Comprehensive understanding of molecular carcinogenesis through omics analysis and development of molecular diagnostics for personalized medicine
| Project/Area Number |
25250019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Johji Inazawa 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
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| Co-Investigator(Kenkyū-buntansha) |
Kozaki Ken-ichi 岡山大学, 医歯薬学総合研究科, 教授 (50270715)
Inoue Jun 東京医科歯科大学, 難治疾患研究所, 講師 (50568326)
Tanimoto Kosuke 東京医科歯科大学, 難治疾患研究所, 助教 (60611613)
Muramatsu Tomoki 東京医科歯科大学, 難治疾患研究所, 助教 (90732553)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Keywords | がん個別化医療 / オミクス解析 / 上皮間葉転換 / p62 / マイクロRNA / バイオマーカー / 治療標的 / オートファジー / EMT / ビメンチン / 難治がん / 癌遺伝子 / 癌抑制遺伝子 / ゲノム / エピゲノム / DNAメチル化 / 分子標的薬 |
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| Outline of Final Research Achievements |
The principle aim of this research project is to understand the molecular mechanism underlying intractable cancer and to contribute to the development of molecular target-therapy and diagnosis for the personalized cancer medicine. Our achievements of the project as follows; (1) The hypusine cascade involved in protein synthesis was identified as a novel cancer therapeutic target. (2) Using function-based screening we identified a novel EMT-inducing microRNA, miR-544a in gastric cancer cell line. (3) We found that high expression of p62 is associated with poor prognosis in endometrial cancers. (4) Overexpression of miR-634 activates the mitochondrial apoptotic pathway, indicating the utility of miR-634 therapy against NRF2-activated tumors.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Overexpression of SMYD2 contributes to malignant outcome in gastric cancer2014
Author(s)
Komatsu S, Ichikawa D, Hirajima S, Nagata H, Nishimura Y, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Imoto I, Inazawa J, Otsuji E
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Journal Title
Br J Cancer
Volume: 112
Issue: 2
Pages: 357-64
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression.2014
Author(s)
Uno M, Saitoh Y, Mochida K, Tsuruyama E, Kiyono T, Imoto I, Inazawa J, Yuasa Y, Kubota T, Yamaoka S.
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Journal Title
PLoS One
Volume: 9(2)
Issue: 2
Pages: e88347-e88347
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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