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Hydrogel-Based Conducting Polymer Electrode for Efficient Stimulation of Cells

Research Project

Project/Area Number 25246016
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Nano/Microsystems
Research InstitutionTohoku University

Principal Investigator

Nishizawa Matsuhiko  東北大学, 工学研究科, 教授 (20273592)

Co-Investigator(Kenkyū-buntansha) 鳥光 慶一  東北大学, 工学研究科, 特任教授 (00393728)
長峯 邦明  東北大学, 工学研究科, 助教 (00551540)
Co-Investigator(Renkei-kenkyūsha) KANZAKI Makoto  東北大学, 医工学研究科, 准教授 (10272262)
YAMAZAKI Kenshi  東北大学, 医学系研究科, 准教授 (40294798)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2016: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2015: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2014: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywordsハイドロゲル / 電極 / 生体親和性 / 生体電極 / 神経電極 / 導電性高分子
Outline of Final Research Achievements

We have succeeded in developing a technique to laminate the composite of conducting polymer PEDOT and polyurethan (PEDOT-PU) onto hydrogel substrates by the novel interfacial photo-initiated radical polymerization of the polymer of adhesion layer. This technique enable the lamination of even the insulated PEDOT-PU electrodes, improving the accuracy and sensitivity on the medical use. In addition the possible function of self-immobilization to organs was demonstrated by using the PEDOT-PU-laminated hydrogel devices. As an example, the the expansion force of the gel substrate showed self-fixing to the gaps of brain. The curling force of the gel sheet showed self-wrapping to a neuronal bundle.

Report

(5 results)
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (17 results)

All 2018 2017 2016 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Contractile Skeletal Muscle Cells Cultured with a Conducting Soft Wire for Effective, Selective Stimulation2018

    • Author(s)
      Kuniaki Nagamine, Hirotaka Sato, Hiroyuki Kai, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2253-2253

    • DOI

      10.1038/s41598-018-20729-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Portable Micropatterns of Neuronal Cells Supported by Thin Hydrogel Films2015

    • Author(s)
      K. Nagamine et al.
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 1 Issue: 5 Pages: 329-334

    • DOI

      10.1021/acsbiomaterials.5b00020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Highly Stretchable Cell-Cultured Hydrogel Sheet2015

    • Author(s)
      K. Nagamine et al.
    • Journal Title

      RSC Advances

      Volume: 5 Issue: 81 Pages: 66334-66338

    • DOI

      10.1039/c5ra11059a

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stretchable Biofuel Cell with Enzyme-Modified Conductive Textiles2015

    • Author(s)
      Y. Ogawa et al.
    • Journal Title

      Biosensor and bioelectronics

      Volume: 74 Pages: 947-852

    • DOI

      10.1016/j.bios.2015.07.063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering2014

    • Author(s)
      Masato Sasaki, Bijoy Chandapillai Karikkineth, Kuniaki Nagamine, Hirokazu Kaji, Keiichi Torimitsu, and Matsuhiko Nishizawa
    • Journal Title

      Advanced Healthcare Materials

      Volume: 3 Issue: 11 Pages: 1919-1927

    • DOI

      10.1002/adhm.201400209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hydrogel-based bioassay sheets for in vitro evaluation of contraction-dependent metabolic regulation in skeletal muscle cells2014

    • Author(s)
      Kuniaki Nagamine, Kohei Okamoto, Shingo Otani, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa
    • Journal Title

      Biomater. Sci.

      Volume: 2 Issue: 2 Pages: 252-256

    • DOI

      10.1039/c3bm60179j

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroporation of Adherent Cells by Direct Lamination of Hydrogel-Based Microelectrode Substrates2014

    • Author(s)
      Daisuke Takahashi, Masato Sasaki, Kuniaki Nagamine, Keiichi Torimitsu, and Matsuhiko Nishizawa
    • Journal Title

      Chemistry Letters

      Volume: 43 Issue: 4 Pages: 444-446

    • DOI

      10.1246/cl.131083

    • NAID

      130004868056

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices2014

    • Author(s)
      Kuniaki Nagamine, Kohei Okamoto, Hirokazu Kaji, Matsuhiko Nishizawa
    • Journal Title

      J. Biosci. Bioeng.

      Volume: (in press) Issue: 1 Pages: 94-97

    • DOI

      10.1016/j.jbiosc.2013.12.024

    • NAID

      110009838776

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Biocompatible Moist Microelectrode Systems2017

    • Author(s)
      Matsuhiko Nishizawa
    • Organizer
      International Conference on Flow Dynamics
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Moist Electronic Devices with High Affinity to Living Systems2014

    • Author(s)
      M. Nishizawa
    • Organizer
      EMNT2014
    • Place of Presentation
      沖縄 コンベンションセンター
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Hydrogel-Based Stretchable Electrodes for Stimulation of Cells and Tissues2014

    • Author(s)
      M. Nishizawa
    • Organizer
      2014MRS Spring Meeting
    • Place of Presentation
      米国 San Fransico
    • Year and Date
      2014-04-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hydrogel-Based Contractile Electrodes for Stimulation of Cells and Tissues2013

    • Author(s)
      Matsuhiko Nishizawa
    • Organizer
      IEEE EMBC’13
    • Place of Presentation
      Osaka
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生体親和性パッチ型医療デバイス開発の提案2013

    • Author(s)
      西澤松彦
    • Organizer
      第4回次世代医療システム産業化フォーラム2013
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生体親和ウェットエレクトロニクスに向けたバイオ発電・ゲル電極の開発2013

    • Author(s)
      西澤松彦
    • Organizer
      プリンタブルデバイス実装研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Electrochemistry-Based Smart Biodevices2016

    • Author(s)
      Matsuhiko Nishizawa
    • Total Pages
      21
    • Publisher
      Springer
    • ISBN
      9784431564294
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 複合材料、複合材料の製造方法2015

    • Inventor(s)
      西澤松彦、長峯邦明
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-30
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体組織貼付用パッチ2014

    • Inventor(s)
      西澤松彦、三宅丈雄、新本由紀子、紺野義一、阿部茜
    • Industrial Property Rights Holder
      西澤松彦、三宅丈雄、新本由紀子、紺野義一、阿部茜
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-070039
    • Filing Date
      2014-03-28
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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