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Molecullar Biological Approach to Oral Implant Treatment for Aged and Metabolically Compromized Patients

Research Project

Project/Area Number 25253103
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu Dental College

Principal Investigator

Hosokawa Ryuji  九州歯科大学, 歯学部, 教授 (60211546)

Co-Investigator(Kenkyū-buntansha) 近藤 祐介  九州歯科大学, 歯学部, 助教 (00611287)
向坊 太郎  九州歯科大学, 歯学部, 助教 (50635117)
正木 千尋  九州歯科大学, 歯学部, 准教授 (60397940)
中本 哲自  九州歯科大学, 歯学部, 准教授 (30514989)
柄 慎太郎  九州歯科大学, 歯学部, 助教 (20759386)
Co-Investigator(Renkei-kenkyūsha) GANEKO Kiyota  九州歯科大学, 歯学部, 特別研究員 (80759382)
IWANABE Yujiro  九州歯科大学, 歯学部, 特別研究員 (40781711)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2016: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2013: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords骨質 / AGE / コラーゲン架橋 / 老化 / 歯科インプラント / ナノインデンテーション / 放射光 / 応力緩和 / コラーゲン / クロスリンク / 力学解析
Outline of Final Research Achievements

We demonstrate an impaired bone toughening mechanism caused by mimicking aging in a methionine-rich diet rabbit, which enabled an enhanced non-enzymatically cross-linked bone matrix. Although the corrected elastic moduli from each dynamic test did not vary in the Met-diet group, the storage moduli of the Norm-diet group at higher strain rates (1.0 and 10 Hz) were significantly larger than those obtained from the lower strain-rate nanoindentation tests (0.1 Hz) The Met-diet group allowed faster and larger force reduction (stress relaxation) against the slower load indentation (20 nm/s) during the constant strain displacement-controlled indentation test than those of the Norm-diet group, whereas the Norm-diet group showed a more substantial reduction in time-dependent force against the rapid-load indentation (40 nm/s) than that of the Met-diet group. In conclusion, the primary bone toughening mechanism comprised of the enzymatically cross-linked collagen network may be affected by AGEs.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] The effect of low-intensity pulsed ultrasound on wound healing using scratch assay in epithelial cells2016

    • Author(s)
      Yujiro Iwanabe, Chihiro Masaki, Akiko Tamura, Sintaro Tsuka, Taro Mukaibo, Yusuke Kondo, Ryuji Hosokawa
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 60 Issue: 4 Pages: 308-314

    • DOI

      10.1016/j.jpor.2016.03.002

    • NAID

      130005172122

    • ISSN
      1883-1958, 1883-9207
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone aging by advanced glycation end products: multi-scale mechanical analysis.2015

    • Author(s)
      9.Ganeko K., Masaki C., Shibata Y., Kondo Y., Mukaibo T., Nakamoto T., Miyazaki T., Hosokawa R.
    • Journal Title

      Journal of Dental Research

      Volume: 94 Issue: 12 Pages: 1684-1690

    • DOI

      10.1177/0022034515602214

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The Effect of LIPUS against Wound Healing in Epithelial Cells2016

    • Author(s)
      Yujiro Iwanabe, Chihiro Masaki, Akiko Tamura, Shintaro Tsuka, Taro Mukaibo, Yusuke Kondo, Ryuji Hosokawa
    • Organizer
      The 94th General Session & Exhibition of the IADR
    • Place of Presentation
      Seoul
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨質劣化におけるコラーゲン架橋構造の及ぼす影響2015

    • Author(s)
      我如古清太、正木千尋、柴田陽、向坊太郎、近藤祐介、中本哲自、宮﨑隆、細川隆司
    • Organizer
      日本補綴歯科学会 第124回 学術大会
    • Place of Presentation
      埼玉
    • Year and Date
      2015-05-30 – 2015-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低出力超音波パルスは歯肉創傷治癒モデルの創閉鎖を促進する2015

    • Author(s)
      我如古清太, 正木千尋, 柴田陽, 向坊太郎, 近藤祐介,中本哲自, 宮崎隆, 細川隆司
    • Organizer
      第124回日本補綴歯科学会学術大会
    • Place of Presentation
      大宮
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非酵素的コラーゲン架橋によって骨強度の劣化は起るか?2014

    • Author(s)
      我如古清太、正木千尋、駒井英基、岡本耕造、細川隆司
    • Organizer
      第44回 日本口腔インプラント学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microstructural analysis of bone strength in rabbits with hyperhomocysteinemia2014

    • Author(s)
      K. Ganeko, C. Masaki, Y. Seo, C. Mukai, T. Mukaibo, Y. Kondo, T. Nakamoto and R. Hosokawa
    • Organizer
      IADR general session & exhibition
    • Place of Presentation
      CAPE TOWN, SOUTH AFRICA
    • Related Report
      2013 Annual Research Report
  • [Presentation] インプラント治療における骨質の術前診断は可能か? ―Advanced glycation end products (AGEs)による骨質劣化の検討―2014

    • Author(s)
      我如古清太,正木千尋,妹尾吉則,向井知理,向坊太郎,近藤祐介,中本哲自,細川隆司
    • Organizer
      日本補綴歯科学会第123回学術大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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