Efficient Synthesis of Natural Products Useful for Drug Discovery Based on Innovative Synthetic Methodologies
Project/Area Number |
25253002
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Nagasaki University |
Principal Investigator |
HATAKEYAMA Susumi 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (20143000)
|
Co-Investigator(Kenkyū-buntansha) |
ISHIHARA JUN 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (80250413)
TAKAHASHI KEISUKE 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (60380854)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2013: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
|
Keywords | 合成化学 / 全合成 / 天然物 |
Outline of Final Research Achievements |
We have studied on the total synthesis of natural products having intriguing structures and biological activities useful for drug discovery. As a result, we have achieved the total syntheses of lajollamycin B and N-methylwelwitindolinone C isothiocyanate. In addition, we have developed a new methodology for tetrahydrofuran synthesis which relies on a Rh(II)/Zn(II)-catalyzed [4 + 1]-cycloaddition reaction of a homopropargyl alcohol, and have achieved the total syntheses of cinatrin C1, ophiodilactones A and B, and marinomycin A.
|
Report
(4 results)
Research Products
(33 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] チランダリジジンの全合成2015
Author(s)
吉村 光、高橋圭介、石原 淳、畑山 範
Organizer
第45回複素環化学討論会
Place of Presentation
東京都、早稲田大学国際会議場
Year and Date
2015-11-19
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-