| Budget Amount *help |
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
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| Outline of Final Research Achievements |
In the present study we examined physiological and molecular mechanisms underlying acquisition of audition during development by using zebrafish embryo and larva. We showed first that otolish size in the larval ear is crucial to differentially sense auditory and vestibular information. Second, Mauthner cell among the hindbrain reticulospinal neurons receiving auditory nerve inputs acquires single firing property during early development, while other neurons keep regular spiking in response to membrane depolarization. Third, expression of two types of low threshold potassium channels plays a key role in the Mauthner cell's acquisition of the unique firing property.
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