| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2015: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Outline of Final Research Achievements |
We have previously found that in glioblastoma, glioma stem cells can attract blood vessels from the normal brain and form an invasion complex with the endothelial cells of the co-opted vessels. The purpose of the present research was to elucidate the molecular mechanisms underlying the formation of the invasion complex and to develop a new anti-invasion therapy. Using a mouse GBM model, we identified the factors that determine the endothelial cells to participate in the formation of the invasion complex. Furthermore, by evaluating the anti-invasion potential of various classes of drugs using the brain slice culture assay, we found that inhibiting energy production can drastically reduce the invasion of glioma stem cells. We are now testing the most effective metabolic inhibitors in combination with chemotherapeutic agents in several animal models of glioma.
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