| Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
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| Outline of Final Research Achievements |
We investigated the relationship between chronic optic neuropathy disease, glaucoma, and astrocytes, which accounts for the first cause of acquired blindness in our country. Morphological changes suggesting reactive astrocytes could be observed in stretching stimulus loading on mouse primary optic nerve head astrocytes and laser induced ocular hypertensive model mice. Furthermore, we successfully induced efficient differentiation of optic nerve head astrocytes from mouse ES cells, but it did not lead to separation. On the other hand, whole eye regeneration was completed by the method called SEAM. In future, we aim to develop astrocytes from disease-specific iPS cells based on genetic mutations obtained from the genome of glaucoma patients, aiming to elucidate the mechanism of onset in glaucoma and development of novel therapeutic methods.
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