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Mechanism of intracellular formation of cysteine polysulfide and reactive oxygen species signaling

Research Project

Project/Area Number 25253020
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

AKAIKE Takaaki  東北大学, 医学系研究科, 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) 澤 智裕  熊本大学, 生命科学研究部, 教授 (30284756)
井田 智章  東北大学, 医学系研究科, 助教 (70570406)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2015: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2014: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2013: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Keywordsメタボロミクス / プロテオミクス / 活性酸素 / シグナル伝達 / レドックス / 活性イオウ分子種 / 8-ニトロ-cGMP
Outline of Final Research Achievements

We investigated physiological roles of reactive sulfur species having extra sulfur atoms in cysteine thiol moiety, such as cysteine polysulfides. Quantitation of these species indicated that high levels of glutathione persulfide (over 100 microM) and other cysteine persulfides were produced in cells and its roles in regulation of reactive oxygen species signaling and protein functions were revealed. We also found a new cysteine persulfide-producing system in cells, which is originally known as a master enzyme for protein translation, and elucidated its pivotal roles in protein polysulfidation and regulation of mitochondrial function.

Report

(4 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (101 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (43 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 32 results,  Open Access: 19 results,  Acknowledgement Compliant: 6 results) Presentation (53 results) (of which Int'l Joint Research: 4 results,  Invited: 35 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] Washington State University/Sonoma State University/University of California, Davis(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Persistent activation of cGMP-dependent protein kinase by a nitrated cyclic nucleotide via site specific protein S-guanylation2016

    • Author(s)
      Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
    • Journal Title

      Biochemistry

      Volume: 55 Issue: 5 Pages: 751-761

    • DOI

      10.1021/acs.biochem.5b00774

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 2 Pages: 91-98

    • DOI

      10.3164/jcbn.15-111

    • NAID

      130005132519

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.2015

    • Author(s)
      Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    • Journal Title

      Chem Res Toxicol.

      Volume: 印刷中 Issue: 5 Pages: 838-847

    • DOI

      10.1021/tx500416y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation.2015

    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Journal Title

      Chemical Research in Toxicology.

      Volume: 28 Issue: 6 Pages: 1301-1306

    • DOI

      10.1021/acs.chemrestox.5b00101

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 8-Mercapto-cyclic GMP mediates hydrogen sulfide-induced stomatal closure in Arabidopsis.2015

    • Author(s)
      Honda K, Yamada N, Yoshida R, Ihara H, Sawa T, Akaike T, Iwai S.
    • Journal Title

      Plant Cell Physiol.

      Volume: 56 Issue: 8 Pages: 1481-1489

    • DOI

      10.1093/pcp/pcv069

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.2015

    • Author(s)
      Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
    • Journal Title

      J Mol Med (Berl).

      Volume: 印刷中 Issue: 8 Pages: 879-889

    • DOI

      10.1007/s00109-015-1271-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides.2015

    • Author(s)
      Abiko Y., Ishii I., Kamata S., Tsuchiya Y., Watanabe Y., Ihara H., Akaike T., Kumagai Y.
    • Journal Title

      Chem. Res. Toxicol.

      Volume: 28 Issue: 9 Pages: 1796-1802

    • DOI

      10.1021/acs.chemrestox.5b00245

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP252015

    • Author(s)
      K. Kunieda, H. Tsutsuki, T. Ida, Y. Kishimoto, S. Kasamatsu, T. Sawa, N. Goshima, M. Itakura, M. Takahashi, T. Akaike, H. Ihara
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 6 Issue: 10 Pages: 1715-1725

    • DOI

      10.1021/acschemneuro.5b00196

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia2015

    • Author(s)
      Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F
    • Journal Title

      J Am Heart Assoc

      Volume: 4 Issue: 11

    • DOI

      10.1161/jaha.115.002125

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Development of Fluorescent Probes for Visualizing Intracellular Hydrogen Polysulfides2015

    • Author(s)
      Wei Chen, Ethan W. Rosser, Tetsuro Matsunaga, Armando Pacheco, Takaaki Akaike, and Ming Xian
    • Journal Title

      Angewandte Chemie - International Edition

      Volume: 54 Issue: 47 Pages: 13961-13965

    • DOI

      10.1002/anie.201506887

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles.2015

    • Author(s)
      Saund, S. S., Sosa, V., Henriquez, S., Nguyen, Q. N. N., Soeda, S., Bianco, C. L., Millikin, R., White, C., Le, H., Ono, K., Tantillo, D. J., Kumagai, Y., Akaike, T., Lin, J., Fukuto, J. M.
    • Journal Title

      Arch. Biochem. Biophys.

      Volume: 588 Pages: 15-24

    • DOI

      10.1016/j.abb.2015.10.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 感染性微生物:H. cinaedi2015

    • Author(s)
      松永哲郎, 藤井重元, 赤池孝章.
    • Journal Title

      動脈硬化予防

      Volume: 14 Pages: 66-71

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性イオウ分子による酸化・ニトロ化ストレス制御2015

    • Author(s)
      笠松真吾、井田智章、藤井重元、赤池孝章.
    • Journal Title

      Respiratory Medical Research

      Volume: 3 Pages: 70-75

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性イオウ分子種による酸化ストレス制御2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 502-506

    • NAID

      40020484751

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host defense and oxidative stress signaling in bacterial infection2015

    • Author(s)
      赤池孝章.
    • Journal Title

      Nippon Saikingaku Zasshi

      Volume: 70 Issue: 3 Pages: 339-349

    • DOI

      10.3412/jsb.70.339

    • NAID

      130005094695

    • ISSN
      0021-4930, 1882-4110
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nitric Oxide (NO)2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      生体の科学

      Volume: 66 Pages: 396-397

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mesenchymal Stem Cells Correct Inappropriate Epithelial-mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1.2015

    • Author(s)
      Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
    • Journal Title

      Mol Ther

      Volume: 23 Issue: 3 Pages: 549-560

    • DOI

      10.1038/mt.2014.217

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] H2Sの生体内生成とシグナル機能の正体:システインパースルフィドの再発見と新機能2015

    • Author(s)
      赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 346-348

    • Related Report
      2014 Annual Research Report
  • [Journal Article] RSSによる抗酸化・レドックスシグナル制御2015

    • Author(s)
      井田智章、藤井重元、赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 354-357

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons.2014

    • Author(s)
      Kasamats S, Watanabe Y, Sawa T, Akaike T, Ihara H.
    • Journal Title

      Biochem. J.

      Volume: 459 Issue: 2 Pages: 251-263

    • DOI

      10.1042/bj20131262

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell Metab.

      Volume: 9 Issue: 4 Pages: 712-721

    • DOI

      10.1016/j.cmet.2014.03.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.2014

    • Author(s)
      Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
    • Journal Title

      Sci. Rep.

      Volume: (印刷中) Issue: 1 Pages: 4680-4680

    • DOI

      10.1038/srep04680

    • NAID

      120005649608

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014

    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: (印刷中) Issue: 21 Pages: 7606-7611

    • DOI

      10.1073/pnas.1321232111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrop hilic signaling2014

    • Author(s)
      Nishida M, Toyama T and Akaike T
    • Journal Title

      J Mol Cell Cardiol

      Volume: (In press) Pages: 10-17

    • DOI

      10.1016/j.yjmcc.2014.02.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and bacteriological characteristics of Helicobacter cinaedi infection2014

    • Author(s)
      Kawamura Y, Tomida J, Morita Y, Fujii S, Okamoto T, Akaike T.
    • Journal Title

      J Infect Chemother

      Volume: 20 Issue: 9 Pages: 517-526

    • DOI

      10.1016/j.jiac.2014.06.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The redox chemistry and chemical biology of H2S, hydropersulfides and derivaed species: implications to their possible biological activity and utility.2014

    • Author(s)
      Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
    • Journal Title

      Free Radic. Biol. Med.

      Volume: 77 Pages: 82-94

    • DOI

      10.1016/j.freeradbiomed.2014.09.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helicobacter cinaedi meningitis: a case report and review of previous cases.2014

    • Author(s)
      Okubo H, Goto M, Sato M, Sugiyama T, Kawano M, Matsunaga T, Akaike T.
    • Journal Title

      J Neurol Sci.

      Volume: 347 Issue: 1-2 Pages: 396-397

    • DOI

      10.1016/j.jns.2014.10.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素による多階層シグナル伝達機構とレドックス恒常性制御2014

    • Author(s)
      赤池孝章.
    • Journal Title

      Yakugaku Zasshi

      Volume: 134 Pages: 515-519

    • NAID

      130003391199

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 活性酸素と炎症2014

    • Author(s)
      井田智章、赤池孝章、澤 智裕、藤井重元.
    • Journal Title

      感染・炎症・免疫

      Volume: 44 Pages: 104-109

    • Related Report
      2014 Annual Research Report
  • [Journal Article] フリーラジカル制御系:硫化水素・活性イオウ分子と炎症2014

    • Author(s)
      藤井重元、井田智章、澤 智裕、赤池孝章.
    • Journal Title

      実験医学

      Volume: 32 Pages: 2803-2809

    • Related Report
      2014 Annual Research Report
  • [Journal Article] S-Guanylation proteomics for redox-based mitochondrial signaling.2014

    • Author(s)
      Rahaman MM, Sawa T, Ahtesh am AK, Khan S, Inoue H, Irie A. Fujii S, and Akaike T.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 20 Issue: 2 Pages: 295-307

    • DOI

      10.1089/ars.2012.4606

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress2014

    • Author(s)
      Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Masuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H and Oike Y
    • Journal Title

      Mol. Cancer Res

      Volume: 12 Issue: 2 Pages: 239-249

    • DOI

      10.1158/1541-7786.mcr-13-0336

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 寄り道研究:Serendipityと8-ニトロ-cGMPとの出会い2014

    • Author(s)
      赤池孝章
    • Journal Title

      化学療法の領域

      Volume: 30 Pages: 122-128

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Fluorescent probes for live cell imaging of endogenous guanine nitration2013

    • Author(s)
      Saito Y, Ito C, Fujii S, Sawa T, Akaike T and Arimoto H.
    • Journal Title

      Chembiochem.

      Volume: 14 Issue: 9 Pages: 1068-1071

    • DOI

      10.1002/cbic.201300129

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of H3K18 deacetylation of SIRT7 by Myb-binding protein la (Mybbpla)2013

    • Author(s)
      Karim Md F, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, A kaike T and Yamagata K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 441 Issue: 1 Pages: 157-163

    • DOI

      10.1016/j.bbrc.2013.10.020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative evaluation of the agar dilution and broth microdilution methods for antibiotic susceptibility testing of Helicobacter cinaedi2013

    • Author(s)
      Tomida J, Oumi A, Okamoto T, Morita Y, Okayama A, Misawa N, Hayashi T, Akaike T, Kawamura Y
    • Journal Title

      Microbiol Immunol

      Volume: 57 Issue: 5 Pages: 353-358

    • DOI

      10.1111/1348-0421.12044

    • NAID

      40019653259

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013

    • Author(s)
      Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
    • Journal Title

      Mol. Cell

      Volume: 52 Issue: 6 Pages: 794-804

    • DOI

      10.1016/j.molcel.2013.10.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate : nitric oxide- and reactive oxygen species-derived electrophilic messenger2013

    • Author(s)
      Fujii S and Akaike T.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 19 Issue: 11 Pages: 1236-1246

    • DOI

      10.1089/ars.2012.5067

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide.2013

    • Author(s)
      Sawa T, Ihara H, Ida T, Fujii S, Nishida M and Akaike T.
    • Journal Title

      Nitric Oxide

      Volume: 34 Pages: 10-18

    • DOI

      10.1016/j.niox.2013.04.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レドックスシグナル制御と酸化ストレスバイオマーカー2013

    • Author(s)
      赤池孝章, 藤井重元.
    • Journal Title

      精神科救急

      Volume: 16 Pages: 69-72

    • Related Report
      2013 Annual Research Report
  • [Journal Article] NOシグナリング研究の最前線2013

    • Author(s)
      澤 智裕, 赤池孝章.
    • Journal Title

      Heart View

      Volume: 17 Pages: 88-92

    • Related Report
      2013 Annual Research Report
  • [Journal Article] はじめにー活性酸素と分子状酸素のバイオセンサーと生体応答2013

    • Author(s)
      赤池孝章, 末松 誠.
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 727-727

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 活性酸素とガス状分子のシグナルネットワーク2013

    • Author(s)
      澤 智裕, 赤池孝章.
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 776-780

    • Related Report
      2013 Annual Research Report
  • [Presentation] 細菌の新しいシグナル伝達物質:8-ニトロ-cGMPの生成と機能解析2016

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪市天王寺区)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性システインパースルフィドの生合成機構とレドックス制御機能2016

    • Author(s)
      赤池孝章
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜市西区)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Polysulfides and redox signaling2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott(Ventura, CA, USA)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of metabolome analysis for reactive sulfur species2016

    • Author(s)
      Ida T, Kasamatsu S, Fujii S, Sawa T, Ihara H, Akaike T.
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott(Ventura, CA, USA)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性イオウ分子種:新しい活性酸素制御因子の生合成と制御機構2016

    • Author(s)
      赤池孝章
    • Organizer
      昭和大学学士会後援セミナー
    • Place of Presentation
      昭和大学(東京都品川区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種:総論2016

    • Author(s)
      赤池孝章
    • Organizer
      新学術領域研究「酸素生物学」・「レドックス委員会」合同シンポジウム2016「活性イオウ分子種の科学と生体機能の解明に向けて」
    • Place of Presentation
      名古屋大学シンポジオン(名古屋市千種区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性イオウメタボライトのLC-MS/MS解析2016

    • Author(s)
      井田智章、居原 秀、澤 智裕.
    • Organizer
      新学術領域研究「酸素生物学」・「レドックス委員会」合同シンポジウム2016「活性イオウ分子種の科学と生体機能の解明に向けて」
    • Place of Presentation
      名古屋大学シンポジオン(名古屋市千種区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論2016

    • Author(s)
      赤池孝章
    • Organizer
      平成27年度 学校法人北里研究所 第25回学会受賞者特別講演会
    • Place of Presentation
      北里大学白金キャンパス薬学部コンベンションホール(東京都港区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種の生体内生成と生理機能2016

    • Author(s)
      赤池孝章
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Antioxidant electrophilic signaling regulated by reactive sulfur species and its translational biosynthesis2015

    • Author(s)
      赤池孝章
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明2015

    • Author(s)
      井田智章、居原 秀、魏 范研、富澤一仁、長尾翌手可、鈴木 勉、熊谷嘉人、澤 智裕、笠松真吾、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein-bound reactive sulfur species and its translational biosynthesis: potential implication for oxidative stress and tumor biology2015

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 46th International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      パレスホテル東京(東京都千代田区)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reactive persulfide species: Its antioxidant redox signaling and translational biosynthesis2015

    • Author(s)
      Takaaki Akaike
    • Organizer
      文部科学省 私立大学戦略的研究基盤形成支援事業 生体分子コバレント修飾の革新的解析拠点形成 第2回国際シンポジウム New Aspects of Covalent modifications from Small to Large Molecules
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性イオウ分子システインパースルフィドのタンパク質翻訳機構:タンパク質ポリチオール化2015

    • Author(s)
      赤池孝章
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県音楽堂、金沢市アートホール、ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドのメタボロームおよびプロテオーム解析2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第15回日本NO学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] システインパースルフィドの新しいタンパク質翻訳機構:タンパク質ポリチオール化2015

    • Author(s)
      赤池孝章
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわ銀ホール(徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性酸素のシグナル伝達機構の解明(学会賞受賞講演)2015

    • Author(s)
      赤池孝章
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論(浅川賞受賞講演)2015

    • Author(s)
      赤池孝章.
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ含有分子の再発見とその生物活性2015

    • Author(s)
      井田智章、赤池孝章.
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Redox-active cysteine polysulfide modulates NO and electrophilic protein modification2015

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 2015 Nitric Oxide Gordon Research Conference
    • Place of Presentation
      Four Points Sheraton / Holiday Inn Express (Ventura, CA, USA)
    • Year and Date
      2015-02-15 – 2015-02-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子とADH3によるホルムアルデヒド解毒代謝機構2015

    • Author(s)
      井田智章、Md. Morshedul Alam、松永哲郎、藤井重元、居原 秀、本橋ほづみ、赤池孝章.
    • Organizer
      第14回分子予防環境医学研究会
    • Place of Presentation
      大阪市立大学医学部(大阪市阿倍野区)
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炎症・酸化ストレス応答とフリーラジカル・活性酸素制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      第44回日本創傷治癒学会
    • Place of Presentation
      ホテルメトロポリタン仙台(仙台市青葉区)
    • Year and Date
      2014-12-02 – 2014-12-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種によるレドックスシグナルと酸化ストレス制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      第386回東北医学会例会シンポジウム
    • Place of Presentation
      東北大学艮陵会館(仙台市青葉区)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスを制御する2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、末松 誠、本橋ほづみ、藤井重元、松永哲郎、山本雅之、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリサルファ化とタンパク質レドックス制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      レドックスシンポジウム:酸素生物学の誕生
    • Place of Presentation
      名古屋大学ES総合館ESホール(名古屋市千種区)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種による酸化ストレス制御とポリサルファーバイオロジー2014

    • Author(s)
      赤池孝章.
    • Organizer
      フォーラム2014 衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 活性システインパーサルファイドによる酸化ストレス制御2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、藤井重元、松永哲郎、Jon M Fukuto、赤池孝章.
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学今出川キャンパス良心館(京都市上京区)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性イオウ分子種システインパースルフィドによる酸化ストレス制御2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第8回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Year and Date
      2014-08-21 – 2014-08-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細菌の新しいシグナル伝達物:8-ニトロ-cGMPの同定と機能解析2014

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第25回日本生体防御学会学術総会
    • Place of Presentation
      東北大学 片平さくらホール(仙台市青葉区)
    • Year and Date
      2014-07-09 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] タンパク質過イオウ化:酸化ストレスの新しい制御システム2014

    • Author(s)
      赤池孝章.
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター(神戸市中央区)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Redox signal regulation by 8-nitro-cGMP and its metabolism involving reactive cysteine presulfide2014

    • Author(s)
      Takaaki Akaike
    • Organizer
      8th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      Renaissance Cleveland Hotel (Cleveland, OH, USA)
    • Year and Date
      2014-06-17 – 2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Metabolism of 8-nitro-cGMP and regulation of electrophilic signaling by reactive sulfur species2014

    • Author(s)
      Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanabe, Yoshito Kumagai, Hozumi Motohashi, Shigemoto Fujii, Tetsuro Matsunaga, Masayuki Yamamoto, Katsuhiko Ono, Jon M Fukuto, Takaaki Akaike.
    • Organizer
      8th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      Renaissance Cleveland Hotel (Cleveland, OH, USA)
    • Year and Date
      2014-06-17 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスとレドックスシグナルを制御する2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第14回日本NO学会学術集会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀市)
    • Year and Date
      2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸化ストレス応答とポリチオールバイオロジー2014

    • Author(s)
      赤池孝章
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      京王プラザホテル、明治大学生田キャンパス(東京都新宿区、川崎市多摩区)
    • Year and Date
      2014-03-27 – 2014-03-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] プロテインキナーゼGの活性化ドメインへのS-グアニル化とその敗血症における遷延性血圧低下への関与2014

    • Author(s)
      澤 智裕、Ahmed Ahtesham、藤井重元、井田智章、赤池孝章.
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船橋(東京都江戸川区)
    • Year and Date
      2014-03-26 – 2014-03-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細菌の新しいシグナル伝達物質8-ニトロ-cGMPの同定と機能解析2014

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョンミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船橋(東京都江戸川区)
    • Year and Date
      2014-03-26 – 2014-03-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] Formation and regulation of electrophilic signaling mediated by 8-nitro-cGMP.2014

    • Author(s)
      Takaaki Akaike.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-03-23 – 2014-03-26
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Unique thiolation mechanism of a nitrated nucleotide involving sulfur metabolizing enzymes2014

    • Author(s)
      Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, Shingo Kasamatsu, Kohei Kunieda, Shigemoto Fujii, Takaaki Akaike.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-03-23 – 2014-03-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] Redox regulation of autophagy via protein S-guanylation of H-Ras.2014

    • Author(s)
      Tomohiro Sawa, Shigemoto Fujii, Motohiro Nishida, Hirofumi Inoue, Tomoaki Ida, Takaaki Akaike.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-03-23 – 2014-03-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] 環境応答とチオールバイオロジー2014

    • Author(s)
      赤池孝章.
    • Organizer
      第30回高峰カンファレンス
    • Place of Presentation
      東京會館(東京都千代田区)
    • Year and Date
      2014-03-07
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulation of 8-nitro-cGMP electrophilic signal transduction2014

    • Author(s)
      Akaike T.
    • Organizer
      The Environmental Response Ⅳ
    • Place of Presentation
      東北大学 片平さくらホール(仙台市青葉区)
    • Year and Date
      2014-02-28 – 2014-03-02
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレスとオートファジー2014

    • Author(s)
      赤池孝章.
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所(吹田市)
    • Year and Date
      2014-02-20 – 2014-02-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] H-RasのS-グアニル化を介したオートファジーのレドックス制御2013

    • Author(s)
      澤 智裕、藤井重元、西田基宏、井上博文、井田智章、赤池孝章.
    • Organizer
      第19回MPO研究会
    • Place of Presentation
      国立国際医療研究センター大会議室(東京都新宿区)
    • Year and Date
      2013-10-25 – 2013-10-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] Protein S-guanylation in cGMP binding domain of PKG: Implication for persistent hypotension in sepsis2013

    • Author(s)
      Tomoaki Ida, Ahmed Khandaker Ahtesham, Tomohiro Sawa, Shigemoto Fujii, Takaaki Akaike.
    • Organizer
      第19回MPO研究会
    • Place of Presentation
      国立国際医療研究センター大会議室(東京都新宿区)
    • Year and Date
      2013-10-25 – 2013-10-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] 活性酸素シグナル制御とポリスルフィドミクス2013

    • Author(s)
      赤池孝章.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] システインパースルフィドの生体内生成と酸化ストレス制御2013

    • Author(s)
      澤 智裕、井田智章、赤池孝章.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新規レドックス制御因子:過イオウ化システイン誘導体のメタボローム解析2013

    • Author(s)
      井田智章、澤 智裕、土屋幸弘、小野勝彦、藤井重元、渡邊泰男、居原 秀、赤池孝章.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] 活性イオウ分子による活性酸素シグナル制御2013

    • Author(s)
      赤池孝章.
    • Organizer
      第22回日本Cell Death学会
    • Place of Presentation
      京都大学医学部 芝蘭会館(京都市左京区)
    • Year and Date
      2013-07-19 – 2013-07-20
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ポリサルファーバイオロジーによるROS・NOシグナル制御2013

    • Author(s)
      澤 智裕、井田智章、赤池孝章.
    • Organizer
      第13回日本NO学会学術集会
    • Place of Presentation
      沖縄県医師会館(沖縄県南風原町)
    • Year and Date
      2013-06-28 – 2013-06-29
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生体内システインパースルフィドの生成動態とその生理機能の解析2013

    • Author(s)
      井田智章、澤 智裕、土屋幸弘、小野勝彦、藤井重元、渡邊泰男、居原 秀、赤池孝章.
    • Organizer
      第13回日本NO学会学術集会
    • Place of Presentation
      沖縄県医師会館(沖縄県南風原町)
    • Year and Date
      2013-06-28 – 2013-06-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヘリコバクター・シネディ感染症2013

    • Author(s)
      藤井重元、赤池孝章.
    • Organizer
      第19回日本ヘリコバクター学会
    • Place of Presentation
      長崎大学 良順会館(長崎市)
    • Year and Date
      2013-06-28 – 2013-06-29
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 過イオウ化システインメタボローム解析による新規レドックス制御機構の解明2013

    • Author(s)
      井田智章、澤 智裕、居原 秀、赤池孝章.
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      ウインクあいち(名古屋市中村区)
    • Year and Date
      2013-06-13 – 2013-06-14
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 別冊・医学のあゆみ「レドックスUPDATE ― ストレス制御の臨床医学・健康科学」2015

    • Author(s)
      赤池孝章、藤井重元.
    • Total Pages
      341
    • Publisher
      医歯薬出版社(東京都)
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科環境保健医学分野ホームページ

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 環境保健医学分野ホームページ

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 環境保健医学分野ホームページ

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2022-01-28  

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