Molecullar Biological Approach to Oral Implant Treatment for Aged and Metabolically Compromized Patients
| Project/Area Number |
25253103
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 祐介 九州歯科大学, 歯学部, 助教 (00611287)
向坊 太郎 九州歯科大学, 歯学部, 助教 (50635117)
正木 千尋 九州歯科大学, 歯学部, 准教授 (60397940)
中本 哲自 九州歯科大学, 歯学部, 准教授 (30514989)
柄 慎太郎 九州歯科大学, 歯学部, 助教 (20759386)
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| Co-Investigator(Renkei-kenkyūsha) |
GANEKO Kiyota 九州歯科大学, 歯学部, 特別研究員 (80759382)
IWANABE Yujiro 九州歯科大学, 歯学部, 特別研究員 (40781711)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2016: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2013: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
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| Keywords | 骨質 / AGE / コラーゲン架橋 / 老化 / 歯科インプラント / ナノインデンテーション / 放射光 / 応力緩和 / コラーゲン / クロスリンク / 力学解析 |
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| Outline of Final Research Achievements |
We demonstrate an impaired bone toughening mechanism caused by mimicking aging in a methionine-rich diet rabbit, which enabled an enhanced non-enzymatically cross-linked bone matrix. Although the corrected elastic moduli from each dynamic test did not vary in the Met-diet group, the storage moduli of the Norm-diet group at higher strain rates (1.0 and 10 Hz) were significantly larger than those obtained from the lower strain-rate nanoindentation tests (0.1 Hz) The Met-diet group allowed faster and larger force reduction (stress relaxation) against the slower load indentation (20 nm/s) during the constant strain displacement-controlled indentation test than those of the Norm-diet group, whereas the Norm-diet group showed a more substantial reduction in time-dependent force against the rapid-load indentation (40 nm/s) than that of the Met-diet group. In conclusion, the primary bone toughening mechanism comprised of the enzymatically cross-linked collagen network may be affected by AGEs.
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Report
(5 results)
Research Products
(8 results)
