Analytical chemistry in nano- and microspace confined by ice

• Project/Area Number: 25248034
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Okada Tetsuo 東京工業大学, 理学院, 教授 (20183030)
• Co-Investigator(Kenkyū-buntansha): 大塚 拓洋 東京工業大学, 理工学研究科, 助教 (20280993) ; 半田 友衣子 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 (20586599) ; 火原 彰秀 東京工業大学, 理工学研究科, 准教授 (30312995) ; 原田 誠 東京工業大学, 理工学研究科, 助教 (60313326) ; 山本 佳孝 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 (80358283)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000); Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2013: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
• Keywords: 氷 / 凍結 / 液相空間 / アイスクロマトグラフィー / 共存液相 / 分離 / マイクロ・ナノデバイス / 界面 / イメージング / 氷粒界 / 凍結濃縮 / 粒子センシング / 高感度分析 / イオンの氷への分配

Outline of Final Research Achievements

In this project, we have developed novel methods based on the functionality and have revealed phenomena related to freezing of aqueous solutions; (1) size control of grain boundary channels and application to resolution of particle size; (2) particle counting; (3) chiral separation with frozen proline or leucine; (4) shear-flow ice chromatography; (5) 1000-fold sample enrichment for capillary electrophoresis; (6) enhanced sensitivity of voltammetry; (7) distribution of ions into the ice phase; (8) properties of liquid inclusion formed in frozen electrolyte systems; (9) X-ray fluorescence two- and three-dimensional imaging of frozen NaCl solution containing transition metal ions; (10) hydration of ions in frozen systems: (11) enhanced kinetics by freezing and its dependence on the size of a liquid phase.

Research Products

• [Journal Article] Voltammetry of Viologens Revealing Reduction of Hydrophobic Interaction in Frozen Aqueous Electrolyte Solutions (2017)
  • Author(s): Hui Qu, Makoto Harada, and Tetsuo Okada
  • Journal Title: ChemElectroChem Volume: 4 Issue: 1 Pages: 35-38
  • DOI: 10.1002/celc.201600560
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An efficient method for measuring excess adsorption isotherms of organic eluent components on reversed-phase packing materials (2017)
  • Author(s): Junji Ohashi, Makoto Harada, and Tetsuo Okada
  • Journal Title: Journal of Separation Science Volume: 40 Issue: 4 Pages: 842-848
  • DOI: 10.1002/jssc.201601032
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Freezing-Facilitated Dehydration Allowing Deposition of ZnO from Aqueous Electrolyte (2017)
  • Author(s): Kouki Tokumasu, Makoto Harada, and Tetsuo Okada
  • Journal Title: ChemPhysChem Volume: 18 Issue: 4 Pages: 329-333
  • DOI: 10.1002/cphc.201601192
  • Peer Reviewed / Open Access
• [Journal Article] Shear-Driven Flow Ice Chromatography as a Possible Tool Probing Ice/Water Interface (2016)
  • Author(s): Masaya Shimizu, Makoto Harada, Akihide Hibara, and Tetsuo Okada,
  • Journal Title: Analytical Sciences Volume: 32 Issue: 7 Pages: 805-808
  • DOI: 10.2116/analsci.32.805
  • NAID: 130005163077
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Specific Reactions Occurring in Spaces Confined by Water-ice (2016)
  • Author(s): 岡田哲男、原田誠
  • Journal Title: BUNSEKI KAGAKU Volume: 65 Issue: 3 Pages: 119-128
  • DOI: 10.2116/bunsekikagaku.65.119
  • NAID: 130005143534
  • ISSN: 0525-1931
  • Peer Reviewed / Open Access
• [Journal Article] Chiral Resolution with Frozen Aqueous Amino Acids (2016)
  • Author(s): S.Takahashi, M.Harada, T.Okada
  • Journal Title: Analytical Methods Volume: 8 Issue: 1 Pages: 105-110
  • DOI: 10.1039/c5ay02522b
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] X-ray Fluorescence Imaging of Frozen Aqueous NaCl (2016)
  • Author(s): K.Tokumasu, A.Hibara, T.Okada
  • Journal Title: Langmuir Volume: 32 Issue: 2 Pages: 527-533
  • DOI: 10.1021/acs.langmuir.5b04411
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Microfluidic Protein Crystallisation Controlled Using Spontaneous Emulsification (2015)
  • Author(s): M.Fukuyama, A.Akiyama, M.Harada, T.Okada, A.Hibara
  • Journal Title: Analytical Methods Volume: 7 Issue: 17 Pages: 7128-7131
  • DOI: 10.1039/c5ay00578g
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Freeze Enrichment Protocol Based on Voltammetric Probing of Liquid-Phase Growth in Frozen Aqueous Electrolyte Solutions (2015)
  • Author(s): Q.Hui, M.Harada, T.Okada
  • Journal Title: Analytical Chemistry Volume: 87 Issue: 8 Pages: 4314-4320
  • DOI: 10.1021/acs.analchem.5b00747
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ion-Transfer Voltammetry at the Interface between Organic and Salt-Doped Ice Phases (2015)
  • Author(s): Q.Hui, M.Harada, T.Okada
  • Journal Title: ChemElectroChem Volume: 2 Pages: 1249-1253
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fluidic Grooves on Doped-Ice Surface as Size-Tunable Channels (2015)
  • Author(s): A.Inagawa, M.Harada, T.Okada
  • Journal Title: Scientific Reports Volume: 5 Issue: 1
  • DOI: 10.1038/srep17308
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Design of Analytical Systems Based on Functionality of Doped Ice (2014)
  • Author(s): Tetsuo Okada
  • Journal Title: Analytical Sciences Volume: 30 Issue: 1 Pages: 43-49
  • DOI: 10.2116/analsci.30.43
  • NAID: 130004442244
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Imbalance between Anion and Cation Distribution at Ice Interface with Liquid Phase in Frozen Electrolyte as Evaluated by Fluorometric Measurements of pH (2014)
  • Author(s): Hiroki Watanabe, Takuhiro Otsuka, Makoto Harada, and Tetsuo Okada
  • Journal Title: Journal of Physical Chemistry C Volume: 2014 Issue: 29 Pages: 15723-15731
  • DOI: 10.1021/jp5031653
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Single Micro-channel Formation in a Gap between Probe Electrodes by Freezing an Aqueous Electrolyte (2014)
  • Author(s): Yuta Arai, Makoto Harada, and Tetsuo Okada
  • Journal Title: Analytical Sciences Volume: 30 Issue: 11 Pages: 1035-1037
  • DOI: 10.2116/analsci.30.1035
  • NAID: 130004704334
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 氷を用いる分離と計測：アイ スクロマトグラフィーと氷マイクロリアクター (2014)
  • Author(s): 岡 田哲男
  • Journal Title: ぶ んせき Pages: 275-282
  • Peer Reviewed
• [Journal Article] イオン交換機構の解明とそれを基盤とする新規計測法の展開 (2014)
  • Author(s): 岡田哲男
  • Journal Title: イオン交換学会誌 Volume: 25 Pages: 17-25
  • NAID: 130004555864
• [Journal Article] Constant Number Density of Liquid Inclusions Formed in Frozen Aqueous Electrolyte (2013)
  • Author(s): Takuya Hashimoto, Makoto Harada, Shuichi Nojima, and Tetsuo Okada
  • Journal Title: ChemPhysChem Volume: 14 Issue: 14 Pages: 3410-3416
  • DOI: 10.1002/cphc.201300380
  • Peer Reviewed
• [Journal Article] Freeze Sample Enrichment Highly Adaptable to Capillary Electrophoresis (2013)
  • Author(s): Kenich Ito and Tetsuo Okada
  • Journal Title: Analytical Methods Volume: 5 Issue: 21 Pages: 5912-5912
  • DOI: 10.1039/c3ay41307a
  • Peer Reviewed
• [Journal Article] Enhanced Kinetics of Pseudo First-Order Hydrolysis in Liquid Phase Coexistent with Ice (2013)
  • Author(s): Kenji Anzo, Makoto Harada, and Tetsuo Okada
  • Journal Title: Journal of Physical Chemistry A Volume: 117 Issue: 41 Pages: 10619-10625
  • DOI: 10.1021/jp409126p
  • Peer Reviewed
• [Journal Article] Behavior of Polyhydric Alcohols at Ice/Liquid Interface (2013)
  • Author(s): Makoto Uyama, Makoto Harada, Takehiko Tsukahara, and Tetsuo Okada
  • Journal Title: Journal of Physical Chemistry C Volume: 117 Issue: 47 Pages: 24873-24882
  • DOI: 10.1021/jp408722x
  • Peer Reviewed
• [Journal Article] 氷を用いる分離と計測 (2013)
  • Author(s): 岡田哲男、高橋さつき、田崎友衣子
  • Journal Title: 低温科学 Volume: 71 Pages: 29-38
  • Peer Reviewed
• [Presentation] 分析プラットフォームとしての氷、凍結溶液 (2016)
  • Author(s): 岡田哲男
  • Organizer: 日本分析化学会第65年会
  • Place of Presentation: 札幌
  • Year and Date: 2016-09-14
  • Invited
• [Presentation] 氷と共存する水溶液で起きる種々の現象 (2016)
  • Author(s): 岡田哲男
  • Organizer: 日本分析化学会第65年会
  • Place of Presentation: 札幌
  • Year and Date: 2016-09-14
  • Invited
• [Presentation] Synergistic Effect of Histidine on Cyclodextrin Chiral Resolution in Aqueous Phase Supported by Silica Gel Stationary Phase (2016)
  • Author(s): Y.Iimura, T.Okada
  • Organizer: HPLC2016
  • Place of Presentation: San Francisco
  • Year and Date: 2016-06-21
  • Int'l Joint Research
• [Presentation] 新規な特性と機能を持つ分離場の開拓と界面計測への展開 (2015)
  • Author(s): 岡田哲男
  • Organizer: 日本分析化学会第64年会
  • Place of Presentation: 福岡
  • Year and Date: 2015-09-10
  • Invited
• [Presentation] Separation with Ice as Functional Material (2015)
  • Author(s): Tetsuo Okada
  • Organizer: The 8th Asia-Pacific Symposium on Ion Analysis
  • Place of Presentation: 千葉
  • Year and Date: 2015-09-01
  • Int'l Joint Research / Invited
• [Presentation] ize Tunable Channels Fabricated with Ice for Nano/Microseparation (2015)
  • Author(s): Arinori Inagawa, Tetsuo Okada
  • Organizer: HPLC2015
  • Place of Presentation: ジュネーブ
  • Year and Date: 2015-06-21
  • Int'l Joint Research
• [Presentation] 氷を機能性材料とする分離・計測の設計 (2014)
  • Author(s): 岡田哲男
  • Organizer: 高分子学会九州支部フォーラム
  • Place of Presentation: 熊本大学
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] 分離場、計測場としての氷 (2014)
  • Author(s): 岡田哲男
  • Organizer: 日本分析化学会中部支部岐阜講演会
  • Place of Presentation: 岐阜薬科大学
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] 氷と共存する液相の化学と計測への展開 (2014)
  • Author(s): 岡田哲男
  • Organizer: 日本分析化学会第63年会
  • Place of Presentation: 広島大学
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] Design of Analytical Methods with Ice as a Functional Material (2014)
  • Author(s): Tetsuo Okada
  • Organizer: JASIS Korean Forum
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2014-09-04
  • Invited
• [Presentation] Chiral Chromatography with Cyclodextrin Complexation in Silica Nanopores (2014)
  • Author(s): Satsuki Takahashi and Tetsuo Okada
  • Organizer: 17th International Cyclodextrin Symposium
  • Place of Presentation: Saarbrucken, Germany
  • Year and Date: 2014-05-29
• [Presentation] Ice as a Platform for Various Analytical Methods
  • Author(s): Tetsuo Okada
  • Organizer: Asianalysis
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Tetrahydrofuran (THF) Hydrate Growth on Ice Surface in Contact with THF/Hexane and Its Relation to Quasi Liquid Layer Formation
  • Author(s): Tetsuo Okada
  • Organizer: Advanced Vibrational Spectroscopy (ICAVS)
  • Place of Presentation: 神戸
  • Invited
• [Book] トコトンやさしいイオン交換の本 (2013)
  • Author(s): 岡田哲男、早下隆士
  • Total Pages: 130
  • Publisher: 日刊工業新聞社