Development of novel methods for evaluating RA pathogenesis and activity
| Project/Area Number |
25253070
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University |
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Principal Investigator |
ISHII Masaru 大阪大学, 生命機能研究科, 教授 (10324758)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
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| Keywords | 関節リウマチ / イメージング / 関節炎 / 細胞動態 / 免疫・炎症 / 骨破壊 / 骨髄環境 / 免疫 / 炎症 / 細胞・組織 / シグナル伝達 / 医療・福祉 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
In this study, by using an advanced intravital imaging technology in our hand, we have elucidated the mode of cellular dynamics of different immune and inflammatory cells in arthritic joints. In addition, we have focused on the in vivo pharmacological actions of various biological agents used in clinic, and propose a new line of drug differentiation and development for rheumatic diseases.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo.2014
Author(s)
Kagawa Y, Matsumoto S, Kamioka Y, Mimori M, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M
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Journal Title
PLoS One
Volume: 8
Issue: 12
Pages: e83629-e83629
DOI
Related Report
Peer Reviewed / Open Access
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