| Project/Area Number |
25247070
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Tohoku University |
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Principal Investigator |
Imai Masayuki 東北大学, 理学(系)研究科(研究院), 教授 (60251485)
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| Co-Investigator(Kenkyū-buntansha) |
SAKUMA Yuka 東北大学, 大学院理学研究科, 助教 (40630801)
URAKAMI Naohito 山口大学, 理工学研究科, 准教授 (50314795)
SUZUKI Kentaro 神奈川大学, 理学部, 外部資金雇用研究者 (60512324)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2015: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2014: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2013: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Keywords | プロトセル / ベシクル / 化学刺激 / 膜分子合成 / 分子シミュレーション |
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| Outline of Final Research Achievements |
in this research we have investigated vesicle dynamics triggered by chemical stimuli, which might be the first step of the evolution from vesicles to cellular life. By applying chemical stimuli, vesicles show unique dynamics, such as migration, deformations, relevant to biological functions. We revealed that chemical modifications of the surface tension and molecular cross section are responsible for the observed vesicle dynamics. In addition we succeeded to synthesize a new artificial lipid precursor molecule, which is hydrolyzed to produce the membrane molecule at the membrane surface. The membrane molecules are incorporated into the vesicle membrane and causes the vesicle growth.The growing vesicle produces offspring vesicles by division. The vesicle division process was investigated by a molecular dynamics simulation. the simulation revealed that the coupling of molecular shape and vesicle shape plays an important role in the vesicle division.
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