| Co-Investigator(Kenkyū-buntansha) |
江草 宏 東北大学, 歯学研究科(研究院), 教授 (30379078)
加藤 隆史 大阪大学, 歯学研究科(研究院), 講師 (50367520)
萱島 浩輝 大阪大学, 歯学研究科(研究院), 助教 (50632121)
峯 篤史 大阪大学, 歯学研究科(研究院), 助教 (60379758)
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| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2016: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Outline of Final Research Achievements |
In physiological approach, human and animal studies suggest that sympathetic tone and stress can play roles in the intra-individual fluctuation of sleep bruxism activity while age/development and behavioral characteristics can be a contributing factor for the intra-individual difference of masticatory muscle activity during sleep. In cell biology approach, we aimed to find patient-dependent biological factors responsible for cluster failure of osseointegration in dental implants using patient-derived iPS cells. During the course of experiments, an efficient osteogenic induction protocol for iPS cells was established. In regard to a material science approach, the material-human interface with the individual difference of tooth was evaluated. In consideration of individual differences of teeth as a random effect, the adhesion position, the void existence at interface and the adhesion area size were detected as a significant factor for bond strength by the liner mixed effect model.
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