|Budget Amount *help
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|Outline of Final Research Achievements
The neural activity was electrophysiologically recorded from the surface layer of barrel cortex while the multiple whiskers of a W-TChR2V4 rat were optogenetically stimulated with a certain spatiotemporal pattern. The results suggested the presence of two types of whisker-barrel projections in combination, the zone projection and the topographical projection. Using a W-TChR2V4 rat, the behavioral responses were conditioned with the optogenetic stimulation of whisker area as a cue. The perceptual threshold was evaluated by the response time, which was measured quantitatively with high precision, and was significantly reduced by the early visual deprivation of the animal.
We fabricated an all-optical system to measure the neuronal activity by light in the layer 5 of mouse S1 cortex while providing optogenetic inputs in it. As a result of reciprocal inhibition among cortical neurons, a column-like architecture was functionally emerged around the cortical input.