| Budget Amount *help |
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2016: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
In multi-organ creatures, including human beings, inter-organ metabolic communication is essential to regulate systemic metabolism. We examined how the inter-organ communication functions in response to alterations in external environment.
Thereafter, we elucidated that 1) increased amino acid intake induces hypertriglyceridemia via a neuronal relay system, 2) hypoxic responses in steatotic liver are involved in gallstone formation, and 3) fatty acids promote glucose-stimulated insulin secretion via a newly-identified receptor family. Thus, a variety of inter-organ systems for metabolic homeostasis are ironically involved in obesity-related disorders.
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