Innovative electrochemical imaging device for bioanalysis
Project/Area Number |
25248032
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Analytical chemistry
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Research Institution | Tohoku University |
Principal Investigator |
Matsue Tomokazu 東北大学, 原子分子材料科学高等研究機構, 教授 (70173797)
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Co-Investigator(Kenkyū-buntansha) |
INO KOSUKE 東北大学, 大学院環境科学研究科, 助教 (00509739)
TAKAHASHI YASUFUMI 東北大学, 原子分子材料科学高等研究機構, 助教 (90624841)
RAMON JAVIER 東北大学, 原子分子材料科学高等研究機構, 助教 (50613270)
SHIKU HITOSHI 東北大学, 大学院環境科学研究科, 准教授 (10361164)
INOUE KUMI 東北大学, 大学院環境科学研究科, 講師 (20597249)
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Project Period (FY) |
2013-05-31 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2014: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2013: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
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Keywords | 電気化学イメージング / バイオ分析 / バイオMEMS / 生体分子 / マイクロ・ナノ化学 / 細胞機能解析 / 微小電極アレイ |
Outline of Final Research Achievements |
In the present study, we have developed two-types of electrochemical devices for bioimaging. One was a bio-LSI device which was based on large-scale integrated (LSI) circuits dedicated to bioanalysis. The other was a local redox cycling-based electrochemical (LRC-EC) device utilizing local redox cycling. The device consisted of many switching sensors incorporated into a small chip device to detect electrochemical responses. These bioimaging devices were successfully applied for evaluation of oxygen consumption and secreted chemicals from cells, and cell differentiation.
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Report
(4 results)
Research Products
(240 results)
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[Journal Article] Potentiometric bioimaging with a large-scale integration (LSI)-based electrochemical device for detection of enzyme activity2016
Author(s)
Kanno Y, Ino K, Sakamoto C, Inoue KY, Matsudaira M, Suda A, Kunikata R, Ishikawa T, Abe H, Shiku H, Matsue T
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Journal Title
Biosens. Bioelectron.
Volume: 77
Pages: 709-714
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Electrochemical imaging of dopamine release from three-dimensional-cultured PC12 cells using LSI-based amperometric sensors2015
Author(s)
Abe H, Ino K, Li CZ, Kanno Y, Inoue KY, Suda A, Kunikata R, Matsudaira M, Takahashi Y, Shiku H, Matsue T
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Journal Title
Anal. Chem.
Volume: 87
Issue: 12
Pages: 6364-6370
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Feedback mode-based electrochemical imaging of conductivity and topography for large substrate surfaces using an LSI-based amperometric chip device with 400 sensors2015
Author(s)
Kanno Y, Ino K, Inoue KY, Sen M, Suda A, Kunikata R, Matsudaira M, Abe H, Li CZ, Shiku H, Matsue T
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Journal Title
J. Electroanal. Chem.
Volume: 741
Pages: 109-113
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Advanced LSI-based amperometric sensor array with light-shielding structure for effective removal of photocurrent and mode selectable function for individual operation of 400 electrodes2015
Author(s)
Inoue KY, Matsudaira M, Nakano M, Ino K, Sakamoto C, Kanno Y, Kubo R, Kunikata R, Kira A, Suda A, Tsurumi R, Shioya T, Yoshida S, Muroyama M, Ishikawa T, Shiku H, Satoh S, Esashi M, Matsue T
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Journal Title
Lab Chip
Volume: 15
Issue: 3
Pages: 848-56
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Nanoscale visualization of redox activity at lithium-ion battery cathodes2014
Author(s)
Takahashi Y, Kumatani A, Munakata H, Inomata H, Ito K, Ino K, Shiku H, Unwin PR, Korchev YE, Kanamura K, Matsue T
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Journal Title
Nat. Commun.
Volume: 5
Issue: 1
Pages: 5450-5450
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation of the Differentiation Status of Single Embryonic Stem Cells Using Scanning Electrochemical Microscopy2013
Author(s)
Matsumae, Y., Arai, T., Takahashi, Y., Ino, K., Shiku, H. & Matsue, T.
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Journal Title
Chemical Communications
Volume: 49
Issue: 58
Pages: 6498-6500
DOI
Related Report
Peer Reviewed
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[Presentation] LSI-BASED AMPEROMETRIC DEVICE FOR ELECTROCHEMICAL IMAGING OF DRUG EFFECT ON DOPAMINE RELEASE FROM THREE-DIMENSIONAL CULTURED PC12 CELLS2015
Author(s)
Hiroya Abe, Kosuke Ino, Chen-zhong Li, Yusuke Kanno, Kumi Y. Inoue, Ryota Kunikata, Atsushi Suda, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue
Organizer
The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of Presentation
Gyeongju-si (Korea)
Year and Date
2015-10-25
Related Report
Int'l Joint Research
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[Presentation] Dopamine Detection from Three-Dimensinal Cultured PC12 Cells Using an LSI-Based Electrochemical Device2015
Author(s)
Hiroya Abe, Kosuke Ino, Chen-Zhong Li, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue
Organizer
isCEBT 2015
Place of Presentation
台北(台湾)
Year and Date
2015-09-06
Related Report
Int'l Joint Research
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[Presentation] LSI-based amperometric device for electrochemical imaging of neurotransmitters from three-dimensional cultured PC12 cells2015
Author(s)
Hiroya Abe, Kosuke Ino, Chen-Zhong Li, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue
Organizer
ISMM2015 (7th International Symposium on Microchemistry and Microsystems)
Place of Presentation
京都大学(京都府・京都市)
Year and Date
2015-06-08
Related Report
Int'l Joint Research
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[Presentation] Activity evaluation of cellular spheroids using LSI-based electrochemical Device2014
Author(s)
H. Abe, CZ. Li, K. Takara, Y. Kanno, K. Ino, K. Y. Inoue, R. Kunikata, A. Suda, M. Matsudaicra, Y. Takahashi, H. Shiku, T. Matsue,
Organizer
International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT2014)
Place of Presentation
Chang Gung University(Taiwan)
Year and Date
2014-09-10 – 2014-09-13
Related Report
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[Presentation] Improvement of LSI-based amperometric sensor array for wide application of bioimaging and biosensing2014
Author(s)
Kumi Y. Inoue, Masahki Matsudaira, Kosuke Ino, Masanori Nakano, Kosuke Takara, Atsushi Suda, Ryota Kunikata, Shinya Yoshida,Takeshi Hayasaka Yoshiyuki Kikuchi, Xijiang Chang, Tomohiro Kubota, Hitoshi Shiku, Shuj Tanaka, Seij Samukawa, Tomokazu Matsue,
Organizer
65th Annual Meeting of the International Society of Electrochemistry
Place of Presentation
Lausanne(Switzerland)
Year and Date
2014-09-01 – 2014-09-05
Related Report
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[Presentation] Integration of LSI technology to advanced electrochemical array sensor and its application for biomedical assays2013
Author(s)
Kumi Y. Inoue, Kosuke Ino, Kosuke Takara, Mustafa Sen, Shinichiro Takano, Reyushi Kubo, Masanori Nakano, Shusaku Shiomoto, Yuka Hashi, Atsushi Suda, Ryota Kunikata, Hitoshi Shiku, and Tomokazu Matsue
Organizer
ACCS 2013
Place of Presentation
Chiang Mai(Thailand)
Year and Date
2013-11-11 – 2013-11-14
Related Report
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