Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2013: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
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Outline of Final Research Achievements |
We have studied on the total synthesis of natural products having intriguing structures and biological activities useful for drug discovery. As a result, we have achieved the total syntheses of lajollamycin B and N-methylwelwitindolinone C isothiocyanate. In addition, we have developed a new methodology for tetrahydrofuran synthesis which relies on a Rh(II)/Zn(II)-catalyzed [4 + 1]-cycloaddition reaction of a homopropargyl alcohol, and have achieved the total syntheses of cinatrin C1, ophiodilactones A and B, and marinomycin A.
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