| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
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| Outline of Final Research Achievements |
Endoplasmic reticulum (ER) stress and its stress response play important roles in differentiation and maturation of various cells, and are also involved in onset of several diseases. In this research, we found that the signaling from the ER stress sensors activates vascularization in developmental bone tissues and is involved in differentiation of osteoclasts, and that the luminal domains of ER stress sensors are secreted from cells to extracellular spaces and facilitate cell proliferation through the activation of hedgehog signaling pathway. Further, we developed the method for inhibiting cell growth of cancer cells by application of monoclonal antibody against the luminal domain of ER stress sensors.
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