Innovative treatment of refractory digestive cancers based on the stemness visualization system

• Project/Area Number: 25253081
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Tanaka Shinji 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30253420)
• Co-Investigator(Kenkyū-buntansha): MORI Masaki 大阪大学, 大学院医学系研究科, 教授 (70190999) ; NAKAMURA Noriaki 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10372442) ; AIHARA Arihiro 東京医科歯科大学, 医学部附属病院, 助教 (90451939) ; AKIYAMA Yoshimitsu 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (80262187) ; SHIMADA Shu 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (20609705)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2015: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2013: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
• Keywords: 癌 / 幹細胞 / トランスレーショナルリサーチ / 転移 / 治療標的 / がん予防 / 外科 / 再生医学 / シグナル伝達 / 炎症

Outline of Final Research Achievements

A real-time visualization system for cancer stem cells (CSCs) was established (Clin Cancer Res, in press). We found that human pancreatic CSCs were highly metastatic and dominantly localized at the invading margins in liver metastasis. Microarray and siRNA screening assays showed that DCLK1 was predominantly expressed with histone modification in pancreatic CSCs with invasive and metastatic potential. Overexpression of DCLK1 led to amoeboid morphology which promotes the migration of pancreatic cancer cells. Knockdown of DCLK1 profoundly suppressed in vivo liver metastasis of pancreatic CSCs. Clinically, the specific expression of DCLK1 was detected in the metastatic tumors in patients with pancreatic cancer. Our studies identified DCLK1, that is essential for the metastatic properties of CSCs, as a promising epigenetic and therapeutic target in human pancreatic cancer (PLoS One 2016). In addition, we revealed transgenic mice with this system are useful for cancer prevention strategies.

Research Products

• [Int'l Joint Research] Peking University(China)
• [Int'l Joint Research] Seoul National University(韓国)
• [Journal Article] Dominant expression of DCLK1 in human pancreatic cancer stem cells accelerates tumor invasion and metastasis. (2016)
  • Author(s): Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M.
  • Journal Title: PloS One Volume: 11
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. (2016)
  • Author(s): Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
  • Journal Title: Int. J. Oncol. Volume: 48 Issue: 2 Pages: 657-669
  • DOI: 10.3892/ijo.2015.3299
  • Peer Reviewed / Open Access
• [Journal Article] Molecular pathogenesis and targeted therapy of pancreatic cancer. (2016)
  • Author(s): Tanaka S.
  • Journal Title: Annals of Surgical Oncology Volume: 23 Issue: S2 Pages: 197-205
  • DOI: 10.1245/s10434-015-4463-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression. (2016)
  • Author(s): Akiyama Y, Koda Y, Byeon S, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S.
  • Journal Title: Oncotarget Volume: 7(4) Issue: 4 Pages: 3966-3983
  • DOI: 10.18632/oncotarget.6681
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. (2016)
  • Author(s): Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Sayuri Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M.
  • Journal Title: Journal of Gastroenterology Volume: 51 Issue: 5 Pages: 473-486
  • DOI: 10.1007/s00535-015-1126-4
  • Peer Reviewed
• [Journal Article] Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors. (2016)
  • Author(s): Akahoshi K, Tanaka S, Mogushi K, Shimada S, Matsumura S, Akiyama Y, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M.
  • Journal Title: Journal of Gastroenterology Volume: [Epub ahead of print]
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Macroscopic morphology for estimation of malignant potential in pancreatic neuroendocrine neoplasm. (2016)
  • Author(s): Katsuta E, Kudo A, Akashi T, Mitsunori Y, Matsumura S, Aihara A, Ban D, Ochiai T, Tanaka S, Eishi Y, Tanabe M.
  • Journal Title: Journal of Cancer Research and Clinical Oncology Volume: [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Cancer stem cells as therapeutic targets of hepato-biliary-pancreatic cancers. (2015)
  • Author(s): Tanaka S.
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: in press Issue: 7 Pages: 531-537
  • DOI: 10.1002/jhbp.248
  • Peer Reviewed
• [Journal Article] DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences. (2015)
  • Author(s): Watanabe Y, Yamamoto H, Oikawa R, Toyota M, Yamamoto M, Kokudo N, Tanaka S, Arii S, Yotsuyanagi H, Koike K, Itoh F.
  • Journal Title: Genome Research Volume: 25(3) Issue: 3 Pages: 328-337
  • DOI: 10.1101/gr.175240.114
  • Peer Reviewed / Open Access
• [Journal Article] A novel Aurora/VEGFR dual kinase inhibitor as treatment for hepatocellular carcinoma. (2015)
  • Author(s): Nakao K, Tanaka S, Miura T, Sato K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M.
  • Journal Title: Cancer Science Volume: 106(8) Issue: 8 Pages: 1016-1022
  • DOI: 10.1111/cas.12701
  • Peer Reviewed / Open Access
• [Journal Article] A novel therapeutic combination targeting sequentially Aurora B and Bcl-xL in hepatocellular carcinoma. (2015)
  • Author(s): Matsunaga H, Tanaka S, Aihara A, Ogawa K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Arii S, Tanabe M.
  • Journal Title: Annals of Surgical Oncology Volume: 22(9) Issue: 9 Pages: 1016-1022
  • DOI: 10.1245/s10434-014-4292-3
  • Peer Reviewed
• [Journal Article] Distinct clinicopathological phenotype of hepatocellular carcinoma with EOB-MRI hyperintensity: association with gene expression signature (2015)
  • Author(s): Miura T, Ban D, Tanaka S, Mogushi K, Kudo A, Matsumura S, Mitsunori Y, Ochiai T, Tanaka H, Tanabe M.
  • Journal Title: Am J Surg. Volume: 210 Issue: 3 Pages: 561-569
  • DOI: 10.1016/j.amjsurg.2015.03.027
  • Peer Reviewed
• [Journal Article] DNA methylation in the exon 1 region and complex regulation of Twist1 expression in gastric cancer. (2015)
  • Author(s): Sakamoto A, Akiyama Y, Shimada S, Zhu W-G, Yuasa Y, Tanaka S.
  • Journal Title: PloS One Volume: 10(12) Issue: 12 Pages: e0145630-e0145630
  • DOI: 10.1371/journal.pone.0145630
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic role of Child-Pugh score 5 and 6 in hepatocellular carcinoma patients who underwent curative hepatic resection. (2015)
  • Author(s): Okajima C, Arii S, Tanaka S, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanabe M.
  • Journal Title: Am J Surg. Volume: 209 Issue: 1 Pages: 199-205
  • DOI: 10.1016/j.amjsurg.2014.03.009
  • Peer Reviewed
• [Journal Article] EVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-β-mediated growth inhibition in hepatocellular carcinoma. (2015)
  • Author(s): Yasui K, Konishi C, Gen Y, Endo M, Dohi O, Tomie A, Kitaichi T, Yamada N, Iwai N, Nishikawa T, Yamaguchi K, Moriguchi M, Sumida Y, Mitsuyoshi H, Tanaka S, Arii S, Itoh Y.
  • Journal Title: Cancer Sci. Volume: 106 Issue: 7 Pages: 929-937
  • DOI: 10.1111/cas.12694
  • Peer Reviewed / Open Access
• [Journal Article] Advances in reduced port laparoscopic liver resection. (2015)
  • Author(s): Ban D, Kudo A, Irie T, Ochiai T, Aihara A, Matusmura S, Tanaka S, Tanabe M.
  • Journal Title: Asian Journal of Endoscopic Surgery Volume: in press
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis and targeted therapy of pancreatic cancer. (2015)
  • Author(s): Tanaka S.
  • Journal Title: Annals of Surgical Oncology Volume: in press
  • Peer Reviewed
• [Journal Article] EpCAM-targeted therapy for human hepatocellular carcinoma. (2014)
  • Author(s): Ogawa K, Tanaka S, Matsumura S, Murakata A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanabe M, Arii S.
  • Journal Title: Annals of Surgical Oncology Volume: 21(4) Issue: 4 Pages: 1314-1322
  • DOI: 10.1245/s10434-013-3430-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients. (2014)
  • Author(s): Yasui Y, Kudo A, Kurosaki M, Matsuda S, Muraoka M, Tamaki N, Suzuki S, Hosokawa T, Ueda K, Matsunaga K, Nakanishi H, Tsuchiya K, Itakura J, Takahashi Y, Tanaka S, Asahina Y, Enomoto N, Arii S, Izumi N.
  • Journal Title: Oncology Volume: 86(1) Issue: 1 Pages: 53-62
  • DOI: 10.1159/000356643
  • Peer Reviewed
• [Journal Article] Anatomic resection reduces the recurrence of solitary hepatocellular carcinoma ≤5 cm without macro-vascular invasion. (2014)
  • Author(s): Kudo A, Tanaka S, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Arii S.
  • Journal Title: American Journal of Surgery, Volume: 207(6) Issue: 6 Pages: 863-869
  • DOI: 10.1016/j.amjsurg.2013.06.009
  • Peer Reviewed
• [Journal Article] Age-related clinicopathological and molecular features of patients received curative hepatectomy for hepatocellular carcinoma. (2014)
  • Author(s): Katsuta E, Tanaka S, Mogushi K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Tanabe M, Arii S.
  • Journal Title: American Journal of Surgery Volume: 208(3) Issue: 3 Pages: 450-456
  • DOI: 10.1016/j.amjsurg.2014.01.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] EpCAM-Targeted therapy for human hepatocellular carcinoma. (2014)
  • Author(s): Katsuta E
  • Journal Title: Ann Surg Oncol Volume: 21 Issue: 3 Pages: 1314-1322
  • DOI: 10.3892/or.2013.2952
  • Peer Reviewed
• [Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study. (2014)
  • Author(s): Kudo A, Mogushi K, Takayama T, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Tanaka H, Anzai N, Sakamoto M, Tanaka S, Arii S.
  • Journal Title: J Gastroenterol. Volume: 49 Issue: 3 Pages: 502-10
  • DOI: 10.1007/s00535-013-0791-4
  • Peer Reviewed
• [Journal Article] Alcohol consumption and recurrence of non-B or non-C hepatocellular carcinoma after hepatectomy: a propensity score analysis. (2014)
  • Author(s): Kudo A, Tanaka S, Ban D, Matsumura S, Irie T, Ochiai T, Nakamura N, Arii S, Tanabe M.
  • Journal Title: J Gastroenterol. Volume: 49 Issue: 9 Pages: 1352-61
  • DOI: 10.1007/s00535-013-0899-6
  • Peer Reviewed
• [Journal Article] Severe postoperative hemorrhage caused by antibody-mediated coagulation factor deficiencies: report of two cases. (2014)
  • Author(s): Miura T, Ban D, Koyama T, Kudo A, Ochiai T, Irie T, Nakamura N, Tanaka S, Arii S.
  • Journal Title: Surgery Today Volume: 44(5) Issue: 5 Pages: 976-981
  • DOI: 10.1007/s00595-013-0584-7
  • Peer Reviewed
• [Journal Article] A simple index to predict liver functional reserve after hepatectomy. (2014)
  • Author(s): Kudo A, Igari T, Kumagai J, Tanaka S, Ban D, Noguchi N, Irie T, Nakamura N, Arii S.
  • Journal Title: Hepatogastroenterology Volume: 61 Pages: 712-716
  • Peer Reviewed
• [Journal Article] Does the Preoperative alpha-fetoprotein predict the recurrence and mortality after hepatectomy for hepatocellular carcinoma without macrovascular invasion in patients with normal liver function? (2014)
  • Author(s): Kudo A, Matusmura S, Ban D, Irie T, Ochiai T, Tanaka S, Arii S, Tanabe M. .
  • Journal Title: Hepatology Research Volume: 44(14) Issue: 14
  • DOI: 10.1111/hepr.12335
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma. (2014)
  • Author(s): Dohi O, Yasui K, Gen Y, Takada H, Endo M, Tsuji K, Konishi C, Yamada N, Mitsuyoshi H, Naito Y, Tanaka S, Arii S, Yoshikawa T.
  • Journal Title: Int J Oncol, Volume: 42(2) Issue: 2 Pages: 411-418
  • DOI: 10.3892/ijo.2012.1724
  • Peer Reviewed
• [Journal Article] Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma; clinical and biological significance. (2013)
  • Author(s): Sato K
  • Journal Title: Hepatology Volume: 57 Issue: 4 Pages: 1436-1447
  • DOI: 10.1002/hep.26122
  • Peer Reviewed
• [Journal Article] Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication. (2013)
  • Author(s): Muramatsu S
  • Journal Title: Hepatology Volume: 58 Issue: 1 Pages: 218-228
  • DOI: 10.1002/hep.26345
  • Peer Reviewed
• [Journal Article] The Tumor-suppressive mir-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. (2013)
  • Author(s): Furuta M
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e60155-e60155
  • DOI: 10.1371/journal.pone.0060155
  • Peer Reviewed
• [Journal Article] Contrast-enhanced intraoperative ultrasound for hepatocellular carcinoma: high sensitivity of diagnosis and therapeutic impact (2013)
  • Author(s): Mitsunori Y, Tanaka S, Nakamura N, Ban D, Irie T, Noguchi N, Kudo A, Iijima H, Arii S
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 20(2) Issue: 2 Pages: 234-42
  • DOI: 10.1007/s00534-012-0507-9
  • NAID: 10031168214
  • Peer Reviewed
• [Journal Article] Upregulation of protein tyrosine phosphatase type IVA member 3 (PTP4A3/PRL-3) associated with tumor differentiation and a poor prognosis in human hepatocellular carcinoma. (2013)
  • Author(s): Mayinuer A, Yasen M, Mogushi K, Obulhasim G, Xieraili M, Aihara A, Tanaka S, Mizushima H, Tanaka H, Arii S.
  • Journal Title: Ann Surg Oncol Volume: 20(1) Issue: 1 Pages: 305-317
  • DOI: 10.1245/s10434-012-2395-2
  • Peer Reviewed
• [Journal Article] High resectability of colorectal liver metastases with aggressive chemotherapy in the era of molecular target-based agents. (2013)
  • Author(s): Ochiai T, Ohta K, Iida M, Kumagai Y, Mitsunori Y, Aihara A, Noguchi N, Tanaka S, Arii S, Yamazaki S.
  • Journal Title: Hepatogastroenterology Volume: 60(125) Pages: 955-960
  • Peer Reviewed
• [Journal Article] Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report. (2013)
  • Author(s): Ochiai T, Igari K, Furuyama T, Ito H, Mitsunori Y, Aihara A, Kumagai Y, Iida M, Odajima H, Tanaka S, Arii S, Yamazaki S.
  • Journal Title: Int Surg Volume: 98(4) Issue: 4 Pages: 340-345
  • DOI: 10.9738/intsurg-d-13-00031.1
  • Peer Reviewed
• [Journal Article] Alterations of the SWI/SNF chromatin remodeling subunit-BRG1 and BRM in hepatocellular carcinoma (2012)
  • Author(s): Endo M, Yasui K, Zen Y, Gen Y, Zen K, Tsuji , Dohi O, Mitsuyoshi H, Tanaka S, Taniwaki M, Nakanuma Y, Arii S, Yoshikawa T
  • Journal Title: Liver Int Volume: 33(1) Issue: 1 Pages: 105-172013
  • DOI: 10.1111/liv.12005
  • Peer Reviewed
• [Presentation] Symposium: Surgical oncology for identification of novel molecular targets in refractory cancers. (2015)
  • Author(s): Tanaka S.
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya
  • Year and Date: 2015-10-09
• [Presentation] Symposium: Molecular pathogenesis and targeted therapy for major vascular invasiveness of hepatocellular carcinoma. (2015)
  • Author(s): Tanaka S, Aihara A, Tanabe M.
  • Organizer: The 13th General Meeting of the Japanese Society of Gastroenterological Surgery
  • Place of Presentation: Tokyo
  • Year and Date: 2015-10-08
• [Presentation] シンポジウム：難治性消化器癌の幹細胞性解析を基盤とした標的治療の前臨床試験 (2015)
  • Author(s): 田中真二、島田周、伊藤浩光、古山隆貴、藍原有弘、松村聡、伴大輔、落合高徳、工藤篤、田邉稔
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2015-07-15
• [Presentation] シンポジウム：幹細胞特性の機能的解析に基づいた肝癌標的治療の前臨床試験 (2015)
  • Author(s): 田中真二、古山隆貴、田邉稔
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-21
• [Presentation] パネルディスカッション：高度脈管侵襲肝細胞癌に対する術後補助療法の意義と分子生物学的解析 (2015)
  • Author(s): 田中真二、伊藤浩光、茂櫛薫、小川康介、藍原有弘、松村聡、伴大輔、落合高徳、入江工、工藤篤、田中博、有井滋樹、田邉稔
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-17
• [Presentation] A preclinical study of EpCAM-targeted therapy for human hepatocellular carcinoma with stem cell features. (2014)
  • Author(s): Tanaka S, Ogawa K, Matsumura S, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Arii S, Tanabe M.
  • Organizer: 65th Annual Meeting of the American Association for the Study of Liver diseases
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-11-10
• [Presentation] ワークショップ「消化器における神経内分泌腫瘍」 膵神経内分泌腫瘍の癌幹細胞解析に基づいた新規分子標的治療の開発 (2014)
  • Author(s): 田中真二、勝田絵里子、田邉稔
  • Organizer: 第56回日本消化器病学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-24
• [Presentation] ワークショップ「高齢者肝疾患の最適医療：個別化医療の工夫」 高齢者肝癌切除症例の臨床病理と遺伝子発現パターン解析に基づいた応用展開 (2014)
  • Author(s): 田中真二、勝田絵里子、田邉稔
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23
• [Presentation] シンポジウム「明日の肝癌診療のためのバイオマーカーの探索」 難治性肝癌を予測するバイオマーカーの探索と治療応用 (2014)
  • Author(s): 田中真二、中尾圭介、田邉稔
  • Organizer: 第12回日本消化器外科学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-22
• [Presentation] Symposia "Visualized cancer stem cells for analysis of heterogenic expansion and microenvironments with tumor-host interaction" (2014)
  • Author(s): Tanaka S, Adikrisna R, Mogushi K, Matsunaga H, Matsumura S, Aihara A, Ochiai T, Tanaka H, Yamaoka S, Arii S.
  • Organizer: 第73回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25
• [Presentation] ワークショップ「ベンチからベッドへ 消化器癌の基礎研究成果」 肝癌臨床および代謝解析に基づく難治性機序解明と癌幹細胞性を標的とする前臨床試験 (2014)
  • Author(s): 田中真二、藍原有弘、松村聡、伴大輔、入江工、落合高徳、工藤篤、中村典明、有井滋樹、田邉稔
  • Organizer: 第69回日本消化器外科学会総会
  • Place of Presentation: 郡山
  • Year and Date: 2014-07-17
• [Presentation] Symposium “Molecular targeted therapy for major vascular invasiveness of hepatocellular carcinoma” (2014)
  • Author(s): Tanaka S, Aihara A, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Arii S, Tanabe M.
  • Organizer: 第26回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 和歌山
  • Year and Date: 2014-06-12
• [Presentation] Novel molecular targets and therapeutic combinations in hepatocellular carcinoma; rationale and significance (2014)
  • Author(s): Tanaka S
  • Organizer: 4th International Kyoto Liver Cancer Symposium
  • Place of Presentation: 京都
  • Year and Date: 2014-06-08
  • Invited
• [Presentation] パネルディスカッション「ゲノム・エピゲノム解析に基づく肝癌診療の将来展望」 (2014)
  • Author(s): 田中真二
  • Organizer: 第50回日本肝癌研究会
  • Place of Presentation: 京都
  • Year and Date: 2014-06-05
  • Invited
• [Presentation] パネルディスカッション「DMとNAFLD・NASHの病態を考える：診断と治療の新たな展開」 肝切除症例における非ウイルス性DM関連肝癌の分子特異性の解明 (2014)
  • Author(s): 田中真二、松村聡、田邉稔
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29
• [Presentation] パネルディスカッション「進行肝細胞癌の治療選択」 高度進行肝細胞癌に対するconversion治療の解析と術後高度進行再発に対する治療開発 (2014)
  • Author(s): 田中真二、藍原有弘、田邉稔
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-25
• [Presentation] Preclinical studies of EpCAM-targeted therapy for human hepatocellular carcinoma with specific inhibition of stem cell features (2014)
  • Author(s): Tanaka S, Ogawa K, Murakata A, Mogushi K, Matsumura S, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S, Tanabe M.
  • Organizer: 105th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-06
• [Presentation] 肝細胞癌の腫瘍形態に基づく新たな治療アルゴリズムの提唱と遺伝子発現パターンの応用（プレナリーセッション） (2014)
  • Author(s): 田中真二、松永浩子、小川康介、村形綾乃、茂櫛薫、松村聡、伴大輔、落合高徳、入江工、工藤篤、中村典明、田中博、有井滋樹、田邉稔
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03
• [Presentation] Real-time imaging of pancreatic cancer stem cells for identification of the selectively targeting therapy. (2013)
  • Author(s): Tanaka S, Adikrisna R, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Yamaoka S, Arii S.
  • Organizer: 104th Annual Meeting of the American Association for Cancer Researc
  • Place of Presentation: Washington, DC, USA
• [Presentation] Visualization of stem cell features in human hepatocellular carcinoma; tumor-host Interaction and clinical impact (2013)
  • Author(s): Tanaka S, Muramatsu S, Adikrisna R, Mogushi K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Nakayama K, Tanaka H, Yamaoka S, Tanabe M, Arii S.
  • Organizer: 64th Annual Meeting of the American Association for the Study of Liver diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] パネルディスカッション「分子生物学的手法を用いた肝細胞癌治療戦略」 肝細胞癌の再発様式に基づく新規分子標的治療の開発 (2013)
  • Author(s): 田中真二、茂櫛薫、藍原有弘、村松俊輔、Rama Adikrisna、三浦智也、中尾圭介、松永浩子、勝田絵里子、松村聡、伴大輔、入江工、落合高徳、工藤篤、中村典明、田中博、有井滋樹
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] ワークショップ「癌幹細胞を視る」 光る癌幹細胞から「がん」の難治性メカニズムを視る (2013)
  • Author(s): 田中真二
  • Organizer: 第54回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Visualization of stem cell features in human hepatocellular carcinoma and tumor-host interaction (2013)
  • Author(s): Tanaka S, Adikrisna R, Mogushi K, Matsumura S, Aihara A, Ochiai T, Tanaka H, Yamaoka S, Arii S
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] シンポジウム「生物学的悪性度評価を加味した肝細胞癌治療戦略」 腫瘍形態に基づく肝細胞癌の遺伝子解析と特異的分子標的による治療戦略 (2013)
  • Author(s): 田中真二、小川康介、有井滋樹
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] ワークショップ「消化器癌に対する幹細胞研究の現状と展望」 可視化癌幹細胞に基づいた分子生物学的特徴の解明と治療開発への展開 (2013)
  • Author(s): 田中真二、伊藤浩光、有井滋樹
  • Organizer: 第11回日本消化器外科学会大会
  • Place of Presentation: 東京
• [Presentation] シンポジウム「肝がん治療の最前線」 臨床検体に基づく肝細胞癌再発機序の解明と新規分子標的治療への応用展開 (2013)
  • Author(s): 田中真二、藍原有弘、松永浩子、茂櫛薫、中尾圭介、三浦智也、松村聡、伴大輔、入江工、落合高徳、工藤篤、中村典明21098、田中博、田邉稔
  • Organizer: 第5１回日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] パネルディスカッション「再発癌の治療戦略（肝癌）」 肝癌の再発治療の解析：再発パターンに基づく新規分子標的治療の開発 (2013)
  • Author(s): 田中真二、勝田絵里子、藍原有弘、松永浩子、中尾圭介、松村聡、伴大輔、落合高徳、入江工、工藤篤、中村典明、有井滋樹、田邊稔
  • Organizer: 第75回日本臨床外科学会総会
  • Place of Presentation: 名古屋
• [Presentation] パネルディスカッション「肝癌に対する各種治療の取り組み」 肝細胞癌に対する分子標的薬の現状と展望 (2013)
  • Author(s): 田中真二
  • Organizer: 第75回日本臨床外科学会総会
  • Place of Presentation: 名古屋
  • Invited
• [Book] Cancer stem cells as therapeutic targets. (Human Stem Cell Toxicity; ed. Sherley JL) (2016)
  • Author(s): Tanaka S.
  • Publisher: Royal Society of Chemistry
• [Book] Bioencapsulation of Living Cells for Diverse Medical Applications (2013)
  • Author(s): Sakai S, Tanaka S, Kawakami K, Arii S.
  • Total Pages: 25
  • Publisher: Bentham Science Publishers
• [Remarks]
  • URL: http://www.tmd.ac.jp/grad/monc/index.html
• [Patent(Industrial Property Rights)] Compositions and methods for detection and treatment of hepatocellular carcinoma (2014)
  • Inventor(s): Tanaka S, MacDonald G
  • Industrial Property Rights Holder: Tanaka S, MacDonald G
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-14
  • Overseas