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Ultrasound viscoelastography: development of quantitative imaging of tissue viscoelasticity based on fusion of static and dynamic tissue excitation

Research Project

Project/Area Number 25242049
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

SHIINA TSUYOSHI  京都大学, 医学(系)研究科(研究院), 教授 (40192603)

Co-Investigator(Kenkyū-buntansha) YAMAKAWA MAKOTO  京都大学, 医学研究科, 特定准教授 (60344876)
KONDO KENGO  京都大学, 医学研究科, 特定助教 (50649233)
TOI MASAKAZU  京都大学, 医学研究科, 教授 (10207516)
KUDO MASAOSHI  近畿大学, 医学部, 教授 (10298953)
Project Period (FY) 2013-05-31 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2013: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Keywords医用超音波システム / 組織粘弾性 / 医用イメージング / がん診断 / 肝疾患診断
Outline of Final Research Achievements

Ultrasound elastography is now widely used in many clinical fields for visualization of tissue hardness. Although its basic principles are categorized into two methods, there remain problems to be solved: strain image by static method is qualitative, while shear wave imaging by dynamic method is subjective to artifact due to inhomogeneous speed of shear wave. Moreover, imaging of tissue viscosity has not been put in practice. In this research, we aim to develop the viscoelastography, that is, technology of quantitative imaging of viscosity and elasticity of tissue for improvement in diagnosis of diseases such as cancer and chronic hepatitis by integration of static and dynamic excitation of tissue

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (31 results)

All 2016 2015 2014 2013 Other

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Invited: 5 results) Book (1 results)

  • [Journal Article] Shear wavelength estimation based on inverse filtering and multiple-point shear wave generation2016

    • Author(s)
      Kitazaki T, Kondo K, Yamakawa M, and Shiina T
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55

    • NAID

      210000146835

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Study on the Application of Shear-wave Elastography to Thin-Layered Media and Tubular Structure: Finite-Element Analysis and Experiment Verification2016

    • Author(s)
      Jang J, Kondo K, Namita T, Yamakawa M, and Shiina T
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55

    • NAID

      210000146833

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] WFUMB Guidelines and recommendations for clinical use of ultrasound elastography: PART 1: Basic principles and Terminology2015

    • Author(s)
      Shiina T, Nightingale KR, Palmeri ML, Hall TJ, Bamber JC, Barr RG, Castera L, Choi BI, Chou YH, Cosgrove D, Dietrich CF, Ding H, Amy D, Farrokh A, Ferraioli G, Filice C, Friedrich-Rust M, Nakashima K, Schafer F, Sporea I, Suzuki S, Wilson S, Kudo M
    • Journal Title

      Ultrasound in Medicine & Biology

      Volume: 41(5) Issue: 5 Pages: 1126-1147

    • DOI

      10.1016/j.ultrasmedbio.2015.03.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mapping viscoelastic properties by Multi-Line(ML) acoustic radiation force2015

    • Author(s)
      M. Gomyo, K. Kondo, M. Yamakawa, T. Shiina
    • Journal Title

      Proc. of SPIE

      Volume: 9419 Pages: 94191A-94191A

    • DOI

      10.1117/12.2082456

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound elastography: Development of novel technologies and standardization2014

    • Author(s)
      T. Shiina
    • Journal Title

      Jpn. J. Appl. Physics.

      Volume: 53 Issue: 7S Pages: 07KA02-07KA02

    • DOI

      10.7567/jjap.53.07ka02

    • NAID

      210000144196

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex Vivo and In Vivo Assessment of The Non-Linearity of Elasticity Properties of Breast Tissues for Quantitative Strain Elastography2014

    • Author(s)
      T. Umemoto, E. Ueno, T. Matsumura, M.Yamakawa, H. Bando, T. Mitake and T. Shiina,
    • Journal Title

      Ultrasound in Medicine and Biology

      Volume: 40 Pages: 1755-1768

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shear wave elasticity imaging using inverse filtering and multiple-point shear wave generation2014

    • Author(s)
      Kitazaki, T ; Shiina, T. ; Kondo, K. ; Yamakawa, M
    • Journal Title

      2014 IEEE International Ultrasonics Symposium

      Volume: 1 Pages: 1121-1123

    • DOI

      10.1109/ultsym.2014.0275

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 受動励振による組織粘弾性評価 の実験的検討2014

    • Author(s)
      小江 啓介,近藤 健悟,山川 誠,椎名 毅
    • Journal Title

      日本超音波医学会 基礎技術研究会抄録集

      Volume: 1 Pages: 7-8

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 粘弾性評価用ファントムの試作と剪断波を用いた定量的評価2014

    • Author(s)
      五明 美香子† 近藤 健悟 山川 誠 椎名 毅
    • Journal Title

      超音波エレクトロニクスシンポジウム講演論文集

      Volume: 35 Pages: 335-356

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent Trends in Research and Development of Ultrasound Elastography2014

    • Author(s)
      椎名 毅
    • Journal Title

      Medical Imaging Technology

      Volume: 32 Issue: 2 Pages: 63-68

    • DOI

      10.11409/mit.32.63

    • NAID

      130004554959

    • ISSN
      0288-450X, 2185-3193
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Principle of Ultrasound Elastography Based on Shear Wave Propagation2014

    • Author(s)
      山川 誠
    • Journal Title

      Medical Imaging Technology

      Volume: 32 Issue: 2 Pages: 75-80

    • DOI

      10.11409/mit.32.75

    • NAID

      130004554961

    • ISSN
      0288-450X, 2185-3193
    • Related Report
      2014 Annual Research Report
  • [Journal Article] JSUM ultrasound elastography practice quidelines: basics and terminology2013

    • Author(s)
      椎名毅
    • Journal Title

      J. of Medical Ultrasonics

      Volume: 40 (4) Issue: 4 Pages: 309-323

    • DOI

      10.1007/s10396-013-0490-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JSUM ultrasound elastography practice guidelines: liver2013

    • Author(s)
      M.Kudo, T.Shiina, F. Moriyasu, H. IIjima, R. Tateishi, N. Yada, K. Fujimoto, H. Morikawa, M. Hirooka, Y. Sumino
    • Journal Title

      J. of Medical Ultrasonics

      Volume: 40(4) Issue: 4 Pages: 325-357

    • DOI

      10.1007/s10396-013-0460-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JSUM ultrasound elastography practice guidelines: breast2013

    • Author(s)
      K.Nakashima, T.Shiina, M. Sakurai, K.Enokido, T.Endo, H.Tsunoda, TE.Takada, T.Umemoto, E. Ueno
    • Journal Title

      J. of Medical Ultrasonics

      Volume: 40(4) Issue: 4 Pages: 359-391

    • DOI

      10.1007/s10396-013-0457-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] SWE を薄板状媒質に適用するためのHilbert-Huang Transform に基づくTime-of-flight 法2015

    • Author(s)
      張 俊根, 近藤 健悟, 浪田 健, 山川 誠, 椎名 毅
    • Organizer
      第36 回 超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多点励振と逆フィルタによる剪断波の波長推定2015

    • Author(s)
      北﨑 智明, 近藤 健悟, 山川 誠, 椎名 毅
    • Organizer
      第36 回 超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 最近の超音波診断装置におけるイノベーション2015

    • Author(s)
      椎名 毅
    • Organizer
      第110 回日本医学物理学会学術大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Ultrafast Imaging 法を用いた探触子加振による組織粘弾性計測の精度向上2015

    • Author(s)
      山川 誠,椎名 毅
    • Organizer
      日本超音波医学会第88回学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Basic Principles and Terminology2014

    • Author(s)
      椎名 毅
    • Organizer
      日本超音波医学会第41回関西地方会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ガイド波理論に基づく Shear Wave を用いた動脈壁の弾性率推定2014

    • Author(s)
      張 俊根, 近藤 健悟, 山川 誠, 椎名 毅
    • Organizer
      日本超音波医学会第41回関西地方会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Shear wave を用いた粘性・弾性分布イメージング法のファントム実験による検証2014

    • Author(s)
      五明美香子, 近藤 健悟 , 山川 誠 , 椎名 毅
    • Organizer
      日本超音波医学会第41回関西地方会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estimation of tissue viscoelasticity using inverse filter and multiple point shear wave generation2014

    • Author(s)
      T Kitazaki , K Kondo, M Yamakawa, T Shiin
    • Organizer
      13th International Tissue Elasticity Conference
    • Place of Presentation
      Snowbird
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Real-time Tissue Elastography: theory and usefulness for breast cancer diagnosis2014

    • Author(s)
      T. Shiina
    • Organizer
      12th International Workshop on Breast Imaging
    • Place of Presentation
      Gifu
    • Year and Date
      2014-06-29 – 2014-06-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 剪断波による組織粘性・弾性分布の画像化の検討2014

    • Author(s)
      五明美香子,近藤健悟,山川 誠,椎名 毅
    • Organizer
      日本超音波医学会 第87回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 組織弾性評価手法の最新技術動向2014

    • Author(s)
      椎名 毅
    • Organizer
      日本超音波医学会 第87回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] プローブ加振によるせん断波を用いた2-D Transient elastography の基礎検2014

    • Author(s)
      山川 誠,椎名 毅
    • Organizer
      日本超音波医学会 第87回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanical Modeling and Ultrasound Elasticity Imaging for Quantification of Hepatic Fibrosis

    • Author(s)
      T.Shiina
    • Organizer
      IEEE EMBC 2013
    • Place of Presentation
      Osaka
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel imaging technology by fusion of ultrasound and optics

    • Author(s)
      T.Shiina
    • Organizer
      IEEE EMBC2013 Workshop
    • Place of Presentation
      Osaka
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Theory and practice of ultrasound tissue elasticity imaging in breast cancer diagnosis

    • Author(s)
      T.Shiina
    • Organizer
      MICCAI 2013 Workshop on Breast Imaging Analysis
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mapping Viscoelastic Properties using acoustic radiation force

    • Author(s)
      M.Gomyo, K.Kondo, M. Yamakawa, T. Shiina.
    • Organizer
      12th International Tissue Elasticity Conference
    • Place of Presentation
      Lingfield
    • Related Report
      2013 Annual Research Report
  • [Book] 図解診療放射線技術実践ガイド、断層撮影へのアプローチ2014

    • Author(s)
      椎名 毅
    • Total Pages
      1084
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report

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Published: 2013-06-20   Modified: 2019-07-29  

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