Elucidation of performance-associated functional polymorphisms in sprinters and endurance runners in the world and Japan
Project/Area Number |
25242062
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Sports science
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Tanaka Masashi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60155166)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2013: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
|
Keywords | 運動能力 / 持久力 / 瞬発力 / 有酸素運動能力 / 無酸素運動能力 / 全ゲノム領域関連解析 / 全ゲノム塩基配列決定 / 全ゲノム領域塩基配列 / アスリート / 遺伝子多型 / 全エクソン領域解析 / 全ゲノム領域解析 |
Outline of Final Research Achievements |
We analyzed 240K functional SNPs in 4150 Japanese controls by use of HumanExome BeadChip. We also analyzed functional SNPs in 93 Jamaican sprinters and 306 controls as well as 112 American sprinters and 200 controls after whole genome amplification (WGA). The genotyping error rates were markedly high for the samples after WGA. Therefore, we selected 8 Ethiopian and 8 Kenyan endurance runners, re-extracted DNA from their buccal swab samples, and started whole genome re-sequencing analysis.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Identification of EGFLAM, SPATC1L, and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
Int J Mol Med
Volume: 39
Issue: 5
Pages: 1091-1100
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of STXBP2 as a novel susceptibility locus for myocardial infarction in Japanese individuals by an exome-wide association study2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
Oncotarget
Volume: 印刷中
Issue: 20
Pages: 33527-33535
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese individuals by exome-wide association studies2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
Oncotarget
Volume: 印刷中
Issue: 28
Pages: 45259-45273
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
Oncotarget
Volume: 印刷中
Issue: 24
Pages: 39296-39308
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
Int J Mol Med
Volume: 39
Issue: 6
Pages: 1477-1491
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
Oncotarget
Volume: 印刷中
Issue: 24
Pages: 38950-38961
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of TNFSF13, SPATC1L, SLC22A25, and SALL4 as novel susceptibility loci for atrial fibrillation by an exome-wide association study2017
Author(s)
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer2017
Author(s)
Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi, Masafumi Ito
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Journal Title
BMC Cancer
Volume: 316
Issue: 1
Pages: 316-316
DOI
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Peer Reviewed / Open Access
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[Journal Article] A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese2015
Author(s)
Zhou H, Mori S, Tanaka M, Sawabe M, Arai T, Muramatsu M, Mieno MN, Shinkai S, Yamada Y, Miyachi M, Murakami H, Sanada K, Ito H.
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Journal Title
Journal of Bone and Mineral Metabolism.
Volume: ‐
Issue: 6
Pages: 694-700
DOI
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Peer Reviewed / Open Access
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[Journal Article] Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.2015
Author(s)
Yatsuga S, Fujita Y, Ishii A, Fukumoto Y, Arahata H, Kakuma T, Kojima T, Ito M, Tanaka M, Saiki R, Koga Y.
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Journal Title
Ann Neurol
Volume: 78
Issue: 5
Pages: 814-823
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population2015
Author(s)
Heying Zhou, Seijiro Mori, Masashi Tanaka, Motoji Sawabe, Tomio Arai, Masaaki Muramatsu, Makiko Naka Mieno, Shoji Shinkai, Yoshiji Yamada, Motohiko Miyachi, Haruka Murakami, Kiyoshi Sanada, Hideki Ito
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Journal Title
Journal of Bone and Mineral Metabolism
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] ACTN3 R577X genotype is associated with sprinting in elite Japanese a thletes.2014
Author(s)
Mikami E, Fuku N, Murakami H, Tsuchie H, Takahashi H, Ohiwa N, Tanaka H, Pitsiladis YP, Higuchi M, Miyachi M, Kawahara T. Tanaka M.
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Journal Title
International Journal of Sports Medicine
Volume: 35
Issue: 02
Pages: 172-177
DOI
Related Report
Peer Reviewed
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[Journal Article] New genetic MT-ND6 and NDUFA1mutations in Mitochondrial Respiratory Chain Disorders.2014
Author(s)
Uehara N, Mori M, Tokuzawa Y, Mizuno Y, Tamaru S, Kohda M, Moriyama Y, Nakachi Y, Matoba N, Yamazaki T, Harashima H, Murayama K, Hattori K, Hayashi J, Yamagata T, Fujita Y, Ito M, Tanaka M, Nibu K, Ohtake A, Okazaki Y.
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Journal Title
Annals of Clinical and Translational Neurology
Volume: 1
Issue: 5
Pages: 361-369
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Peer Reviewed / Open Access
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[Journal Article] Comprehensive analysis of common and rare mitochondrial DNA variants in elite Japanese athletes : a case-control study.2013
Author(s)
Mikami E, Fuku N, Kong QP, Takahashi H, Ohiwa N, Murakami H, Miyachi M, Higuchi M, Tanaka M, Pitsiladis YP, Kawahara T.
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Journal Title
Journal of Human Genetics
Volume: 58
Issue: 12
Pages: 780-787
DOI
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Peer Reviewed
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[Journal Article] Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases2013
Author(s)
Zhou H, Mori S, Kou I, Fuku N, Naka Mieno M, Honma N, Arai T, Sawabe M, Tanaka M, Ikegawa S, Ito H
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Journal Title
J Hum Genet
Volume: 58
Issue: 2
Pages: 109-12
DOI
NAID
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Peer Reviewed
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013
Author(s)
Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
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Journal Title
BMC Genomics.
Volume: 14(1):
Issue: 1
Pages: 248-248
DOI
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Peer Reviewed / Open Access
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