Origin of Anterior-Posterior Polarity Axis in the Mouse
Project/Area Number |
25251029
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | Osaka University |
Principal Investigator |
HAMADA Hiroshi 大阪大学, 生命機能研究科, 教授 (00208589)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
|
Keywords | 胚発生 / 体軸 / 非対称性 / 細胞系譜 |
Outline of Final Research Achievements |
How is the anterior-posterior polarity of mammalian body determined? Exactly when is it determined, and what is the mechanism? We have addressed these questions, and have obtained following results. 1) The mechanism that specifies DVE, a group of cells that determines the anterior-posterior polarity: DVE is induced by Nodal signaling, the number of future DVE cells is negatively regulated by Lefty, an inhibitor of Nodal, future DVE cells are randomly selected from blastomeres before implantation. 2) Nodal signaling in oocytes acts as a maternal factor and regulates cell specification during pre-implantation development. We have searched for target genes of maternal Nodal signaling, and have identified a few functional target genes of maternal Nodal signaling.
|
Report
(4 results)
Research Products
(23 results)
-
[Journal Article] Overall architecture of the IFT-B complex containing Cluap1/IFT38 as an essential component of the IFT-B peripheral subcomplex.2016
Author(s)
Katoh, Y., Terada, M., Nishijima, Y., Takei, R., Nozaki, S., Hamada, H. and Nakayama, K.
-
Journal Title
J. Biol. Chem.
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Absence of radial spokes in mouse node cilia is required for rotational movement but confers ultrastructural instability as a trade-off.2015
Author(s)
Shinohara, K., Chen, D., Nishida, T., Misaki, K., Yonemura, S. and Hamada, H.
-
Journal Title
Dev Cell
Volume: 35
Issue: 2
Pages: 236-246
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
[Journal Article] Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo2015
Author(s)
Ioannis Kokkinopoulos, Hidekazu Ishida, Rie Saba, Prashant Ruchaya, Claudia Cabrera, Monika Struebig, Michael Barnes, Anna Terry, Masahiro Kaneko, Yasunori Shintani, Steven Coppen, Hidetaka Shiratori, Torath Ameen, Charles Mein, Hiroshi Hamada, Ken Suzuki, Kenta Yashiro
-
Journal Title
PLos One
Volume: 10(10)
Issue: 10
Pages: e0140831-e0140831
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Journal Article] Self-regulated left-right asymmetric expression of Pitx2c in the developing limb2014
Author(s)
Shiratori, H., Yashiro, Iwai, N., Oki, S., Ikawa, Y., Kanata, K., and Hamada, H.
-
Journal Title
Dev. Biol.
Volume: 395
Issue: 2
Pages: 331-341
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
[Journal Article] Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.2014
Author(s)
Dong, F., Shinohara, K., Nabeshima, R., Botilde, Y., Asai, Y., Fukumoto, A., Hasegawa, T., Matsuo, M., Takeda, H., Shiratori, H., Nakamura T., and Hamada, H.
-
Journal Title
J. Cell Biol.
Volume: 204
Issue: 2
Pages: 203-213
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo2013
Author(s)
Botilde, Y., Yoshiba, S., Shinohara, K., Hasegawa, T., Nishimura, H., Shiratori, H. and Hamada, H.
-
Journal Title
Developmental Biology
Volume: 381
Issue: 1
Pages: 203-212
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Presentation] 濱田博司2015
Author(s)
Hamada, H.
Organizer
第38回日本分子生物学会年会
Place of Presentation
神戸国際会議場(兵庫県神戸市)
Year and Date
2015-12-01
Related Report
Invited
-
-
-
-
-
-
-