Development of a novel anti-invasion therapy targeting the glioma stem cell/endothelial cell invasion complex
| Project/Area Number |
25253085
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
Saya Hideyuki 慶應義塾大学, 医学部, 教授 (80264282)
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| Co-Investigator(Kenkyū-buntansha) |
SAMPETREAN OLTEA 慶應義塾大学, 医学部, 特任助教 (50571113)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2015: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Keywords | 細胞・組織 / 癌 / 発生・分化 |
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| Outline of Final Research Achievements |
We have previously found that in glioblastoma, glioma stem cells can attract blood vessels from the normal brain and form an invasion complex with the endothelial cells of the co-opted vessels. The purpose of the present research was to elucidate the molecular mechanisms underlying the formation of the invasion complex and to develop a new anti-invasion therapy. Using a mouse GBM model, we identified the factors that determine the endothelial cells to participate in the formation of the invasion complex. Furthermore, by evaluating the anti-invasion potential of various classes of drugs using the brain slice culture assay, we found that inhibiting energy production can drastically reduce the invasion of glioma stem cells. We are now testing the most effective metabolic inhibitors in combination with chemotherapeutic agents in several animal models of glioma.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016
Author(s)
Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H and Nagano O
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Journal Title
Cancer Res
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression2015
Author(s)
Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR and Chen CC
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Journal Title
Proc Natl Acad Sci USA
Volume: 112
Issue: 30
Pages: 112-130
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model2014
Author(s)
Saga I, Shibao S, Okubo J, Osuka S, Kobayashi Y, Yamada S, Fujita S, Urakami K, Kusuhara M, Yoshida K, Saya H, Sampetrean O
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Journal Title
Neuro Oncol.
Volume: 16
Issue: 8
Pages: 1048-1056
DOI
Related Report
Peer Reviewed / Open Access
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