| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥31,590,000 (Direct Cost: ¥24,300,000、Indirect Cost: ¥7,290,000)
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| Outline of Final Research Achievements |
Mesial temporal lobe epilepsy (MTLE) is the most frequent focal epileptic syndrome in adults, and the majority of seizures originate primarily from the hippocampus. The resected hippocampus shows several degrees of neuronal loss (hippocampal sclerosis: HS), accordingly there would arise a paradox between clinical and pathological findings; how these atrophic tissues cause epilepsy? Here we investigated epileptiform activities using hippocampal specimens taken from MTLE patients ex vivo. Flavoprotein fluorescence imaging and local field potential recordings (LFPs) revealed that epileptiform activities were arise from subiculum of MTLE groups. Moreover, loss of inwardly rectifying K+ channel 4.1 (Kir 4.1) was evident in the astrocytes of the subiculum of HS. These results suggest that epileptogenic mechanisms would correlate to the distinct pathologies, and Kir 4.1 may play a pivotal role in epileptogensis of the HS.
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