| Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2015: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2014: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2013: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
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| Outline of Final Research Achievements |
The purpose of current proposal is to show the paradigm shift of two conventional concepts (paradigms A and B) regarding the roles of mammalian mitochondrial genome (mtDNA). Paradigm A is that the products of mtDNA are localized into mitochondrial inner membranes but not into cell membranes. The results of current study propose that the products of unknown cytoplasmic genetic factors but not the products of mtDNA are localized into cell membrane. Paradigm B is that the mutations in mtDNA are responsible not only for mitochondrial diseases, but also for aging and age-related disorders including tumor development. With respect to Paradigm B shift, we have proposed that aging phenotypes observed in elderly human fibroblasts are not caused by mtDNA mutations but by the reversible epigenetic regulations of nuclear-coded genes.
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