Development of a Y-shaped tissue-engineered artificial trachea for carinal reconstruction.

• Project/Area Number: 25253082
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: Nakamura Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000); Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2014: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2013: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
• Keywords: 人工気管 / 組織工学 / コラーゲン / 気道再建 / 胸部外科 / 分岐部気管 / 再生 / 生体内再生 / 気管再生 / 代用気管 / 人工臓器 / 呼吸器外科 / 再生医学 / 場の理論 / 組織再生 / 気管分岐部 / コンポジット / 吻合離開 / 狭窄

Outline of Final Research Achievements

The aim of this study was to develop a tracheal prosthesis for carinal reconstruction. We have studied more than 20years tracheal reconstruction with the base of the concept of in situ Tissue Engineering., where the inner surface is designed to be replased with regenerated host epithelium. Newly developed tracheal prosthesis were evaluated in the animal experiment in terms of feasibility and its safety.

In this project, several types of Y-shaped artificial trachea were manufactured in our laboratory. The material of the tracheal wall were Marlex mesh or bioabsorbable Vicryl mesh.Tracheal bifurcations were reconstructed on 26 beagle adult dogs, Azygos vein was cut, then the tracheal carina was replaced with prosthesis and wrapped the greater omentum. Bronchoscope and CT examinations were performed to evaluate patency of airway and luminal tissue regeneration. These results were now prepared to report on JTCVS.

Research Products

• [Journal Article] Basic experiments of bioabsorbable materials in prevention of postoperative intrapleural adhesions following thoracotomy. (2016)
  • Author(s): Hamaji, M., Burt, BM., Date, H., Nakamura, T.
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 64 Issue: 2 Pages: 82-86
  • DOI: 10.1007/s11748-015-0612-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and 18F Misonidazole PET in Murine Tumor Models. (2016)
  • Author(s): Koyasu, S., Tsuji, Y., Harada, H., Nakamoto, Y., Nobashi, T., Kimura, H., Sano, K., Koizumi, K., Hamaji, M., Togashi, K.
  • Journal Title: Radiology. Volume: 278 Issue: 3 Pages: 734-41
  • DOI: 10.1148/radiol.2015150416
  • Peer Reviewed / Open Access
• [Journal Article] The efficacy of a novel collagen-gelatin scaffold with basic fibroblast growth factor for the treatment of vocal fold scar. (2016)
  • Author(s): Hiwatashi, N., Hirano, S., Mizuta, M., Kobayashi, T., Kawai, Y., Kanemaru, SI., Nakamura, T., Ito, J., Kawai, K., Suzuki, S.
  • Journal Title: J Tissue Eng Regen Med. Volume: in press Issue: 5 Pages: 0-0
  • DOI: 10.1002/term.2060
  • Peer Reviewed
• [Journal Article] A successful attempt to prevent postoperative adhesions between the mediastinum and a lung: a canine model. (2015)
  • Author(s): Hamaji, M., Nakamura, T.
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 63 Issue: 8 Pages: 483-484
  • DOI: 10.1007/s11748-015-0563-6
  • NAID: 120005672616
  • Peer Reviewed
• [Journal Article] A rigid and bioabsorbble material for anterior chest wall reconstruction in a canine model. (2015)
  • Author(s): Hamaji, M., Kojima, F., Koyasu, S., Nobashi, T., Tsuruyama, T., Date, H., Nakamura, T.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 20 Issue: 3 Pages: 322-328
  • DOI: 10.1093/icvts/ivu416
  • Peer Reviewed / Open Access
• [Journal Article] Treatment and Prognosis of Isolated Local Relapse after Stereotactic Body Radiotherapy for Clinical Stage I Non-Small-Cell Lung Cancer: Importance of Salvage Surgery. (2015)
  • Author(s): Hamaji, M., Chen, F., Matsuo, Y., Ueki, N., Hiraoka, M., Date, H.
  • Journal Title: J Thorac Oncol. Volume: 10 Issue: 11 Pages: 1616-24
  • DOI: 10.1097/jto.0000000000000662
  • Peer Reviewed
• [Journal Article] Surgery versus SABR for resectable non-small-cell lung cancer. (2015)
  • Author(s): Hamaji, M., Groth, SS., Sugarbaker, DJ., Burt, BM.
  • Journal Title: Lancet Oncol. Volume: 16 Issue: 8 Pages: e372-e372
  • DOI: 10.1016/s1470-2045(15)00091-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pleurectomy and decortication for metastatic renal cell carcinoma. (2015)
  • Author(s): Bettenhausen, A., Hamaji, M., Burt, BM., Ali, SO.
  • Journal Title: J Thorac Cardiovasc Surg. Volume: 150 Issue: 1 Pages: e3-e5
  • DOI: 10.1016/j.jtcvs.2015.05.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-Term Outcomes of Surgical and Nonsurgical Management of Stage IV Thymoma: A Population-Based Analysis of 282 Patients. (2015)
  • Author(s): Hamaji, M., Burt, BM.
  • Journal Title: Semin Thorac Cardiovasc Surg. Volume: 27 Issue: 1 Pages: 1-3
  • DOI: 10.1053/j.semtcvs.2015.02.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A meta-analysis of induction therapy for advanced thymic epithelial tumors. (2015)
  • Author(s): Hamaji, M., Ali, SO., Burt, BM.
  • Journal Title: Ann Thorac Surg. Volume: 99 Issue: 5 Pages: 1848-56
  • DOI: 10.1016/j.athoracsur.2014.12.048
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A meta-analysis of resected metachronous second non-small cell lung cancer. (2015)
  • Author(s): Hamaji, M., Ali, SO., Burt, BM.
  • Journal Title: Ann Thorac Surg. Volume: 99 Issue: 4 Pages: 1470-8
  • DOI: 10.1016/j.athoracsur.2014.11.033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Video-assisted thoracoscopic lobectomy versus stereotactic radiotherapy for stage I lung cance (2015)
  • Author(s): Hamaji, M., Chen, F., Matsuo, Y., Kawaguchi, A., Morita, S., Ueki, N., Sonobe, M., Nagata, Y., Hiraoka, M., Date, H.
  • Journal Title: Ann Thorac Surg. Volume: 99 Issue: 4 Pages: 1122-9
  • DOI: 10.1016/j.athoracsur.2014.11.009
  • Peer Reviewed
• [Journal Article] Unicentric, multifocal castleman disease of the mediastinum associated with cerebellitis. (2015)
  • Author(s): Hamaji, M., Neal, JW., Burt, BM.
  • Journal Title: Ann Thorac Surg. Volume: 99 Issue: 1 Pages: e7-e9
  • DOI: 10.1016/j.athoracsur.2014.10.028
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury. (2015)
  • Author(s): Tamura, K., Harada, Y., Kunimi, M., Takemitsu, H., Hara, Y., Nakamura, T., Tagawa, M.
  • Journal Title: Exp Clin Transplant. Volume: 13 Pages: 100-5
  • Peer Reviewed / Open Access
• [Journal Article] Mechanical properties of a bioabsorbable nerve guide tube for long nerve defects. (2015)
  • Author(s): Ichihara, S., Facca, S., Liverneaux, P., Inada, Y., Takigawa, T., Kaneko, K., Nakamura, T.
  • Journal Title: Chir Main. Volume: 34 Issue: 4 Pages: 186-192
  • DOI: 10.1016/j.main.2015.05.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mobile locally operated detachable end-effector manipulator for endoscopic surgery. (2015)
  • Author(s): Toshikazu Kawai, Myongyu Shin, Yuji Nishizawa, Yuki Horise, Atsushi Nishikawa, Tatsuo Nakamura
  • Journal Title: International Journal of Computer Assisted Radiology and Surgery Volume: 10 Issue: 2 Pages: 161-169
  • DOI: 10.1007/s11548-014-1062-4
  • Peer Reviewed
• [Journal Article] Comparison of a Hydroxyapatite-Coated and an Anodic Oxidized Titanium Implant for Experimentally Induced Peri-Implantitis: Macroscopic and Novel Radiographic Evaluations in a Canine Model (2015)
  • Author(s): Nakamura, H., Matsuno, T., Hashimoto, Y., Nakamura, T., Mataga, I.
  • Journal Title: Journal of Hard Tissue Biology Volume: 24 Issue: 4 Pages: 347-356
  • DOI: 10.2485/jhtb.24.347
  • NAID: 130005104335
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access
• [Journal Article] Biocompatibility and Efficacy of Collagen/Gelatin Sponge Scaffold With Sustained Release of Basic Fibroblast Growth Factor on Vocal Fold Fibroblasts in 3-Dimensional Culture. (2015)
  • Author(s): Hiwatashi, N., Hirano, S., Mizuta, M., Tateya, I., Kanemaru, SI., Nakamura, T., Ito, J., Kawai, K., Suzuki, S.
  • Journal Title: Ann Otol Rhinol Laryngol. Volume: 124 Issue: 2 Pages: 116-25
  • DOI: 10.1177/0003489414546396
  • Peer Reviewed
• [Journal Article] Spread of tumor microenvironment contributes to colonic obstruction through subperitoneal fibroblast activation in colon cancer. (2015)
  • Author(s): Yokota M, Kojima M, Higuchi Y, Nishizawa Y, Kobayashi A, Ito M, Saito N, Ochiai A.
  • Journal Title: Cancer Sci Volume: in press Issue: 4 Pages: 466-474
  • DOI: 10.1111/cas.12615
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Patterns and treatment of recurrence following pulmonary resection for colorectal metastases. (2015)
  • Author(s): Yokota, M., Kobayashi, A., Nomura, S., Nishizawa, Y., Ito, M., Nagai, K., Saito, N.
  • Journal Title: World J Surg. Volume: 39 Issue: 7 Pages: 1758-1766
  • DOI: 10.1007/s00268-015-3006-8
  • Peer Reviewed
• [Journal Article] Effect of intratracheal administration of adipose-derived stromal cells on bloemycin-induced lung injury in a rat model. (2015)
  • Author(s): Uji, M., Nakada, A., Nakamura, T., Hirata, K.
  • Journal Title: Osaka City Med. J. Volume: 61 Pages: 81-91
  • Peer Reviewed / Open Access
• [Journal Article] A synthetic bioabsorbable sheet may prevent postoperative intrapleural adhesions following thoracotomy: a canine model. (2014)
  • Author(s): Hamaji, M., Kojima, F., Komatsu, T., Tsuruyama, T., Date, H., Nakamura, T.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 19 Issue: 6 Pages: 914-920
  • DOI: 10.1093/icvts/ivu299
  • Peer Reviewed / Open Access
• [Journal Article] Development of a composite and vascularized tracheal scaffold in the omentum for in situ tissue engineering: a canine model. (2014)
  • Author(s): Hamaji, M., Kojima, F., Koyasu, S., Tsuruyama, T., Komatsu, T., Ikuno, T., Date, H., Nakamura, T.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 19 Issue: 3 Pages: 357-362
  • DOI: 10.1093/icvts/ivu177
  • Peer Reviewed / Open Access
• [Journal Article] Collagen fleece failed to prevent intrapleural adhesions in a canine model: failure of murine models to translate into a large animal model. (2014)
  • Author(s): Hamaji, M., Kojima, F., Nakamura, T.:
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 62 Issue: 3 Pages: 202-203
  • DOI: 10.1007/s11748-013-0369-3
  • Peer Reviewed / Open Access
• [Journal Article] Modified Robicsek procedure for pectus excavatum in adult patients. (2014)
  • Author(s): Hamaji, M., Hiraoka, K., Jaroszewski, DE., Deschamps, C.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 18 Issue: 5 Pages: 611-614
  • DOI: 10.1093/icvts/ivt555
  • Peer Reviewed / Open Access
• [Journal Article] The outcome of pulmonary resection for invasive fungal infection complicating haematological malignancy. (2014)
  • Author(s): Hamaji, M., Cassivi, SD., Shen, KR., Wigle, DA., Allen, MS., Nichols, FC., Deschamps, C.
  • Journal Title: Eur J Cardiothorac Surg Volume: 45 Issue: 2 Pages: e1-e5
  • DOI: 10.1093/ejcts/ezt518
  • Peer Reviewed / Open Access
• [Journal Article] Restoration of scarred vocal folds using 5 amino acid-deleted type hepatocyte growth factor (2014)
  • Author(s): Mizuta M, Hirano S, Ohno S, Kanemaru SI, Nakamura T, Ito J
  • Journal Title: Laryngoscope Volume: 124(3) Issue: 3
  • DOI: 10.1002/lary.24413
  • Peer Reviewed / Open Access
• [Journal Article] Effect of AST on age-associated changes of vocal folds in a rat model. (2014)
  • Author(s): Mizuta, M. Hirano, S., Hiwatashi, N., Kobayashi, T., Tateya, I., Kanemaru, S., Nakamura, T., Ito, J.
  • Journal Title: Laryngoscope. Volume: 124 Issue: 10
  • DOI: 10.1002/lary.24733
  • NAID: 120005661538
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetics and safety of human recombinant hepatocyte growth factor administered to vocal folds. (2014)
  • Author(s): Mizuta, M., Hirano, S., Kishimoto, Y., Hiwatashi, N., Tateya, I., Kanemaru, S., Nakamura, T., Ito, J.
  • Journal Title: Laryngoscopoe. Volume: 124 Issue: 9 Pages: 2131-2135
  • DOI: 10.1002/lary.24690
  • Peer Reviewed / Open Access
• [Journal Article] Adipose-derived stem cells versus bone marrow-derived stem cells for vocal fold regeneration. (2014)
  • Author(s): Hiwatashi, N., Hirano, S., Mizuta, M., Tateya, I., Kanemaru, S., Nakamura, T., Ito, J
  • Journal Title: Laryngoscope. Volume: 12 Issue: 12 Pages: E461-E469
  • DOI: 10.1002/lary.24816
  • NAID: 120005663254
  • Peer Reviewed / Open Access
• [Journal Article] Anorectal autotransplantation in a canine model: the first successful report in the short term with the non-laparotomy approach. (2014)
  • Author(s): Araki J, Nishizawa Y, Nakamura T, Sato T, Naito M, Hatayama N, Hirai S, Tashiro K, Koshima I.
  • Journal Title: Sci Rep Volume: 4 Issue: 1 Pages: 6312-6312
  • DOI: 10.1038/srep06312
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel surgical marking system for small peripheral lung nodules based on radio frequency identification technology : Feasibility study in a canine model (2014)
  • Author(s): Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura, T
  • Journal Title: J Thorac Cardiovasc Surg Volume: 147 Issue: 4 Pages: 1384-9
  • DOI: 10.1016/j.jtcvs.2013.05.048
  • Peer Reviewed / Open Access
• [Journal Article] Development of a novel marking system for laparoscopoic gastrectomy using endoclips with radio frequency identification tags: feasibility study in a canine model. (2014)
  • Author(s): Kojima, F., Sato, T., Tsunoda, S., Takahata, H., Hamaji, M., Komatsu, T., Okada, M., Sugiura, T., Oshiro, O., Sakai, Y., Date, H., Nakamura, T.
  • Journal Title: Surg Endosc. Volume: 28 Issue: 9 Pages: 2752-2759
  • DOI: 10.1007/s00464-014-3501-2
  • Peer Reviewed / Open Access
• [Journal Article] 生体内組織再生誘導型の人工気管 (2014)
  • Author(s): 大森孝一、多田靖宏、野本幸男、谷亜希子、仲江川雄太、金丸眞一、中村達雄
  • Journal Title: Surgery Frontier Volume: 21 Pages: 31-37
• [Journal Article] 〈特集 みみ・はな・のどの局所薬物療法〉喉頭腫瘤性病変に対する局所薬物療法 (2014)
  • Author(s): 多田靖宏, 仲江川雄太, 大森孝一
  • Journal Title: ENTONI Volume: 168 Pages: 57-62
• [Journal Article] Regenerative treatment for soft tissue defects of the external auditory meatus. (2014)
  • Author(s): Kanemearu, S., Umeda, H., Kanai, R., Tsuji, T., Kuboshima, F., Yamamoto, M., Hirano, S., Nakamura, T.
  • Journal Title: Otol Neurotol. Volume: 35 Issue: 3 Pages: 442-448
  • DOI: 10.1097/mao.0b013e3182a361e6
  • Peer Reviewed / Open Access
• [Journal Article] Survival and treatments in patients with incompletely resected thymoma. (2014)
  • Author(s): Hamaji, M., Omasa, M., Chen, F., Yamada, T., Sato, M., Menju, T., Sato, T., Aoyama, A., Sonobe, M., Bando, T., Date, H.
  • Journal Title: Asian Thoracic and Cardiovascular Annals. Volume: in press
  • Peer Reviewed
• [Journal Article] Prior thoracoscopic surgery may improve reoperative pulmonary resection. (2014)
  • Author(s): Hamaji, M., Cassivi, SD., Shen, KR., Allen, MS., Nichols, FC., Deschamps, C., Wigle, DA.
  • Journal Title: Asian Thoracic and Cardiovascular Annals. Volume: in press
  • Peer Reviewed
• [Journal Article] Long-term follow-up of autologous bone marrow mononuclear cell transplantation following surgical decompression in a dog with chronic spinal cord injury. (2014)
  • Author(s): Tamura, K., Harada, Y., Kunimi, M., Takemitsu, H., Hara, Y., Nakamura, T., Tagawa, M.
  • Journal Title: Exp Clin Transplant Volume: in press
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptor subtype EP4 agonist serves better to protect cochlea than prostaglandin E1. (2013)
  • Author(s): Hori R, Nakagawa T, Yamamoto N, Hamaguchi K, Ito J.
  • Journal Title: Auris Nasus Larynx. Volume: 40 Issue: 1 Pages: 539-542
  • DOI: 10.1002/lary.24197
  • NAID: 120005323027
  • Peer Reviewed / Open Access
• [Journal Article] Novel tracheal prosthesis using in situ Tissue Engineering. (2013)
  • Author(s): Nakamura, T., Kojima, F., Sato, T., Hamaji, M., Kaneko, M., Kanemaru, S., Nakada, A., Omori, K., Shigeno, K., Wakatsuki, M., Endo, K.
  • Journal Title: Int J Artif Organs Volume: 36 Pages: 585-585
  • Peer Reviewed
• [Journal Article] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma. (2013)
  • Author(s): Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T.
  • Journal Title: Int J Artif Organs. Volume: 36 Pages: 571-571
  • Peer Reviewed
• [Journal Article] Sequential Changes of Bone Repairing in Rabbit Skull Defect Implanted Octacalcium Phosphate and Collagen Composite. (2013)
  • Author(s): Kaneko, M., Wakatsuki, M., Shigeno, K., Nakada, A., Nakamura, T.
  • Journal Title: Int J Artif Organs Volume: 36 Pages: 572-572
  • Peer Reviewed
• [Journal Article] Promotion of Bone Repairing by Use of Collagen Scaffold Incorporating Reconbinant Human FGF-2 in Rabbit Skull Defect Model. (2013)
  • Author(s): Wakatsuki, M., Kaneko, M.,Nakada, A., Shigeno, K., Nakamura, T.
  • Journal Title: Int J Artif Organs Volume: 36 Pages: 551-551
  • Peer Reviewed
• [Journal Article] Manufacture of a weakly denatured collagen fiber scaffold with excellent biocompatibility and space maintenance ability. (2013)
  • Author(s): Nakada, A., Shigeno, K., Sato, T., Kobayashi, T., Wakatsuki, M., Uji, M., Nakamura, T.
  • Journal Title: Biomed Meter. Volume: 8 Issue: 4 Pages: 45010-45019
  • DOI: 10.1088/1748-6041/8/4/045010
  • Peer Reviewed
• [Journal Article] Cellular interactions via conditioned media induce in vivo nephron generation from tubular epithelial cells or mesenchymal stem cells. (2013)
  • Author(s): Machiguchi, T., Nakamura, T.
  • Journal Title: Biochemical and Biophysical Research Communications. Volume: 435 Issue: 3 Pages: 327-333
  • DOI: 10.1016/j.bbrc.2013.04.050
  • Peer Reviewed
• [Journal Article] 生体内組織再生誘導型の人工気管を用いた気道再建. (2013)
  • Author(s): 大森孝一、多田靖宏、野本幸男、谷亜希子、金丸眞一、中村達雄
  • Journal Title: 再生医療 Volume: 12 Pages: 57-63
• [Journal Article] Evaluation of the Use of Induced Pluripotent Stem Cells (iPSCs) for the Regeneration of Tracheal Cartilage (2013)
  • Author(s): Imaizumi M, Omori K, et al.
  • Journal Title: Cell Transplantation Volume: 22 Issue: 2 Pages: 341-353
  • DOI: 10.3727/096368912x653147
  • Peer Reviewed
• [Journal Article] Bioengineered trachea using autologous chondrocytes for regeneration of tracheal cartilage in a rabbit model (2013)
  • Author(s): Nomoto, M., Nomoto, Y., Tada, Y., Tani, A., Otsuki, K., Suzuki, R., Nakamura, T., Omori, K
  • Journal Title: Laryngoscope Volume: 123 Issue: 9 Pages: 2195-2201
  • DOI: 10.1002/lary.23784
  • Peer Reviewed
• [Journal Article] Improvement of eustachian tube function by Tissue-Engineered regeneration of mastoid air cells (2013)
  • Author(s): Kanemaru, S., Umeda, H., Yamashita, M., Hiraumi, H., Hirano, S., Nakamura, T., Ito, J
  • Journal Title: Laryngoscope Volume: 123 Issue: 2 Pages: 472-476
  • DOI: 10.1002/lary.23626
  • Peer Reviewed
• [Journal Article] Functional regeneration of laryngeal muscle using bone marrow-derived stromal cells (2013)
  • Author(s): Kanemaru SI, Kitani Y, Ohno S, Shigemoto T, Kojima T, Ishikawa S, Mizuta M, Hirano S, Nakamura T, Dezawa M
  • Journal Title: Laryngoscope Volume: 123(11) Issue: 11 Pages: 2728-34
  • DOI: 10.1002/lary.24060
  • NAID: 10031144966
  • Peer Reviewed
• [Journal Article] Protracted delay in taste sensation recovery after surgical lingual nerve repair : a case report (2013)
  • Author(s): Seo, K., Inada, Y., Terumitsu, M. Nakamura, T., Shigeno, K., Tanaka, Y., Tsurumaki, T., Kurata, S., Matsuzawa, H
  • Journal Title: Journal of Medical Case Reports Volume: 7 Issue: 1 Pages: 77-81
  • DOI: 10.1186/1752-1947-7-77
  • Peer Reviewed
• [Journal Article] Intravenous administration of adipose-derived stromal cells does not ameliorate bleomycin-induced lung injury in rats. (2013)
  • Author(s): Uji, M., Nakada, A., Nakamura, T.
  • Journal Title: Open J Regen Med. Volume: 2 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Regenerative phonosurgical treatments for vocal fold scar and sulcus with basic fibroblast growth factor. (2013)
  • Author(s): Hirano S, Mizuta M, Kaneko M, Tateya I, Kanemaru SI, Ito J.
  • Journal Title: Laryngoscope. Volume: 123 Issue: 11 Pages: 2749-55
  • DOI: 10.1002/lary.24092
  • Peer Reviewed
• [Journal Article] An incidental and uncommon pulmonary sequestration with an uncommon feeding artery. (2013)
  • Author(s): Hamaji, M., Burt, BM., Ali, SO., Mirkovic, J.
  • Journal Title: Int J Surg Case Rep Volume: 4 Pages: 861-2
  • Peer Reviewed
• [Journal Article] A microthymoma and no germinal centre in myasthenia gravis. (2013)
  • Author(s): Hamaji, M., Vanderlaan, PA., Sugarbaker, DJ., McNamee, CJ.
  • Journal Title: Eur J Cardiothorac Surg Volume: 44 Issue: 6 Pages: 1146-7
  • DOI: 10.1093/ejcts/ezt208
  • Peer Reviewed
• [Journal Article] Surgical treatment of metachronous second primary lung cancer after complete resection of non-small cell lung cancer. (2013)
  • Author(s): Hamaji, M., Allen, MS., Cassivi, SD., Deschamps, C., Nichols, FC., Wigle, DA., Shen, KR.
  • Journal Title: J Thorac Cardiovasc Surg Volume: 145 Issue: 3 Pages: 683-90
  • DOI: 10.1016/j.jtcvs.2012.12.051
  • Peer Reviewed
• [Journal Article] A personal experience of 2-year general thoracic surgery training programs in Japan and the United States. (2013)
  • Author(s): Hamaji, M., Tanaka, T.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 61 Issue: 3 Pages: 139-42
  • DOI: 10.1007/s11748-012-0191-3
  • Peer Reviewed
• [Journal Article] Spontaneous diaphragm rupture associated with vaginal delivery. (2013)
  • Author(s): Hamaji, M., Burt, BM., Ali, SO., Cohen. DM.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 61 Issue: 8 Pages: 473-5
  • DOI: 10.1007/s11748-012-0146-8
  • Peer Reviewed
• [Journal Article] Intrahepatic biliary ablation with pure ethanol: an experimental model of biliary atresia (2012)
  • Author(s): Yukihiro Tatekawa. Akira Nakada. Tatsuo Nakamura
  • Journal Title: Surg Today Volume: in press Issue: 6 Pages: 661-669
  • DOI: 10.1007/s00595-012-0379-2
  • NAID: 10031176089
  • Peer Reviewed
• [Presentation] 末梢神経の再生医療とin situ Tissue Engineering（生体内再生）． (2015)
  • Author(s): 中村達雄
  • Organizer: 第37回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-09
• [Presentation] Effect of intratracheal administration of adipose-derived stromal cells on bleomycin-induced lung injury in a rat model. (2015)
  • Author(s): Uji, M., Kureya, Y., Yamada, K., Watanabe, T., Konishi, K., Asai, K., Nakamura, T., Hirata, K.
  • Organizer: European Respiratory Society 2015 International Congress
  • Place of Presentation: Amsterdam
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] in situ Tissue Engineering（生体内再生）の臨床応用． (2015)
  • Author(s): 中村達雄
  • Organizer: 第16回耳鼻咽喉科再生医学研究会
  • Place of Presentation: 福島
  • Year and Date: 2015-04-28
• [Presentation] Prevention of vocal fold scarring with local application of basic fibroblast growth factor in rat model. (2015)
  • Author(s): Suzuki, R., Hirano, S., Tateya, I., Kishimoto, Y., Hiwatashi, N., Kawai, Y., Ito, J.
  • Organizer: COSM Combined Otolaryngology Spring Meeting 2015
  • Place of Presentation: U.S.A
  • Year and Date: 2015-04-22
  • Int'l Joint Research
• [Presentation] インプラント周囲炎モデルにおける骨吸収の経時的変化～HAとチタンによる違い～． (2014)
  • Author(s): 中村浩樹、松野智宣、中村達雄、又賀 泉
  • Organizer: 第18回日本顎顔面インプラント学会総会・学術大会
  • Place of Presentation: 出雲
  • Year and Date: 2014-11-29 – 2014-11-30
• [Presentation] The way to the practical use of artificial trachea as medical equipment on the basis of Japanese regulations. (2014)
  • Author(s): Nakaegawa, Y., Tada, Y., Nakamura, T., Omori, K.
  • Organizer: The 9th East Asian Conference on Phonosurgery
  • Place of Presentation: Taipei
  • Year and Date: 2014-11-29
• [Presentation] インプラントの表面性状の違いが実験的インプラント周囲炎に及ぼす影響． (2014)
  • Author(s): 中村浩樹、松野智宣、中村達雄、又賀 泉
  • Organizer: 第59回 公益社団法人 日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Verify the effect on nerve regeneration from increased blood flow in the nerve control area due to stellate ganglion blocks. (2014)
  • Author(s): Shigeno, K., Shionoya, Y., Kaneko, M., Wakatsuki, M., Nakada, A., Honda, M., Kojima, F., Sato, T., Inada, Y., Kanemaru, S., Nakamura, T.
  • Organizer: 41th Annual ESAO Congress
  • Place of Presentation: Roma
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] Bone repairing in the canine frontal sinus implanted octacalcium phosphate and collagen composite (II). (2014)
  • Author(s): Kaneko, M., Wakatsuki, M., Shigeno, K., Nakada, A., Nakamura, T.
  • Organizer: 41th Annual ESAO Congress
  • Place of Presentation: Roma
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] 肛門機能における陰部神経の役割-陰部神経切離・吻合モデルの検討-． (2014)
  • Author(s): 西澤祐吏、齋藤典男、伊藤雅昭、中村達雄、荒木淳、内藤宗和
  • Organizer: 第20回大腸肛門機能障害研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-08
• [Presentation] Generation of ciliated epithelium derived from mouse indeuced pluripotent stem cells. (2014)
  • Author(s): Omori, K., Otsuki, K., Yoshie, S., Imaizumi, M., Nomoto, Y., Nakamura, T.
  • Organizer: The 61th CORLAS Meeting.Istanbul
  • Place of Presentation: Istanbul
  • Year and Date: 2014-08-24
• [Presentation] Comparison of hydroxyapatite-coated implant with titanium implant in experimental peri-implantitis. (2014)
  • Author(s): Nakamura, H., Matsuno, T., Nakamura, T., Mataga, I.
  • Organizer: The 9th Congress of the Asian Academy of Osseointegration.
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] Development of new artificial nerve: Influence of sodium chloride in the scaffold. (2014)
  • Author(s): Nakamura, T., Kojima, F., Sato, T., Hamaji, M., Kaneko, M., Kanemaru, S., Nakada, A., Omori, K., Shigeno, K., Wakatsuki, M., Endo, K.
  • Organizer: ASAIO 60th Annual Conference
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-06-18 – 2014-06-21
• [Presentation] Effect of astaxanthin on the age-associated change of vocal folds in a rat model. (2014)
  • Author(s): Mizuta, M., Hirano, S., Kobayashi, T., Kanemaru, S., Ito, J.:
  • Organizer: The 135th American Laryngological Association
  • Place of Presentation: Las Vegas
  • Year and Date: 2014-05-14 – 2014-05-15
• [Presentation] Concept of solo-surgery using a locally operated detachable end-effector manipulator to support endoscopic surgery. (2014)
  • Author(s): Nishizawa, Y., Kawai, T., Nakamura, T., Fujiwara, M., Okano, K., Suzuki, Y.
  • Organizer: SAGES 2014
  • Place of Presentation: Salt Lake City
  • Year and Date: 2014-04-02 – 2014-04-05
• [Presentation] Novel tracheal prosthesis using in situ Tissue Engineering. (2013)
  • Author(s): Nakamura, T., Kojima, F., Sato, T., Hamaji, M., Kaneko, M., Kanemaru, S., Nakada, A., Omori, K., Shigeno, K., Wakatsuki, M., Endo, K.
  • Organizer: 40th Annual ESAO Congress
  • Place of Presentation: Scotland (UK)
• [Presentation] Sequential Changes of Bone Repairing in Rabbit Skull Defect Implanted Octacalcium Phosphate and Collagen Composite. (2013)
  • Author(s): Kaneko, M., Wakatsuki, M., Shigeno, K., Nakada, A., Nakamura, T.
  • Organizer: 40th Annual ESAO Congress
  • Place of Presentation: Scotland (UK)
• [Presentation] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma. (2013)
  • Author(s): Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T.
  • Organizer: 40th Annual ESAO Congress
  • Place of Presentation: Scotland (UK)
• [Presentation] Promotion of Bone Repairing by Use of Collagen Scaffold Incorporating Reconbinant Human FGF-2 in Rabbit Skull Defect Model. (2013)
  • Author(s): Wakatsuki, M., Kaneko, M.,Nakada, A., Shigeno, K., Nakamura, T.
  • Organizer: 40th Annual ESAO Congress
  • Place of Presentation: Scotland (UK)
• [Presentation] The effect of astaxanthin on vocal fold wound healing. (2013)
  • Author(s): Mizuta, M., Hirano, S., Tateya, I., Hiwatashi, N., Kanemaru, S. Ito, J.
  • Organizer: The 134th American Laryngological Association
  • Place of Presentation: Orlando (USA)
• [Presentation] Impact of Transmission Power Variation to the Position Estimation Error Performance of RFID-tag Assisted Surgery Support System． (2013)
  • Author(s): Takahata, H., Sugiura, T., Kojima, F., Sato, T., Okada, M., Oshiro, O.
  • Organizer: The 35th Annual International Conference of the Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka
• [Presentation] Sensing Elasticity from the Phase Difference of the Stepper Motor. (2013)
  • Author(s): Kawai, T., Nishio, K., Morita, Y., Nishizawa, Y., Nakamura, T.
  • Organizer: The 35th Annual International Conference of the Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka
• [Presentation] In-Vivo Localization of Micro Radio Frequency Identification Tag: Concept Proof of Novel Surgical Marking System for Small Peripheral Lung Nodule.
  • Author(s): Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura. T.
  • Organizer: 第２１回アジア胸部心臓血管外科学会
  • Place of Presentation: 神戸
• [Presentation] Local operated detachable endo-effect of manipulator for endoscopic surgery.
  • Author(s): Nishizawa, Y., Kawai, T., Nakamura, T., Suzuki, Y.
  • Organizer: 2013Society of American Gastrointestinal and Endoscopic Surgeons
  • Place of Presentation: Baltimore (USA)
• [Presentation] Mobile-type Locally Operated Detachable End-effector Manipulator for Laparoscopic Surgery.
  • Author(s): Kawai, T., Shin, M., Horise, Y., Nisihkawa, A., Nishizawa, Y., Nakamura, T.
  • Organizer: International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Heidelberg (Germany)
• [Presentation] Experimental study of new vascularized composite allotransplantation: Anorectal transplantation with rats, dogs, and human cadavers.
  • Author(s): Araki, J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I.
  • Organizer: 11th Meeting of the International Hand and Composite Tissue Allotransplantation Society
  • Place of Presentation: Wroctaw (Republic of Poland)
• [Presentation] Anorectal transplantation research for the stoma patients.
  • Author(s): Araki. J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I.
  • Organizer: 6th European Plastic Surgery Research Council
  • Place of Presentation: Hamburg (Germany)
• [Presentation] Anorectal transplantation research with rats, dogs, and human cadavers.
  • Author(s): Araki, J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I.
  • Organizer: World Society of Reconstructive Microsurgery 2013 Congress
  • Place of Presentation: Chicago (USA)
• [Remarks] 京都大学再生医科学研究所 臓器再建応用分野 ホームページ
  • URL: http://www.frontier.kyoto-u.ac.jp/ca04/
• [Remarks] 京都大学再生医科学研究所 臓器再建応用分野ホームページ
  • URL: http://www.frontier.kyoto-u.ac.jp/ca04/
• [Remarks] 京都大学再生医科学研究所 臓器再建応用分野ホームページ
  • URL: http://www.frontier.kyoto-u.ac.jp/ca04/