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Intelligent decision support systems for total hip arthroplasty (THA): Towards fully automated preoperative planning of orthopedic surgery

Research Project

Project/Area Number 25242051
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionNara Institute of Science and Technology (2014-2016)
Osaka University (2013)

Principal Investigator

Sato Yoshinobu  奈良先端科学技術大学院大学, 情報科学研究科, 教授 (70243219)

Co-Investigator(Kenkyū-buntansha) 大竹 義人  奈良先端科学技術大学院大学, 情報科学研究科, 准教授 (80349563)
横田 太  奈良先端科学技術大学院大学, 情報科学研究科, 助教 (60759900)
鍵山 善之  山梨大学, 総合研究部, 助教 (30506506)
高尾 正樹  大阪大学, 医学(系)研究科(研究院), 助教 (30528253)
鈴木 直樹  東京慈恵会医科大学, 医学部, 教授 (40147327)
田中 正夫  大阪大学, 基礎工学研究科, 教授 (40163571)
多田 幸生  神戸大学, システム情報学研究科, 教授 (70135812)
菅野 伸彦  大阪大学, 医学(系)研究科(研究院), 教授 (70273620)
中本 将彦  大阪大学, 医学系研究科, 助教 (00380634)
Co-Investigator(Renkei-kenkyūsha) Miki Hidenobu  独立行政法人国立病院機構大阪医療センター, 臨床研究センター, 医長 (10335391)
Research Collaborator Zheng Guoyan  University of Bern, Associate Professor
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2016: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2014: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2013: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Keywords遠隔診断治療システム / 医用画像・バイオイメージング / 関節病学 / 機械学習 / 画像情報処理 / 生体生命情報学 / 情報システム / 人工知能 / 手術支援 / 臨床意思決定支援 / 手術計画 / コンピュータ外科 / ネットワーク医療 / 統計モデル / 統計アトラス / 医療情報システム
Outline of Final Research Achievements

We developed automated preoperative planning systems from bone anatomy models, especially focusing on total hip arthroplasty (THA). In order to optimize both anatomical compatibility and joint functionalities from different aspects, the frameworks of multi-objective optimization and Bayesian estimation were adopted. A statistical surgical case model is constructed, and the problem is formulated as fitting the patient data with the statistical model. The formulation was generalized so as to deal with different types of the femoral stem implants and 2D X-ray images as input patient data (without 3D CT images). Further, the system was shown to be useful for other parts of bones and joints. Finally, we showed potential usefulness of fully automated preoperative planning of THA directly from CT images by combining both automation of CT segmentation and preoperative planning towards clinical applications.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (32 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (27 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results)

  • [Int'l Joint Research] ベルン大学(スイス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Change in pelvic sagittal inclination from supine to standing position before hip arthroplasty2017

    • Author(s)
      Uemura K, Takao M, Otake Y, Koyama K, Yokota F, Hamada H, Sakai T, Sato Y, Sugano N
    • Journal Title

      The Journal of Arthroplasty

      Volume: A083-5403 Issue: 8 Pages: 30217-30222

    • DOI

      10.1016/j.arth.2017.03.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Shape-based acetabular cartilage segmentation: application to CT and MRI datasets2016

    • Author(s)
      Tabrizi PR, Zoroofi RA, Yokota F, Nishii T, Sato Y
    • Journal Title

      International journal of computer assisted radiology and surgery

      Volume: 11 Issue: 7 Pages: 1247-1265

    • DOI

      10.1007/s11548-015-1313-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CT-based automated planning of acetabular cup for total hip arthroplasty (THA) based on hybrid use of two statistical atlases.2016

    • Author(s)
      Kagiyama, Y, Sato Y, Otomaru I, Takao M, Nakamoto M, Yokota F, Tomiyama N, Tada Y, Sugano N.
    • Journal Title

      International Journal of Computer Assisted Radiology and Surgery.

      Volume: 11(12) Issue: 12 Pages: 2253-2271

    • DOI

      10.1007/s11548-016-1428-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cup Implant Planning Based on 2D/3D Radiographic Pelvis Reconstruction-First Clinical Results2015

    • Author(s)
      Schumann, Steffen, Yoshinobu Sato, Yuki Nakanishi, Futoshi Yokota, Masaki Takao, Nobuhiko Sugano, and Guoyan Zheng
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 62, No.11 Issue: 11 Pages: 2665-2673

    • DOI

      10.1109/tbme.2015.2441378

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] STATISTICAL ESTIMATION OF ATTACHMENT OF HIP MUSCLES BASED ON MEASUREMENT IN CADAVERS2016

    • Author(s)
      Norio Fukuda, Otake Yoshito, Masaki Takao, Futoshi Yokota, Takeshi Ogawa, Keisuke Uemura, Ryota Nakaya, Kazunori Tamura, Robert Grupp, Amirhossein Farvardin, Mehran Armand, Nobuhiko Sugano, Sato Yoshinobu
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SHAPE CORRESPONDENCE BETWEEN HEALTHY AND DISEASED SHAPES TOWARDS STATISTICAL MODELING OF PATHOLOGICAL PROGRESSION OF HIP JOINT2016

    • Author(s)
      Futoshi Yokota, Otake Yoshito, Masaki Takao, Yuta Otani, Takeshi Ogawa, Keisuke Uemura, Nobuhiko Sugano, Sato Yoshinobu
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FULLY AUTOMATED MEASUREMENT OF THE CHANGE IN PELVIC SAGITTAL INCLINATION FROM THE SUPINE TO THE STANDING POSITION IN 373 CASES BEFORE TOTAL HIP ARTHROPLASTY2016

    • Author(s)
      Keisuke Uemura, Otake Yoshito, Masaki Takao, Koki Koyama, Hidetoshi Hamada, Futoshi Yokota, Takashi Sakai, Sato Yoshinobu, Nobuhiko Sugano
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ANALYSIS OF MUSCLE FIBER STRUCTURE USING CLINICAL CT: PRELIMINARY ANALYSIS USING CADAVERIC IMAGES2016

    • Author(s)
      Otake Yoshito, Futoshi Yokota, Masaki Takao, Norio Fukuda, Nobuhiko Sugano, Sato Yoshinobu
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AN AUTOMATED METHOD FOR MEASURING FEMORAL ANTEVERSION ANGLE: TOWARDS A LARGE-SCALE POPULATION STUDY2016

    • Author(s)
      Yuji Horimoto, Otake Yoshito, Futoshi Yokota, Masaki Takao, Takeshi Ogawa, Keisuke Uemura, Nobuhiko Sugano, Sato Yoshinobu
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AN AUTOMATED PIPELINE OF BONE SEGMENTATION AND 2D-3D REGISTRATION ON HIP RADIOGRAPHS: TOWARDS LARGE-SCALE POPULATION STUDY ON HIP JOINT BIOMECHANICS2016

    • Author(s)
      Koki Koyama, Otake Yoshito, Keisuke Uemura, Masaki Takao, Takeshi Ogawa, Yuta Hiasa, Futoshi Yokota, Nobuhiko Sugano, Sato Yoshinobu
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] “大規模患者データベースにおける 骨盤傾斜角測定を目的とした 2D-3Dレジストレーション手法の検討”2016

    • Author(s)
      児山昂生, 大竹 義人, 上村 圭亮,日朝 祐太, 横田 太, 高尾 正樹,小川 剛, 菅野 伸彦, 佐藤 嘉伸
    • Organizer
      電子情報通信学会医用画像研究会(MI)
    • Place of Presentation
      ぶんかテンプス館 (沖縄県那覇市)
    • Year and Date
      2016-01-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 臨床用CTから骨頭内の部位別骨密度を計測する試み~臨床用CTとμCTの比較~2015

    • Author(s)
      上村圭亮,山中大幸,横田太,大竹義人,高尾正樹,坂井孝司,西井孝,佐藤嘉伸,菅野伸彦
    • Organizer
      第24回日本コンピュータ外科学会大会
    • Place of Presentation
      東京大学 (東京都文京区)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 階層的マルチアトラス法を用いた股関節CT画像からの筋肉領域自動抽出~最終階層に用いるアトラス選択による影響とその効果的な選択方法~2015

    • Author(s)
      横田太,Boëda Guitiera,大竹義人,高尾正樹,小川剛,菅野伸彦,岡田俊之,佐藤嘉伸
    • Organizer
      第24回日本コンピュータ外科学会大会
    • Place of Presentation
      東京大学 (東京都文京区)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大腿骨前捻角半自動計測法における操作者による影響低減方法の検討2015

    • Author(s)
      堀本悠司,中西裕紀,横田太,大竹義人,高尾正樹,小川剛,上村圭亮,菅野伸彦,佐藤嘉伸
    • Organizer
      第24回日本コンピュータ外科学会大会
    • Place of Presentation
      東京大学 (東京都文京区)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] “統計解析による股関節、膝関節手術の最適化を目的とした大規模患者データベースの構築”2015

    • Author(s)
      高尾正樹, 大竹義人, 小川剛, 横田太, 佐藤嘉伸, 菅野伸彦
    • Organizer
      日本コンピュータ外科学会大会
    • Place of Presentation
      東京大学 (東京都文京区)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] “下肢筋肉付着部、走行アトラスの構築(第一報)~ Cadaverを用いた筋肉付着部、走行情報の取得~”2015

    • Author(s)
      高尾正樹, 大竹義人, 小川剛, 福田紀生, 上村圭亮, 横田太, 佐藤嘉伸, 菅野伸彦
    • Organizer
      日本コンピュータ外科学会大会
    • Place of Presentation
      東京大学 (東京都文京区)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] “人体連続切片標本画像とCT画像を用いた筋質・筋線維方向の解析”2015

    • Author(s)
      大竹 義人, 横田 太, Florent Marie, 福田 紀生, 高尾 正樹, 小川 剛, 上村 圭亮, 菅野 伸彦, 佐藤 嘉伸
    • Organizer
      電子情報通信学会医用画像研究会(MI)
    • Place of Presentation
      奈良先端科学技術大学院大学 (奈良県生駒市)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] “Handling different designs of femoral stems for automated THA planning: Determination of stem anteversion angle using statistical prediction”2015

    • Author(s)
      Nakanishi Y, Kagiyama Y, Yokota F, Ogawa T, Takao M, Sugano N, Tada Y, Otake Y,Sato Y
    • Organizer
      Annual Meeting of International Society of Computer Assisted Orthopaedic Sugery
    • Place of Presentation
      Vancouver, Canada (accepted for special poster presentation)
    • Year and Date
      2015-06-17 – 2015-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Handling different designs of femoral stems for automated THA planning: Determination of stem anteversion angle using statistical prediction2015

    • Author(s)
      Y Nakanishi, Y Kagiyama, F Yokota, M Takao, T Ogawa, N Sugano, Y Tada, Y Otake and Y Sato
    • Organizer
      CAOS 15TH Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery 2015
    • Place of Presentation
      Canada,Vancouber, The Fairmont Hotel Vancouber
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Are 2d Measurements Of Muscle Atrophy And Degeneration Valid In Patients With Hip Disease?2015

    • Author(s)
      T Ogawa, M Takao, F Yokota, T Sakai, T Nishii, Y Otake, Y Sato and N Sugano
    • Organizer
      CAOS 15TH Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery 2015
    • Place of Presentation
      Canada,Vancouber, The Fairmont Hotel Vancouber
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 階層的マルチアトラス法を用いた股関節CT画像からの筋肉領域自動抽出の精度評価2014

    • Author(s)
      横田太, 高尾正樹, 小川剛, 菅野伸彦, 岡田俊之, 大竹義人, 多田幸生, 佐藤嘉伸
    • Organizer
      J JSCAS, 16(3), 213, 2014
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工股関節自動手術計画システム実用化に向けた最小限の手入力による疾患股関節のCTセグメンテーション高精度化 ~股関節・膝関節上の2点を条件とする統計形状モデルの適用~2014

    • Author(s)
      横田太, 高尾正樹, 小川剛, 菅野伸彦, 岡田俊之, 大竹義人, 多田幸生, 佐藤嘉伸
    • Organizer
      J JSCAS, 16(3), 214, 2014
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工股関節自動手術計画システム実用化に向けた関節機能バランスを考慮した最適化と性能評価 ~関節機能統計モデルを用いた脚長差・関節可動域・適合性調整~2014

    • Author(s)
      鍵山善之, 中西裕紀, 横田太, 高尾正樹, 小川剛, 菅野伸彦, 大竹義人, 伊藤安海, 多田幸生,佐藤嘉伸
    • Organizer
      J JSCAS, 16(3), 242, 2014
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工股関節自動手術計画システム実用化に向けた異機種大腿骨ステムヘの対応 ~大腿骨・ステム統合統計形状モデルを用いたステム前捻角決定~2014

    • Author(s)
      中西裕紀, 鍵山善之,横田太, 小川剛, 高尾正樹, 菅野伸彦, 多田幸生, 大竹義人, 佐藤嘉伸
    • Organizer
      J JSCAS, 16(3), 243, 2014
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工股関節手術計画統計アトラス構築のための代表症例選択-異種大腿骨インプラントへの拡張の容易化-2014

    • Author(s)
      中西 裕紀,鍵山 善之,横田 太,高尾 正樹,菅野 伸彦,多田 幸生,富山 憲幸,佐藤 嘉伸
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      沖縄(沖縄ぶんかテンブス館)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多階層・条件付き統計形状モデルを用いた疾患股関節CT画像からの骨盤・大腿骨領域自動抽出 ~ グラフカットを用いた精密抽出 ~2013

    • Author(s)
      横田 太,岡田 俊之, 高尾 正樹, 菅野 伸彦, 多田 幸生, 富山 憲幸, 佐藤 嘉伸
    • Organizer
      電子情報通信学会信学技報
    • Place of Presentation
      東北大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimization of surgical planning of total hip arthroplasty based on computational anatomy2013

    • Author(s)
      Yoshiyuki Kagiyama and Masaki Takao and Nobuhiko Sugano and Yukio Tada and Noriyuki Tomiyama and Yoshinobu Sato
    • Organizer
      Proceedings of 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC2013)
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] CTベース人工股関節自動手術計画の臨床応用可能なプロトコルの開発と性能評価2013

    • Author(s)
      中西 裕紀,横田 太,鍵山 善之,岡田 俊之,高尾 正樹,菅野 伸彦,多田 幸生,富山 憲幸,佐藤 嘉伸
    • Organizer
      第32回日本医用画像工学会大会
    • Place of Presentation
      東京(産業技術総合研究所臨海副都心センター/日本科学未来館)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 最大事後確率推定に基づく人工股関節手術計画自動立案システム2013

    • Author(s)
      鍵山 善之
    • Organizer
      システム制御情報学会SFA研究分科会第15回研究例会資料
    • Place of Presentation
      大阪府大阪市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 股関節CT画像からの個別筋肉・筋肉群領域の自動抽出 ~ 個別筋肉の辺縁情報に基づく統計予測法の改良 ~2013

    • Author(s)
      高谷 美郁,横田 太,岡田 俊之, 高尾 正樹, 菅野 伸彦, 多田 幸生, 富山 憲幸, 佐藤 嘉伸
    • Organizer
      電子情報通信学会信学技報
    • Place of Presentation
      千葉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Automated CT Segmentation of Diseased Hip Using Hierarchical and Conditional Statistical Shape Models2013

    • Author(s)
      F Yokota, T Okada, M Takao, N Sugano, Y Tada, N Tomiyama, Y Sato
    • Organizer
      Medical Image Computing and Computer-Assisted Intervention MICCAI 2013
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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