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An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis

Research Project

Project/Area Number 25253104
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontology
Research InstitutionNiigata University

Principal Investigator

YOSHIE Hiromasa  新潟大学, 医歯学系, 教授 (20143787)

Co-Investigator(Kenkyū-buntansha) 高柴 正悟  岡山大学, 医歯(薬)学総合研究科, 教授 (50226768)
永田 俊彦  徳島大学, 大学院医歯薬学研究部, 教授 (10127847)
三谷 章雄  愛知学院大学, 歯学部, 教授 (50329611)
石原 裕一  松本歯科大学, 歯学部, 教授 (50261011)
小林 哲夫  新潟大学, 医歯学総合病院, 准教授 (00215344)
木戸 淳一  徳島大学, 大学院医歯薬学研究部, 准教授 (10195315)
大森 一弘  岡山大学, 大学病院, 講師 (20549860)
前田 博史  大阪歯科大学, 歯学部, 教授 (00274001)
野口 俊英  愛知学院大学, 歯学部, 教授 (50014262)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2014: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2013: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Keywordsサイトカイン遺伝子 / 歯周炎 / 糖尿病 / 関節リウマチ
Outline of Final Research Achievements

The aim of this study was to identify the shared risk cytokine gene for periodontitis, diabetes mellitus (DM), and rheumatoid arthritis (RA). A total of 17 candidate single nucleotide polymorphisms were assessed in 185 patients with RA and chronic periodontitis (CP), 149 patients with type 2 DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults. The results indicated that the potassium voltage-gated channel KQT-like subfamily, member 1 (KCNQ1) rs2237892 and the peptidylarginine deiminase type 4 (PADI4)_104 rs1748033 polymorphisms were significantly associated with the comorbidity of RA and CP. Additionally, a trend toward increase was shown in the serum levels of anti-cyclic citrullinated peptide immunoglobulin G in the patients with RA and CP as compared to those with RA only. These results suggest that the KCNQ1 and possibly the PADI4_104 may constitute a shared risk gene for RA and CP in Japanese adults.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (85 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (29 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 29 results,  Open Access: 18 results,  Acknowledgement Compliant: 20 results) Presentation (55 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Clinical significance of GCF sIL-6R and calprotectin to evaluate the periodontal inflammation.2017

    • Author(s)
      Kajiura Y, Lew JH, Ikuta T, Nishikawa Y, Kido J, Nagata T, Naruishi K. ANNALS EXPRESS
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: 印刷中 Issue: 6 Pages: 1-7

    • DOI

      10.1177/0004563216680232

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calprotectin induces IL-6 and MCP-1 production via Toll-like receptor 4 signaling in human gingival fibroblasts.2017

    • Author(s)
      Nishikawa Y, Kajiura Y, Lew JH, Kido J, Nagata T, Naruishi K.
    • Journal Title

      Journal of Cellular Physiolog

      Volume: 印刷中 Issue: 7 Pages: 1862-1871

    • DOI

      10.1002/jcp.25724

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis2016

    • Author(s)
      Kobayashi T, Ito S, Kobayashi D, Shimada A, Narita I, Murasawa A, Nakazono K, Yoshie H.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 4 Pages: e0154182-e0154182

    • DOI

      10.1371/journal.pone.0154182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumor necrosis factor-alpha gene promoter methylation in Japanese adults with chronic periodontitis and rheumatoid arthritis2016

    • Author(s)
      Kojima A, Kobayashi T, Ito S, Murasawa A, Nakazono K, Yoshie H.
    • Journal Title

      Journal of Periodontal Research.

      Volume: 51 Issue: 3 Pages: 350-358

    • DOI

      10.1111/jre.12314

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased expression of interleukin-6 (IL-6) gene transcript in relation to IL-6 promoter hypomethylation in gingival tissue from patients with chronic periodontitis2016

    • Author(s)
      Kobayashi T, Ishida K, Yoshie H.
    • Journal Title

      Archives of Oral Biology

      Volume: 69 Pages: 89-94

    • DOI

      10.1016/j.archoralbio.2016.05.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitory effects of advanced glycation end-products and Porphyromonas gingivalis lipopolysaccharide on the expression of osteoblastic markers of rat bone marrow cells in culture2016

    • Author(s)
      Sakamoto E, Mihara C, Ikuta T, Inagaki Y, Kido J, Nagata T
    • Journal Title

      Journal of Periodontal Research

      Volume: 印刷中 Issue: 3 Pages: 313-320

    • DOI

      10.1111/jre.12310

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Smad2 overexpression enhances adhesion of gingival epithelial cells.2016

    • Author(s)
      Hongo S, Yamamoto T, Yamashiro K, Shimoe M, Tomikawa K, Ugawa Y, Kochi S, Ideguchi H, Maeda H, Takashiba S.
    • Journal Title

      Archives of Oral Biology.

      Volume: 71 Pages: 46-53

    • DOI

      10.1016/j.archoralbio.2016.06.025

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial.2016

    • Author(s)
      Takeuchi-Hatanaka K, Yasuda T, Naruishi K, Katsuragi-Fuke K, Inubushi J, Ootsuki H, Maeda H, Takashiba S.
    • Journal Title

      Journal of Periodontal Research

      Volume: 51 Issue: 3 Pages: 321-31

    • DOI

      10.1111/jre.12311

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis2016

    • Author(s)
      Suzuki Y, Nakamura N, Miyabe M, Nishikawa T, Miyajima S, Adachi K, Mizutani M, Kikuchi T, Miyazawa K, Goto S, Tsukiyama K, Yamada Y, Ohno N, Noguchi T, Mitani A, Matsubara T, Naruse K
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 印刷中 Issue: 4 Pages: 497-505

    • DOI

      10.1111/jdi.12450

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum Amyloid A Promotes E-Selectin Expression via Toll-Like Receptor 2 in Human Aortic Endothelial Cells2016

    • Author(s)
      Nishida E, Aino M, Kobayashi SI, Okada K, Ohno T, Kikuchi T, Hayashi JI, Yamamoto G, Hasegawa Y, Mitani A.
    • Journal Title

      Mediators of Inflammation

      Volume: 7150509 Pages: 7150509-7150509

    • DOI

      10.1155/2016/7150509

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4+ T cells.2016

    • Author(s)
      Okada K, Fujimura T, Kikuchi T, Aino M, Kamiya Y, Izawa A, Iwamura Y, Goto H, Okabe I, Miyake E, Hasegawa Y, Mogi M, Mitani A.
    • Journal Title

      Peer J.

      Volume: e2999 Pages: e2999-e2999

    • DOI

      10.7717/peerj.2999

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis2016

    • Author(s)
      Shimada A, Kobayashi T, Ito S, Okada M, Murasawa A, Nakazono K, Yoshie H
    • Journal Title

      Journal of Periodontal Research

      Volume: 51 Issue: 1 Pages: 103-111

    • DOI

      10.1111/jre.12288

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Interleukin-6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors2016

    • Author(s)
      Kobayashi T, Ito S, Kobayashi D, Kojima A, Shimada A, Narita I, Murasawa A, Nakazono K, Yoshie H
    • Journal Title

      Clinical and Experimental Dental Research

      Volume: 1 Issue: 2 Pages: 63-73

    • DOI

      10.1002/cre2.11

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes2015

    • Author(s)
      Kido J, Bando Y, Bando M, Kajiura Y, Hiroshima Y, Inagaki Y, Murata H, Ikuta T, Kido R, Naruishi K, Funaki M, Nagata T.
    • Journal Title

      Oral Diseases

      Volume: 21 Issue: 5 Pages: 667-673

    • DOI

      10.1111/odi.12334

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.2015

    • Author(s)
      Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 10 Pages: e0140942-e0140942

    • DOI

      10.1371/journal.pone.0140942

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Osteopontin localization in the rat gingival tissues in an experimental model of periodontitis associated with obesity-related diabetes2015

    • Author(s)
      稲垣裕司、中島由紀子、堀部ますみ、生田貴久、梶浦由加里、成石浩司、木戸淳一、永田俊彦
    • Journal Title

      Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)

      Volume: 57 Issue: 4 Pages: 149-158

    • DOI

      10.2329/perio.57.149

    • NAID

      130005116213

    • ISSN
      0385-0110, 1880-408X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Host Responses in the Link between Periodontitis and Rheumatoid Arthritis2015

    • Author(s)
      Kobayashi T, Yoshie H
    • Journal Title

      Current Oral Health Reports

      Volume: 2 Issue: 1 Pages: 1-8

    • DOI

      10.1007/s40496-014-0039-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased Expression of Interleukin-35 and -17, but not -27, in Gingival Tissues with Chronic Periodontitis.2015

    • Author(s)
      Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T.
    • Journal Title

      J Periodontol

      Volume: 86 Pages: 301-309

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Periodontal and Serum Protein Profiles in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitor Adalimumab.2014

    • Author(s)
      Kobayashi T, Yokoyama T, Ito S, Kobayashi D, Yamagata A, Okada M, Oofusa K, Narita I, Murasawa A, Nakazono K, Yoshie H
    • Journal Title

      Journal of Periodontology

      Volume: 85 Issue: 11 Pages: 1480-1488

    • DOI

      10.1902/jop.2014.140194

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glycated albumin and calprotectin levels in gingival crevicular fluid from patients with periodontitis and type 2 diabetes.2014

    • Author(s)
      Kajiura Y, Bando M, Inagaki Y, Nagata T, Kido J.
    • Journal Title

      J Periodontol

      Volume: 85 Issue: 12 Pages: 1667-1675

    • DOI

      10.1902/jop.2014.140241

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells.2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
    • Journal Title

      Modern Research in Inflammation

      Volume: 3 Pages: 37-47

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture.2014

    • Author(s)
      Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
    • Journal Title

      Inflammation

      Volume: 37 Pages: 657-669

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in Japanese.2014

    • Author(s)
      Kamei H, Ishihara Y, Fuma D, Niwa T, Kamiya Y, Yokoi T, Suzuki M, Izawa A, Mizutani H, Hayashi J, Sakaki Y, Noguchi T, Kojima T.
    • Journal Title

      Arch. Oral Biol.

      Volume: 59 Pages: 756-763

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1.2014

    • Author(s)
      Kato Y, Hagiwara M, Ishihara Y, Isoda R, Sugiura S, Komatsu T, Ishida N, Noguchi T, Matsushita K.
    • Journal Title

      BMC Microbiology

      Volume: 14 Pages: 229-229

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Periodontitis-activated monocytes/macrophages cause aortic inflammation.2014

    • Author(s)
      Miyajima S, Naruse K, Kobayashi Y, Nakamura N, Nishikawa T, Adachi K, Suzuki Y, Kikuchi T, Mitani A, Mizutani M, Ohno N, Noguchi T, Matsubara T.
    • Journal Title

      Sci. Rep.

      Volume: 4 Pages: 5171-5171

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis2014

    • Author(s)
      Tetsuo Kobayashi, et al.
    • Journal Title

      Open Journal of Stomatology

      Volume: 4 Issue: 02 Pages: 49-55

    • DOI

      10.4236/ojst.2014.42009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in IL-1Ra knockout mice.2014

    • Author(s)
      Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J, Nishihara T, Maeda H, Noguchi T.
    • Journal Title

      Infect Immun

      Volume: 82 Issue: 5 Pages: 1904-1913

    • DOI

      10.1128/iai.01618-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide of Aggregatibacter actinomycetemcomitans up-regulates inflammatory cytokines, prostaglandin E2 synthesis and osteoclast formation in interleukin-1 receptor antagonist-deficient mice2013

    • Author(s)
      Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T.
    • Journal Title

      J Periodont Res

      Volume: 48 Issue: 6 Pages: 748-756

    • DOI

      10.1111/jre.12065

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Interleukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Chronic Periodontitis2013

    • Author(s)
      Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H
    • Journal Title

      J. Periodontol

      Volume: (in press) Issue: 1 Pages: 57-67

    • DOI

      10.1902/jop.2013.120696

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 関節リウマチ患者におけるPorphyromonas gingivalis PAD血清抗体価とbiologic DMARDs反応性との関連性2016

    • Author(s)
      小林哲夫、伊藤 聡、小林大介、成田一衛、村澤 章、中園 清、吉江弘正
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Porphyromonas gingivalis PAD血清抗体価のサイトカイン標的療法反応性への影響2016

    • Author(s)
      小林哲夫、島田惇史、吉江弘正
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯周炎併発と関節リウマチ活動度との関連性の解析2016

    • Author(s)
      小林哲夫、島田惇史、吉江弘正
    • Organizer
      日本歯科保存学会2016年度春季学術大会(第144回)
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性歯周炎罹患歯肉組織におけるIL-6プロモーター低メチル化と遺伝子転写発現亢進2016

    • Author(s)
      小林哲夫、石田光平、吉江弘正
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Porphyromonas gingivalis PAD IgG抗体価と関節リウマチ治療応答性との関連2016

    • Author(s)
      小林哲夫、島田惇史、吉江弘正
    • Organizer
      日本歯科保存学会2016年度秋季学術大会(第145回)
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 最終糖化産物はヒト歯肉線維芽細胞におけるIL-6およびICAM1の発現を増加する2016

    • Author(s)
      板東美香、樋浦由香里、野中康平、坂本英次郎、成石浩司、木戸淳一、永田俊彦
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ・新潟コンベンションセンター(新潟市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Interleukin (IL)-35 and IL-17 may play important role in periodontitis.2016

    • Author(s)
      Mitani A.
    • Organizer
      The 102 nd. Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アンジオポエチン様タンパク2は歯肉上皮細胞におけるPorphyromonas gingivalis菌由来LPSによる炎症反応を制御する2016

    • Author(s)
      大野祐、山本弦太、林潤一郎、西田栄作、後藤久嗣、岡田康佑、佐々木康行、村瀬尚子、茂木眞希雄、福田光男、三谷章雄
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Glucose-dependent Insulinotolopic Polypeptide(GIP)による歯周病抑制効果の検討2016

    • Author(s)
      鈴木佑基、成瀬桂子、中村信久、宮部 愛、宮島真一、菊池 毅、宮澤 健、後藤滋己、松原達明、三谷章雄
    • Organizer
      第23回日本歯科医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県博多市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] IL-6レセプター阻害による関節リウマチ患者の歯周炎症の改善2015

    • Author(s)
      小林哲夫
    • Organizer
      日本歯科保存学会2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京都文京区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 破骨細胞原性に対するIL-15とRANKLの相乗効果について2015

    • Author(s)
      菊池毅
    • Organizer
      日本歯科保存学会2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京都文京区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] SAAは血管内皮細胞における接着分子の発現を上昇させる2015

    • Author(s)
      西田英作
    • Organizer
      日本歯科保存学会2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京都文京区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Porphyromonas gingivalis由来LPSは歯肉上皮細胞のアンジオポエチン様タンパク質2産生を誘導する2015

    • Author(s)
      大野祐
    • Organizer
      日本歯科保存学会2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京都文京区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病関連歯周炎の診断と治療2015

    • Author(s)
      永田俊彦
    • Organizer
      日本歯周病学会中国四国3大学・日本臨床歯周病学会中国四国支部合同研修会
    • Place of Presentation
      徳島県郷土文化会館(徳島市)
    • Year and Date
      2015-10-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 破骨細胞原性に対するIL-15とRANKLの相乗効果について2015

    • Author(s)
      岡部猪一郎
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯周炎併発関節リウマチ患者におけるPorphyromonas gingivalis PADに対する血清抗体価2015

    • Author(s)
      島田惇史
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 最終糖化産物はヒト口腔上皮細胞の遺伝子発現を調節する2015

    • Author(s)
      坂本英次郎
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 破骨細胞原性に対するIL-15とRANKLの相乗効果について2015

    • Author(s)
      岡部猪一郎
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Examination of the periodontal disease suppressor pathway by GIP2015

    • Author(s)
      Suzuki Y
    • Organizer
      75th American Diabetes Association
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor necrosis factor-alpha gene promoter methylation in patients with periodontitis and rheumatoid arthritis2015

    • Author(s)
      Kojima A
    • Organizer
      EuroPerio 8
    • Place of Presentation
      London, UK
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of periodontal treatment on serum peptidylarginine deiminase levels in patients with rheumatoid arthritis2015

    • Author(s)
      Shimada A
    • Organizer
      EuroPerio 8
    • Place of Presentation
      London, UK
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Determination of glycated albmin and calprotectin in gingival crevicular fluid from patients with periodontitis and diabetes2015

    • Author(s)
      Kajiura Y
    • Organizer
      EuroPerio 8
    • Place of Presentation
      London, UK
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] YKL-40 in gingival crevicular fliuid from patients with periodontitis and diabetes2015

    • Author(s)
      Ikuta T
    • Organizer
      EuroPerio 8
    • Place of Presentation
      London, UK
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GIPによる歯周炎抑制経路の検討2015

    • Author(s)
      鈴木佑基
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関 (山口県下関市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-6受容体阻害薬トシリズマブ投与前後での歯周・血清サイトカインプロファイル2015

    • Author(s)
      小林哲夫
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ(千葉県幕張市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] GIPは歯周炎を抑制する2015

    • Author(s)
      鈴木佑基
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ(千葉県幕張市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] アダリムマブ投与前後での歯周・血清蛋白プロファイル2015

    • Author(s)
      小林哲夫
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-6/sIL-6R enhances cathepsin-B secretion via caveolin-1-mediated ERK1/2 in gingival fibroblasts.2015

    • Author(s)
      Goto A, Omori K, Yamaguchi-Tomikawa, Kobayashi H, Yamamoto T, Maeda H, Takashiba S
    • Organizer
      the 93rd International Association for Dental Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腫瘍壊死因子抑制薬治療前後における歯周・血清蛋白プロファイル2014

    • Author(s)
      小林哲夫、横山智子、岡田 萌、吉江弘正
    • Organizer
      日本歯科保存学会2014年度秋季学術大会(第141回)
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 関節リウマチ患者における生物学的製剤治療反応へのPorphyromonas gingivalis感染の影響2014

    • Author(s)
      岡田 萌、小林哲夫、吉江弘正
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性歯周炎患者および関節リウマチ患者におけるTNF-alpha61537;遺伝子プロモーター領域のメチル化解析2014

    • Author(s)
      小島杏里、小林哲夫、石田光平、岡田 萌、吉江弘正
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 最終糖化産物は口腔由来線維芽細胞・上皮細胞での炎症関連因子と酸化ストレス因子の発現に影響する2014

    • Author(s)
      板東美香,梶浦由加里,中島由紀子,木戸淳一,稲垣裕司,村田裕美,永田俊彦
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] I-6s/IL-6Rは歯肉線維芽細胞から活性を有するリソソーム酵素カテプシンB, Lの分泌を亢進す2014

    • Author(s)
      後藤絢香,大森一弘,冨川知子,小林寛也,成石浩司,前田博史,高柴正悟
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する2014

    • Author(s)
      後藤久嗣,石原裕一,伊澤有郎,岡部栄治郎,久保勝俊,杉田好彦,前田初彦,野口俊英,三谷章雄
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯周炎により活性化された単核球が大動脈の炎症を惹起する機序の検討2014

    • Author(s)
      宮島真一,成瀬桂子,中村信久,西川徹,足立圭,鈴木佑基,水谷誠,菊池毅,野口俊英,大野紀和,松原達昭,三谷章雄
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
    • Organizer
      the 100th Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト歯槽骨由来未分化骨芽細胞の骨原性維持に関わるマーカーの探索.2014

    • Author(s)
      齋藤正寛,相野 誠,三谷章雄
    • Organizer
      日本歯科保存学会2014年度春季学術大会(第140回)
    • Place of Presentation
      滋賀県立芸術劇場(滋賀県大津市)
    • Year and Date
      2014-06-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] TNF抑制療法中の関節リウマチ患者における血漿アミノ酸と歯周状態2014

    • Author(s)
      小林哲夫、岡田 萌、吉江弘正
    • Organizer
      第57回春季日本歯周病学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病ラット歯周炎に対するpoly (ADP-ribose) polymerase阻害薬の効果.2014

    • Author(s)
      足立圭, 成瀬桂子, 小林泰子, 中村信久, 西川徹, 宮島真一, 鈴木佑基, 水谷誠, 菊池毅, 大野紀和, 野口俊英, 松原達昭
    • Organizer
      第57回春季日本歯周病学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 最終糖化産物は歯周組織細胞での炎症関連因子と酸化ストレス因子の発現に影響する2014

    • Author(s)
      板東美香,中島由紀子,梶浦由加里,木戸淳一,稲垣裕司,村田裕美,永田俊彦
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] TNF阻害療法中の関節リウマチ患者のアミノ酸・歯周プロファイル2014

    • Author(s)
      小林哲夫、伊藤 聡、岡田 萌、小林大介、成田一衛、中園 清、村澤 章、吉江弘正
    • Organizer
      第58回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯周治療による関節リウマチ活動度と血清シトルリン濃度の低下2014

    • Author(s)
      岡田 萌、小林哲夫、伊藤 聡、阿部麻美、村澤 章、吉江弘正
    • Organizer
      第58回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Advanced glycation end-product increases oxidative stress in human gingival fibroblasts.2013

    • Author(s)
      Kajiura Y, Bando M, Inagaki Y, Murata H, Kido J, Nagata T.
    • Organizer
      Korean Academy of Periodontology Meeting
    • Place of Presentation
      ソウル市(大韓民国)
    • Year and Date
      2013-11-22 – 2013-11-23
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周炎罹患組織におけるIL-6遺伝子プロモーター領域のメチル化解析2013

    • Author(s)
      石田光平、小林哲夫、横山智子、岡田 萌、小島杏里、小松康高、吉江弘正
    • Organizer
      日本歯科保存学会2013年度秋季学術大会(第139回)
    • Place of Presentation
      秋田県総合生活文化会館(秋田市)
    • Year and Date
      2013-10-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] 慢性歯周炎患者におけるTNF-a遺伝子プロモーター領域のメチル化解析2013

    • Author(s)
      小島杏里、小林哲夫、石田光平、岡田 萌、吉江弘正
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋市市民文化会館(前橋市)
    • Year and Date
      2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響2013

    • Author(s)
      後藤久嗣,石原裕一,伊澤有郎,岡部栄治郎,久保勝俊,杉田好彦,前田初彦,野口俊英
    • Organizer
      第56回秋季日本歯周病学会
    • Place of Presentation
      前橋市市民文化会館(前橋市)
    • Year and Date
      2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者における歯周状態のTNF標的療法反応性に及ぼす影響2013

    • Author(s)
      横山智子、小林哲夫、岡田 萌、吉江弘正
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋市市民文化会館(前橋市)
    • Year and Date
      2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of Interkeukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Periodontitis.2013

    • Author(s)
      Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H.
    • Organizer
      The 10th. Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Year and Date
      2013-09-03 – 2013-09-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] Interkeukin-6 Gene Promoter Methylation in Periodontal Tissues.2013

    • Author(s)
      Ishida K, Kobayashi T, Yokoyama T, Okada M, Kojima A, Yoshie H.: Interkeukin-6
    • Organizer
      The 10th. Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Year and Date
      2013-09-03 – 2013-09-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of Periodontal Treatment on Antibodies to Porphyromonas gingivalis and Citrulline levels and Rheumatoid Arthritis Condition2013

    • Author(s)
      Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A, Yoshie H
    • Organizer
      The 10th. Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Year and Date
      2013-09-03 – 2013-09-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tumor Necrosis Factor-Alpha Gene Promoter Methylation in Chronic Periodontitis.2013

    • Author(s)
      Kojima A, Kobayashi T, Ishida K, Okada M, Yoshie H.:
    • Organizer
      The 10th. Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Year and Date
      2013-09-03 – 2013-09-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者におけるトシリズマブ治療の歯周状態への影響.2013

    • Author(s)
      小林哲夫、岡田 萌、石田光平、小島杏里、吉江弘正
    • Organizer
      日本歯科保存学会2013年度春季学術大会(第138回)
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2013-06-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] 最終糖化産物が歯肉線維芽細胞における酸化ストレス反応に及ぼす影響2013

    • Author(s)
      梶浦由加里,板東美香,稲垣裕司,木戸淳一,永田俊彦
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2013-06-01
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-6受容体抑制治療中の関節リウマチ患者の歯周状態2013

    • Author(s)
      小林哲夫、岡田 萌、石田光平、小島杏里、吉江弘正
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2013-05-31
    • Related Report
      2013 Annual Research Report
  • [Presentation] トシリズマブ(TCZ)療法中の関節リウマチ患者の歯周状態2013

    • Author(s)
      小林哲夫、伊藤 聡、小林大介、成田一衛、村澤 章、吉江弘正:
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2013-04-19
    • Related Report
      2013 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科歯周診断・再建学分野ホームページ

    • URL

      http://mds.niigata-u.ac.jp/organization/ols/obs/per/index_j.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2018-03-22  

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