| Budget Amount *help |
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
|
|---|
| Outline of Final Research Achievements |
NASH is a liver disease involved with a steatosis, which can be a cause of a cirrhosis, thereby is sometimes followed by HCC. In this study, we found that HCC was significantly developed in AIM-deficient mice fed a high fat diet for 1 year whereas wild-type mice did not show any HCC development, demonstrating that AIM possesses an anti-NASH-derived HCC effect. AIM was incorporated into normal hepatocytes, in which AIM suppressed progress of fatty liver by interfering with accumulation of triglyceride. However, the states of inflammation or of fibrosis in response to a long-term high-fat diet were not altered in AIM-deficient mice as compared with wild-type mice. Thus, AIM appeared to eliminate the cancerized cells, rather than suppress a cancerization of hepatocytes. We also found that AIM eliminated the HCC by inducing cell death through activation of complement cascades which is prompted by the specific accumulation of AIM on the surface of the HCC.
|
