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Comprehensive understanding of intracellular signaling pathways deregulated by CagA, the oncogenic scaffold protein from H. pylori

Research Project

Project/Area Number 25250016
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor biology
Research InstitutionThe University of Tokyo

Principal Investigator

Hatakeyama Masanori  東京大学, 大学院医学系研究科(医学部), 教授 (40189551)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2014: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2013: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Keywordsヘリコバクター・ピロリ / 胃がん / CagA / SHP2 / チロシンリン酸化 / 感染発がん / 癌 / 感染症 / ピロリ菌 / 胃癌 / ホスファターゼ / 細菌 / シグナル伝達 / 炎症
Outline of Final Research Achievements

We found that the intracellular localization of SHP2, a key cellular target of the Helicobacter pylori CagA oncoprotein, is regulated by binding with the Hippo signal effectors, TAZ and YAP. We also found that parafibromin, a newly identified SHP2 substrate, acts as a transcriptional scaffold that integrates multiple distinct morphogen signals and converts them into adequate transcriptional outputs.
We identified SHP1 as a phosphatase that dephosphorylates CagA on the EPIYA motifs and thereby neutralizes the oncogenic potential of CagA. Meanwhile Pragmin, a human EPIYA-containing protein, was found to interact with and thereby catalytically activate Csk. H. pylori CagA may additionally promote neoplastic transformation of cells by perturbing the Pragmin-Csk signaling axis.

Report

(4 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (114 results)

All 2016 2015 2014 2013 2011 Other

All Journal Article (24 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 9 results,  Acknowledgement Compliant: 6 results) Presentation (81 results) (of which Int'l Joint Research: 7 results,  Invited: 56 results) Book (6 results) Remarks (3 results)

  • [Journal Article] Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA2016

    • Author(s)
      Shimoda A, Ueda K, Nishiumi S, Murata-Kamiya N, Mukai SA, Sawada S, Azuma T, Hatakeyama M, Akiyoshi K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 18346-18346

    • DOI

      10.1038/srep18346

    • NAID

      120005689168

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determination of the catalytic activity of LEOPARD syndrome- associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling2016

    • Author(s)
      Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma and Masanori Hatakeyama
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 469 Issue: 4 Pages: 1133-1139

    • DOI

      10.1016/j.bbrc.2015.12.117

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression2016

    • Author(s)
      Lang, B.
    • Journal Title

      Cell Stress Chaperones

      Volume: 21 Issue: 3 Pages: 1-11

    • DOI

      10.1007/s12192-016-0680-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improvement of Helicobacter pylori CagA crystals by the multi-step soaking method2016

    • Author(s)
      Senda, M.
    • Journal Title

      Cryst. Growth Des.

      Volume: 16 Issue: 3 Pages: 1565-1571

    • DOI

      10.1021/acs.cgd.5b01692

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] <i><b>Helicobacter pylori</b></i><b> induces IL-1β protein through the inflammasome activation in differentiated macrophagic </b><b>cells </b>2016

    • Author(s)
      Kameoka, S.
    • Journal Title

      Biomedical Research

      Volume: 37 Issue: 1 Pages: 21-27

    • DOI

      10.2220/biomedres.37.21

    • NAID

      130005128374

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation and functional analysis of specific tRNA granules caused by low-dose X-ray irradiation2016

    • Author(s)
      Katano, A.
    • Journal Title

      Bioimages

      Volume: 24

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Helicobacter pylori-mediated carcinogenesis and tyrosine phosphatases2015

    • Author(s)
      畠山 昌則
    • Journal Title

      生化学

      Volume: 87 Issue: 5 Pages: 554-559

    • DOI

      10.14952/SEIKAGAKU.2015.870554

    • ISSN
      0037-1017
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein2015

    • Author(s)
      Suzuki, N.
    • Journal Title

      Sci. Rep/

      Volume: 5 Issue: 1 Pages: 10024-10024

    • DOI

      10.1038/srep10024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis2015

    • Author(s)
      Nagase, L.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 15749-15749

    • DOI

      10.1038/srep15749

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 細菌エフェクター・細菌毒素の分子標的と疾病脆弱性2015

    • Author(s)
      清水 健
    • Journal Title

      日本細菌学雑誌

      Volume: 70 Pages: 319-328

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein.2015

    • Author(s)
      Suzuki, N., Murata-Kamiya, N., Yanagiya, K., Suda, W., Hattori, M., Hiroaki Kanda, H., Bingo, A., Yumiko Fujii, Y., Maeda, S., Koike, K. and Hatakeyama, M.
    • Journal Title

      Sci Rep

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis.2014

    • Author(s)
      Hatakeyama, M.
    • Journal Title

      Cell Host Microbe

      Volume: 15 Issue: 3 Pages: 306-316

    • DOI

      10.1016/j.chom.2014.02.008

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR12014

    • Author(s)
      Hashi, K.
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 3 Pages: 245-251

    • DOI

      10.1111/cas.12342

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes2014

    • Author(s)
      Bessede, E.
    • Journal Title

      Oncogene

      Volume: 33 Issue: 32 Pages: 4123-4131

    • DOI

      10.1038/onc.2013.380

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase2013

    • Author(s)
      Miura, K.
    • Journal Title

      Oncogene

      Volume: 32 Issue: 45 Pages: 5292-5301

    • DOI

      10.1038/onc.2012.571

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.2013

    • Author(s)
      Tsutsumi, D., Masoodi, M., Takahashi, A., Fujii, Y., Hayashi, T, . Kikuchi, I., et al.
    • Journal Title

      Developmental Cell

      Volume: 26(6) Issue: 6 Pages: 658-665

    • DOI

      10.1016/j.devcel.2013.08.013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?2013

    • Author(s)
      Hayashi, T.
    • Journal Title

      Cell. Microbiol.

      Volume: 15 Issue: 3 Pages: 377-385

    • DOI

      10.1111/cmi.12040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein2013

    • Author(s)
      Yamahashi, Y.
    • Journal Title

      Cell Adh. Migr.

      Volume: 7 Issue: 1 Pages: 11-17

    • DOI

      10.4161/cam.21936

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ピロリ菌由来胃がん発症因子CagAの立体構造解明2013

    • Author(s)
      畠山 昌則
    • Journal Title

      Isotope News

      Volume: 707 Pages: 2-7

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ヘリコバクター・ピロリ癌タンパク質CagA―その分子構造と機能―2013

    • Author(s)
      畠山 昌則
    • Journal Title

      日本臨床

      Volume: 72 (増刊号 1) Pages: 92-99

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ヘリコバクター・ピロリ菌およびその胃炎や胃潰瘍における役割の発見2013

    • Author(s)
      畠山 昌則
    • Journal Title

      Surgery Frontier

      Volume: 20 Pages: 15-18

    • Related Report
      2013 Annual Research Report
  • [Journal Article] H. pyloriによる腸上皮化生の誘導機構と発癌2013

    • Author(s)
      畠山 昌則
    • Journal Title

      消化器の臨床

      Volume: 16 Pages: 351-356

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 胃がん発症の基盤となる限定的細胞リプログラミング2013

    • Author(s)
      藤井 裕美子
    • Journal Title

      実験医学

      Volume: 31 Pages: 2095-2100

    • Related Report
      2013 Annual Research Report
  • [Journal Article] チロシンホスファターゼSHP2による核における基質タンパク質parafibrominを介したWnt経路の活性化2011

    • Author(s)
      高橋 昌史
    • Journal Title

      First Author's

      Volume: 33 Pages: 123

    • DOI

      10.7875/first.author.2011.123

    • Related Report
      2015 Annual Research Report
  • [Presentation] ピロリキンCagAの発がん活性を規定するSHP2結合能の非線形的変動2015

    • Author(s)
      畠山 昌則
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同年会
    • Place of Presentation
      ポートピアホテル、神戸
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori CagA oncoprotein and gastric cancer2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      The 20th Korea-Japan Cancer Workshop
    • Place of Presentation
      Royal Park Hotel The Shiodome, Tokyo
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ピロリ菌による胃がん発症機構2015

    • Author(s)
      畠山 昌則
    • Organizer
      昭和薬科大学・特別講演会
    • Place of Presentation
      昭和薬科大学、町田
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of Helicobacter pylori CagA oncoprotein in determining gastric caner risk2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      2015 International Symposium on Infectious Disease and Signal Transduction
    • Place of Presentation
      National Cheng Kung University, Tainan, Taiwan
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural determinant for the oncogenic potential of the Helicobacter pylori CagA protein2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      The 2015 Cold Spring Harbor Asia Conference on Bacterial Infection and Host Defense
    • Place of Presentation
      CSHA Conference Centre, Jangsu, China
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The stomach microbiota and gastric cancer,2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya Congress Center, Nagoya, Japan
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Function and regulation of the H. pylori CagA oncoprotein2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      16th FASEB Conference on Gastrointestinal Tract
    • Place of Presentation
      Stemboat Springs, Colorado, USA
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヘリコバクター・ピロリ菌による発がん機構2015

    • Author(s)
      畠山 昌則
    • Organizer
      第26回がん・エピゲノム研究会
    • Place of Presentation
      東北大学医学部艮陵会館記念ホール、仙台
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Function and Regulation of the Helicobacter pylori CagA oncoprotein2015

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      10th International Symposium of the Institute Network
    • Place of Presentation
      Frate Hall, Hokkaido University, Sapporo
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヘリコバクター・ピロリがんタンパク質CagAと胃がん2015

    • Author(s)
      畠山 昌則
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      ロイトン札幌/ホテルさっぽろ芸文館/札幌市教育文化会館、札幌
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌がんタンパク質CagAの機能とその制御2015

    • Author(s)
      畠山 昌則
    • Organizer
      第21回日本ヘリコバクター学会学術集会
    • Place of Presentation
      神戸ポートピアホテル、神戸
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヘリコバクター・ピロリ病原因子 CagAの構造・機能とその制御2015

    • Author(s)
      畠山 昌則
    • Organizer
      第43回日本潰瘍学会・OIST合同シンポジウム
    • Place of Presentation
      沖縄科学技術大学院大学、沖縄
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌癌タンパク質CagAと炎症発癌2015

    • Author(s)
      畠山 昌則
    • Organizer
      日本プロバティクス学会プロバイオティクスシンポジウム 2015
    • Place of Presentation
      三井プラザホール (霞ヶ関ビル)、東京
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori and gastric cancer2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      Academia Sinica Concerence of Frontiers in Biological Chemistry
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Linking inflammation and carcinogenesis by Helicobacter pylori CagA2015

    • Author(s)
      Hatakeyama, M.
    • Organizer
      Seoul National University Cancer Research Institute Cancer Symposium 2015
    • Place of Presentation
      Hwasun Kumho Resort, Korea
    • Year and Date
      2015-04-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural basis for the interaction of the Helicobacter pylori CagA oncoprotein with cellular targets2015

    • Author(s)
      畠山 昌則
    • Organizer
      第5回 新学術領域研究 発がんスパイラル国際シンポジウム
    • Place of Presentation
      神戸ポートピアホテル、兵庫県
    • Year and Date
      2015-02-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ParafibrominはWnt-Notch経路間の協調的クロストークを担うシグナルハブタンパク質として機能する2015

    • Author(s)
      菊地 逸平
    • Organizer
      平成26年度「がん研究分野等踏まえた支援活動」公開シンポジウム
    • Place of Presentation
      一橋講堂、東京都
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロリ菌がんタンパク質CagAと細菌EPIYAエフェクターファミリー2015

    • Author(s)
      畠山 昌則
    • Organizer
      大阪大学微生物研究所アドバンストセミナー
    • Place of Presentation
      大阪大学微生物病研究所、吹田、大阪府
    • Year and Date
      2015-01-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Keynote Lecture “Infection, Inflammation and Cancer: the eternal triangle?”2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      Max Planck Society-The University of Tokyo Joint Meerting 2014
    • Place of Presentation
      Max Planck Gesellschaft, Tagungsstatte harnack Hous, Gerlin, Germany
    • Year and Date
      2014-12-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of Helicobacter pylori CagA oncoprotein in gastric carcinogenesis.2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      VI Simposio Internacional Helicobacter pylori: Historia natural e implicaciones en ls salud humana.
    • Place of Presentation
      Instituto de Investigaciones en Salud, INISA, Universidad de Costa Rica, San Jose, Costa Rica
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌感染による胃上皮細胞リプログラミングと発がん2014

    • Author(s)
      畠山 昌則
    • Organizer
      第37回 日本分子生物学会(MBSJ 2014)ワークショップ「サーフェスバリア・共生と感染」
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Protein tyrosine phosphatase SHP1 negatively regulates the oncogenic action of the Helicobacter pylori CagA protein2014

    • Author(s)
      畠山 昌則
    • Organizer
      第4回 日仏がんワークショップ
    • Place of Presentation
      関西セミナーハウス、京都府
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 胃がん発症におけるピロリ菌がんタンパク質CagAの役割2014

    • Author(s)
      畠山 昌則
    • Organizer
      第5回 癌と炎症と抗酸化研究会(CIA研究会)
    • Place of Presentation
      大分県 別府コンベンションセンター
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Opposing roles for SHP1 and SHP2 phosphatases in the oncogenic action of Helicobacter pylori CagA protein2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      第11回日本プロテインホスファターゼ国際カンファレンス
    • Place of Presentation
      艮陵会館、東北大学、宮城県
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structure and function of the Helicobacter pylori CagA oncoprotein2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      Department of Molecular Microbiology and Immunology Seminar at USC-Keck School of Medicine
    • Place of Presentation
      Keck School of Medicinen of Southeren California, Los Angels, USA
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structure and function of the Helicobacter pylori CagA oncoprotein2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      The Saban Research Institute at Children’s Hospital Los Angeles
    • Place of Presentation
      The Saban Research Building Auditorium, Los Angels, USA
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌による胃癌発症の分子機構2014

    • Author(s)
      畠山 昌則
    • Organizer
      平成26年度日本医師会医学賞受賞講演
    • Place of Presentation
      日本医師会館、東京都
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌から胃の健康を守る~プロバイオティクスの可能性~2014

    • Author(s)
      畠山 昌則
    • Organizer
      四国新聞国際健康フォーラム
    • Place of Presentation
      サンポート高松、香川県
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Instigation of carcinogenesis by mutual reinforcement of the Helicobacter pylori CagA oncoprotein and inflammation2014

    • Author(s)
      畠山 昌則
    • Organizer
      5th Asian Pacific Topic Conference (APTC 2014) JSGE-APAGE Joint Conference
    • Place of Presentation
      神戸ポートピアホテル、兵庫県
    • Year and Date
      2014-10-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 胃がん発症におけるピロリ菌がんタンパク質CagAのリン酸化依存的活性化2014

    • Author(s)
      畠山 昌則
    • Organizer
      第87回日本生化学会大会「タンパク質リン酸化の破綻による、がんを中心とした疾患発症機構」
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌由来のがんタンパク質CagAの構造-機能相関研究2014

    • Author(s)
      千田 俊哉
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロリ菌がんタンパク質CagAと炎症による発がんスパイラルの形成2014

    • Author(s)
      畠山 昌則
    • Organizer
      第73回癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌CagAによる宿主分子撹乱機構の構造と機能2014

    • Author(s)
      林 剛瑠
    • Organizer
      第73回癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロリ菌がんタンパク質CagAと標的分子Cskとの相互作用における生物物理化学的解析2014

    • Author(s)
      林 剛瑠
    • Organizer
      第73回癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロリ菌CagA発現マウス胃粘膜における粘液細胞化生(SPEM)の誘導2014

    • Author(s)
      柳谷 公平
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] SHP1 is a cytoplasmic tyrosine phosphatase that dephosphorylates the Helicobacter pylori CagA oncoprotein.2014

    • Author(s)
      Priya Saju
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ParafibrominはWnt-Notch経路間の協調的クロストークを担うシグナルハブタンパク質として機能する2014

    • Author(s)
      菊地 逸平
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pragmin/C-terminal Srcキナーゼ (Csk) 複合体形成の機能的意義2014

    • Author(s)
      千田 淑恵
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Xenopus遺伝学を用いたヘリコバクター・ピロリがんタンパク質CagAの機能解析2014

    • Author(s)
      田尻 諒
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional collaboration between H. pylori CagA oncoprotein and inflammation2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      European Helicobacter Study Group 27th International Workshop on Helicobacter & Microbiota in Inflammation & Cancer
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structure and function of the CagA oncoprotein from Helicobacter pylori2014

    • Author(s)
      Toshiya Senda
    • Organizer
      23rd Congress of the IUCr
    • Place of Presentation
      Montreal ,Canada
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロリ菌による上皮極性破壊と胃発がん2014

    • Author(s)
      畠山 昌則
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      千里ライフサイエンスセンター、大阪府
    • Year and Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌感染と炎症・発がん2014

    • Author(s)
      畠山 昌則
    • Organizer
      第38回 阿蘇シンポジウム
    • Place of Presentation
      阿蘇リゾートグランドヴィリオホテル、熊本県
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Enhanced carcinogenesis by mutual reinforcement between Helicobacter pylori CagA and inflammation2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      Singapore Gastric Cancer Consortium 7th Annual Scientific Meeting
    • Place of Presentation
      National University Health System, Singapore
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori感染によるInterleukin-1β産生誘導機構の解析2014

    • Author(s)
      亀岡 章一郎
    • Organizer
      日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      札幌、北海道
    • Year and Date
      2014-06-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロリ菌による胃がん発症の分子機構2014

    • Author(s)
      畠山 昌則
    • Organizer
      第24回国立感染症研究所シンポジウム“微生物が関与する悪性腫瘍”
    • Place of Presentation
      国立感染症研究所、東京都
    • Year and Date
      2014-05-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of Helicobacter pylori CagA in inflammation and carcinogenesis2014

    • Author(s)
      Masanori Hatakeyama
    • Organizer
      American Association for Canxcer Research (AACR)-Japanese Cancer Association (JCA) Joint Symposium at the 105th AACR Annual Meeting of AACR (AACR 2014): Inflammation in gastric cancer
    • Place of Presentation
      San Diego Convention Center, Sai Diego, USA
    • Year and Date
      2014-04-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] YAP1-mRNAの選択的スプライシングによるSHP2/YAP1相互作用の制御2014

    • Author(s)
      高橋 昌史
    • Organizer
      がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
    • Place of Presentation
      学術総合センタ-、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] LEOPARD症候群特異的変異型SHP2のチロシンホスファターゼ活性解析2014

    • Author(s)
      野田 沙織
    • Organizer
      第6回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      三重大学、津
    • Related Report
      2013 Annual Research Report
  • [Presentation] LEOPARD症候群由来変異型SHP2ホスファターゼのin vitro酵素活性解析2013

    • Author(s)
      野田 沙織
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Helicobacter pyloriアメリンド株由来CagAの病態生理学的活性2013

    • Author(s)
      橋 香奈
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子CDX1による幹細胞性リプログラミング因子の発現誘導を介した胃上皮細胞の腸上皮細胞様分化形質転換2013

    • Author(s)
      藤井 裕美子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヘリコバクター・ピロリがんタンパク質CagAの分子多型と生物活性2013

    • Author(s)
      長瀬 里沙
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] EBウィルスによる上皮腫瘍化における癌幹細胞の存在について2013

    • Author(s)
      吉山 裕規
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biochemical and Biophysical Analysis for the Oncogenic Interaction between H. pylori CagA and SHP22013

    • Author(s)
      林 剛瑠
    • Organizer
      The 3rd French-Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Natural Variant of Helicobacter pylori Carrying CagA with a Reduced Oncogenic Potential2013

    • Author(s)
      橋 香奈
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート, 舞浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of SHP2-YAP Interaction by Differential Splicing of YAP mRNA2013

    • Author(s)
      Mohammad Masoudi
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート, 舞浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of EPIYA-C Repeat Number on the Interaction of Helicobacter pylori Oncoprotein CagA with SHP2 Phosphatase2013

    • Author(s)
      長瀬 里沙
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート, 舞浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of Stemness Factors in the Intestinal Transdifferentiation of Gastric Epithelial Cells2013

    • Author(s)
      藤井 裕美子
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート, 舞浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tyrosine Phosphatase Activity of SHP2 Mutants Derived from LEOPARD Syndrome2013

    • Author(s)
      野田 沙織
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート, 舞浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ピロリ菌CagAとチロシンホスファターゼSHP2の発がん複合体形成における生化学的解析2013

    • Author(s)
      林 剛瑠
    • Organizer
      2013年度CREST/さきがけ 合同キックオフミーティング
    • Place of Presentation
      ホテルラフォーレ琵琶湖、滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 発がん性足場タンパク質としてのピロリ菌CagAの機能と構造

    • Author(s)
      畠山 昌則
    • Organizer
      第50回日本臨床医学会学術集会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌癌タンパク質CagAの構造と機能

    • Author(s)
      畠山 昌則
    • Organizer
      第44回広島消化管研究会
    • Place of Presentation
      ホテルグランヴィア広島、広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Structure and function of the H. pylori CagA oncoprotein

    • Author(s)
      畠山 昌則
    • Organizer
      40th Institute of Medical Science, The University of Tokyo (IMSUT) Commemorative Symposium
    • Place of Presentation
      東京大学医科学研究所、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヘリコバクター・ピロリによる胃癌発症機構

    • Author(s)
      畠山 昌則
    • Organizer
      第49回姫路市医師会夏期大会
    • Place of Presentation
      姫路市医師会館、姫路
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori and gastric cancer: recent development

    • Author(s)
      畠山 昌則
    • Organizer
      6th Annual Scientific Meeting of Singapore Gastric Cancer Consortium
    • Place of Presentation
      Singapore, Singapore
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヘリコバクター・ピロリCagAによる胃がん発症機構

    • Author(s)
      畠山 昌則
    • Organizer
      平成25年度文科省がん支援「がん若手研究者ワークショップ」
    • Place of Presentation
      蓼科グランドホテル、長野
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori CagA directs gastric intestinal metaplasia by inducing stemness-related reprogramming factors

    • Author(s)
      畠山 昌則
    • Organizer
      26th European Helicobacter study group International Workshop
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Oncogenic mechanism of Helicobacter pylori

    • Author(s)
      畠山 昌則
    • Organizer
      Seminar Series at Centro National de Investigaciones Oncologicas (CNIO)
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Function and regulation of SHP2 phosphatase, a cellular target of Helicobacter pylori oncoprotein CagA

    • Author(s)
      畠山 昌則
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヘリコバクター・ピロリ菌による胃がん発症機構

    • Author(s)
      畠山 昌則
    • Organizer
      第61回日本ウイルス学会学術集会・特別講演
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of Helicobacter pylori in gastric carcinogenesis

    • Author(s)
      畠山 昌則
    • Organizer
      UTokyo Forum in Brazil 2013
    • Place of Presentation
      Sao Paulo, Brazil
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mechanisms determining subcellular localization of the oncogenic protein tyrosine phosphatase SHP2

    • Author(s)
      畠山 昌則
    • Organizer
      The 3rd French-Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Function and regulation of SHP2 tyrosine phosphatase

    • Author(s)
      畠山 昌則
    • Organizer
      The 2rd Taiwan-Japan Bilateral Conference on Protein Phosphatases
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of Helicobacter pylori CagA in Gastric Carcinogenesis

    • Author(s)
      畠山 昌則
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート, 舞浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌がんタンパク質CagAの構造と機能

    • Author(s)
      畠山 昌則
    • Organizer
      宮城県立がんセンターセミナー
    • Place of Presentation
      名取、宮城
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of Helicobacter pylori CagA in Gastric Carcinogenesis

    • Author(s)
      畠山 昌則
    • Organizer
      The 4th International Symposium on Carcinogenic Spiral
    • Place of Presentation
      京王プラザホテル札幌、札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 胃発がんにおけるピロリ菌がんタンパク質CagAの役割

    • Author(s)
      畠山 昌則
    • Organizer
      愛媛大学プロテオサイエンスセンター 第1回学術シンポジウム
    • Place of Presentation
      愛媛大学、松山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Oncogenic mechanisms of the Helicobacter pylori CagA protein

    • Author(s)
      畠山 昌則
    • Organizer
      Seminar at the Institute of Biological Chemistry, Academia Sinica
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Oncogenic mechanisms of the Helicobacter pylori CagA protein

    • Author(s)
      畠山 昌則
    • Organizer
      Tsu-Chi Hospital and University Seminar Series
    • Place of Presentation
      Hua-Lien, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌エフェクターによる細胞がん化機構

    • Author(s)
      畠山 昌則
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Recent Advances in Gastrointestinal Carcinogenesis2016

    • Author(s)
      Senda, Y., Hatakeyama, M.
    • Total Pages
      14
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] ピロリ菌因子CagAの発癌病原性活性化機構2014

    • Author(s)
      畠山 昌則
    • Publisher
      感染・炎症・免疫
    • Related Report
      2014 Annual Research Report
  • [Book] Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御2014

    • Author(s)
      高橋 昌史、堤 良平、畠山 昌則
    • Publisher
      細胞工学
    • Related Report
      2014 Annual Research Report
  • [Book] ピロリ菌の発がんタンパク質CagAの構造と機能2014

    • Author(s)
      千田 俊哉、千田 美紀、林 剛瑠、畠山 昌則
    • Publisher
      実験医学
    • Related Report
      2014 Annual Research Report
  • [Book] Helicobacter pyloriがんタンパク質CagAとEPIYAエフェクターファミリー2014

    • Author(s)
      畠山 昌則
    • Publisher
      生化学(総説)
    • Related Report
      2014 Annual Research Report
  • [Book] ピロリ菌による胃癌発症の分子機構2014

    • Author(s)
      畠山 昌則
    • Publisher
      日本医師会雑誌
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科・医学部 微生物学研究室

    • URL

      http://www.microbiol.m.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 医学系研究科 医学部 微生物学教室のホームページ

    • URL

      http://www.microbiol.m.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学医学系研究科・医学部 微生物学研究室

    • URL

      http://www.microbiol.m.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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