Creation of novel drug nanoparticles based on the conventional reverse molecular design using poor water-soluble compounds and the efficacy evaluation
Project/Area Number |
25248044
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Organic and hybrid materials
|
Research Institution | Tohoku University |
Principal Investigator |
KASAI HITOSHI 東北大学, 多元物質科学研究所, 教授 (30312680)
|
Co-Investigator(Kenkyū-buntansha) |
中澤 徹 東北大学, 医学(系)研究科(研究院), 教授 (30361075)
村上 達也 京都大学, 物質-細胞統合システム拠点, 准教授 (90410737)
|
Co-Investigator(Renkei-kenkyūsha) |
OIKAWA Hidetoshi 東北大学, 多元物質科学研究所, 教授 (60134061)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2014: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2013: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
|
Keywords | ナノ薬剤 / 再沈法 / 抗癌薬 / 点眼薬 / ナノ抗癌薬 / ナノ点眼薬 / 薬剤ナノ粒子 / 抗がん薬 / 抗がん剤 |
Outline of Final Research Achievements |
In this project, we introduced a new concept of introducing a poorly water-soluble substituent into anticancer medicinal compounds. Next, we synthesized them and then created the drug nanoparticles by using our own technique of the reprecipitation method. And, it was found that, by covering polymers or proteins on these drug nanoparticles, dispersion stability of the nanodrug could be improved. In vivo experiment, it was revealed that the nanodrugs could be delivered into the inside of cells of the tumor tissue. And this technique could be applied as eye drops including the glaucoma and so on.
|
Report
(5 results)
Research Products
(85 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] Cytotoxicity of pure nanodrugs of SN-38 and podophyllotoxin dimers in human cancer HepG2, KPL-4 and MCF-7 cellsc2015
Author(s)
Y. Koseki, Y. Ikuta, T. Murakami, T. Onodera, H. Oikawa, L. Cong, H. Tada, K. Gonda, N. Ohuchi, H. Kasai
-
Journal Title
Mol. Cryst. Liq. Cryst.
Volume: 622
Issue: 1
Pages: 1-5
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 抗がん活性ナノ粒子作製技術の開発2014
Author(s)
幾田良和, 小関良卓, 小野寺恒信, 及川英俊, 笠井均
Organizer
第75回応用物理学会秋季学術討論会
Place of Presentation
札幌
Year and Date
2014-09-17 – 2014-09-20
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-