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Elucidation of performance-associated functional polymorphisms in sprinters and endurance runners in the world and Japan

Research Project

Project/Area Number 25242062
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Tanaka Masashi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60155166)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2013: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Keywords運動能力 / 持久力 / 瞬発力 / 有酸素運動能力 / 無酸素運動能力 / 全ゲノム領域関連解析 / 全ゲノム塩基配列決定 / 全ゲノム領域塩基配列 / アスリート / 遺伝子多型 / 全エクソン領域解析 / 全ゲノム領域解析
Outline of Final Research Achievements

We analyzed 240K functional SNPs in 4150 Japanese controls by use of HumanExome BeadChip. We also analyzed functional SNPs in 93 Jamaican sprinters and 306 controls as well as 112 American sprinters and 200 controls after whole genome amplification (WGA). The genotyping error rates were markedly high for the samples after WGA. Therefore, we selected 8 Ethiopian and 8 Kenyan endurance runners, re-extracted DNA from their buccal swab samples, and started whole genome re-sequencing analysis.

Report

(4 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (42 results)

All 2017 2016 2015 2014 2013

All Journal Article (39 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 38 results,  Open Access: 29 results,  Acknowledgement Compliant: 24 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Identification of EGFLAM, SPATC1L, and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Int J Mol Med

      Volume: 39 Issue: 5 Pages: 1091-1100

    • DOI

      10.3892/ijmm.2017.2927

    • NAID

      120007129065

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of STXBP2 as a novel susceptibility locus for myocardial infarction in Japanese individuals by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 20 Pages: 33527-33535

    • DOI

      10.18632/oncotarget.16536

    • NAID

      120007129044

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese individuals by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 28 Pages: 45259-45273

    • DOI

      10.18632/oncotarget.16696

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 24 Pages: 39296-39308

    • DOI

      10.18632/oncotarget.16945

    • NAID

      120007128952

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Int J Mol Med

      Volume: 39 Issue: 6 Pages: 1477-1491

    • DOI

      10.3892/ijmm.2017.2972

    • NAID

      120007129063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中

    • NAID

      120007128873

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 24 Pages: 38950-38961

    • DOI

      10.18632/oncotarget.17159

    • NAID

      120007128954

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of TNFSF13, SPATC1L, SLC22A25, and SALL4 as novel susceptibility loci for atrial fibrillation by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Mol Med Rep

      Volume: 印刷中

    • NAID

      120007128795

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of macrophage capping protein (CAPG) Arg335His polymorphism and cancer susceptibility in the elderly2017

    • Author(s)
      Sariya Dechamethakun, Noriko Sato, Shinobu Ikeda, Motoji Sawabe, Seijiro Mori, Yoshiji Yamada, Masashi Tanaka, Masaaki Muramatsu, Tomio Arai
    • Journal Title

      J Gerontol Geriatr Res

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer2017

    • Author(s)
      Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi, Masafumi Ito
    • Journal Title

      BMC Cancer

      Volume: 316 Issue: 1 Pages: 316-316

    • DOI

      10.1186/s12885-017-3301-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 健康長寿ゲノム探索研究と超高齢者疾患の遺伝学的解析 ―長寿あるいは運動能力に関連するゲノム多型―2017

    • Author(s)
      田中雅嗣
    • Journal Title

      肝胆膵

      Volume: 73 Pages: 341-347

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Association of non-synonymous variants in WIPF3 and LIPA genes with abdominal aortic aneurysm: an autopsy study2016

    • Author(s)
      Yuko Maeda, Noriko Sato, Makiko Naka-Mieno, Seijiro Mori, Tomio Arai, Masashi Tanaka, Masaaki Muramatsu, Motoji Sawabe
    • Journal Title

      J Geriatr Cardiol

      Volume: 13 Pages: 960-967

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated with Extreme Longevity in East Asian Populations2016

    • Author(s)
      Kumpei Tanisawa, Masashi Tanaka, et al.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: 00 Pages: 1-10

    • DOI

      10.1093/gerona/glw074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] STED super-resolution imaging of mitochondria labeled with TMRM in living cells2016

    • Author(s)
      Masaya Ishigaki, Masumi Iketani, Maki Sugaya, Mayumi Takahashi, Masashi Tanaka, Seisuke Hattori, Ikuroh Ohsawa
    • Journal Title

      Mitochondrion

      Volume: 28 Pages: 79-87

    • DOI

      10.1016/j.mito.2016.03.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Advancing sports and exercise genomics: moving from hypothesis-driven single study approaches to large multi-omics collaborative science2016

    • Author(s)
      Masashi Tanaka, Guan Wang, Yannis P. Pitsiladis
    • Journal Title

      Physiol Genomics

      Volume: 48 Issue: 3 Pages: 173-174

    • DOI

      10.1152/physiolgenomics.00009.2016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Athlome Project Consortium: a concerted effort to discover genomic and other “omic” markers of athletic performance2016

    • Author(s)
      Yannis P. Pitsiladis, Masashi Tanaka, et al.
    • Journal Title

      Physiol Genomics

      Volume: 48 Issue: 3 Pages: 183-190

    • DOI

      10.1152/physiolgenomics.00105.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gene-exercise interactions in the development of cardiometabolic diseases2016

    • Author(s)
      Kumpei Tanisawa, Masashi Tanaka, Mitsuru Higuchi
    • Journal Title

      Phys Fitness Sports Med

      Volume: 5 Pages: 001-012

    • NAID

      130005138387

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders2016

    • Author(s)
      Yasunori Fujita, Yu Taniguchi, Shoji Shinkai, Masashi Tanaka, Masafumi Ito
    • Journal Title

      Geriatr Gerontol Int

      Volume: 16 (Suppl. 1) Issue: S1 Pages: 17-29

    • DOI

      10.1111/ggi.12724

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] (2014) GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases2015

    • Author(s)
      Yasunori Fujita, Masafumi Ito, Toshio Kojima, Shuichi Yatsuga, Yasutoshi Koga, Masashi Tanaka
    • Journal Title

      Mitochondrion

      Volume: 20 Pages: 34-42

    • DOI

      10.1016/j.mito.2014.10.006

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese2015

    • Author(s)
      Zhou H, Mori S, Tanaka M, Sawabe M, Arai T, Muramatsu M, Mieno MN, Shinkai S, Yamada Y, Miyachi M, Murakami H, Sanada K, Ito H.
    • Journal Title

      Journal of Bone and Mineral Metabolism.

      Volume: ‐ Issue: 6 Pages: 694-700

    • DOI

      10.1007/s00774-014-0636-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking2015

    • Author(s)
      Miki Yamada, Noriko Sato, Shinobu Ikeda, Tomio Arai, Motoji Sawabe, Seijiro Mori, Yoshiji Yamada, Masaaki Muramatsu, Masashi Tanaka
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 54 Issue: 2 Pages: 122-128

    • DOI

      10.1002/gcc.22227

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.2015

    • Author(s)
      Honda Y, Araki Y, Hata T, Ichihara K, Ito M, Tanaka M, Honda S.
    • Journal Title

      Journal Aging Research

      Volume: 2015 Pages: 425261-425261

    • DOI

      10.1155/2015/425261

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.2015

    • Author(s)
      Nishizawa D et al.
    • Journal Title

      Mol Brain.

      Volume: 8 Issue: 1 Pages: 50-50

    • DOI

      10.1186/s13041-015-0142-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.2015

    • Author(s)
      Yatsuga S, Fujita Y, Ishii A, Fukumoto Y, Arahata H, Kakuma T, Kojima T, Ito M, Tanaka M, Saiki R, Koga Y.
    • Journal Title

      Ann Neurol

      Volume: 78 Issue: 5 Pages: 814-823

    • DOI

      10.1002/ana.24506

    • NAID

      120007135881

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolution of mitochondrial power in vertebrate metazoans2015

    • Author(s)
      Yasuhiro Kitazoe, Masashi Tanaka
    • Journal Title

      PloS One

      Volume: 9 Issue: 6 Pages: e98188-e98188

    • DOI

      10.1371/journal.pone.0098188

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population2015

    • Author(s)
      Heying Zhou, Seijiro Mori, Masashi Tanaka, Motoji Sawabe, Tomio Arai, Masaaki Muramatsu, Makiko Naka Mieno, Shoji Shinkai, Yoshiji Yamada, Motohiko Miyachi, Haruka Murakami, Kiyoshi Sanada, Hideki Ito
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Polygenic risk for hypertriglyceridemia is attenuated in high-fitness men.2014

    • Author(s)
      Tanisawa K, Ito T, Sun XM, Cao ZB, Sakamoto S, Tanaka M, Higuchi M.
    • Journal Title

      Physiol Genomics.

      Volume: 46 Issue: 6 Pages: 207-215

    • DOI

      10.1152/physiolgenomics.00182.2013

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese Men2014

    • Author(s)
      Kunpei Tanisawa, Tomoko Ito, Xiaomin Sun, Ryuken Ise, Satomi Oshima, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
    • Journal Title

      Physiol Genomics

      Volume: 46 Issue: 14 Pages: 497-504

    • DOI

      10.1152/physiolgenomics.00027.2014

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity2014

    • Author(s)
      Tanisawa K, Ito T, Sun X, Ise R, Oshima S, Cao ZB, Sakamoto S, Tanaka M, Higuchi M.
    • Journal Title

      Genes & Nutrition

      Volume: 9(5) Issue: 5 Pages: 416-416

    • DOI

      10.1007/s12263-014-0416-4

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ACTN3 R577X genotype is associated with sprinting in elite Japanese a thletes.2014

    • Author(s)
      Mikami E, Fuku N, Murakami H, Tsuchie H, Takahashi H, Ohiwa N, Tanaka H, Pitsiladis YP, Higuchi M, Miyachi M, Kawahara T. Tanaka M.
    • Journal Title

      International Journal of Sports Medicine

      Volume: 35 Issue: 02 Pages: 172-177

    • DOI

      10.1055/s-0033-1347171

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New genetic MT-ND6 and NDUFA1mutations in Mitochondrial Respiratory Chain Disorders.2014

    • Author(s)
      Uehara N, Mori M, Tokuzawa Y, Mizuno Y, Tamaru S, Kohda M, Moriyama Y, Nakachi Y, Matoba N, Yamazaki T, Harashima H, Murayama K, Hattori K, Hayashi J, Yamagata T, Fujita Y, Ito M, Tanaka M, Nibu K, Ohtake A, Okazaki Y.
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 1 Issue: 5 Pages: 361-369

    • DOI

      10.1002/acn3.59

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study.2014

    • Author(s)
      Fujii T, Nozaki F, Saito K, Hayashi A, Nishigaki Y, Murayama K, Tanaka M, Koga Y, Hiejima I, Kumada T.
    • Journal Title

      Mol Genet Metab

      Volume: 112 Issue: 2 Pages: 133-138

    • DOI

      10.1016/j.ymgme.2014.04.008

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 7501 T>A mitochondrial DNA variant in a patient with glomerulosclerosis2014

    • Author(s)
      Imasawa T (corresponding author), Tanaka M, Yamaguchi Y, Nakazato T, Kitamura H, Nishimura M.
    • Journal Title

      Ren Fail

      Volume: 36 Issue: 9 Pages: 1461-1465

    • DOI

      10.3109/0886022x.2014.945181

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy2014

    • Author(s)
      Imasawa T (corresponding author), Tanaka M, Maruyama N, Kawaguchi T, Yamaguchi Y, Rossignol R, Kitamura H, Nishimura M
    • Journal Title

      Diagn Pathol

      Volume: 9 Issue: 1 Pages: 181-181

    • DOI

      10.1186/s13000-014-0181-0

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive analysis of common and rare mitochondrial DNA variants in elite Japanese athletes : a case-control study.2013

    • Author(s)
      Mikami E, Fuku N, Kong QP, Takahashi H, Ohiwa N, Murakami H, Miyachi M, Higuchi M, Tanaka M, Pitsiladis YP, Kawahara T.
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Issue: 12 Pages: 780-787

    • DOI

      10.1038/jhg.2013.102

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status2013

    • Author(s)
      Noriyuki Fuku, Eri Mikami, Masashi Tanaka
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 2 Issue: 1 Pages: 17-27

    • DOI

      10.7600/jpfsm.2.17

    • NAID

      10031159013

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases2013

    • Author(s)
      Zhou H, Mori S, Kou I, Fuku N, Naka Mieno M, Honma N, Arai T, Sawabe M, Tanaka M, Ikegawa S, Ito H
    • Journal Title

      J Hum Genet

      Volume: 58 Issue: 2 Pages: 109-12

    • DOI

      10.1038/jhg.2012.145

    • NAID

      10031156433

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers2013

    • Author(s)
      Guan Wang
    • Journal Title

      Med Sci Sports Exerc

      Volume: 45 Issue: 5 Pages: 892-900

    • DOI

      10.1249/mss.0b013e31827c501f

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013

    • Author(s)
      Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
    • Journal Title

      BMC Genomics.

      Volume: 14(1): Issue: 1 Pages: 248-248

    • DOI

      10.1186/1471-2164-14-248

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The 1000 Athlomes Project: An Initiative for Whole Genome Sequencing of Elite Athletes2016

    • Author(s)
      Masashi Tanaka
    • Organizer
      International Federation of Sports Medicine 34th WORLD CONGRESS OF SPORTS MEDICINE
    • Place of Presentation
      Ljubljana, Slovenia
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The 1000 Athlomes Project: An Initiative for Whole Genome Sequencing of Elite Athletes2016

    • Author(s)
      Masashi Tanaka
    • Organizer
      ICSEMIS 2016 (International Council of Sport Science and Physical Education)
    • Place of Presentation
      Santos, Brazil
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] テキスト健康科学 「遺伝と健康」2017

    • Author(s)
      田中雅嗣
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-15   Modified: 2018-03-22  

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