| Project/Area Number |
25248033
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kitamori Takehiko 東京大学, 工学(系)研究科(研究院), 教授 (60214821)
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| Co-Investigator(Kenkyū-buntansha) |
MAWATARI Kazuma 東京大学, 大学院工学系研究科, 准教授 (60415974)
KAZOE Yutaka 東京大学, 大学院医学系研究科, 特任講師 (20600919)
SHIMIZU Hisashi 東京大学, 大学院工学系研究科, 助教 (60631281)
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| Research Collaborator |
MIURA Kiyotaka 京都大学, 大学院工学系研究科, 教授 (60418762)
SAKAKURA Masaaki 京都大学, 産官学連携本部, 特定准教授 (90402958)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Keywords | 光熱変換分光 / マイクロ化学チップ / ナノフルイディクス / 光熱変換分光法 / 熱レンズ顕微鏡 / 拡張ナノ空間 / マイクロ・ナノ化学デバイス |
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| Outline of Final Research Achievements |
Recently, analytical chemistry has been miniaturized as represented by microchemical chips and single cell analysis. Our group studies novel analytical devices including immunoassay and chromatography using extended-nano (10-1000 nm) space and developed a differential interference contrast thermal lens microscope (DIC-TLM) to detect nonfluorescent molecules. Although the DIC-TLM can detect heat that is produced by nonfuorescent molecules through optical absorption and nonradiative relaxation sensitively, the problem was that the system was large and design of the optics was difficult. Therefore, in this study, a Mach-Zehnder interferometer was fabricated using optical waveguide on a glass chip for device integration of DIC-TLM. The device developed in this study is expected to replace spectrophotometers which are used as detectors of liquid chromatography. Furthermore, the device explores a new field of device engineering which integrates fluidics, optics and electronics.
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