| Co-Investigator(Kenkyū-buntansha) |
野坂 みずほ 和歌山県立医科大学, 医学部, 助教 (00244731)
石田 裕子 和歌山県立医科大学, 医学部, 講師 (10364077)
木村 章彦 和歌山県立医科大学, 医学部, 博士研究員 (60136611)
池松 和哉 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80332857)
前田 均 大阪市立大学, 医学(系)研究科(研究院), 教授 (20135049)
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| Budget Amount *help |
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Outline of Final Research Achievements |
We investigated the influences of circadian rhythms in forensic practices using several injury/disease models. We have found that the magnitude/severity of deep vein thrombosis, acetaminophen-induced hepatotoxicity, drug-induced nephrotoxicity (cisplatin and arsenite), ischemia-reperfusion muscle injury or systemic organ damages, cecal-ligation and puncture-induced sepsis and wound-induced local autophagy activity could be influenced by individual circadian rhythm, implying that considering time of injury, drug intake and infection onset would be essential for more elucidating each pathophysiological state. Additionally, severe brain injury would suppress clock gene expression in peripheral organs such as heart, indicating that clock gene-based death-time estimation has to be carefully employed in cases with severe head trauma. Collectively, forensic pathologists should always take into consideration the aspects of chronopathophysiology in order to make more accurate diagnosis.
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