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Study on paper micro analysis chip and the system integration

Research Project

Project/Area Number 25249027
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionThe University of Tokyo

Principal Investigator

Miyake Ryo  東京大学, 工学(系)研究科(研究院), 教授 (50417052)

Co-Investigator(Kenkyū-buntansha) FUNAHASHI hisakage  広島大学, サステナブル・ディベロップメント実践研究センター, 特任講師 (60552429)
Co-Investigator(Renkei-kenkyūsha) KURODA Akio  広島大学, 先端物質科学研究科, 教授 (50205241)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥35,750,000 (Direct Cost: ¥27,500,000、Indirect Cost: ¥8,250,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2013: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywordsマイクロ流体デバイス / 紙 / 医用検査装置 / 情報機構 / 情報機器
Outline of Final Research Achievements

The purpose of this study is to enhance analysis-chip technologies based on paper material to allow us to reduce manufacturing cost and environmental load caused by medical wastes. We were aiming at developing a detection method for small amount of sample on a paper analysis chip and prototyping an automatic analysis system in order to envision problems and propose solutions towards practical use. Consequently, a micro detection cell for an absorptiometry with thermal lens effect and thin gold electrodes (t=100~150nm) for an alternating current impedance measurement (10kHz) were designed and fabricated on paper chips. They allowed us to measure an absorbance (644nm) of trace amount of sample (~1uL) and signal related to electrolyte (Na+) in the sample. In addition, we prototyped an automatic analysis system with including newly developed detectors, reagent dispensers, paper-chip precision positining mechanism etc. This system successfully demonstrated cooperative automatic operation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] A split G-quadruplex-based DNA nano-tweezers structure as a signnal-transducing molecule for the homogeneous detection of specific nucleic acids2015

    • Author(s)
      Keisuke Nakatsuka, Hajime Shigeto, Akio Kuroda, Hsakage Funabashi
    • Journal Title

      Jounal of Biosensors and Bioelectronics

      Volume: 74 Pages: 222-226

    • DOI

      10.1016/j.bios.2015.06.055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 紙ベースのマイクロチップ作製技術2014

    • Author(s)
      三宅亮
    • Journal Title

      機能紙研究会誌

      Volume: 52 Pages: 39-42

    • NAID

      130005098436

    • Related Report
      2013 Annual Research Report
  • [Presentation] ペーパー分析チップの作成技術とシステム化2016

    • Author(s)
      三宅亮
    • Organizer
      神奈川科学技術アカデミー教育講座
    • Place of Presentation
      神奈川サイエンスパーク(川崎市)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ペーパー分析チップの作成技術とシステム化2015

    • Author(s)
      三宅亮
    • Organizer
      神奈川科学技術アカデミー教育講座
    • Place of Presentation
      川崎市KSP
    • Year and Date
      2015-03-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エンドトキシン凝固過程のインピーダンス計測2014

    • Author(s)
      小谷紘、舟橋久景、黒田章夫、三宅亮
    • Organizer
      日本機械学会第6回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      松江市くにびきメッセ
    • Year and Date
      2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ペーパーマイクロ分析チップ用電極センサの開発2014

    • Author(s)
      中原和貴、三宅亮、松垣仁、小谷紘
    • Organizer
      日本機械学会第6回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      松江市くにびきメッセ
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 熱レンズセンサによる紙チップ上微量液の吸光度計測2014

    • Author(s)
      松垣仁、中原和貴、三宅亮
    • Organizer
      化学とマイクロ・ナノシステム学会第30回研究会
    • Place of Presentation
      札幌市北海道大学
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロ流体技術の魅力と実用化2014

    • Author(s)
      三宅亮
    • Organizer
      農工大・多摩小金井ベンチャーポートセミナー
    • Place of Presentation
      小金井市農工大
    • Year and Date
      2014-05-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マイクロ流路を用いたエンドトキシン凝固反応の計測2013

    • Author(s)
      小谷紘、舟橋久景、黒田章夫、三宅亮
    • Organizer
      日本機械学会第5回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      仙台国際センター、宮城県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 紙ベースのマイクロチップ作製技術2013

    • Author(s)
      三宅亮
    • Organizer
      第52回機能紙研究発表講演会
    • Place of Presentation
      徳島市あわぎんホール、徳島県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ペーパー分析チップの作成技術とシステム化

    • Author(s)
      三宅亮
    • Organizer
      神奈川科学技術アカデミー教育講座
    • Place of Presentation
      川崎市神奈川サイエンスパーク、神奈川県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 紙ベースのマイクロチップ作製技術

    • Author(s)
      三宅亮
    • Organizer
      岐阜県産業技術センター紙業部研究成果発表会
    • Place of Presentation
      岐阜県産業技術センター、岐阜県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 機能紙最前線2016

    • Author(s)
      編集:機能紙研究会、共著
    • Total Pages
      290
    • Publisher
      加工技術研究会
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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