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New mechanisms for heat stroke during exercise in the heat and development of the countermeasures

Research Project

Project/Area Number 25242061
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

NISHIYASU Takeshi  筑波大学, 体育系, 教授 (90237751)

Co-Investigator(Kenkyū-buntansha) 林 恵嗣  静岡県立大学短期大学部, 一般教養等, 准教授 (00431677)
本田 靖  筑波大学, 体育系, 教授 (20165616)
近藤 徳彦  神戸大学, 人間発達環境学研究科, 教授 (70215458)
小川 剛司  大阪教育大学, 教育学部, 講師 (70451698)
前田 清司  筑波大学, 体育系, 教授 (30282346)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2014: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords体温調節 / 換気調節 / 運動 / 高体温誘発性換気亢進 / 暑熱耐性 / 間欠的運動 / 体温 / 熱中症 / 体温上昇 / 換気応答 / 安静加温 / 深部体温 / 換気量 / 食道温
Outline of Final Research Achievements

Elevations in body temperature at rest and during exercise lead to increase in ventilation, which can reduce arterial CO2 pressure (PaCO2) and, in turn, cerebral blood flow (CBF) and thermoregulatory response. We investigated 1) whether humans can voluntarily suppress hyperthermic hyperventilation during prolonged exercise and passive heating at rest, and 2) the effects of voluntary breathing control on PaCO2, CBF, sweating and skin blood flow. Our results indicated that during prolonged exercisein the heat and passive heating at rest, humans can voluntarily suppress hyperthermic hyperventilation, and this suppression mitigates changes in PaCO2 and CBF.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 6 results,  Acknowledgement Compliant: 7 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Diurnal variation in the control of ventilation in response to rising body temperature during exercise in the heat.2016

    • Author(s)
      Tsuji B, Honda Y, Kondo N, Nishiyasu T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 311(2) Issue: 2 Pages: R401-R409

    • DOI

      10.1152/ajpregu.00484.2015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maximal workload but not peak oxygen uptake is decreased during immersed incremental exercise at cooler temperatures.2016

    • Author(s)
      Fujimoto T, Sasaki Y, Wakabayashi H, Sengoku Y, Tsubakimoto S, Nishiyasu T
    • Journal Title

      Eur J Appl Physiol.

      Volume: 116(9) Issue: 9 Pages: 1819-27

    • DOI

      10.1007/s00421-016-3438-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of hyperthermia-induced hyperventilation in humans2016

    • Author(s)
      Tsuji B, Hayashi K, Kondo N, Nishiyasu T
    • Journal Title

      Temperature

      Volume: 3 Issue: 1 Pages: 146-160

    • DOI

      10.1080/23328940.2016.1143760

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Influence of forearm muscle metaboreceptors activation on sweating and cutaneous vascular responses during dynamic exercise2016

    • Author(s)
      Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kenny G, Kondo N
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 309 Issue: 11 Pages: 1332-1339

    • DOI

      10.1152/ajpregu.00545.2015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of short-term exercise-heat acclimation on ventilatory and cerebral blood flow responses to passive heating at rest in humans.2015

    • Author(s)
      Fujii N, Tsuji B, Honda Y, Kondo N, Nishiyasu T.
    • Journal Title

      J Appl Physiol

      Volume: 119(5) Issue: 5 Pages: 435-444

    • DOI

      10.1152/japplphysiol.01049.2014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of voluntary hypocapnic hyperventilation on the metabolic response during Wingate anaerobic test.2015

    • Author(s)
      Fujii N, Tsuchiya S, Tsuji B, Watanabe K, Sasaki Y, Nishiyasu T.
    • Journal Title

      European Journal of Applied Physiology.

      Volume: 115(9) Issue: 9 Pages: 1967-1974

    • DOI

      10.1007/s00421-015-3179-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Voluntary suppression of hyperthermia-induced hyperventilation mitigates the reduction in cerebral blood flow velocity during exercise in the heat.2015

    • Author(s)
      Tsuji B, Honda Y, Ikebe Y, Fujii N, Kondo N, Nishiyasu T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 308(12) Issue: 8 Pages: 990-997

    • DOI

      10.1152/ajpregu.00419.2014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypervolemia induced by fluid ingestion at rest: effect of sodium concentration.2014

    • Author(s)
      .Sugihara A, Fujii N, Tsuji B, Watanabe K, Niwa T, Nishiyasu T
    • Journal Title

      Eur J Appl Physiol.

      Volume: 114(10) Issue: 10 Pages: 2139-2145

    • DOI

      10.1007/s00421-014-2933-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of voluntary hypocapnic hyperventilation on the relationship between core temperature and heat loss responses in exercising humans.2014

    • Author(s)
      Fujii N, Honda Y, Komura K, Tsuji B, Sugihara A, Watanabe K, Kondo N, Nishiyasu T.
    • Journal Title

      J Appl Physiol

      Volume: 117(11) Pages: 1317-1324

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans2014

    • Author(s)
      Amano T, Ichinose M, Nishiyasu T, Inoue Y, Koga S, Miwa M, Kondo N
    • Journal Title

      American Journal of Physiology Regulatory, Integrative and Comparative Physiology

      Volume: 306(10) Issue: 10 Pages: 728-734

    • DOI

      10.1152/ajpregu.00515.2013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans2013

    • Author(s)
      1. Fujii N, Ichinose M, Honda Y, Tsuji B, Watanabe K, Kondo N, Nishiyasu T
    • Journal Title

      Eur J Appl Physiol

      Volume: 113 Pages: 51-62

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans2013

    • Author(s)
      Ichinose M, Watanabe K, Fujii N, Kondo N, Nishiyasu T
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 304 Pages: 1568-1575

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of sweating responses and peripheral sweat gland function during passive heating in sprinters2013

    • Author(s)
      Amano T, Koga S, Inoue Y, Nishiyasu T, Kondo N
    • Journal Title

      Eur J Appl Physiol

      Volume: 113 Pages: 2067-2075

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characteristics of heat-induced hyperventilation at rest and during exercise in humans.2016

    • Author(s)
      Takeshi Nishiyasu, Bun Tsuji, Naoto Fujii, Yashushi Honda, Narihiko Kondo.
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      ホテルブエナビスタ(長野県松本市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 暑熱下における高強度間欠的運動時の呼吸代謝応答及びパフォーマンス―ラグビーの競技特性に着目して―2016

    • Author(s)
      奥山 道陽、藤本 知臣、渡辺 和仁、辻 文、西保 岳
    • Organizer
      第71回 日本体力医学会大会
    • Place of Presentation
      マリオス(盛岡市民文化ホール)(岩手県盛岡市)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 冷気吸入が暑熱下運動時における深部体温、換気及び脳血流反応に及ぼす影響2016

    • Author(s)
      辻 文、鎭田 頼宣、本田 靖、近藤 徳彦、西保 岳
    • Organizer
      第71回 日本体力医学会大会
    • Place of Presentation
      マリオス(盛岡市民文化ホール)(岩手県盛岡市)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動に対する循環反応の個人差に関する研究:筋代謝受容器反射と動脈圧受容器反射の関与2014

    • Author(s)
      辻 文、Davide Filingeri、本田 靖、江口 翼、藤井 直人、近藤 徳彦、西保 岳
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 局所発汗量と皮膚コンダクタンス関係から汗腺の塩分再吸収能力を評価する試み2014

    • Author(s)
      天野達郎、井上芳光、西保 岳、近藤徳彦
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖電解質飲料摂取が換気亢進時の脳血流量および呼吸代謝反応に及ぼす影響2014

    • Author(s)
      杉原 輝、辻 文、西保 岳
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of CO2 on ventilatory and cerebrovascular responses during passive heating in humans2014

    • Author(s)
      Tsuji B, Davide F, Fujii N, Hayashi K, Eguchi T, Kondo N, Nishiyasu T
    • Organizer
      19th annual congress of the european college of sport science
    • Place of Presentation
      アムステルダム、オランダ
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characteristics of heat-induced hyperventilation in humans: implications for SBC?,Therapeutic Cranial Cooling and Selective Brain Cooling in Humans

    • Author(s)
      Takeshi Nishiyasu
    • Organizer
      2013 Experimental Biology
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒトの体温上昇時に見られる過換気反応

    • Author(s)
      辻 文、本田 靖、藤井直人、林 恵嗣、近藤徳彦、西保 岳
    • Organizer
      27回運動と体温の研究会
    • Place of Presentation
      立教大学池袋キャンパス(東京都豊島区)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-15   Modified: 2019-07-29  

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