Molecular mechanisms of biological regulation by endoplasmic reticulum stress response
| Project/Area Number |
25251014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
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| Keywords | 細胞内情報伝達機構 / 小胞体 / 発生・分化 / 疾患生物学 / ストレス |
|---|
| Outline of Final Research Achievements |
Endoplasmic reticulum (ER) stress and its stress response play important roles in differentiation and maturation of various cells, and are also involved in onset of several diseases. In this research, we found that the signaling from the ER stress sensors activates vascularization in developmental bone tissues and is involved in differentiation of osteoclasts, and that the luminal domains of ER stress sensors are secreted from cells to extracellular spaces and facilitate cell proliferation through the activation of hedgehog signaling pathway. Further, we developed the method for inhibiting cell growth of cancer cells by application of monoclonal antibody against the luminal domain of ER stress sensors.
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.2015
Author(s)
Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K.
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Journal Title
J Cell Sci
Volume: 128
Pages: 4353-4365
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7.2015
Author(s)
Iwamoto H, Matsuhisa K, Saito A, Kanemoto S, Asada R, Hino K, Takai T, Cui M, Cui X, Kaneko M, Arihiro K, Sugiyama K, Kurisu K, Matsubara A, Imaizumi K.
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Journal Title
Plos One
Volume: 10
Issue: 5
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells2015
Author(s)
Okada M, Ikegawa S, Morioka M, Yamashita A, Saito A, Sawai H,Murotsuki J, Ohashi H, Okamoto T, Nishimura G, Imaizumi K, Tsumaki N
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Journal Title
Hum Mol Genet
Volume: 24
Issue: 2
Pages: 299-313
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes.2014
Author(s)
Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K.
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Journal Title
Journal of Biological Chemistry
Volume: 289
Issue: 20
Pages: 13810-13820
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor.2014
Author(s)
Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, Kudo T.
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Journal Title
Cell Death & Disease
Volume: 5
Related Report
Peer Reviewed / Open Access
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[Journal Article] Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells.2013
Author(s)
Miyagi H, Kanemoto S, Saito A, Asada R, Iwamoto H, Izumi S, Kido M, Gomi F, Nishida K, Kiuchi Y, Imaizumi K.
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Journal Title
PLOS ONE
Volume: 8
Issue: 1
Pages: 55155-55155
DOI
Related Report
Peer Reviewed
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