Physics of development from molecular assembly to protocell
| Project/Area Number |
25247070
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Tohoku University |
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Principal Investigator |
Imai Masayuki 東北大学, 理学(系)研究科(研究院), 教授 (60251485)
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| Co-Investigator(Kenkyū-buntansha) |
SAKUMA Yuka 東北大学, 大学院理学研究科, 助教 (40630801)
URAKAMI Naohito 山口大学, 理工学研究科, 准教授 (50314795)
SUZUKI Kentaro 神奈川大学, 理学部, 外部資金雇用研究者 (60512324)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2015: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2014: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2013: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Keywords | プロトセル / ベシクル / 化学刺激 / 膜分子合成 / 分子シミュレーション |
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| Outline of Final Research Achievements |
in this research we have investigated vesicle dynamics triggered by chemical stimuli, which might be the first step of the evolution from vesicles to cellular life. By applying chemical stimuli, vesicles show unique dynamics, such as migration, deformations, relevant to biological functions. We revealed that chemical modifications of the surface tension and molecular cross section are responsible for the observed vesicle dynamics. In addition we succeeded to synthesize a new artificial lipid precursor molecule, which is hydrolyzed to produce the membrane molecule at the membrane surface. The membrane molecules are incorporated into the vesicle membrane and causes the vesicle growth.The growing vesicle produces offspring vesicles by division. The vesicle division process was investigated by a molecular dynamics simulation. the simulation revealed that the coupling of molecular shape and vesicle shape plays an important role in the vesicle division.
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Report
(4 results)
Research Products
(109 results)
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[Presentation] 多細胞モデルの形態形成2015
Author(s)
河野拓馬・海老原隆太・佐久間由香・今井正幸・Primoz Ziherl
Organizer
第５回ソフトマター研究会, 東北大学, 2015年12月17～19日
Place of Presentation
東北大学, 宮城県仙台市
Year and Date
2015-12-17
Related Report
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[Presentation] 化学刺激によるリン脂質ベシクルの駆動2015
Author(s)
兒玉篤治, 佐久間由香, 今井正幸, 大矢豊大, 川勝年洋, Nicolas Puff, Miglena I. Angelova
Organizer
日本物理学会2015年秋大会
Place of Presentation
関西大学, 大阪府吹田市
Year and Date
2015-09-16
Related Report
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[Presentation] A key for self-reproduction of vesicles2015
Author(s)
T. Jimbo, Y. Sakuma, P. Ziherl, N. Urakami, and M. Imai
Organizer
International Symposium on Fluctuation and Structure out of Equilibrium 2015, (2015. 8. 20-23)
Place of Presentation
Kyoto university, Kyoto, Kyoto, Japan
Year and Date
2015-08-20
Related Report
Int'l Joint Research
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[Presentation] Sustainability of Recursive Vesicle-based Protocell2015
Author(s)
Tadashi Sugawara, Kensuke Kurihara, Muneyuki Matsuo, Taro Toyota, and Kentaro Suzuki
Organizer
International Symposium on Fluctuation and Structure out of Equilibrium 2015
Place of Presentation
Kyoto university, Kyoto, Kyoto, Japan
Year and Date
2015-08-20
Related Report
Int'l Joint Research
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[Presentation] Construction of Photo-sensitive GV in GV2015
Author(s)
Kentaro Suzuki, Kotaro Machida, Kazuo Yamaguchi, and Tadashi Sugawara
Organizer
International Symposium on Fluctuation and Structure out of Equilibrium 2015
Place of Presentation
Kyoto university, Kyoto, Kyoto, Japan
Year and Date
2015-08-20
Related Report
Int'l Joint Research
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[Presentation] リン脂質ベシクルの化学駆動2015
Author(s)
兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova
Organizer
新学術領域「ゆらぎと構造の協奏」研究会「アクティブ・マター研究の過去・現在・未来」
Place of Presentation
東北大学、仙台
Year and Date
2015-03-14 – 2015-03-15
Related Report
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[Presentation] リン脂質ベシクルの化学駆動とそれに伴う変形と破裂2015
Author(s)
兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova
Organizer
第4回ソフトマター研究会
Place of Presentation
名古屋大学、名古屋
Year and Date
2015-01-06 – 2015-01-08
Related Report
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[Presentation] Constructive Approach towards a Vesicle-based Protcell2014
Author(s)
T. Sugawara, M. Matsuo, K. Kurihara, T. Toyota, K. Suzuki
Organizer
Origins2014, 2nd ISSOL – The International Astrobiology Society and Bioastronomy (IAU C51) Joint International Conference
Place of Presentation
Nara-ken New Public Hall, Nara
Year and Date
2014-07-06 – 2014-07-11
Related Report
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[Presentation] Chemophoresis of Vesicle
Author(s)
A. Kodama, Y. Sakuma, M. Imai, T. Kawakatsu, N. Puff and M. I. Angelova
Organizer
Workshop on Cross Correlation & Transport Phenomena in Soft Matter
Place of Presentation
Tokyo, Japan
Related Report
Invited
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