Physiological and Molecular Biological Studies on Mechanisms underlying Acquisition of Audition during Development
| Project/Area Number |
25250002
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Nagoya University |
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Principal Investigator |
Oda Yoichi 名古屋大学, 理学研究科, 名誉教授 (00144444)
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| Co-Investigator(Kenkyū-buntansha) |
坂内 博子 名古屋大学, 理学(系)研究科(研究院), 講師 (40332340)
高木 新 名古屋大学, 理学研究科, 准教授 (90171420)
谷本 昌志 名古屋大学, 理学研究科, 研究員 (30608716)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
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| Keywords | ゼブラフィッシュ / 内耳 / 有毛細胞 / 耳石 / マウスナー細胞 / カリウムチャネル / 網様体脊髄路ニューロン / 特徴抽出 / 反回性抑制回路 / 相反性抑制回路 / 網様体ニューロン / 反回性回路 / 興奮性 / 単発発火 / 発達 / 第８神経 / 発火特性 / 低閾値型カリウムチャネル |
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| Outline of Final Research Achievements |
In the present study we examined physiological and molecular mechanisms underlying acquisition of audition during development by using zebrafish embryo and larva. We showed first that otolish size in the larval ear is crucial to differentially sense auditory and vestibular information. Second, Mauthner cell among the hindbrain reticulospinal neurons receiving auditory nerve inputs acquires single firing property during early development, while other neurons keep regular spiking in response to membrane depolarization. Third, expression of two types of low threshold potassium channels plays a key role in the Mauthner cell's acquisition of the unique firing property.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Video-rate volumetric functional imaging of the brain at synaptic resolution2017
Author(s)
Lu R, Sun W, Liang Y, Kerlin A, Bierfeld J, Seelig JD, Wilson DE, Scholl B, Mohar B, Tanimoto M, Koyama M, Fitzpatrick D, Orger MB, Ji N
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Journal Title
Nature Neuroscience
Volume: 20
Issue: 4
Pages: 620-628
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] X-ray crystallographic structure of thermophilic rhodopsin: implications for high thermal stability and optogenetic function2016
Author(s)
Tsukamoto T, Mizutani K, Hasegawa T, Takahashi M, Honda N, Hashimoto N, Shimono K, Yamashita K, Yamamoto M, Miyauchi S, Takagi S, Hayashi S, Murata T, Sudo Y.
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Journal Title
J. Biol. Chem.
Volume: in press
Issue: 23
Pages: 12223-12232
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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