Epidemiological study of stroke, dementia, and depression based on brain MRI in an elderly population: the Hisayama Study
Project/Area Number |
25253048
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Kyushu University |
Principal Investigator |
Yutaka Kiyohara 九州大学, 医学(系)研究科(研究院), 教授 (80161602)
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Co-Investigator(Kenkyū-buntansha) |
KANBA Shigenobu 九州大学, 大学院医学研究院, 教授 (50195187)
KITAZONO Takanari 九州大学, 大学院医学研究院, 教授 (70284487)
NINOMIYA Toshiharu 九州大学, 大学院医学研究院, 教授 (30571765)
HATA Jun 九州大学, 大学院医学研究院, 准教授 (00448432)
OHARA Tomoyuki 九州大学, 大学院医学研究院, 助教 (20623630)
KOKUBO Yosihhiro 独立行政法人国立循環器病研究センター, 医長 (20393217)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
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Keywords | 頭部MRI / 糖尿病 / 脳萎縮 / 海馬萎縮 / アルツハイマー病 / 微小脳出血 / 有病率 / 認知症 / うつ病 / ADL / 海馬 / 疫学研究 / 脳血管障害 |
Outline of Final Research Achievements |
(1) Association of diabetes mellitus with brain and hippocampal atrophy in the elderly: We examined the association between diabetes-related parameters and morphological changes in the brain using the MRI data from the residents of Hisayama, Fukuoka, aged 65 years or older in 2012-2013. Diabetes was a significant risk factor for brain atrophy, particularly hippocampal atrophy. A longer duration of diabetes and elevated 2-hour postload glucose levels were significantly associated with smaller hippocampal volume. (2) Prevalence of cerebral microbleeds (CMBs) in the elderly: The prevalence of CMBs in the Hisayama residents aged 65 years or older was 19%. The prevalence was significantly higher in men than in women, and increased significantly with aging.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Association between diabetes mellitus and hippocampal atrophy in elderly Japanese: the Hisayama Study2016
Author(s)
Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
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Journal Title
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The long-term association between physical activity and risk of dementia in the community: the Hisayama Study.2016
Author(s)
Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara.
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Journal Title
Euro J Epidemiol
Volume: 31
Issue: 3
Pages: 267-274
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia2016
Author(s)
Chatterjee S, Peters SA, Woodward M, Mejia Arango S, Batty GD, Beckett N, Beiser A, Borenstein AR, Crane PK, Haan M, Hassing LB, Hayden KM, Kiyohara Y, Larson EB, Li CY, Ninomiya T, Ohara T, Peters R, Russ TC, Seshadri S, Strand BH, Walker R, Xu W, Huxley RR
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Journal Title
Diabetes Care
Volume: 39
Issue: 2
Pages: 300-307
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study2015
Author(s)
Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y
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Journal Title
J Am Geriatr Soc
Volume: 63
Issue: 11
Pages: 2332-2339
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study2015
Author(s)
Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y
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Journal Title
Atherosclerosis
Volume: 242
Issue: 1
Pages: 199-204
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study2015
Author(s)
Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
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Journal Title
Cardiovasc Diabetol
Volume: 14
Issue: 1
Pages: 84-84
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.2015
Author(s)
Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.
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Journal Title
Psychiatr Genet.
Volume: 25(4)
Issue: 4
Pages: 139-146
DOI
Related Report
Peer Reviewed
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[Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community2014
Author(s)
Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
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Journal Title
Circulation Journal
Volume: 78
Issue: 2
Pages: 403-409
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community2014
Author(s)
Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y
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Journal Title
Circulation Journal
Volume: 78
Issue: 3
Pages: 732-737
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.2014
Author(s)
Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
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Journal Title
Atherosclerosis
Volume: 233
Issue: 2
Pages: 343-348
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.2014
Author(s)
Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
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Journal Title
J Am Geriatr Soc
Volume: 62
Issue: 7
Pages: 1224-1230
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population: the Hisayama Study.2014
Author(s)
Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M.
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Journal Title
PLoS One
Volume: 9
Issue: 3
Pages: e90984-e90984
DOI
Related Report
Peer Reviewed
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[Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.2014
Author(s)
Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
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Journal Title
Cardiovasc Diabetol
Volume: 13
Issue: 1
Pages: 45-45
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study.2013
Author(s)
Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.
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Journal Title
Atherosclerosis
Volume: 231
Issue: 2
Pages: 261-267
DOI
Related Report
Peer Reviewed
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[Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study.2013
Author(s)
Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
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Journal Title
Cardiovasc Diabetol
Volume: 12
Issue: 1
Pages: 164-164
DOI
Related Report
Peer Reviewed
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[Journal Article] Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study.2013
Author(s)
Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y.
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Journal Title
BMC Public Health
Volume: 13
Issue: 1
Pages: 862-862
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis.2013
Author(s)
Asano K, Matsumoto T, Umeno J, Hirano A, Esaki M, Hosono N, Matsui T, Kiyohara Y, Nakamura Y, Kubo M, Kitazono T.
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Journal Title
Inflamm Bowel Dis
Volume: 19
Issue: 10
Pages: 2061-2068
DOI
Related Report
Peer Reviewed
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[Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009).2013
Author(s)
Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
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Journal Title
Circulation
Volume: 128
Issue: 11
Pages: 1198-1205
DOI
Related Report
Peer Reviewed
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[Journal Article] Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study.2013
Author(s)
Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N, Nagata M, Yamashita Y.
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Journal Title
J Clin Periodontol
Volume: 40
Issue: 8
Pages: 743-752
DOI
Related Report
Peer Reviewed
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[Journal Article] Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study.2013
Author(s)
Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.
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Journal Title
Diabet Med
Volume: 30
Issue: 12
Pages: 1487-1494
DOI
Related Report
Peer Reviewed
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[Journal Article] Angiopoietin-Like Protein 2 Is Associated With Chronic Kidney Disease in a General Japanese Population2013
Author(s)
Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y.
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Journal Title
Circulation Journal
Volume: 77
Issue: 9
Pages: 2311-2317
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study.2013
Author(s)
Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
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Journal Title
Stroke
Volume: 44
Issue: 6
Pages: 1512-1517
DOI
Related Report
Peer Reviewed
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[Journal Article] Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study.2013
Author(s)
Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
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Journal Title
Kidney Int
Volume: 84
Issue: 2
Pages: 373-380
DOI
Related Report
Peer Reviewed
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[Presentation] 久山町健診2015
Author(s)
清原 裕
Organizer
第64回日本医学検査学会
Place of Presentation
福岡市
Year and Date
2015-05-16
Related Report
Invited
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