| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
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| Outline of Final Research Achievements |
How is the anterior-posterior polarity of mammalian body determined? Exactly when is it determined, and what is the mechanism? We have addressed these questions, and have obtained following results.
1) The mechanism that specifies DVE, a group of cells that determines the anterior-posterior polarity: DVE is induced by Nodal signaling, the number of future DVE cells is negatively regulated by Lefty, an inhibitor of Nodal, future DVE cells are randomly selected from blastomeres before implantation.
2) Nodal signaling in oocytes acts as a maternal factor and regulates cell specification during pre-implantation development. We have searched for target genes of maternal Nodal signaling, and have identified a few functional target genes of maternal Nodal signaling.
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