| Budget Amount *help |
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2016: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2014: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Outline of Final Research Achievements |
Heart often develops heart failure after myocardial infarction, if proper revascularization is not provided. Inflammatory responses are believed to be a factor to progress to heart failure after myocardial infarction. As inflammation is induced by the cellular components released from dead cells, the quick and efficient removal of dead cells in myocardial infarction is important for preventing the development of heart failure. So far, phagocytes such as macrophages and dendritic cells infiltrating infarct area are supposed to be the players of removing dead cells. In this study, myofibroblasts remove dead cell as well as phagocytes do. The removal of dead cells by myofibroblasts requires MFG-E8 that bridges between apoptotic cells and phagocytes. Thus, myofibroblasts remove dead cells after myocardial infarction, and suppress the progression to heart failure.
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