Role of myeloid-derived suppressor cells in tumor microenvironment

• Project/Area Number: 25252049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Murata Takahisa 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40422365)
• Co-Investigator(Kenkyū-buntansha): 有竹 浩介 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (70390804)
• Project Period (FY): 2013-05-31 – 2017-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2016: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000); Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2013: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: がん / 脂質 / 炎症 / プロスタグランジン / 免疫 / 薬理学 / 免疫学 / 癌

Outline of Final Research Achievements

Myeloid-derived suppressor cells are reported to modulate immunoresponses in tumor microenvironment. However, its detail charactaristics remain unknown.In the present project, we have revealed the anti-inflammatory role of myeloid-derived suppressor cells in tumor growth and metastasis using murine models. In detail, we evidenced that myeloid-derived suppressor cells produce anti-inflammatory lipid mediator prostaglandin D2 in tumor mass and metastatic tissue.

Research Products

• [Int'l Joint Research] Yale University(米国)
• [Int'l Joint Research] Yale University, School of Medicine.(米国)
• [Journal Article] The roles of IgE in allergic diseases (2018)
  • Author(s): Hayashi A, Nakamura T, Murata T.
  • Journal Title: Folia Pharmacologica Japonica Volume: 151 Issue: 3 Pages: 130-130
  • DOI: 10.1254/fpj.151.130
  • NAID: 130006470912
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] Production of lipid mediators across different disease stages of dextran sodium sulfate-induced colitis in mice. (2018)
  • Author(s): Hamabata T, Nakamura T, Masuko S, Maeda S, Murata T.
  • Journal Title: J Lipid Res. Volume: 59(4) Issue: 4 Pages: 586-595
  • DOI: 10.1194/jlr.m079095
  • Peer Reviewed
• [Journal Article] Prostaglandin D2 metabolite in urine is an index of food allergy. (2017)
  • Author(s): Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T.
  • Journal Title: Sci Rep. Volume: 15;7(1) Issue: 1 Pages: 17687-17687
  • DOI: 10.1038/s41598-017-17798-w
  • Peer Reviewed / Open Access
• [Journal Article] Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells (2017)
  • Author(s): Omori Keisuke、Morikawa Teppei、Kunita Akiko、Nakamura Tatsuro、Aritake Kosuke、Urade Yoshihiro、Fukayama Masashi、Murata Takahisa
  • Journal Title: The Journal of Pathology Volume: 244 Issue: 1 Pages: 84-96
  • DOI: 10.1002/path.4993
  • Peer Reviewed / Open Access
• [Journal Article] The role of mast cell in inflammation (2017)
  • Author(s): Yamazaki A, Nakamura T, Omori K, Murata T.
  • Journal Title: Folia Pharmacologica Japonica Volume: 149 Issue: 5 Pages: 204-207
  • DOI: 10.1254/fpj.149.204
  • NAID: 130006777506
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice. (2017)
  • Author(s): Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T.
  • Journal Title: J Allergy Clin Immunol. Volume: 140(2) Issue: 2 Pages: 630-632.e9
  • DOI: 10.1016/j.jaci.2017.02.030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prostaglandin D2 attenuates bleomycin-induced lung inflammation and pulmonary fibrosis (2016)
  • Author(s): Kida Taiki, Ayabe Shinya, Omori Keisuke, Nakamura Tatsuro, Maehara Toko, Aritake Kosuke, Urade Yoshihiro, Murata Takahisa
  • Journal Title: PLoS One Volume: 11(12) Issue: 12 Pages: e0167729-e0167729
  • DOI: 10.1371/journal.pone.0167729
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thromboxane A2 exacerbates acute lung injury via promoting edema formation (2016)
  • Author(s): Kobayashi Koji, Horikami Daiki, Omori Keisuke, Nakamura Tatsuro, Yamazaki Arisa, Maeda Shingo, Murata Takahisa
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 32109-32109
  • DOI: 10.1038/srep32109
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of anti-inflammatory role of prostaglandin D2. (2016)
  • Author(s): Murata T, Maehara T.
  • Journal Title: J Vet Med Sci. Volume: 78(11) Pages: 1643-1647
  • NAID: 130005129751
  • Peer Reviewed
• [Journal Article] Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation (2016)
  • Author(s): Kaji N, Horiguchi K, Iino S, Nakayama S, Ohwada T, Otani Y, Firman, Murata T, Sanders KM, Ozaki H, Hori M
  • Journal Title: Pharmacological Research Volume: 111 Pages: 838-848
  • DOI: 10.1016/j.phrs.2016.07.030
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Physiological role of mast cell (2015)
  • Author(s): Nakamura T, Murata T.
  • Journal Title: Folia Pharmacologica Japonica Volume: 146 Issue: 6 Pages: 349-349
  • DOI: 10.1254/fpj.146.349
  • NAID: 130005129759
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] Discovery of anti-inflammatory role of prostaglandin D₂ (2015)
  • Author(s): Murata T.
  • Journal Title: Folia Pharmacologica Japonica Volume: 146 Issue: 4 Pages: 201-207
  • DOI: 10.1254/fpj.146.201
  • NAID: 130005129751
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] Characteristics of tumor endothelial cells (2015)
  • Author(s): Omori Keisuke, Murata Takahisa
  • Journal Title: Folia Pharmacologica Japonica Volume: 146 Issue: 3 Pages: 174-174
  • DOI: 10.1254/fpj.146.174
  • NAID: 130005097941
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Open Access
• [Journal Article] VEGF-induced blood flow increase causes vascular hyper-permeability in vivo (2015)
  • Author(s): Ashina Kohei, Tsubosaka Yoshiki, Kobayashi Koji, Omori Keisuke, Murata Takahisa
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 464(2) Issue: 2 Pages: 590-5
  • DOI: 10.1016/j.bbrc.2015.07.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. (2015)
  • Author(s): Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
  • Journal Title: Nat Commun Volume: 10;6 Issue: 1 Pages: 7514-7514
  • DOI: 10.1038/ncomms8514
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo (2015)
  • Author(s): Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, Murata T.
  • Journal Title: PLoS One Volume: 9;10(7) Issue: 7 Pages: e0132367-e0132367
  • DOI: 10.1371/journal.pone.0132367
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat (2015)
  • Author(s): Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, Hori M.
  • Journal Title: Journal of Veterinary Medical Science Volume: 77 Issue: 11 Pages: 1443-1449
  • DOI: 10.1292/jvms.15-0198
  • NAID: 130005112081
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice (2015)
  • Author(s): Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M.
  • Journal Title: Journal of Veterinary Medical Science Volume: 77 Issue: 10 Pages: 1195-1199
  • DOI: 10.1292/jvms.15-0182
  • NAID: 130005107606
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus. (2015)
  • Author(s): Maehara T; Matsumoto K; Horiguchi K; Kondo M; Iino S; Horie S; Murata T; Tsubone H; Shimada S; Ozaki H; Hori M.
  • Journal Title: Br J Pharmacol Volume: 172(4) Issue: 4 Pages: 1136-1147
  • DOI: 10.1111/bph.13006
  • Peer Reviewed / Open Access
• [Journal Article] Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis (2014)
  • Author(s): Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M
  • Journal Title: Development Volume: 141(7) Issue: 7 Pages: 1465-1472
  • DOI: 10.1242/dev.104539
  • Peer Reviewed
• [Journal Article] Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. (2014)
  • Author(s): Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
  • Journal Title: Cancer Res. Volume: 74 Issue: 11 Pages: 3011-9
  • DOI: 10.1158/0008-5472.can-13-2792
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor Type 4 Axis Promotes Endothelial Cell Barrier Integrity via Phosphoinositide 3-Kinase and Rac1 Activation. (2014)
  • Author(s): Kobayashi K, Sato K, Kida T, Omori K, Hori M, Ozaki H, Murata T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: Aug;34(8) Issue: 8 Pages: 1716-22
  • DOI: 10.1161/atvbaha.114.303890
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages. (2014)
  • Author(s): Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M.
  • Journal Title: J Pharmacol Sci. Volume: 125(4) Pages: 394-405
  • NAID: 130004677798
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation. (2014)
  • Author(s): Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, Murata T.
  • Journal Title: J Immunol Volume: Dec 15;193(12) Issue: 12 Pages: 5835-40
  • DOI: 10.4049/jimmunol.1303478
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during theprogression of skin inflammation. (2014)
  • Author(s): Hana Sarashina, Yoshiki Tsubosaka, Keisuke Omori, Kosuke Aritake, Takayuki Nakagawa, Masatoshi Hori, Hiroyuki Hirai, Masataka Nakamura, Shuh Narumiya, Yoshihiro Urade, Hiroshi Ozaki and Takahisa Murata
  • Journal Title: The Journal of Immunology Volume: 192(1) Issue: 1 Pages: 459-65
  • DOI: 10.4049/jimmunol.1302080
  • Peer Reviewed / Open Access
• [Journal Article] Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1 (2014)
  • Author(s): Kida T, Omori K, Hori M, Ozaki H, Murata T
  • Journal Title: J Pharmacol Exp Ther Volume: 348(1) Issue: 1 Pages: 125-130
  • DOI: 10.1124/jpet.113.209288
  • Peer Reviewed / Open Access
• [Journal Article] UDP induces intestinal epithelial migration via the P2Y6 receptor (2013)
  • Author(s): Nakamura T, Murata T, Hori M, Ozaki H
  • Journal Title: Br J Pharmacol Volume: 170(4) Issue: 4 Pages: 883-892
  • DOI: 10.1111/bph.12334
  • Peer Reviewed / Open Access
• [Journal Article] Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells (2013)
  • Author(s): Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 33(7) Issue: 7 Pages: 1663-1669
  • DOI: 10.1161/atvbaha.113.301565
  • Peer Reviewed / Open Access
• [Journal Article] eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases (2013)
  • Author(s): Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC
  • Journal Title: J Cell Sc Volume: 126(Pt 24) Pages: 5541-5552
  • DOI: 10.1242/jcs.115972
  • Peer Reviewed / Open Access
• [Presentation] Inhibition of SDF-1α/CXCR4 signaling abrogate diabetic retinopathy (2017)
  • Author(s): Keisuke Omori, Yoko Fukushima, Kaori Kunita, Nobutaka Fujii, Yoshitsugu Takabatake, Akiyoshi Uemura, and Takahisa Murata
  • Organizer: 第90回日本薬理学会
• [Presentation] 食物アレルギーの診断・治療法の開発 (2017)
  • Author(s): 村田幸久
  • Organizer: 第４回お茶ノ水サイエンス倶楽部
  • Invited
• [Presentation] Urinary Prostaglandin D2 Metabolite is a Novel Biomarker of Food Allergy (2017)
  • Author(s): Tatsuro Nakamura1, Shingo Maeda1, Hiroaki Harada2, Shinichiro Inagaki3, Masami Narita3, Kosuke Aritake4, Tatsuo Shimosawa5, Yoshihiro Urade4, Yutaka Yatomi5, Yukihiro Ohya3 and Takahisa Murata1
  • Organizer: American Academy of Allergy, Asthma & Immunology Annual Meeting
  • Int'l Joint Research
• [Presentation] Signal enhancement of PGD2 receptor DP attenuates food allergy (2017)
  • Author(s): Tatsuro Nakamura, Rina Hirai, Takahisa Murata
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] SDF-1α/CXCR4シグナルの阻害は、糖尿病網膜症を改善する (2017)
  • Author(s): 大森啓介, 倉田薫里, 藤井信孝, 植村明嘉, 村田幸久
  • Organizer: 第90回日本薬理学会年会
• [Presentation] 気管支上皮細胞由来のPGD2は慢性アレルギー性肺炎を抑制する (2017)
  • Author(s): 前原都有子1、中村達朗1、前田真吾2、有竹浩介3、裏出良博3、村田幸久1
  • Organizer: 第59回日本脂質生化学会
• [Presentation] 気管支上皮細胞由来のPGD2がアレルギー性肺炎を抑制する (2017)
  • Author(s): 前原 都有子1、中村 達朗1、前田真吾2、有竹 浩介3、裏出 良博3、村田 幸久1
  • Organizer: 第136回日本薬理学会関東部会
• [Presentation] 気管支上皮細胞由来のPGD2は慢性アレルギー性肺炎を抑制する (2017)
  • Author(s): 前原 都有子1、中村 達朗1、前田真吾2、有竹 浩介3、裏出 良博3、村田 幸久1
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] Dynamics of lipid mediators in colitis model mice (2016)
  • Author(s): Taiki Hamabata, Shingo Maeda, Tatsuro Nakamura, Takahisa Murata
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-11
• [Presentation] Characterization of mast cells in tumor (2016)
  • Author(s): Arisa Yamazaki, Tatsuro Nakamura and Takahisa Murata
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-10
• [Presentation] Anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury (2016)
  • Author(s): Naoki Toya, Koji Kobayashi, Keisuke Omori, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-10
• [Presentation] The role of mast cell in food allergy (2016)
  • Author(s): Takahisa Murata, Tatsuro Nakamura, Shingo Maeda, Yuki Fujiwara
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-09
  • Int'l Joint Research
• [Presentation] Epithelial cell-derived PGD2 inhibits airway inflammation (2016)
  • Author(s): Toko Maehara, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-09
• [Presentation] 血管新生促進剤の開発 (2016)
  • Author(s): 村田幸久
  • Organizer: 第2回血管生物若手勉強会
  • Place of Presentation: 東北大学加齢研究所
  • Year and Date: 2016-03-05
  • Invited
• [Presentation] Tumor endothelial cell-derived prostaglandin D2 inhibits vascular hyper-permeability and angiogenesis (2016)
  • Author(s): Omori Keisuke, Murata Takahisa
  • Organizer: 10th AACR-JCA Joint Conference
  • Place of Presentation: Maui, Hawaii, USA
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] The involvement of lipid mediators in colitis and colitis-associated colorectal cancer (2016)
  • Author(s): Yusuke Miyazaki, Taiki Hamabata, Tatsuro Nakamura, Takahisa Murata
  • Organizer: 第16回 東京大学生命科学シンポジウム
• [Presentation] 慢性腸炎続発性大腸がん発症に関与する脂質メディエーターの検討 (2016)
  • Author(s): 宮崎悠介、濱端大貴、中村達郎、村田幸久
  • Organizer: 第134回日本薬理学会関東部会
• [Presentation] 腸炎および腸炎関連大腸がんの進行における脂質メディエーター産生動態 (2016)
  • Author(s): 宮崎悠介、濱端大貴、中村達郎、村田幸久
  • Organizer: 日本大学 湘南キャンパス
• [Presentation] Epithelial cell-derived (2016)
  • Author(s): Toko Maehara, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
  • Organizer: 第89回日本薬理学会
• [Presentation] 気管支上皮細胞由来のPGD2はアレルギー性肺炎を抑制する (2016)
  • Author(s): 前原都有子、中村達朗、前田真吾、有竹浩介、裏出良博、村田幸久
  • Organizer: 第65回日本アレルギー学会学術大会
• [Presentation] Bronchoepithelial cell-derived prostaglandin D2 inhibits allergic lung inflammation (2016)
  • Author(s): Toko Maehara, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
  • Organizer: 16th INTERNATIONAL CONGRESS OF IMMUNOLOGY
  • Int'l Joint Research
• [Presentation] Mast cell-derived PGD2 attenuates anaphylaxis via DP receptor (2016)
  • Author(s): Yuki Fujiwara, Tatsuro Nakamura, Ryota Yamada, Takahisa Murata
  • Organizer: 第16回東京大学生命科学シンポジウム
• [Presentation] 肥満細胞由来のPGD2はDP受容体に作用してアナフィラキシーを抑制する (2016)
  • Author(s): 藤原祐樹, 中村達朗, 山田涼太, 濱端大貴, 村田幸久
  • Organizer: 第134回日本薬理学会関東部会
• [Presentation] 肥満細胞由来のPGD2はDP受容体を介してアナフィラキシーを抑制する (2016)
  • Author(s): 藤原祐樹, 中村達朗, 山田涼太, 濱端大貴, 村田幸久
  • Organizer: 第159回日本獣医学会学術集会
• [Presentation] Tumor endothelial cell-derived prostaglandin D2 suppresses tumor angiogenesis (2016)
  • Author(s): Keisuke Omori, Teppei, Morikawa, Akiko Kunita, Kosuke Aritake, Yoshihiro Urade, Masashi Fukayama, and Takahisa Murata
  • Organizer: 第2回春季特別日本血管生物医学会シンポジウム
• [Presentation] Tumor endothelial cell-derived prostaglandin D2 inhibits vascular hyper-permeability and angiogenesis (2016)
  • Author(s): Keisuke Omori, Teppei, Morikawa, Akiko Kunita, Kosuke Aritake, Yoshihiro Urade, Masashi Fukayama, and Takahisa Murata
  • Organizer: Internarional Vascular Biology Meeting 2016 navbo
  • Int'l Joint Research
• [Presentation] SDF-1α-CXCR4シグナルの阻害は糖尿病網膜症を改善する (2016)
  • Author(s): 大森啓介, 倉田薫里, 藤井信孝, 植村明嘉, 村田幸久
  • Organizer: 第26回日本循環薬理学会
• [Presentation] 食物アレルギーにおけるプロスタグランジンD2の役割解明とその応用 (2016)
  • Author(s): 中村達朗 前田真吾 村田幸久
  • Organizer: 第159回日本獣医学会学術集会
• [Presentation] Anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury (2016)
  • Author(s): Naoki Toya1, Koji Kobayashi1, Keisuke Omori1, Tatsuro Nakamura1, Kosuke Aritake2, Yoshihiro Urade2, Takahisa Murata1
  • Organizer: 第89回日本薬理学会年会
• [Presentation] Dynamics of lipid mediators in colitis model mice (2016)
  • Author(s): Taiki Hamabata, Shingo Maeda, Tatsuro Nakamura, Takahisa Murata
  • Organizer: 第89回日本薬理学会年会
• [Presentation] 癌血管内皮細胞から産生されるPGD2は血管新生を抑制する (2015)
  • Author(s): 大森啓介、有竹浩介、裏出良博、村田幸久
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-12-10
• [Presentation] 肥満細胞由来PGD2はアナフィラキシーを抑制する (2015)
  • Author(s): 中村達朗、山田涼太、有竹浩介、裏出良博、村田幸久
  • Organizer: 第25回日本循環薬理学会
  • Place of Presentation: 奈良 東大寺総合文化センター金鐘ホール
  • Year and Date: 2015-12-04
• [Presentation] Mast cell-derived PGD2 attenuates anaphylaxis via endothelial DP receptor (2015)
  • Author(s): Nakamura Tasturo, Murata Takahisa
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-20
• [Presentation] "The anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury (2015)
  • Author(s): Naoki Toya, Koji Kobayashi, Keisuke Omori, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
  • Organizer: American Heart Association Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-10
  • Int'l Joint Research
• [Presentation] 肥満細胞由来のPGD2はアナフィラキシーを抑制する (2015)
  • Author(s): 中村達朗、山田涼太、有竹浩介、裏出良博、村田幸久
  • Organizer: 第133回日本薬理学会関東部会
  • Place of Presentation: 千葉 柏の葉カンファレンスセンター
  • Year and Date: 2015-10-10
• [Presentation] トロンボキサンA2は浮腫を促進して急性肺障害を悪化する (2015)
  • Author(s): 堀上大貴、小林幸司、大森啓介、中村達朗、前田慎吾、堀正敏、尾崎博、村田幸久
  • Organizer: 第133回日本薬理学会関東部会
  • Place of Presentation: 千葉 柏の葉カンファレンスセンター
  • Year and Date: 2015-10-10
• [Presentation] Discovery of anti-tumor effects of prostaglandin D2 and its application (2015)
  • Author(s): Takahisa Murata
  • Organizer: 第74回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] Tumor endothelial cell-derived prostaglandin D2 suppresses tumor angiogenesis (2015)
  • Author(s): Omori Keisuke, Murata Takahisa
  • Organizer: 第74回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-08
• [Presentation] 肥満細胞由来のPGD2はアナフィラキシーを抑制する (2015)
  • Author(s): 中村達朗、山田涼太、前田真吾、有竹浩介、裏出良博、村田幸久
  • Organizer: 第158回日本獣医学会
  • Place of Presentation: 北里大学 十和田キャンパス
  • Year and Date: 2015-09-07
• [Presentation] 癌血管内皮細胞から産生されるPGD2は血管新生を抑制する (2015)
  • Author(s): 大森啓介、有竹浩介、裏出良博、村田幸久
  • Organizer: 第158回日本獣医学会
  • Place of Presentation: 北里大学 十和田キャンパス
  • Year and Date: 2015-09-07
• [Presentation] Characterization of mast cells in cancer (2015)
  • Author(s): 山崎愛理沙、中村達朗、村田幸久
  • Organizer: 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2015-06-27
• [Presentation] Dynamics of lipid mediators in intestinal inflammation (2015)
  • Author(s): 濱端大貴、前田真吾、中村達朗、村田幸久
  • Organizer: 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2015-06-27
• [Presentation] The anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury (ALI) (2015)
  • Author(s): 遠矢直樹、小林幸司、大森啓介、前田真吾、中村達朗、有竹浩介、裏出良博、村田幸久
  • Organizer: 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2015-06-27
• [Presentation] トロンボキサンA2は浮腫を促進して急性肺障害を悪化する (2015)
  • Author(s): 堀上大貴、小林幸司、大森啓介、中村達朗、前田慎吾、堀正敏、尾崎博、村田幸久
  • Organizer: 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2015-06-27
• [Presentation] 肥満細胞由来のPGD2は食物アレルギーを抑制する (2015)
  • Author(s): 中村達朗、前田真吾、前原都有子、有竹浩介、裏出良博、村田幸久
  • Organizer: 第64回日本アレルギー学会学術集会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2015-05-26
• [Presentation] Discovery of Anti-inflammatory Role of Prostaglandin D2 (2015)
  • Author(s): Ｔａｋａｈｉｓａ Ｍｕｒａｔａ
  • Organizer: 第88回薬理学会
  • Place of Presentation: 名古屋国際会議場(名古屋・愛知)
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] Tumor endothelial cell-derived prostaglandin D2 suppresses tumor angiogenesis (2015)
  • Author(s): Keisuke Omori, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
  • Organizer: 第88回薬理学会
  • Place of Presentation: 名古屋国際会議場(名古屋・愛知)
  • Year and Date: 2015-03-18
• [Presentation] Mast cell-derived PGD2 attenuates anaphylaxis (2015)
  • Author(s): Ryota Yamada, Tatsuro Nakamura, Shingo Maeda, Kosuke Aritake, Masatoshi Hori, Yoshihiro Urade, Hiroshi Ozaki, Takahisa Murata
  • Organizer: 第88回薬理学会
  • Place of Presentation: 名古屋国際会議場(名古屋・愛知)
  • Year and Date: 2015-03-08
• [Presentation] PGD2と癌の血管新生の関係 (2015)
  • Author(s): 大森啓介、有竹浩介、裏出良博、村田幸久
  • Organizer: 第1回日本血管生物若手研究会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2015-02-06
• [Presentation] アナフィラキシーショックにおけるPGD2の役割 (2015)
  • Author(s): 山田涼太、中村達朗、前田真吾、有竹浩介、堀正敏、裏出良博、尾崎博、村田幸久
  • Organizer: 第1回日本血管生物若手研究会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2015-02-06
• [Presentation] PGD2が血管に与える影響 (2015)
  • Author(s): 村田幸久
  • Organizer: 第1回日本血管生物若手研究会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2015-02-06
• [Presentation] Mast cell-derived prostaglandin D2 inhibits colitis-associated carcinogenesis (2014)
  • Author(s): Tatsuro Nakamura, Koichi Iwanaga, Shingo Maeda, Takahisa Murata.
  • Organizer: 第43回 日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館(京都市・京都)
  • Year and Date: 2014-12-12
• [Presentation] 新しい炎症抑制機構の発見とそれを応用した病態治療法の開発 (2014)
  • Author(s): 村田幸久
  • Organizer: 平成26年度(第13回)日本農学進歩賞授賞式・受賞者講演会
  • Place of Presentation: 東京大学弥生講堂(東京)
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] プロスタグランジンとアレルギーの関係 (2014)
  • Author(s): 村田幸久
  • Organizer: 帯広大学基礎獣医学部門研修
  • Place of Presentation: 帯広畜産大学(帯広市・北海道)
  • Year and Date: 2014-10-24
• [Presentation] Histamineによる血管透過性制御機構の解明 (2014)
  • Author(s): 芦名功平, 壷阪義記, 中村達朗, 大森啓介, 小林幸司, 堀正敏, 尾崎博, 村田幸久
  • Organizer: 第131回日本薬理学会関東部会
  • Place of Presentation: 横浜市立大学福浦キャンパス(横浜市・神奈川)
  • Year and Date: 2014-10-11
• [Presentation] SDF-1αは新規の血管透過性抑制因子である (2014)
  • Author(s): 小林幸司、佐藤加奈子、貴田大樹、大森啓介、堀正敏、尾崎博、村田幸久
  • Organizer: 第131回日本薬理学会関東部会
  • Place of Presentation: 横浜市立大学福浦キャンパス(横浜市・神奈川)
  • Year and Date: 2014-10-11
• [Presentation] トロンボキサンA2は血管透過性の亢進を介して肺炎を悪化させる (2014)
  • Author(s): 堀上大貴、小林幸司、堀正敏、尾崎博、村田幸久
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 北海道大学(札幌市・北海道)
  • Year and Date: 2014-09-10
• [Presentation] 食物アレルギーにおける新規バイオマーカーの発見 (2014)
  • Author(s): 前田真吾、中村達朗、有竹浩介、裏出良博、村田幸久
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 北海道大学(札幌市・北海道)
  • Year and Date: 2014-09-10
• [Presentation] 肥満細胞由来のPGD2は食物アレルギーを抑制する (2014)
  • Author(s): 中村達朗、前田真吾、前原都有子、有竹浩介、裏出良博、村田幸久
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 北海道大学(札幌市・北海道)
  • Year and Date: 2014-09-10
• [Presentation] Prostaglandin D2 inhibits anaphylaxis in mice (2014)
  • Author(s): 山田涼太、中村達朗、前田真吾、有竹浩介、尾崎博、裏出良博、村田幸久
  • Organizer: 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2014-04-28
• [Presentation] Stromal cell derived factor-1α-CXCR4 axis promotes endothelial cell barrier integrity via PI3K and Rac1 activation (2014)
  • Author(s): 小林幸司, 佐藤可奈子, 貴田大樹, 大森啓介, 堀正敏, 尾崎博 村田幸久
  • Organizer: 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2014-04-28
• [Presentation] Multiple roles of prostaglandin E2-EP signal in vascular permeability (2014)
  • Author(s): Omori K, Kida T, Hori M, Izaki H, Murata T.
  • Organizer: The 18th international Vascular Biology Meeting
  • Place of Presentation: 京都都メッセ(京都市・京都)
  • Year and Date: 2014-04-14
  • Int'l Joint Research
• [Presentation] Stromal cell derived factor-1α-CXCR4 axis promotes endothelial cell barrier integrity via PI3K and Rac1 activation (2014)
  • Author(s): Koji Kobayashi, Kanako Sato, Taiki Kida, Keisuke Omori, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata.
  • Organizer: The 18th international Vascular Biology Meeting
  • Place of Presentation: 京都都メッセ(京都市・京都)
  • Year and Date: 2014-04-14
  • Int'l Joint Research
• [Presentation] TXA2 abrogates acute lung inflammation by disrupting vascular endothelial barrier. (2014)
  • Author(s): Kobayashi K, Horikami T, Hori M, Ozaki H, Murata T.
  • Organizer: 第87回日本薬理学会
  • Place of Presentation: 仙台国際センター（宮城県、仙台市）
  • Year and Date: 2014-03-19
• [Presentation] Macrophage-derived prostaglandin D2 ameliorates adjuvant-induced arthritis (2014)
  • Author(s): Tsubosaka Y, Nakamura T, Aritake K, Urade Y, Murata T.
  • Organizer: Angiogenesis2014
  • Place of Presentation: アムステルダム（オランダ）
  • Year and Date: 2014-03-12 – 2014-03-14
• [Presentation] 肥満細胞由来のPGD2は食物アレルギーを抑制する (2014)
  • Author(s): 中村達朗、前田真吾、前原都有子、有竹浩介、裏出良博、村田幸久
  • Organizer: 第8回炎症・脂質代謝・メタボリサーチフォーラム
  • Place of Presentation: 東京大学（東京都、文京区）
  • Year and Date: 2014-02-22
• [Presentation] Ｔhe role of prostaglandin D2 receptor CRTH2 in adjuvant-induced arthritis (2013)
  • Author(s): Tsubosaka Y, Hirai H, Nakamura M, Murata T.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Mast cell-derived prostaglandin D2 suppresses intestinal mastocytosis in murine model of food allergy (2013)
  • Author(s): Nakamura T, Murata T.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Prostaglandin E2による血管透過性制御機構の解明 (2013)
  • Author(s): 大森啓介、貴田大樹、堀正敏、尾崎博、村田幸久
  • Organizer: 循環薬理学会
  • Place of Presentation: 福岡大学メデイカルホール（福岡県、福岡市）
  • Year and Date: 2013-12-06
• [Presentation] CXCL12 is a Novel Suppressor of Endothelial Permeability (2013)
  • Author(s): Kobayashi K, Sato K, Kida T, Omori K, Hori M, Ozaki H, Murata T.
  • Organizer: American Heart Association 2013
  • Place of Presentation: ダラス（アメリカ）
  • Year and Date: 2013-11-16
• [Presentation] 炎症性疾患におけるプロスタグランジンD2の役割 (2013)
  • Author(s): 村田幸久
  • Organizer: 東京脂質談話会
  • Place of Presentation: 東京大学（東京都、文京区）
  • Year and Date: 2013-10-16
  • Invited
• [Presentation] Prostaglandin D2 attenuates colitis and colitis-associated colon cancer. (2013)
  • Author(s): Takahisa Murata
  • Organizer: 第72回日本癌学会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] 術後イレウスにおけるa7nAch受容体を介したマクロファージ選択的抗炎症作用 (2013)
  • Author(s): 猪村優貴、村田幸久、堀正敏、尾崎博
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜県、岐阜市）
  • Year and Date: 2013-09-30
• [Presentation] The mechanism of histamine-induced vascular hyper-permeability (2013)
  • Author(s): Kohei Ashina1, Yoshiki Tsubosaka1, 2, Keisuke Omori1, Masatoshi Hori1, Hiroshi Ozaki1 and Takahisa Murata1, 2.
  • Organizer: 第21回 血管生物医学会
  • Place of Presentation: 千里阪急ホテル（大阪府、豊中市）
  • Year and Date: 2013-09-28
• [Presentation] PGD2-CRTH2シグナルはアジュバント誘発性関節炎を抑制する (2013)
  • Author(s): 壷阪義記、平井博之、堀正敏、中村正孝、尾崎博、村田幸久
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜県、岐阜市）
  • Year and Date: 2013-09-20
• [Presentation] 芦名功平, 壷阪義記, 大森啓介, 堀正敏, 尾崎博, 村田幸久 (2013)
  • Author(s): ヒスタミンによる血管透過性制御機構の解明
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜県、岐阜市）
  • Year and Date: 2013-09-20
• [Presentation] 5-HT3R阻害剤は腹腔内マクロファージに作用し術後イレウスの炎症を軽減する (2013)
  • Author(s): 前原都有子、村田幸久、堀正敏、尾崎博
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜県、岐阜市）
  • Year and Date: 2013-09-20
• [Presentation] Deficiency of prostaglandin D2 receptor CRTH2 deteriorates adjuvant-induced arthritis (2013)
  • Author(s): Yoshiki Tsubosaka1, Hiroyuki Hirai2, Masatoshi Hori1, Masataka Nakamura3, Hiroshi Ozaki1, and Takahisa Murata1. *
  • Organizer: International Conference of Immunology
  • Place of Presentation: ミラノ（イタリア）
  • Year and Date: 2013-08-24
• [Presentation] Mast cell-derived prostaglandin D2 suppresses intestinal mastocytosis in food allergy (2013)
  • Author(s): Tatsuro Nakamura 1, Shigeko Matsumoto 1, Kosuke Aritake 2, Masatoshi Hori 1, Hiroshi Ozaki 1, Yoshihiro Urade 2, Takahisa Murata 1.
  • Organizer: International Conference of Immunology
  • Place of Presentation: ミラノ（イタリア）
  • Year and Date: 2013-08-24
• [Presentation] Prostaglandin D2 Represents Contradicting Roles in Dermatitis (2013)
  • Author(s): Hana Sarashina1, Yoshiki Tsubosaka1, Kosuke Aritake2, Takayuki Nakagawa3, Masatoshi Hori1, Hiroshi Ozaki1, Yoshihiro Urade2, and Takahisa Murata1
  • Organizer: International Conference of Immunology
  • Place of Presentation: ミラノ（イタリア）
  • Year and Date: 2013-08-24
• [Presentation] The role of prostaglandin D2 receptor CRTH2 in adjuvant-induced arthritis (2013)
  • Author(s): Yoshiki Tsubosaka, Masatoshi Hori, Hiroshi Ozaki, and Takahisa Murata.
  • Organizer: 第13回 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学（東京都、文京区）
  • Year and Date: 2013-06-08
• [Presentation] The mechanism of Histamine-induced vascular hyper-permeability (2013)
  • Author(s): Kohei Ashina, Yoshiki Tsubosaka, Masatoshi Hori, Hiroshi Ozaki, and Takahisa Murata.
  • Organizer: 第13回 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学（東京都、文京区）
  • Year and Date: 2013-06-08
• [Presentation] Opposing role of PGE2-EPs signalings on vascular permeability (2013)
  • Author(s): Keisuke Omori, Taiki Kida, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
  • Organizer: 第13回 東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学（東京都、文京区）
  • Year and Date: 2013-06-08
• [Book] 肥満細胞が産生するプロスタグランジンD2は食物アレルギーを抑制する (2016)
  • Author(s): 中村達朗, 村田幸久
  • Publisher: 鳥居薬品株式会社
• [Book] 食物アレルギーの克服を目指して (2016)
  • Author(s): 村田幸久
  • Total Pages: 1
  • Publisher: 東京大学大学院農学生命科学研究科
• [Remarks] 東京大学大学院農学生命科学研究科放射線動物科学研究室
  • URL: http://www.vm.a.u-tokyo.ac.jp/houshasen/index.html
• [Remarks] 東京大学大学院農学生命科学研究科 応用動物科学専攻 放射線動物科学研究室
  • URL: http://www.vm.a.u-tokyo.ac.jp/houshasen/index.html
• [Remarks] 東京大学大学院農学生命科学研究科 応用動物科学専攻 放射線動物科学研究室
  • URL: http://www.vm.a.u-tokyo.ac.jp/houshasen/
• [Patent(Industrial Property Rights)] がん転移抑制剤 (2017)
  • Inventor(s): 村田幸久 小林幸司 大森啓介
  • Industrial Property Rights Holder: 村田幸久 小林幸司 大森啓介
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] がん転移抑制剤 (2016)
  • Inventor(s): 村田幸久 小林幸司 大森啓介
  • Industrial Property Rights Holder: 村田幸久 小林幸司 大森啓介
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016
• [Patent(Industrial Property Rights)] 特許 (2015)
  • Inventor(s): 村田幸久、中村達朗、前田真吾
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-12-16
• [Patent(Industrial Property Rights)] 特許 (2015)
  • Inventor(s): 村田幸久、中村達朗、前田真吾
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-08-16
  • Overseas