| Project/Area Number |
25242045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Okayama University |
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Principal Investigator |
Seno Masaharu 岡山大学, 自然科学研究科, 教授 (90243493)
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| Co-Investigator(Kenkyū-buntansha) |
笠井 智成 岡山大学, 自然科学研究科, 講師 (30530191)
工藤 孝幸 岡山大学, 自然科学研究科, 助教 (00346412)
水谷 昭文 岡山大学, 自然科学研究科, 助教 (50598331)
日沼 州司 千里金蘭大学, 生活科学部, 教授 (60550522)
加来田 博貴 岡山大学, 医歯(薬)学総合研究科, 准教授 (80362961)
村上 宏 岡山大学, 自然科学研究科, 准教授 (90260174)
浜田 博喜 岡山理科大学, 理学部, 教授 (10164914)
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| Project Period (FY) |
2013-10-21 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 薬物送達システム / iPS細胞 / がん幹細胞 / 分子標的薬 / 抗がん剤 / 根本的治療 / 細胞死 / 制がん剤 / 根本治療 / VEGFR-2 阻害剤 |
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| Outline of Final Research Achievements |
For the purpose of the development of the fundamental therapeutic strategies to target cancer stem cells (CSCs), we have been taking advantage of iPS-derived CSCs (iPS-CSCs). In this project, we have proven the direct contribution of CSCs to tumor vasculature development, and have established a new model of pancreatic CSCs. In addition, we performed gene expression profiling of CSCs. These results should be valuable to identify new therapeutic target molecule(s) in CSCs and cancer niche. We also performed drug screening, tried to design new drug. Among the several approved anticancer drugs, we found a drug showing highly effective to iPS-CSCs.
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