| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
It is known that mRNAs, aberrantly bound by U snRNA export factors due to low expression of hnRNP C, are not exported to the cytoplasm. We are interested in studying such a novel mechanism that monitors the integrity of nuclear mRNPs. Here we show that knock-down of PHAX, which has an antagonizing activity against hnRNP C, induced genome instability. We further show that PHAX somehow controls the expression of histone H2AX, which is a key player for DNA lesion responses.
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