Journal Title
Journal of Cancer
Volume: 5
Issue: 7
Pages: 572-584
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Efficient drug delivery of Paclitaxel glycoside: a novel solubility gradient encapsulation into liposomes coupled with immunoliposomes preparation.2014
Author(s)
Shigehiro T, Kasai T, Murakami M, Sekhar SC, Tominaga Y, Okada M, Kudoh T, Mizutani A, Murakami H, Salomon DS, Mikuni K, Mandai T, Hamada H, Seno
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Journal Title
PLoS One
Volume: 9
Issue: 9
Pages: e107976-e107976
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs.2014
Author(s)
El-Aarag BY, Kasai T, Zahran MA, Zakhary NI, Shigehiro T, Sekhar SC, Agwa HS, Mizutani A, Murakami H, Kakuta H, Seno M.
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Journal Title
International Immunopharmacology
Volume: 2
Issue: 2
Pages: 283-92
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Chlorotoxin-Fc Fusion Inhibits Release of MMP-2 from Pancreatic Cancer Cells.2014
Author(s)
El-Ghlban S, Kasai T, Shigehiro T, Yin HX, Sekhar S, Ida M, Sanchez A, Mizutani A, Kudoh T, Murakami H, Seno M
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Journal Title
Biomed Res Int.
Volume: -
Pages: 152659-152659
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells.2014
Author(s)
Chen L, Mizutani A, Kasai T, Yan T, Jin G, Vaidyanath A, El-Aarag BY, Liu Y, Kudoh T, Salomon DS, Fu L, Seno M.
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Journal Title
American Journal of Cancer Research
Volume: 1
Pages: 80-8
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cancer stem cells maintain a hierarchy of differentiation by creating their niche.2013
Author(s)
Matsuda S, Yan T, Mizutani A, Sota T, Hiramoto Y, Prieto-Vila M, Chen L, Satoh A, Kudoh T, Kasai T, Murakami H, Fu L, Salomon DS, Seno M
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Journal Title
Int J Cancer
Volume: 00
Issue: 1
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Cancer stem cells maintain a hierarchy of differentiation by creating their niche2014
Author(s)
Mizutani A, Matsuda S, Yan T, Prieto-Vila M, Chen L, Satoh A, Kasai T, Masuda J, Kudoh T, Murakami H, Fu L, Salomon DS, Seno M
Organizer
AACR Annual meeting 2014
Place of Presentation
サンディエゴ アメリカ
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived exosomes/microvesicles2014
Author(s)
Yan T, Masuda J, Mizutani A, Chen L, Shigehiro T, Matsuda S, Kasai T, Kudoh T, Murakami H, Hendrix MJ, Strizzi L, Salomon DS, Seno M
Organizer
AACR Annual meeting 2014
Place of Presentation
サンディエゴ アメリカ
Year and Date
2014-04-05 – 2014-04-09
Related Report
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