Biofunctionalization of metallic biomaterials by forming ceramic interface layers
| Project/Area Number |
25249094
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Composite materials/Surface and interface engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASUGA Toshihiro 名古屋工業大学, 大学院工学研究科, 教授 (30233729)
OGASAWARA Kouetsu 東北大学, 加齢医学研究所, 教授 (30323603)
UEDA Kyosuke 東北大学, 大学院工学研究科, 准教授 (40507901)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2013: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
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| Keywords | 生体材料 / チタン / 光触媒 / アナターゼ / ルチル / リン酸カルシウム / 生体吸収性 / 抗菌性 / 骨適合性 |
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| Outline of Final Research Achievements |
Ceramic coating layers of amorphous calcium phosphate (ACP) and TiO2 were prepared on Ti, and their antibacterial activities were evaluated. Ag-containing ACP layers fabricated by RF magnetron sputtering exhibited antibacterial activity through the continuous release of Ag ions, caused by the resorbability of ACP. TiO2 layers fabricated by thermal oxidation processes showed photodegradation of organic compounds and antibacterial activity under both UV- and visible-light irradiation. The introduction of Au into TiO2 layers from Ti-Au alloy substrates contributed to the expression of visible-light response. The optimized fabrication processes provided the coating films with both the bone forming ability and antibacterial activity.
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Report
(4 results)
Research Products
(137 results)
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[Journal Article] Co-Cr alloys as effective metallic biomaterials2015
Author(s)
T. Narushima, K. Ueda and Alfirano
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Journal Title
Advances in Metallic Biomaterials: Tissues, Materials and Biological Reactions
Volume: -
Pages: 157-178
DOI
ISBN
9783662468357, 9783662468364
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] NKG2D+ IFN-γ+ CD8+ T cells are responsible for palladium allergy.2014
Author(s)
Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, Ogasawara K.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 生体材料としてのチタン2015
Author(s)
成島尚之
Organizer
仙台青葉工業クラブ第42回講演会
Place of Presentation
エル・パーク仙台 (仙台)
Year and Date
2015-10-18
Related Report
Invited
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