Elucidation of structure-function linkage of the striatal input systems by means of various viral vectors

• Project/Area Number: 25250003
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Kyoto University
• Principal Investigator: TAKADA Mashiko 京都大学, 霊長類研究所, 教授 (00236233)
• Project Period (FY): 2013-10-21 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000); Fiscal Year 2015: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000); Fiscal Year 2014: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2013: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: 神経回路 / 大脳基底核 / 線条体 / ウイルスベクター / 霊長類

Outline of Final Research Achievements

The present research project aims at elucidating the structure and function of neural networks related to the primate basal ganglia by establishing cutting-edge systems for neural network analyses with a variety of viral vectors. In the following three issues, the research plans set beforehand have successfully been progressed, and interesting outcomes concerning each issue have been achieved: (1) functional mapping of the striatum based on the patterns of multisynaptic outputs to the frontal lobe with high-efficiency multi-colored rabies viral vectors and of corticostriatal inputs, (2) input-output analyses of thalamic and nigral neurons projecting to a given region of the striatum, and (3) functional intervention in pathways linking the thalamus, nigra, and frontal lobe to a given region of the striatum.

Research Products

• [Journal Article] Origins of multisynaptic projections from the basal ganglia to the forelimb region of the ventral premotor cortex in macaque monkeys. (2016)
  • Author(s): Ishida H, Inoue K, Takada M, Hoshi E
  • Journal Title: Eur J Neurosci Volume: 43 Issue: 2 Pages: 258-269
  • DOI: 10.1111/ejn.13127
  • NAID: 120005997650
  • Peer Reviewed
• [Journal Article] A primary role for nucleus accumbens and related limbic network in vocal tics. (2016)
  • Author(s): McCairn KW, Nagai Y, Hori Y, Ninomiya T, Kikuchi E, Lee J-Y, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M
  • Journal Title: Neuron Volume: 89 Issue: 2 Pages: 300-307
  • DOI: 10.1016/j.neuron.2015.12.025
  • NAID: 120005997652
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Generation of resonance-dependent oscillation by mGluR-I activation switches single spiking to bursting in mesencephalic trigeminal sensory neurons (2015)
  • Author(s): Chung, G., Saito, M., Kawasaki, Y., Kawano, T., Yin, D., Lee, S., Kogo, M., Takada, M., Bae, Y., Oh, S.B & Kang, Y.
  • Journal Title: European Journal of Neuroscience Volume: 41 Issue: 8 Pages: 998-1012
  • DOI: 10.1111/ejn.12858
  • Peer Reviewed / Open Access
• [Journal Article] Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques. (2015)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 11986-11986
  • DOI: 10.1038/srep11986
  • NAID: 120005758238
  • Peer Reviewed / Open Access
• [Journal Article] Neuronal and behavioral modulations by pathway-selective optogenetic stimulation of the primate oculomotor system. (2015)
  • Author(s): Inoue K, Takada M, Matsumoto M
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 8378-8378
  • DOI: 10.1038/ncomms9378
  • Peer Reviewed / Open Access
• [Journal Article] Roles of the Lateral Habenula and Anterior Cingulate Cortex in Negative Outcome Monitoring and Behavioral Adjustment in Nonhuman Primates. (2015)
  • Author(s): Kawai, T., Yamada, H., Sato, N., Takada, M., & Matsumoto, M.
  • Journal Title: Neuron Volume: 88 Issue: 4 Pages: 792-804
  • DOI: 10.1016/j.neuron.2015.09.030
  • NAID: 120005997651
  • Peer Reviewed / Open Access
• [Journal Article] Distributions of glutamatergic, GABAergic, and glycinergic neurons in the auditory pathways of macaque monkeys. (2015)
  • Author(s): Ito T, Inoue K, Takada M
  • Journal Title: Neuroscience Volume: 310 Pages: 128-151
  • DOI: 10.1016/j.neuroscience.2015.09.041
  • Peer Reviewed / Open Access
• [Journal Article] Morphological study of the accommodative apparatus in the monkey eye. (2015)
  • Author(s): Hiraoka M, Inoue K, Senoo H, Takada M
  • Journal Title: Anat Rec Volume: 298 Issue: 3 Pages: 630-6
  • DOI: 10.1002/ar.23100
  • NAID: 120005555523
  • Peer Reviewed
• [Journal Article] Sporadic premature aging in a Japanese monkey: a primate model for progeria. (2014)
  • Author(s): T. Oishi, H. Imai, Y. Go, M. Imamura, H. Hirai, M. Takada
  • Journal Title: PLoS ONE Volume: 9 Issue: 11 Pages: e111867-e111867
  • DOI: 10.1371/journal.pone.0111867
  • Peer Reviewed / Open Access
• [Journal Article] Efficient in vivo depletion of CD8+ T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration (2013)
  • Author(s): Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H
  • Journal Title: Immunology Letters. Volume: 154 Issue: 1-2 Pages: 12-17
  • DOI: 10.1016/j.imlet.2013.08.005
  • Peer Reviewed
• [Journal Article] Dorsal area 46 is a major target of disynaptic projections from the medial temporal lobe. (2013)
  • Author(s): Hirata Y, Miyachi S, Inoue K, Ninomiya T, Takahara D, Hoshi E, Takada M
  • Journal Title: Cereb Cortex Volume: 23 Issue: 12 Pages: 2965-75
  • DOI: 10.1093/cercor/bhs286
  • Peer Reviewed
• [Journal Article] Methamphetamine increases locomotion and dopamine transporter activity in dopamine D5 (2013)
  • Author(s): Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H , Kodama T, Takada M.
  • Journal Title: PLoS ONE Volume: 8(10) Issue: 10 Pages: 1-8
  • DOI: 10.1371/journal.pone.0075975
  • Peer Reviewed
• [Journal Article] Distinct representations of cognitive and motivational signals in midbrain dopamine neurons. (2013)
  • Author(s): Matsumoto M, Takada M
  • Journal Title: Neuron Volume: 79 Issue: 5 Pages: 1011-1024
  • DOI: 10.1016/j.neuron.2013.07.002
  • Peer Reviewed
• [Journal Article] Reward-modulated motor information in identified striatum neurons. (2013)
  • Author(s): Yoshikazu Isomura, Takashi Takekawa, Rie Harukuni, Takashi Handa, Hidenori Aizawa, Masahiko Takada, and Tomoki Fukai
  • Journal Title: J. Neurosci. Volume: 33 Issue: 25 Pages: 10209-10220
  • DOI: 10.1523/jneurosci.0381-13.2013
  • Peer Reviewed
• [Journal Article] Loss of DARPP-32 and calbindin in multiple system atrophy (2013)
  • Author(s): Hayakawa H, Nagai M, Kawanami A, Nakata Y, Nihira T, Ogino M, Takada M, Saido T, Takano J, Saegusa M, Mikami T, Hamada J, Nishiyama K, Mochizuki H, Mizuno Y
  • Journal Title: Journal of Neural Transmission Volume: 120 Issue: 12 Pages: 1689-1698
  • DOI: 10.1007/s00702-013-1039-4
  • Peer Reviewed
• [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits (2013)
  • Author(s): Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
  • Journal Title: Neuron Volume: 78(5) Issue: 5 Pages: 839-854
  • DOI: 10.1016/j.neuron.2013.03.031
  • Peer Reviewed
• [Journal Article] Multisynaptic projections from the ventrolateral prefrontal cortex to hand and mouth representations of the monkey primary motor cortex. (2013)
  • Author(s): Miyachi S, Hirata Y, Inoue K, Lu X, Nambu A, Takada M
  • Journal Title: Neurosci Res Volume: 76 Issue: 3 Pages: 141-9
  • DOI: 10.1016/j.neures.2013.04.004
  • NAID: 120005296162
  • Peer Reviewed
• [Presentation] ウイルスベクターを用いた外来遺伝子導入による疾患モデル霊長類の開発 (2016)
  • Author(s): 高田昌彦
  • Organizer: 都医学研セミナー
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2016-03-18
  • Invited
• [Presentation] Neuronal and behavioral modulations by pathway-selective optogenetic stimulation of the primate oculomotor system (2016)
  • Author(s): Inoue K, Takada M, Matsumoto M
  • Organizer: International Symposium on Adaptive Circuit Shift 2016
  • Place of Presentation: 同志社大学(京都府京都市）
  • Year and Date: 2016-03-03
  • Int'l Joint Research
• [Presentation] Reorganization of corticospinal tract fibers in a primate model for spinal cord injury (2016)
  • Author(s): Nakagawa H, Yamashita T, Takada M
  • Organizer: International Symposium on Adaptive Circuit Shift 2016
  • Place of Presentation: 同志社大学(京都府京都市）
  • Year and Date: 2016-03-03
  • Int'l Joint Research
• [Presentation] ウイルスベクターを用いた霊長類脳への外来遺伝子導入法とその応用 (2016)
  • Author(s): 高田昌彦
  • Organizer: 新潟大学脳研究所-生理研合同シンポジウム
  • Place of Presentation: 自然科学研究機構(愛知県岡崎市）
  • Year and Date: 2016-03-01
• [Presentation] 大脳基底核の出力系、特に脳幹への下降性出力の構築様式と機能的意義 (2016)
  • Author(s): 高田昌彦
  • Organizer: 第14回ジストニア研究会
  • Place of Presentation: 学士会館（東京都千代田区）
  • Year and Date: 2016-01-17
  • Invited
• [Presentation] 神経回路研究の変遷と今後の霊長類研究 (2015)
  • Author(s): 高田昌彦
  • Organizer: 生理研研究会2015「行動システム脳科学の新展開」
  • Place of Presentation: 生理学研究所(愛知県岡崎市）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] 遺伝子変異に基づく精神・神経疾患霊長類モデルの開発に向けて (2015)
  • Author(s): 高田昌彦
  • Organizer: 第6回脳表現型の分子メカニズム研究会、第10回IGC、第6回COCORO合同会議
  • Place of Presentation: コンベンションルームAP品川アネックス（東京都港区）
  • Year and Date: 2015-11-15
• [Presentation] Development in a novel maze-task device for macaques to explore the neural mechanisms underlying motor skill learning. (2015)
  • Author(s): Yasukochi R, Inoue K, Takada M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] Outcome monitoring and behavioral adjustment by putative pyramidal neurons and interneurons in the primate anterior cingulate cortex during a reversal learning task. (2015)
  • Author(s): Kawai T, Yamada H, Sato N, Takada M, Matsumoto M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Spontaneously emerging Parkinsonism-cerebellar syndrome in a subspecies of japanese macaque (macaca fuscata yakui): a potential analogue of multiple system atrophy. (2015)
  • Author(s): K.W.McCairn, Nagai Y, Kimura K, Go Y, Inoue K, Isoda M, Minamimoto T, Matsumoto M, Ninomiya T, Takada M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] The pattern of reinnervation of sprouting corticospinal tract fibers after spinal cord injury in macaques. (2015)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Layer-specific inputs from the supplementary motor area and the dorsal premotor cortex to the primary motor cortex in macaques. (2015)
  • Author(s): Ninomiya T, Hoshi E, Takada M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Optogenetic stimulation of the pathway from the frontal eye field to the superior colliculus evokes neuronal and behavioral modulations in monkeys. (2015)
  • Author(s): Inoue K, Takada M, Matsumoto M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Midbrain dopamine neurons signal whether planned eye movements are successfully (2015)
  • Author(s): Ogasawara T, Takada M, Matsumoto M
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Recruitment of calbindin into nigral dopaminergic neurons prevents from MPTP-induced parkinsonism. (2015)
  • Author(s): Takada M, Inoue K, Miyachi S
  • Organizer: 2nd World Congress on NeuroTherapeutics
  • Place of Presentation: Prague（Czech Republic）
  • Year and Date: 2015-09-03
  • Int'l Joint Research
• [Presentation] Origins of multisynaptic projections from the basal ganglia to the ventral premotor cortex in macaque monkeys. (2015)
  • Author(s): Ishida H, Inoue K, Takada M, Hoshi E
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-30
• [Presentation] Abnormal information flow through the cortico-basal ganglia circuits in MPTP-treated parkinsonian monkeys. (2015)
  • Author(s): Chiken S, Takada M, Nambu A
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-30
• [Presentation] A comparative analysis of vocal and myoclonic tics in a monkey model of Tourette syndrome: a PET and electrophysiological study. (2015)
  • Author(s): K.W.MacCairn, Nagai Y, Hori Y, Kikuchi W, Auhara T, Minamimoto T, Iriki A, Takada M, Isoda M, Matsumoto M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-30
• [Presentation] Development of a novel device for elucidating the neural mechanisms of motor skill learning in macaques. (2015)
  • Author(s): Yasukochi R, Inoue K, Takada M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-29
• [Presentation] Reinnervation of corticospinal tract fibers after spinal cord injury in macaques. (2015)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-29
• [Presentation] Oculomotor manipulations by pathway-selective optogenetics in nonhuman primates. (2015)
  • Author(s): Inoue K, Fujiwara M, Yasukochi R, Nagaya K, Takada M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-29
• [Presentation] Role of dopamine signals in response inhibition. (2015)
  • Author(s): Ogasawara T, Takada M, Matsumoto M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-28
• [Presentation] Protection against MPTP-induced parkinsonianinsults by calbindin recruitment into nigrostriatal dopamine neurons using recombinant viral vectors. (2015)
  • Author(s): 高田昌彦
  • Organizer: 第21回日本遺伝子治療学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市）
  • Year and Date: 2015-07-26
  • Invited
• [Presentation] Reorganization of corticospinal tract fibers after spinal cord injury in macaques (2015)
  • Author(s): Nakagawa H，Ninomiya T，Yamashita T，Takada M
  • Organizer: 第50回日本理学療法学術大会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2015-06-05
• [Presentation] Contribution of RGMa inhibition to recovery of motor functions after spinal cord injury in macaques. (2015)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Organizer: 11th Goettingen Meeting of the German Neuroscience Society
  • Place of Presentation: ドイツ，ゲッティンゲン
  • Year and Date: 2015-03-19
• [Presentation] 経路選択的な神経回路操作技術のマーモセット脳機能研究への応用 (2015)
  • Author(s): 高田昌彦
  • Organizer: 第4回マーモセット研究会
  • Place of Presentation: 犬山国際観光センターフロイデ（愛知県犬山市）
  • Year and Date: 2015-01-22
  • Invited
• [Presentation] ウィルスベクターを用いた外来遺伝子導入による疾患モデル霊長類の開発 (2014)
  • Author(s): 高田昌彦
  • Organizer: システム神経科学セミナー
  • Place of Presentation: 国立精神・神経医療研究センター（東京都小平市）
  • Year and Date: 2014-12-15
  • Invited
• [Presentation] Enhanced functional recovery after spinal cord injury by inhibition of repulsive guidance molecule in macaques. (2014)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Organizer: VMT2014“Vision, Memory, Thought: how cognition emerges from neural network”
  • Place of Presentation: 伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2014-12-06 – 2014-12-07
• [Presentation] Past outcome monitoring and subsequent behavioral adjustment in the primate lateral habenula and anterior cingulate cortex during a reversal learning task. (2014)
  • Author(s): Kawai T, Yamada H, Sato N, Takada M, Matsumoto M
  • Organizer: VMT2014“Vision, Memory, Thought: how cognition emerges from neural network”
  • Place of Presentation: 伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2014-12-06
• [Presentation] Systemic delivery of an AAV vector in neonatal macaques results in widespread gene transduction into neurons throughout the brain. (2014)
  • Author(s): Inoue K, Kimura K, Yasukouchi R, Sugawara N, Okuda Y, Fujiwara M, Takada M
  • Organizer: VMT2014“Vision, Memory, Thought: how cognition emerges from neural network”
  • Place of Presentation: 伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2014-12-06
• [Presentation] Intravascular administration of an AAV vector to neonatal macaques results in widespread gene transduction into neurons throughout the primate brain. (2014)
  • Author(s): Inoue K, Kimura K, Yasukochi R, Sugawara N, Okuda Y, Fujiwara M, Takada M
  • Organizer: 第44回北米神経学会大会（ＳＦＮ）
  • Place of Presentation: ワシントンＤＣ，ＵＳＡ
  • Year and Date: 2014-11-19
• [Presentation] Effectiveness of inhibition of the repulsive guidance molecule, RGMa on the functional recovery following spinal cord injury in macaques. (2014)
  • Author(s): H. NAKAGAWA*; T. NINOMIYA; T. YAMASHITA; M. TAKADA.
  • Organizer: 第44回北米神経学会大会（ＳＦＮ）
  • Place of Presentation: ワシントンＤＣ，ＵＳＡ
  • Year and Date: 2014-11-19
• [Presentation] Distinct cortical and subcortical networks drive myoclonic and vocal tics in the nonhuman primate model of Tourette syndrome: A PET and electrophysiological study. (2014)
  • Author(s): K. W. McCairn, Nagai Y, Hori Y, Iriki A, Takada M, Minamimoto T, Isoda M, Matsumoto M
  • Organizer: 第44回北米神経学会大会（ＳＦＮ）
  • Place of Presentation: ワシントンＤＣ，ＵＳＡ
  • Year and Date: 2014-11-18
• [Presentation] Enhancement of INaP-mediated resonance by mGluR-I activation induces burst firing in mesencephalic trigeminal sensory neurons. (2014)
  • Author(s): Kang Y, Chung G, Saito M, Takada M, Bae Y, Kim J, Oh S
  • Organizer: 第44回北米神経学会大会（ＳＦＮ）
  • Place of Presentation: ワシントンＤＣ，ＵＳＡ
  • Year and Date: 2014-11-18
• [Presentation] Brain shrinkage and reduced nerve conduction velocity in a progeroid-like macaque monkey. (2014)
  • Author(s): Oishi T, Imai H, Go Y, Hirai H, Takada M
  • Organizer: 第44回北米神経学会大会（ＳＦＮ）
  • Place of Presentation: ワシントンＤＣ，ＵＳＡ
  • Year and Date: 2014-11-17
• [Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaque monkeys. (2014)
  • Author(s): Nagai Y, Kikuchi E, W. Lerchner, Inoue K, Oh-nishi A, Kaneko H, Kato Y, Hori Y, B. Ji, Kumata K, M. Zhang , Aoki I, Suhara T, Takada M, Higuchi M, B. J. Richmond, Minamimoto T
  • Organizer: 第44回北米神経学会大会（ＳＦＮ）
  • Place of Presentation: ワシントンＤＣ，ＵＳＡ
  • Year and Date: 2014-11-17
• [Presentation] 狂犬病ウイルスを駆使した多シナプス性神経ネットワークの解析 (2014)
  • Author(s): 高田昌彦
  • Organizer: 分子精神神経薬理学研究セミナー
  • Place of Presentation: 大阪大学（大阪府吹田市）
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] マカクザル脳における加齢に伴うアミロイドβ蛋白の蓄積変化 (2014)
  • Author(s): 木村活生，井上謙一，田中章景，高田昌彦
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-13
• [Presentation] ニホンザルが示した神経系等の早老症的症状 (2014)
  • Author(s): 大石高生，今井啓雄，郷康広，平井啓久，高田昌彦
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-13
• [Presentation] DREADDを用いたサルの行動制御とPET生体内イメージング (2014)
  • Author(s): 永井裕司，菊池瑛理佳，Walter Lerchner，井上謙一，大西新，金子博之，加藤陽子，堀由紀子，季斌，熊田勝志，張明栄，青木伊知男，須原哲也，高田昌彦，樋口真人，Barry J Richmond，南本敬史
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-13
• [Presentation] 脊髄損傷からの回復過程における皮質脊髄路の再編 (2014)
  • Author(s): 澤田真寛，吉野－斎藤 紀美香，二宮太平，大石高生，山下俊英，高田昌彦，尾上浩隆，西村幸男，伊佐正
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-12
• [Presentation] AAVベクターによる霊長類新生児への全脳的遺伝子導入 (2014)
  • Author(s): 井上謙一，木村 活生，安河内 竜二，菅原 直也，小笠原 宇弥，奥田 泰弘，藤原 真紀，高田昌彦
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-12
• [Presentation] サル脊髄損傷後の運動機能回復と神経再生におけるRGMの役割 (2014)
  • Author(s): 中川浩，二宮太平，高田昌彦，山下俊英
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] 運動課題遂行中のサルにおける淡蒼球ニューロン活動のグルタミン酸およびGABA作動性調節 (2014)
  • Author(s): 金子将也，畑中伸彦，高良沙幸，高田昌彦，南部篤
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] 報酬履歴と行動切替に関わる外側手綱核と前部帯状皮質の異なる神経表現 (2014)
  • Author(s): 川合隆嗣，山田洋，佐藤暢哉，高田昌彦，松本正幸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] 霊長類モデルを用いた今後の研究展開 (2014)
  • Author(s): 高田昌彦
  • Organizer: ワークショップ「システム神経科学の将来展望」
  • Place of Presentation: ホテル鞠水亭（静岡県浜松市）
  • Year and Date: 2014-08-30
• [Presentation] パーキンソン病モデルサルにおける大脳皮質－大脳基底核経路の情報伝達異常 (2014)
  • Author(s): 高田昌彦
  • Organizer: 第39回日本大脳基底核研究会
  • Place of Presentation: 青森国際ホテル（青森県青森市）
  • Year and Date: 2014-08-23
• [Presentation] 黒質ドーパミン神経細胞への外来遺伝子導入によるパーキンソン病の予防的治療戦略 (2014)
  • Author(s): 高田昌彦
  • Organizer: 第10回横浜パーキンソン病治療研究会
  • Place of Presentation: 崎陽軒本店マンダリンイースト（神奈川県横浜市）
  • Year and Date: 2014-07-16
  • Invited
• [Presentation] 手指屈筋由来の運動ニューロン分布とサル脊髄損傷後の手指機能回復について (2014)
  • Author(s): 中川浩，二宮太平，高田昌彦，山下俊英
  • Organizer: 第49回日本理学療法学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] Novel primate models for Parkinson’s disease due to nigrostriatal pathway-selective gene manipulation. (2014)
  • Author(s): Takada M, Inoue K
  • Organizer: New Frontier of Molecular Neuropathology 2014
  • Place of Presentation: 東京医科歯科大学，東京
• [Presentation] サル片側脊髄損傷モデルにおける皮質脊髄路の可塑性変化の解析とリハビリテーション効果の検討 (2014)
  • Author(s): 高田昌彦
  • Organizer: CREST「脳神経回路」研究領域 運動系関連研究チーム合同ワークショップ
  • Place of Presentation: 自然科学研究機構，岡崎
  • Invited
• [Presentation] システム脳科学の趨勢を読む (2014)
  • Author(s): 高田昌彦
  • Organizer: 生理研シンポジウム・グローバルネットワークによる脳情報処理
  • Place of Presentation: 自然科学研究機構，岡崎
• [Presentation] Decoding tourettism and its response to deep brain stimulation. (2014)
  • Author(s): 高田昌彦，Kevin McCairn
  • Organizer: 京都大学‐ブリストル大学シンポジウム
  • Place of Presentation: 京都大学医学部，岡崎
• [Presentation] ニホンザルモデルが拓く新しい医療－脳科学の種が実るまで－ (2013)
  • Author(s): 高田昌彦
  • Organizer: ナショナルバイオリソースプロジェクト「ニホンザル」第10回公開シンポジウム
  • Place of Presentation: フクラシア東京ステーション，東京
  • Invited
• [Presentation] 遺伝子改変サルモデルを用いてパーキンソン病を克服する (2013)
  • Author(s): 高田昌彦
  • Organizer: ナショナルバイオリソースプロジェクト「ニホンザル」第10回公開シンポジウム
  • Place of Presentation: フクラシア東京ステーション，東京
  • Invited
• [Presentation] 精神疾患サルモデルの作出に向けた新規ウイルスベクターとその導入手法の開発 (2013)
  • Author(s): 高田昌彦
  • Organizer: 第4回脳表現型の分子メカニズム研究会
  • Place of Presentation: リファレンス駅東ビル，福岡
  • Invited
• [Presentation] Age-dependent alterations in the distribution of neurons expressing alpha-synuclein in macaque monkeys. (2013)
  • Author(s): Kimura K, Inoue K, Tanaka F, Takada M
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego， USA
• [Presentation] Negative feedback monitoring by lateral habenula and anterior cingulate cortex in monkey during a reversal learning task. (2013)
  • Author(s): Kawai T, Sato N, Takada M, Matsumoto M
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego， USA
• [Presentation] Neuronal networks innervating the jaw-opening and jaw-closing muscles: A retrograde transneuronal tracing study with rabies virus in the rat. (2013)
  • Author(s): Hatanaka N, Miyachi S, Nambu A, Takada M
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego， USA
• [Book] 生体の科学「特集 脳と心の謎はどこまで解けたか」 (2015)
  • Author(s): 川合隆嗣、山田洋、佐藤暢哉、高田昌彦、松本正幸
  • Total Pages: 130
  • Publisher: 医学書院
• [Book] Clinical Neuroscience「メインテーマ 脳の見える化─構造編 伝導路を見る」 (2015)
  • Author(s): 高田昌彦
  • Total Pages: 130
  • Publisher: 中外医学社
• [Book] 脳神経外科診療プラクティス６「脳神経外科医が知っておくべきニューロサイエンスの知識」 (2015)
  • Author(s): 高田昌彦
  • Total Pages: 236
  • Publisher: 文光堂
• [Book] Clinical neuroscience 「メインテーマ 脳のゆらぎ・同期・オシレーション」 (2014)
  • Author(s): 井上謙一，高田昌彦
  • Total Pages: 840
  • Publisher: 中外医学者
• [Remarks] 京都大学霊長類研究所･統合脳システム分野 ホームページ
  • URL: http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/index.html
• [Remarks] 京都大学霊長類研究所・統合脳システム分野 ホームページ
  • URL: http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/index.html
• [Remarks] 京都大学霊長類研究所 分子生理研究部門 統合脳システム分野
  • URL: http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/index.html