Development of diagnostic technology for establishment of tailor-made prosthodontic treatments
| Project/Area Number |
25253102
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江草 宏 東北大学, 歯学研究科(研究院), 教授 (30379078)
加藤 隆史 大阪大学, 歯学研究科(研究院), 講師 (50367520)
萱島 浩輝 大阪大学, 歯学研究科(研究院), 助教 (50632121)
峯 篤史 大阪大学, 歯学研究科(研究院), 助教 (60379758)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2016: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Keywords | テーラーメイド医療 / 術前診断 / iPS細胞分化 / 咀嚼筋活動 / 歯質 / 個人差 |
|---|
| Outline of Final Research Achievements |
In physiological approach, human and animal studies suggest that sympathetic tone and stress can play roles in the intra-individual fluctuation of sleep bruxism activity while age/development and behavioral characteristics can be a contributing factor for the intra-individual difference of masticatory muscle activity during sleep. In cell biology approach, we aimed to find patient-dependent biological factors responsible for cluster failure of osseointegration in dental implants using patient-derived iPS cells. During the course of experiments, an efficient osteogenic induction protocol for iPS cells was established. In regard to a material science approach, the material-human interface with the individual difference of tooth was evaluated. In consideration of individual differences of teeth as a random effect, the adhesion position, the void existence at interface and the adhesion area size were detected as a significant factor for bond strength by the liner mixed effect model.
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Report
(5 results)
Research Products
(92 results)
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[Journal Article] Comparative Analysis of Mouse Induced Pluripotent Stem Cells and Mesenchymal Stem Cells during Osteogenic Differentiation in vitro.2014
Author(s)
Egusa, H., Kayashima, H., Miura, J., Uraguchi, S., Wang, F., Okawa, H., Sasaki, J.I., Saeki, M., Matsumoto, T., and Yatani, H.
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Journal Title
Stem cells and development.
Volume: 23
Issue: 18
Pages: 2156-2169
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 口腔生理学と睡眠．2016
Author(s)
加藤隆史
Organizer
第10回三叉神経領域の感覚-運動統合機構研究会
Place of Presentation
佐久平プラザ21（長野県佐久平市）
Year and Date
2016-11-26
Related Report
Invited
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[Presentation] OSASと歯科疾患．2016
Author(s)
加藤隆史
Organizer
第24回日本PSG研究会全国大会
Place of Presentation
シキボウホール（大阪府大阪市）
Year and Date
2016-11-20
Related Report
Invited
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