Development of individualized radiotherapy with biological-image guidance and four-dimensional irradiation

• Project/Area Number: 25253078
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: HIRAOKA Masahiro 京都大学, 医学研究科, 名誉教授 (70173218)
• Co-Investigator(Kenkyū-buntansha): 佐治 英郎 京都大学, 薬学研究科, 特任教授 (40115853) ; 富樫 かおり 京都大学, 医学研究科, 教授 (90135484) ; 溝脇 尚志 京都大学, 医学研究科, 教授 (90314210) ; 松尾 幸憲 京都大学, 医学研究科, 准教授 (80456897) ; 吉村 通央 京都大学, 医学研究科, 講師 (40597936) ; 中村 光宏 京都大学, 医学研究科, 准教授 (30584255) ; 小久保 雅樹 公益財団法人先端医療振興財団, その他部局等, 研究員(機関長・部門長クラス) (90283605) ; 澤田 晃 京都医療科学大学, 医療科学部, 教授 (80543446) ; 門前 一 京都大学, 医学(系)研究科(研究院), 准教授 (10611593) ; 板坂 聡 京都大学, 医学(系)研究科(研究院), 助教 (90378654)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000); Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
• Keywords: 低酸素イメージング / ４次元ＰＥＴ / ４次元線量計算 / 動体追尾ＩＭＲＴ / 四次元放射線治療 / 低酸素 / 腫瘍動態評価 / 動体追尾照射 / 医学物理学 / 4次元放射線治療 / ４次元放射線治療 / 四次元機能画像 / 低酸素画像 / 追尾照射 / 強度変調放射線治療

Outline of Final Research Achievements

Treatment planning which integrates biological images, and motion management of normal organ and tumors are supposed to be key components for improvement of the current radiotherapy. So, we set the following three research goals: evaluation of biological and functional imaging in radiotherapy planning; development of measurement methods of four-dimensional tumor movement and biological imaging; and development of fundamental techniques toward real-time tumor tracking SIB-IMRT. We achieved the research milestones including optimal timing in hypoxic imaging using F-MISO-PET, usefulness of respiratory-gated FDG-PET, a calculation module for four-dimensional dose distributions, etc. These research achievements would allow us to improve treatment outcomes in cancer patients using more sophisticated radiotherapy near future.

Research Products

• [Journal Article] Comparison of gamma pass rate between the dose-to-water and dose-to-medium reporting modes for patient-specific QA using a helical diode array dosimeter with a fixed phantom density. (2018)
  • Author(s): Hirashima H, Nakamura M, Ishihara Y, Mukumoto N, Akimoto M, Tomita T, Hirose Y, Kitsuda K, Ishigaki T, Mizowaki T.
  • Journal Title: Int. J. Med. Phys., Clin. Eng. Radiat. Oncol. Volume: 7 Pages: 74-86
  • Peer Reviewed / Open Access
• [Journal Article] Inter- and Intrafractional Variation in the 3-Dimensional Positions of Pancreatic Tumors Due to Respiration Under Real-Time Monitoring (2017)
  • Author(s): Akimoto Mami、Nakamura Mitsuhiro、Nakamura Akira、Mukumoto Nobutaka、Kishi Takashi、Goto Yoko、Mizowaki Takashi、Hiraoka Masahiro
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys. Volume: 98 Issue: 5 Pages: 1204-1211
  • DOI: 10.1016/j.ijrobp.2017.03.042
  • Peer Reviewed
• [Journal Article] Three-dimensional intrafractional internal target motions in accelerated partial breast irradiation using three-dimensional conformal external beam radiotherapy (2017)
  • Author(s): Hirata Kimiko、Yoshimura Michio、Mukumoto Nobutaka、Nakamura Mitsuhiro、Inoue Minoru、Sasaki Makoto、Fujimoto Takahiro、Yano Shinsuke、Nakata Manabu、Mizowaki Takashi、Hiraoka Masahiro
  • Journal Title: Radiotherapy and Oncology Volume: 124 Issue: 1 Pages: 118-123
  • DOI: 10.1016/j.radonc.2017.04.023
  • Peer Reviewed
• [Journal Article] Estimation of lung tumor position from multiple anatomical features on 4D-CT using multiple regression analysis (2017)
  • Author(s): Ono Tomohiro、Nakamura Mitsuhiro、Hirose Yoshinori、Kitsuda Kenji、Ono Yuka、Ishigaki Takashi、Hiraoka Masahiro
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 18 Issue: 5 Pages: 36-42
  • DOI: 10.1002/acm2.12121
  • Peer Reviewed / Open Access
• [Journal Article] Use of a second-dose calculation algorithm to check dosimetric parameters for the dose distribution of a first-dose calculation algorithm for lung SBRT plans (2017)
  • Author(s): Tsuruta Yusuke、Nakamura Mitsuhiro、Miyabe Yuki、Nakata Manabu、Ishihara Yoshitomo、Mukumoto Nobutaka、Akimoto Mami、Ono Tomohiro、Yano Shinsuke、Higashimura Kyoji、Matsuo Yukinori、Mizowaki Takashi、Hiraoka Masahiro
  • Journal Title: Physica Medica Volume: 44 Pages: 86-95
  • DOI: 10.1016/j.ejmp.2017.07.020
  • Peer Reviewed
• [Journal Article] Optimization of a newly defined target volume in fiducial marker-based dynamic tumor-tracking radiotherapy (2017)
  • Author(s): Iizuka Yusuke、Matsuo Yukinori、Nakamura Mitsuhiro、Kozawa Satoshi、Ueki Nami、Mitsuyoshi Takamasa、Mizowaki Takashi、Hiraoka Masahiro
  • Journal Title: Physics and Imaging in Radiation Oncology Volume: 4 Pages: 1-5
  • DOI: 10.1016/j.phro.2017.10.001
  • Peer Reviewed / Open Access
• [Journal Article] Dosimetric impact of translational and rotational setup errors for spine stereotactic body radiotherapy: A phantom study (2017)
  • Author(s): Sasaki Makoto、Nakamura Mitsuhiro、Mukumoto Nobutaka、Nakata Manabu、Hiraoka Masahiro
  • Journal Title: Medical Dosimetry Volume: In press Issue: 4 Pages: 320-326
  • DOI: 10.1016/j.meddos.2017.10.009
  • Peer Reviewed
• [Journal Article] Assessment of treatment response after lung stereotactic body radiotherapy using diffusion weighted magnetic resonance imaging and positron emission tomography: A pilot study (2017)
  • Author(s): Shintani Takashi、Matsuo Yukinori、Iizuka Yusuke、Mitsuyoshi Takamasa、Umeoka Shigeaki、Nakamoto Yuji、Mizowaki Takashi、Togashi Kaori、Hiraoka Masahiro
  • Journal Title: Eur J Radiol Volume: 92 Pages: 58-63
  • DOI: 10.1016/j.ejrad.2017.04.022
  • Peer Reviewed
• [Journal Article] Long-term outcomes of intensity-modulated radiotherapy following extra-pleural pneumonectomy for malignant pleural mesothelioma. (2017)
  • Author(s): Matsuo Y, Shibuya K, Okubo K, Ueki N, Aoyama A, Sonobe M, Nakamura M, Mizowaki T, Date H, Hiraoka M.
  • Journal Title: Acta Oncol Volume: 印刷中 Issue: 7 Pages: 1-6
  • DOI: 10.1080/0284186x.2017.1279749
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In Vivo Molecular Imaging. (2017)
  • Author(s): Saji Hideo
  • Journal Title: Biological & pharmaceutical bulletin Volume: 40 Pages: 1605-1615
  • NAID: 130006110589
  • Peer Reviewed
• [Journal Article] Development of a four-dimensional Monte Carlo dose calculation system for real-time tumor-tracking irradiation with a gimbaled x-ray head. (2017)
  • Author(s): Ishihara Y, Nakamura M, Miyabe Y, Mukumoto N, Matsuo Y, Sawada A, Kokubo M, Mizowaki T, Hiraoka M.
  • Journal Title: Phys. Med. Volume: 35 Pages: 59-65
  • DOI: 10.1016/j.ejmp.2017.02.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Difference in dose-volumetric data between the analytical anisotropic algorithm, the dose-to-medium, and the dose-to-water reporting modes of the Acuros XB for lung stereotactic body radiation therapy. (2016)
  • Author(s): Mampuya WA, Nakamura M, Hirose Y, Kitsuda K, Ishigaki T, Mizowaki T, Hiraoka M.
  • Journal Title: J. Appl. Clin. Med. Phys. Volume: 17 Issue: 5 Pages: 341-347
  • DOI: 10.1120/jacmp.v17i5.6338
  • NAID: 120006305883
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differences in dose-volume parameters between averaged CT and end-exhalation CT images in stereotactic body radiotherapy for lung cancer. (2016)
  • Author(s): Mitsuyoshi T, Nakamura M, Matsuo Y, Ueki N, Nakamura A, Iizuka Y, Mampuya WA, Mizowaki T, Hiraoka M.
  • Journal Title: Med Dosim Volume: 41 Issue: 4 Pages: 305-309
  • DOI: 10.1016/j.meddos.2016.07.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of a four-axis moving phantom for patient-specific quality assurance of surrogate signal-based dynamic tumor-tracking intensity-modulated radiotherapy. (2016)
  • Author(s): Mukumoto N, Nakamura M, Yamada M, Takahashi K, Akimoto M, Miyabe Y, Yokota K, Kaneko S, Nakamura A, Itasaka S, Matsuo Y, Mizowaki T, Kokubo M, Hiraoka M.
  • Journal Title: Med Phys Volume: 43 Issue: 12 Pages: 6364-6374
  • DOI: 10.1118/1.4966130
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparative evaluation of respiratory-gated and ungated FDG-PET for target volume definition in radiotherapy treatment planning for pancreatic cancer. (2016)
  • Author(s): Kishi T, Matsuo Y, Nakamura A, Nakamoto Y, Itasaka S, Mizowaki T, Togashi K, Hiraoka M
  • Journal Title: Radiother Oncol. Volume: 120 Issue: 2 Pages: 217-221
  • DOI: 10.1016/j.radonc.2016.07.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dosimetric evaluation of the Acuros XB algorithm for a 4MV photon beam in head and neck intensity-modulated radiation therapy (2015)
  • Author(s): Kimiko Hirata, Mitsuhiro Nakamura, Michio Yoshimura, Nobutaka Mukumoto, Manabu Nakata, Hitoshi Ito, Haruo Inokuchi, Yukinori Matsuo, Takashi Mizowaki, Masahiro Hiraoka
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 16 Issue: 4 Pages: 52-64
  • DOI: 10.1120/jacmp.v16i4.5222
  • NAID: 120005829405
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Interfraction Positional Variation in Pancreatic Tumors using Daily Breath-hold Cone-beam Computed Tomography with Visual Feedback (2015)
  • Author(s): Nakamura M, Akimoto M, Ono T, Nakamura A, Yano S, Nakata M, Itasaka S, Mizowaki T, Shibuya K, Hiraoka M.
  • Journal Title: J Appli Clin Med Phys Volume: 16 Issue: 2 Pages: 108-16
  • DOI: 10.1120/jacmp.v16i2.5123
  • NAID: 120005829404
  • Peer Reviewed
• [Journal Article] Improvement of registration accuracy in accelerated partial breast irradiation using the point-based rigid-body registration algorithm for patients with implanted fiducial markers (2015)
  • Author(s): Minoru Inoue, Michio Yoshimura, Sayaka Sato, Mitsuhiro Nakamura, Masahiro Yamada, Kimiko Hirata,
  • Journal Title: Medical Physics Volume: 42（4） Issue: 4 Pages: 1904-1910
  • DOI: 10.1118/1.4915534
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer. (2015)
  • Author(s): Ueki N, Matsuo Y, Togashi Y, Kubo T, Shibuya K, Iizuka Y, Mizowaki T, Togashi K, Mishima M, Hiraoka M.
  • Journal Title: J Thorac Oncol Volume: 10 Issue: 1 Pages: 116-25
  • DOI: 10.1097/jto.0000000000000359
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Survival outcomes after stereotactic body radiotherapy for 79 Japanese patients with hepatocellular carcinoma. (2015)
  • Author(s): Yamashita H, Onishi H, Murakami N, Matsumoto Y, Matsuo Y, Nomiya T, Nakagawa K.
  • Journal Title: J Radiat Res Volume: in press Issue: 3 Pages: 561-567
  • DOI: 10.1093/jrr/rru130
  • Peer Reviewed / Open Access
• [Journal Article] Pretreatment modified Glasgow Prognostic Score predicts clinical outcomes after stereotactic body radiotherapy for early-stage non-small cell lung cancer. (2015)
  • Author(s): Kishi T, Matsuo Y, Ueki N, Iizuka Y, Nakamura A, Sakanaka K, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys: Volume: in press Issue: 3 Pages: 619-26
  • DOI: 10.1016/j.ijrobp.2015.02.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dosimetric evaluation of the Acuros XB algorithm for a 4 MV photon beam in head and neck intensity-modulated radiation therapy (2015)
  • Author(s): Hirata K, Nakamura M, Yoshimura M, Mukumoto N, Nakata M, Ito H, Inokuchi H, Matsuo Y, Mizowaki T, Hiraoka M.
  • Journal Title: J Appli Clin Med Phys Volume: in press
  • NAID: 120005829405
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Baseline correction of a correlation model for improving the prediction accuracy of infrared marker-based dynamic tumor tracking (2015)
  • Author(s): Akimoto M, Nakamura M, Mukumoto N, Yamada M, Tanabe H, Ueki N, Kaneko S, Matsuo Y, Mizowaki T, Kokubo M, Hiraoka M
  • Journal Title: J Appli Clin Med Phys Volume: 16 Issue: 2 Pages: 14-22
  • DOI: 10.1120/jacmp.v16i2.4896
  • NAID: 120005829403
  • Peer Reviewed / Open Access
• [Journal Article] Influence of the correlation-modeling period on the prediction accuracy of infrared marker-based dynamic tumor tracking using the gimbaled x-ray head of the Vero4DRT (2015)
  • Author(s): Nakamura M, Akimoto M, Mukumoto N, Yamada M, Tanabe H, Ueki N, Matsuo Y, Mizowaki T, Kokubo M, Hiraoka M
  • Journal Title: Phys Med Volume: 31 Issue: 3 Pages: 204-9
  • DOI: 10.1016/j.ejmp.2015.01.004
  • Peer Reviewed
• [Journal Article] Intra- and interfractional variations in geometric arrangement between lung tumours and implanted markers (2014)
  • Author(s): Ueki N, Matsuo Y, Nakamura M, et al.
  • Journal Title: Radiother Oncol Volume: (in press) Issue: 3 Pages: 523-8
  • DOI: 10.1016/j.radonc.2014.01.014
  • NAID: 120005439548
  • Peer Reviewed
• [Journal Article] Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients. (2014)
  • Author(s): Yamashita H, Onishi H, Matsumoto Y, Murakami N, Matsuo Y, Nomiya T, Nakagawa K.
  • Journal Title: Radiat Oncol Volume: 9 Issue: 1 Pages: 112-112
  • DOI: 10.1186/1748-717x-9-112
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac. (2014)
  • Author(s): Matsuo Y, Ueki N, Takayama K, Nakamura M, Miyabe Y, Ishihara Y, Mukumoto N, Yano S, Tanabe H, Kaneko S, Mizowaki T, Monzen H, Sawada A, Kokubo M, Hiraoka M.
  • Journal Title: Radiother Oncol Volume: 112 Issue: 3 Pages: 360-4
  • DOI: 10.1016/j.radonc.2014.08.003
  • NAID: 120005522772
  • Peer Reviewed
• [Journal Article] Comparison of long-term survival outcomes between stereotactic body radiotherapy and sublobar resection for stage I non-small-cell lung cancer in patients at high risk for lobectomy: A propensity score matching analysis. (2014)
  • Author(s): Matsuo Y, Chen F, Hamaji M, Kawaguchi A, Ueki N, Nagata Y, Sonobe M, Morita S, Date H, Hiraoka M.
  • Journal Title: Eur J Cancer Volume: 50 Issue: 17 Pages: 2932-8
  • DOI: 10.1016/j.ejca.2014.09.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Impact of Abdominal Compression on Outcome in Patients Treated with Stereotactic Body Radiotherapy for Primary Lung Cancer. (2014)
  • Author(s): Mampuya WA, Matsuo Y, Ueki N, Nakamura M, Mukumoto N, Nakamura A, Iizuka Y, Kishi T, Mizowaki T, Hiraoka M.
  • Journal Title: J Radiat Res Volume: 印刷中 Issue: 5 Pages: 934-9
  • DOI: 10.1093/jrr/rru028
  • NAID: 120005512252
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of clinical outcome after stereotactic body radiotherapy for non-small cell lung cancer using diffusion-weighted MRI and (18)F-FDG PET. (2014)
  • Author(s): Iizuka Y, Matsuo Y, Umeoka S, Nakamoto Y, Ueki N, Mizowaki T, Togashi K, Hiraoka M.
  • Journal Title: Eur J Radiol Volume: 83 Issue: 11 Pages: 2087-92
  • DOI: 10.1016/j.ejrad.2014.07.018
  • NAID: 120005512258
  • Peer Reviewed
• [Journal Article] Development of a dose verification system for Vero4DRT using Monte Carlo method (2014)
  • Author(s): Ishihara Y, Sawada A, Nakamura M, Miyabe Y, Tanabe H, Kaneko S, Takayama K, Mizowaki T, Kokubo M, Hiraoka M.
  • Journal Title: J Appli Clin Med Phys Volume: 15 Issue: 6 Pages: 160-72
  • DOI: 10.1120/jacmp.v15i6.4961
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Accuracy of positional correction for the floor-mounted kV X-ray IGRT system in angled couch positions (2014)
  • Author(s): Koubuchi S, Takakura T, Nakamura M, Mizowaki T, Nakata M, Hiraoka M.
  • Journal Title: Radiol Phys Technol Volume: 7 Issue: 2 Pages: 373-8
  • DOI: 10.1007/s12194-014-0275-0
  • Peer Reviewed
• [Journal Article] Dosimetric comparison of Acuros XB with AAA and XVMC in stereotactic body radiotherapy for lung cancer (2014)
  • Author(s): Tsuruta Y, Nakata M, Nakamura M, Matsuo Y, Higashimura K, Monzen H, Mizowaki T, Hiraoka M
  • Journal Title: Med Phys Volume: 41 Issue: 8Part1 Pages: 081715-081715
  • DOI: 10.1118/1.4890592
  • Peer Reviewed
• [Journal Article] Weekly administration of paclitaxel and carboplatin with concurrent thoracic radiation in previously untreated elderly patients with locally advanced non-small-cell lung cancer: A case series of 20 patients (2014)
  • Author(s): Takeshita J, Masago K, Fujita S, Hata A, Kaji R, Kawamura T, Tamai K, Matsumoto T, Nagata K, Otsuka Ky, Nakagawa A, Otsuka Ko, Tomii K, Shintani T, Takayama K, Kokubo M, Katakami N
  • Journal Title: Molecular and Clinical Oncology Volume: 2 Issue: 3 Pages: 454-460
  • DOI: 10.3892/mco.2014.249
• [Journal Article] Radiotherapy for patients with isolated local recurrence of primary resected pancreatic cancer : Prolonged disease-free interval associated with favorable prognosis (2014)
  • Author(s): Nakamura, A. Itasaka S, Takaori K, Kawaguchi Y, Shibuya K, Yoshimura M, Matsuo Y, Mizowaki T, Uemoto S, Hiraoka M.
  • Journal Title: Strahlentherapie und Onkologie Volume: MAR 6 Issue: 5 Pages: 485-485
  • DOI: 10.1007/s00066-014-0610-8
  • Peer Reviewed
• [Journal Article] Differences in dose-volumetric data between the analytical anisotropic algorithm and the x-ray voxel Monte Carlo algorithm in stereotactic body radiation therapy for lung cancer (2013)
  • Author(s): Mampuya WA, Matsuo Y, Nakamura A, Nakamura M, Mukumoto N, Miyabe Y, Narabayashi M, Sakanaka K, Mizowaki T, Hiraoka M.
  • Journal Title: Med Dosim. Volume: 38 Issue: 1 Pages: 95-9
  • DOI: 10.1016/j.meddos.2012.07.007
  • Peer Reviewed
• [Journal Article] Interfraction variation in lung tumor position with abdominal compression during stereotactic body radiotherapy. (2013)
  • Author(s): Mampuya WA, Nakamura M, Matsuo Y, Ueki N, Iizuka Y, Fujimoto T, Yano S, Monzen H, Mizowaki T, Hiraoka M
  • Journal Title: Med Phys Volume: 40 Issue: 9 Pages: 91718-91718
  • DOI: 10.1118/1.4819940
  • Peer Reviewed
• [Journal Article] In vivo evaluation of a radiogallium-labeled bifunctional radiopharmaceutical, Ga-DOTA-MN2, for hypoxic tumor imaging. (2013)
  • Author(s): Sano K, Okada M, Hisada H, Shimokawa K, Saji H, Maeda M, Mukai T.
  • Journal Title: Bio Pharm Bull Volume: 36(4) Pages: 602-608
  • NAID: 130003361390
  • Peer Reviewed
• [Journal Article] Development of an Oxygen-Sensitive Degradable Peptide Probe for the Imaging of Hypoxia-Inducible Factor-1-Active Regions in Tumors. (2013)
  • Author(s): Ueda M, Ogawa K, Miyano A, Ono M, Kizaka-Kondoh S, Saji H.
  • Journal Title: Mol Imaging Biol. Volume: 15 Issue: 6 Pages: 713-721
  • DOI: 10.1007/s11307-013-0647-6
  • Peer Reviewed
• [Journal Article] Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers. (2013)
  • Author(s): Kondo N, Temma T, Shimizu Y, Watanabe H, Higano K, Takagi Y, Ono M, Saji H.
  • Journal Title: Cancer Sci. Volume: 104(4) Issue: 4 Pages: 495-501
  • DOI: 10.1111/cas.12102
  • Peer Reviewed
• [Presentation] Hypoxic imaging obtained at 2-h postinjection in FMISO-PET (2017)
  • Author(s): Kawamura M, Yoshimura M, Katagiri T, Mitsuyoshi T, Inokuchi H, Sano K, Shimizu Y, Ishimori T, Nakamoto Y, Hiraoka M , Mizowaki T
  • Organizer: 35th ESTRO
  • Place of Presentation: Reed Messe Vienna GmbH Congress Center , Vienna, Austria
  • Year and Date: 2017-05-05
  • Int'l Joint Research
• [Presentation] Difference in dose-volumetric data between the Analytical Anisotropic Algorithm (AAA), the dose-to-medium and the dose-to-water reporting modes of the Acuros XB for Lung SBRT (2016)
  • Author(s): Mampuya WA, Nakamura M, Hirose Y, Kitsuda K, Ishigaki T, Mizowaki T, Hiraoka M
  • Organizer: 35th ESTRO
  • Place of Presentation: LINGOTTO FIERE TORINO , Turin, Italy
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] Comparative evaluation of respiratory-gated and ungated FDG-PET for target volume definition in radiotherapy treatment planning for pancreatic cancer. (2016)
  • Author(s): Kishi T, Matsuo Y, Nakamura A, Nakamoto Y, Itasaka S, Mizowaki T, Togashi K, Hiraoka M
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜・神奈川県横浜市
• [Presentation] Image comparison between 4-dimensional computed tomography (4DCT) and 320 multi-detector CT (320-MDCT) in lung tumors (2015)
  • Author(s): Iizuka Y, Matsuo Y, Nakamura M, Kozawa S, Takakura T, Mizowaki T, Hiraoka M
  • Organizer: JASTRO(日本放射線腫瘍学会 第28回学術集会)
  • Place of Presentation: 前橋商工会議所会館 群馬県前橋市
  • Year and Date: 2015-11-21
• [Presentation] Vero4DRTを用いた肝腫瘍に対する動体追尾定位放射線治療 (2014)
  • Author(s): 飯塚裕介、松尾幸憲、石原佳知、秋元麻未、田邊裕朗、高山賢二、植木奈美、横田憲治、溝脇尚志、小久保雅樹、平岡眞寛
  • Organizer: JASTRO 第27回学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Comparison of Long-term Survival Outcomes between Stereotactic Body Radiotherapy and Sublobar Resection for Stage I Non-small Cell Lung Cancer in High-risk Operable Patients: Propensity Score Match Analysis. (2014)
  • Author(s): Matsuo Y, Chen F, Hamaji M, Kawaguchi A, Ueki N, Nagata Y, Sonobe M, Morita S, Date H, Hiraoka M.
  • Organizer: Chicago Multidisciplinary Symposium in Thoracic Oncology.
  • Place of Presentation: Chicago Marriott Downtown Magnificent Mile
  • Year and Date: 2014-10-30 – 2014-11-01
• [Presentation] Comparison of Long-term Survival Outcomes between Stereotactic Body Radiotherapy and Sublobar Resection for Stage I Non-small Cell Lung Cancer in High-risk Operable Patients: Propensity Score Match Analysis. (2014)
  • Author(s): Matsuo Y, Chen F, Hamaji M, Kawaguchi A, Ueki N, Nagata Y, Sonobe M, Morita S, Date H, Hiraoka M.
  • Organizer: ASTRO’s 56th Annual Meeting
  • Place of Presentation: Moscone Center, San Francisco
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Evaluation of dose distribution and tracking accuracy in dynamic tumor-tracking irradiation for liver tumors using a gimbaled linac (2014)
  • Author(s): Y. Iizuka, N. Ueki, Y. Ishihara, M. Akimoto, H. Tanabe, K. Takayama, N. Mukumoto, M. Nakamura, Y. Miyabe, S. Kaneko, Y. Matsuo, T. Mizowaki, H. Monzen, A Sawada, M. Kokubo, M. Hiraoka
  • Organizer: ASTRO’s 56th Annual Meeting
  • Place of Presentation: Moscone Center, San Francisco
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] A multi-centric analysis of error components in dynamic tumour tracking radiotherapy. (2014)
  • Author(s): Matsuo Y, Verellen D, Poels K, Mukumoto N, Depuydt T, Akimoto M, Nakamura M, Hiraoka M, De Ridder M.
  • Organizer: EPI2k14
  • Place of Presentation: Hotel Marselis, Aarhus, Denmark
  • Year and Date: 2014-08-31 – 2014-09-03
• [Presentation] Intensity-modulated radiotherapy following extra-pleural pneumonectomy for malignant pleural mesothelioma. (2014)
  • Author(s): Matsuo Y, Shibuya K, Okubo K, Ueki N, Nakamura M, Sonobe M, Aoyama A, Sato M, Date H, Hiraoka M.
  • Organizer: ESTRO 33
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-04-04 – 2014-04-08
• [Presentation] Impact of Pretreatment Interstitial Lung Disease Findings on Radiation Pneum onitis and Survival after Stereotactic Body Radiation Therapy for Lung Cancer. (2014)
  • Author(s): Nami Ueki.
  • Organizer: 第73回日本医学放射線学会
  • Place of Presentation: 横浜市
• [Presentation] Development of a four-axis moving phantom for quality assurance of surrogate signal-based dynamic tumor tracking irradiation． (2013)
  • Author(s): Nobutaka Mukumoto
  • Organizer: 13th AOCMP & 11th SEACOMP 2013
  • Place of Presentation: シンガポール
• [Presentation] Vero4DRTを用いた動体追尾肺定位放射線治療の初期臨床経験 (2013)
  • Author(s): 小久保雅樹，松尾幸憲，植木奈美，藤田史郎，高山賢二，片上信之，平岡真 寛
  • Organizer: 第54回日本肺癌学会
  • Place of Presentation: 東京都
• [Presentation] 間質性疾患の画像所見を有する患者における体幹部定位放射線治療 (2013)
  • Author(s): 植木 奈美
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: 東京都
• [Presentation] Feasibility of stereotactic body radiation therapy with concurrent chemotherapy for patients over 75 years old with Stage I non-small-cell lung cancer． (2013)
  • Author(s): Kokubo M, Kishi T, Uto M, Shintani T, Ueki N, Fujita S, Kaji R, Hata A, Takayama K, Katakami N
  • Organizer: 15th World Conference of Lung Cancer
  • Place of Presentation: シドニー(オーストラリア)
• [Presentation] 前立腺癌腹臥位シェル固定下IMRTにおける呼吸性移動の影響 (2013)
  • Author(s): 池田格,溝脇尚志,小野智博,門前一,中村京平,中村光宏,矢野慎輔,井口治男,平岡真寛
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森市
• [Presentation] Vero4DRT（MHI-TM2000）を用いた動体追尾照射におけるマージン設定 (2013)
  • Author(s): 溝脇尚志, 松尾幸憲, 植木奈美, et al.
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森市
• [Presentation] Patterns of failure after stereotactic body radiotherapy for histologically proven Stage I non-small-cell lung cancer． (2013)
  • Author(s): Kosaka Y, Kokubo M, Takayama K, Katakami N
  • Organizer: 17th European Cancer Congress
  • Place of Presentation: アムステルダム(オランダ)
• [Presentation] Relationship Between Intra-fraction Prostate Motion And Rectal Dilatation. (2013)
  • Author(s): Ikeda I, Mizowaki T, Nakamura M, Yano S, Yamada M, Inokuchi H, Norihisa Y, Hiraoka M.
  • Organizer: American Society for Radiation Oncology 55th Annual Meeting
  • Place of Presentation: アトランタ(米国)
• [Presentation] ジンバル照射ヘッドによる動体追尾強度変調照射に対する四次元モンテカルロ線量計算システムの開発 (2013)
  • Author(s): 石原 佳知，澤田 晃，宮部 結城，小野 智博，溝脇 尚志，小久保 雅樹，平岡 真寛
  • Organizer: 第106回医学物理学会
  • Place of Presentation: 大阪市
• [Presentation] Development of a four-dimensional monte carlo dose calculation system for intensity modulated dynamic tumor-tracking irradiation using a gimbaled x-ray head. (2013)
  • Author(s): Ishihara Y, Sawada A, Miyabe Y, Ono T, Mizowaki T, Kokubo M, and Hiraoka M
  • Organizer: International conference of medical physics 2013
  • Place of Presentation: ブライトン(イギリス)
• [Presentation] Investigation of well-balanced kV x-ray imaging conditions between skin dose and image quality for dynamic tumor-tracking irradiation using Vero4DRT． (2013)
  • Author(s): Nakai T, Sawada A, Tanabe H, Sueoka M, Kubo K, Taniuchi S, Shiinoki T, Ishihara Y, Takayama K, Kokubo M
  • Organizer: 2nd European Society of Therapeutic Radiology and Oncology Forum
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] Stereotactic Body Radiotherapy for the Lung (2013)
  • Author(s): Matsuo Y.
  • Organizer: 37th Annual MD Anderson Radiation Oncology/Gilbert H. Fletcher Society Meeting.
  • Place of Presentation: 京都市
  • Invited
• [Presentation] 非小細胞肺癌に対する定位放射線治療の予後予測における拡散強調 MRI と FDG-PET の検討 (2013)
  • Author(s): 飯塚 裕介
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜市
• [Presentation] Reduction of the number of remapped respiratory phase images in four-dimensional Monte Carlo dose calculation of dynamic tumor tracking irradiation. (2013)
  • Author(s): Ishihara Y, Sawada A, Miyabe Y, Mukumoto N, Nakamura M, Ueki N, Matsuo Y, Mizowaki T, Kokubo M, and Hiraoka M.
  • Organizer: 第105回医学物理学会
  • Place of Presentation: 横浜市
• [Presentation] Gafcromic EBT3を用いたIMRT線量分布検証におけるスキャン方法に関する基 礎的検討 (2013)
  • Author(s): 久保和輝，田邊裕朗，末岡正輝，谷内 翔，中井高宏，高山賢二，小久保雅 樹
  • Organizer: 第105回日本医学物理学会
  • Place of Presentation: 横浜市
• [Presentation] Vero4DRT(MHI-TM2000)を用いた動体追尾照射にお ける皮膚被曝線量を考慮したkV透視画像の最適撮影条件に関する検討 (2013)
  • Author(s): 中井高宏，澤田 晃，田邊裕朗，末岡正輝，久保和輝，谷内 翔，椎木健裕，石原 佳知，高山賢二，小久保雅樹
  • Organizer: 第105回 日本医学物理学会
  • Place of Presentation: 横浜市
• [Presentation] 320列CTによる肺腫瘍と金マーカーの動態解析
  • Author(s): 飯塚 裕介
  • Organizer: 第27回日本高精度放射線外部照射研究会
  • Place of Presentation: 東京都
• [Presentation] 先 端医療センターおよび神戸市立医療センター中央市民病院におけるIMRT
  • Author(s): 高山賢二，小久保雅樹，今葷倍敏行，小坂恭弘，宇藤恵，新谷尭，君野元規
  • Organizer: 第38回 神戸放射線腫瘍懇話会
  • Place of Presentation: 神戸市
• [Presentation] 当院における動体追尾肺定位放射線治療を実施した6例に関する検討．
  • Author(s): 竹下純平，秦明登，加地玲子，真砂勝秦，藤田史郎，片上信之，高山賢二，小久 保雅樹
  • Organizer: 第98回日本肺癌学会関西支部会
  • Place of Presentation: 大阪市
• [Presentation] 早期肺癌に対する体幹部定位放射線治療
  • Author(s): 松尾 幸憲
  • Organizer: 第28回日本肺癌学会ワークショップ
  • Place of Presentation: 京都市
  • Invited