| Project/Area Number |
25250019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Johji Inazawa 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
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| Co-Investigator(Kenkyū-buntansha) |
Kozaki Ken-ichi 岡山大学, 医歯薬学総合研究科, 教授 (50270715)
Inoue Jun 東京医科歯科大学, 難治疾患研究所, 講師 (50568326)
Tanimoto Kosuke 東京医科歯科大学, 難治疾患研究所, 助教 (60611613)
Muramatsu Tomoki 東京医科歯科大学, 難治疾患研究所, 助教 (90732553)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Keywords | がん個別化医療 / オミクス解析 / 上皮間葉転換 / p62 / マイクロRNA / バイオマーカー / 治療標的 / オートファジー / EMT / ビメンチン / 難治がん / 癌遺伝子 / 癌抑制遺伝子 / ゲノム / エピゲノム / DNAメチル化 / 分子標的薬 |
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| Outline of Final Research Achievements |
The principle aim of this research project is to understand the molecular mechanism underlying intractable cancer and to contribute to the development of molecular target-therapy and diagnosis for the personalized cancer medicine. Our achievements of the project as follows; (1) The hypusine cascade involved in protein synthesis was identified as a novel cancer therapeutic target. (2) Using function-based screening we identified a novel EMT-inducing microRNA, miR-544a in gastric cancer cell line. (3) We found that high expression of p62 is associated with poor prognosis in endometrial cancers. (4) Overexpression of miR-634 activates the mitochondrial apoptotic pathway, indicating the utility of miR-634 therapy against NRF2-activated tumors.
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