| Budget Amount *help |
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2014: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2013: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Outline of Final Research Achievements |
LC-MS/MS analyses showed that cholesterol and 7-dehydrocholesterol increased with developmental growth in the prothoracic glands where the insect steroid hormone, ecdysone, was produced. The results of multivariate analysis of steroids compared with other tissues showed that the prothoracic glands have different steroid profiling from other tissues. Furthermore, the localization analyses of lipophorin, a steroid transport lipoprotein, and cholesterol also supported the existence of a steroid uptake mechanism unique to the prothoracic glands. We also could identify one scavenger receptor which might be a molecule involved in steroid uptake from lipophorin in the prothoracic glands.
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