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Development of biomarkers for functional psychoses based on multiple omics analyses

Research Project

Project/Area Number 25253075
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Kunugi Hiroshi  国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第三部, 部長 (40234471)

Co-Investigator(Kenkyū-buntansha) HATTORI Kotaro  国立精神・神経医療研究センター, 神経研研究所疾病研究第三部, 室長 (50415569)
Research Collaborator SASAYAMA Daimei  信州大学, 医学部精神医学教室, 助教 (90447764)
Project Period (FY) 2013-10-21 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2013: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Keywordsプロテオミクス / ゲノム / マイクロRNA / バイオマーカー / うつ病 / 統合失調症 / 双極性障害 / 脳脊髄液
Outline of Final Research Achievements

We collected bioresource including blood and cerebrospinal fluid (CSF) and performed omics analyses in patients with major depressive disorder (MDD), bipolar disorder, schizophrenia, and controls to find biomarkers for diagnosis and severity for the disorders. Based on proteomics approach, we found that CSF fibrinogen levels are increased in a portion of patients with MDD. We also examined the association between CSF protein levels and genetic variations (genome-wide polymorphisms) and constructed a database showing the relationship between CSF protein levels and single nucleotide polymorphisms (SNPs). We also found promising molecules from more than 2000 microRNA molecules as a biomarker for psychiatric diseases. Based on transcriptome approach on peripheral blood samples, we found that expression of some genes (VAMP2, FKBP4, and CRHR2) are altered in drug naive patients with MDD, suggesting that these genes could be biomarkers for MDD.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (21 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] マックスプランク精神医学研究所(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: Integrative genome-wide and candidate gene analyses2016

    • Author(s)
      Hori H, Sasayama D, Teraishi T, Yamamoto N, Nakamura S, Ota M, Hattori K, Kim Y, Higuchi T, Kunugi H.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 18776-18776

    • DOI

      10.1038/srep18776

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase: New targets for future antidepressants2015

    • Author(s)
      Ogawa S, Kunugi H
    • Journal Title

      Curr Neuropharmacol

      Volume: 13 Issue: 6 Pages: 760

    • DOI

      10.2174/1570159x13666150612225212

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased cerebrospinal fluid fibrinogen in major depressive disorder2015

    • Author(s)
      Hattori K, Ota M, Sasayama D, Yoshida S, Matsumura R, Miyakawa T, Yokota Y, Yamaguchi S, Noda T, Teraishi T, Hori H, Higuchi T, Kohsaka S, Goto Y, Kunugi H.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 11412-11412

    • DOI

      10.1038/srep11412

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Biochemical markers subtyping major depressive disorder2015

    • Author(s)
      Kunugi H, Hori H, Ogawa S
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 69 Issue: 10 Pages: 597

    • DOI

      10.1111/pcn.12299

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder2015

    • Author(s)
      Ogawa S, Hattori K, Sasayama D, Yokota Y, Matsumura R, Matsuo J, Ota M, Hori H, Teraishi T, Yoshida S, Noda T, Ohashi Y, Sato H, Higuchi T, Motohashi N, Kunugi H
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 7796-7796

    • DOI

      10.1038/srep07796

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] うつ病の病態仮説と分子マーカー2015

    • Author(s)
      功刀 浩
    • Journal Title

      精神科診断学

      Volume: 8 Pages: 16-20

    • Related Report
      2015 Annual Research Report
  • [Journal Article] うつ病を生物学的に理解する.2015

    • Author(s)
      功刀 浩
    • Journal Title

      医学と薬学

      Volume: 72 Pages: 1841-1849

    • Related Report
      2015 Annual Research Report
  • [Presentation] うつ病を類型化する生化学的マーカー(教育講演)2015

    • Author(s)
      功刀 浩
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      東京 (タワーホール舟堀)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 服薬していない外来うつ病患者における末梢血遺伝子発現プロファイル:網羅的遺伝子発現と候補遺伝子発現の統合的解析.2015

    • Author(s)
      堀 弘明, 篠山大明, 寺石俊也, 山本宜子, 中村誠二, 太田深秀, 服部功太郎, 金 吉晴, 樋口輝彦, 功刀 浩
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      東京(タワーホール舟堀)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Collection of cerebrospinal fluid bioresource and multiple omics approaches to psychiatric disorders. Symposium "Progress in cerebral fluid markers in neuropsychiatric diseases2015

    • Author(s)
      Hattori K, Yoshida S, Goto Y, Kunugi H
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased cerebrospinal fluid fibrinogen delineates a subgroup of major depressive disorder.2015

    • Author(s)
      Hattori K, Ota M, Sasayama D, Yoshida S, Noda T, Teraishi T, Hori H, Kunugi H
    • Organizer
      World Psychiatric Association Regional Congress, Osaka, Japan
    • Place of Presentation
      Osaka 大阪国際会議場
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.2015

    • Author(s)
      Ogawa S, Hattori K, Sasayama D, Yuki Yokota, Matsumura R, Matsuo J, Ota M, Hori H, Teraishi T, Yoshida S, Noda T, Ohashi Y, Sato H, Higuchi T, Motohashi N, Kunugi H
    • Organizer
      Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The change of cocaine- and amphetamine-regulated transcript (CART) peptide levels in human cerebrospinal fluid (hCSF) of major depressive disorder (MDD) and the role of CART to modulate basal anxiety-related behavoiors in rats.2014

    • Author(s)
      Yoon HS, Hattori K, Sasayama D, Kunugi H
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington Convention Center, Washington, D.C. USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] うつ病の病態仮説と分子マーカー2014

    • Author(s)
      功刀浩
    • Organizer
      第34回日本精神科・診断学会
    • Place of Presentation
      愛媛県松山、大和屋本店
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳脊髄液fibrinogen上昇は大うつ病性障害の亜型を反映している2014

    • Author(s)
      服部功太郎、篠山大明、太田深秀、吉田寿美子、横田悠季、松村亮、宮川友子、野田隆正、功刀浩
    • Organizer
      第36回日本生物学的精神医学会第57回日本神経化学会大会
    • Place of Presentation
      奈良県文化会館・奈良県新公会堂
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] うつ病の診断マーカー

    • Author(s)
      功刀浩
    • Organizer
      第36回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 疾病研究第三部

    • URL

      http://www.ncnp.go.jp/nin/guide/r3/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 疾病研究第三部の紹介

    • URL

      http://www.ncnp.go.jp/nin/guide/r3/index.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] miRNAを用した精神疾患判定マーカー2015

    • Inventor(s)
      服部功太郎、功刀浩、後藤雄一、高坂新一
    • Industrial Property Rights Holder
      独)国立精神・神経医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-008710
    • Filing Date
      2015-01-20
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 精神疾患判定マーカー2014

    • Inventor(s)
      服部功太郎、功刀浩、後藤雄一、髙坂新一
    • Industrial Property Rights Holder
      (独)国立精神・神経医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-102090
    • Filing Date
      2014-05-16
    • Related Report
      2014 Annual Research Report

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Published: 2013-10-24   Modified: 2019-07-29  

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