Molecular and functional properties of Opn5
| Project/Area Number |
25251036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAMOTO Yasushi 京都大学, 大学院理学研究科, 准教授 (80263200)
YAMASHITA Takahiro 京都大学, 大学院理学研究科, 助教 (50378535)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2013: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Keywords | 光受容体 / オプシン / 機能多様性 / 分子メカニズム / モデル動物 / 光受容 |
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| Outline of Final Research Achievements |
Animal photoreceptor proteins, opsins, have been widely diversified to acquire various new physiological functions in the course of molecular evolution. In this study, we have investigated the molecular properties of opsins in Opn5 group, one of the opsin groups that was most recently discovered in mammals, and found that they were diversified into not only UV- and visible-light absorbing receptors but also a reverse photoreceptor that loses G protein activation activity by light. We have also investigated localizations of Opn5 in eyes and brain and explored their functions by generating knock-out medaka fishes. The results indicated that some of the Opn5 subgroups would be responsible for uncharacterized physiological functions. Furthermore, we have investigated the molecular properties of opsins diversified in the vertebrate visual opsin group to obtain insights into molecular mechanisms underlying diversification in Opn5 group.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Origin of the low thermal isomerization rate of rhodopsin chromophore2015
Author(s)
Yanagawa, M.; Kojima, K.; Yamashita, T.; Iwamoto, Y.; Matsuyama, T.; Nakanishi, K.; Yamano, Y.; Wada, A.; Sako, Y.; Shichida, Y.
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Journal Title
Sci. Rep.
Volume: 5
Issue: 1
Pages: 11081-11081
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Diversification of non-visual photopigment parapinopsin in spectral sensitivity for diverse pineal functions2015
Author(s)
M. Koyanagi, S. Wada, E. Kawano-Yamashita, Y. Hara, S. Kuraku, S. Kosaka, K. Kawakami, S. Tamotsu, H. Tsukamoto, Y. Shichida, A. Terakita
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Journal Title
BMC Biology
Volume: 13
Issue: 1
Pages: 73-73
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ligand-induced population shift leads to the activation of rhodopsin, a G-protein coupled receptor2014
Author(s)
Maeda, R., Hiroshima, M., Yamashita, T., Wada, A., Nishimura, S., Sako, Y., Shichida, Y., and Imamoto, Y
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Journal Title
Biophys. J
Volume: 106 (4)
Issue: 4
Pages: 915-924
DOI
Related Report
Peer Reviewed
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