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Nha Trang Birth Cohort Study: a comprehensive prospective study to identify the risk factors for major paediatric health problems in Central Vietnam.

Research Project

Project/Area Number 25257509
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Infectious disease medicine
Research InstitutionNagasaki University

Principal Investigator

ARIYOSHI Koya  長崎大学, 熱帯医学研究所, 教授 (30311400)

Co-Investigator(Kenkyū-buntansha) 安波 道郎  地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所), ライフサイエンス研究所, 部長 (80244127)
森内 浩幸  長崎大学, 医歯薬学総合研究科(医学系), 教授 (90315234)
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Keywords感染症 / 臨床疫学 / 分子疫学 / ゲノム / コホート研究
Outline of Final Research Achievements

A longitudinal observational study of the children who were born in a catchment area in Nha Trang City, Vietnam between May 2009 and May 2010 was continued until the children reached six years of age. We succeeded to obtain the data for the evaluation of development, specimens for urinalysis and stool examination as well as history of past and present illness including respiratory/gastrointestinal infections, asthma and allergic diseases upon medical check at school age from more than 1200 children. Exposure to environmental tobacco smoke (ETS) increased the incidence of respiratory infections in infants and certain genetic factors, such as the Asian variant of aldehyde dehydrogenase 2 (ALDH2*2), augmented the effect of ETS. Further the factors which influence the prevalence of asthma and other allergy status were found in the present study.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (33 results)

All 2017 2016 2014 2013 Other

All Int'l Joint Research (3 results) Journal Article (17 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 17 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] ニャチャン・パスツール研究所/国立衛生疫学研究所(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 国立衛生疫学研究所/ベトナム保健省・カンホワ保健局/ニャチャン市パスツール研究所(ベトナム)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 国立衛生疫学研究所(ベトナム)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia2017

    • Author(s)
      Suzuki Motoi、Dhoubhadel Bhim Gopal、Katoh Shungo、Ariyoshi Koya、Morimoto Konosuke
    • Journal Title

      The Lancet Infectious Diseases

      Volume: 17 Issue: 8 Pages: 803-804

    • DOI

      10.1016/s1473-3099(17)30411-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exposure to paternal tobacco smoking increased child hospitalization for lower respiratory infections but not for other diseases in Vietnam.2017

    • Author(s)
      Miyahara R, Takahashi K, Anh NT, Thiem VD, Suzuki M, Yoshino H, Tho LH, Moriuchi H, Cox SE, Yoshida LM, Anh DD, Ariyoshi K, Yasunami M.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 45481-45481

    • DOI

      10.1038/srep45481

    • NAID

      120006987529

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Serotype-specific effectiveness of 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia in adults aged 65 years or older: a multicentre, prospective, test-negative design study2017

    • Author(s)
      Suzuki Motoi、Dhoubhadel Bhim Gopal、Ishifuji Tomoko、Yasunami Michio、Yaegashi Makito、Asoh Norichika、Ishida Masayuki、Hamaguchi Sugihiro、Aoshima Masahiro、Ariyoshi Koya、Morimoto Konosuke
    • Journal Title

      The Lancet Infectious Diseases

      Volume: 17 Issue: 3 Pages: 313-321

    • DOI

      10.1016/s1473-3099(17)30049-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey2017

    • Author(s)
      Do HT, Nguyen DT, Nguyen LAT, Do DH, Le HX, Trinh XMT, Ton HVN, Sawada I, Kitamura N, Le MN, Yoshihara K, Phan THT, Bui CT, Ariyoshi K, Yoshida LM
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 70 Issue: 6 Pages: 621-627

    • DOI

      10.7883/yoken.JJID.2016.512

    • NAID

      130006210254

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam.2016

    • Author(s)
      Yoshihara K, Le MN, Okamoto M, Wadagni AC, Nguyen HA, Toizumi M, Pham E, Suzuki M, Nguyen AT, Oshitani H, Ariyoshi K, Moriuchi H, Hashizume M, Dang DA, Yoshida LM.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 27856-27856

    • DOI

      10.1038/srep27856

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein (G) gene in central Vietnam.2016

    • Author(s)
      Yoshihara K, Le MN, Nagasawa K, Tsukagoshi H, Nguyen HA, Toizumi M, Moriuchi H, Hashizume M, Ariyoshi K, Dang DA, Kimura H, Yoshida LM.
    • Journal Title

      Infect Genet Evol.

      Volume: 45 Pages: 437-446

    • DOI

      10.1016/j.meegid.2016.10.010

    • NAID

      120006987496

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modeling the impact of rubella vaccination in Vietnam.2016

    • Author(s)
      Vynnycky E, Yoshida LM, Huyen DT, Trung ND, Toda K, Cuong NV, Thi Hong D, Ariyoshi K, Miyakawa M, Moriuchi H, Tho le H, Nguyen HA, Duc Anh D, Jit M, Hien NT.
    • Journal Title

      Hum Vaccin Immunother.

      Volume: 12 Issue: 1 Pages: 150-158

    • DOI

      10.1080/21645515.2015.1060380

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Early indication for a reduced burden of radiologically confirmed pneumonia in children following the introduction of routine vaccination against Haemophilus influenzae type b in Nha Trang, Vietnam.2014

    • Author(s)
      Flasche S, Takahashi K, Vu DT, Suzuki M, Nguyen TH, Le H, Hashizume M, Dang DA, Edmond K, Ariyoshi K, Mulholland EK, Edmunds WJ, Yoshida LM.
    • Journal Title

      Vaccine

      Volume: 32 Issue: 51 Pages: 6963-6970

    • DOI

      10.1016/j.vaccine.2014.10.055

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population Based Cohort Study for Pediatric Infectious Diseases Research in Vietnam2014

    • Author(s)
      Yoshida LM, Suzuki M, Thiem VD, Smith WP, Tsuzuki A, Huong VT, Takahashi K, Miyakawa M, Anh NT, Watanabe K, Ai NT, Tho le H, Kilgore P, Yoshino H, Toizumi M, Yasunami M, Moriuchi H, Anh DD, Ariyoshi K
    • Journal Title

      Tropical Medicine and Health

      Volume: 42 Issue: 2SUPPLEMENT Pages: S47-S58

    • DOI

      10.2149/tmh.2014-S07

    • NAID

      130004463458

    • ISSN
      1348-8945, 1349-4147
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial load of pneumococcal serotypes correlates with their prevalence and multiple serotypes is associated with acute respiratory infections among children less than 5 years of age2014

    • Author(s)
      Dhoubhadel BG, Yasunami M, Nguyen HA, Suzuki M, Vu TH, Thi Thuy Nguyen A, Dang DA, Yoshida LM, Ariyoshi K
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: e110777-e110777

    • DOI

      10.1371/journal.pone.0110777

    • NAID

      120006986336

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mortality associated with pulmonary hypertension in congenital rubella syndrome2014

    • Author(s)
      Toizumi M, Motomura H, Vo HM, Takahashi K, Pham E, Nguyen HA, Le TH, Hashizume M, Ariyoshi K, Dang DA, Moriuchi H, Yoshida LM
    • Journal Title

      Pediatrics

      Volume: 134 Issue: 2 Pages: e519-e526

    • DOI

      10.1542/peds.2013-4184

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of 2009 pandemic influenza among Vietnamese children based on a population-based prospective surveillance from 2007 to 2011.2014

    • Author(s)
      Le MN, Yoshida LM, Suzuki M, Nguyen HA, Le HT, Moriuchi H, Dang DA, Ariyoshi K.
    • Journal Title

      Influenza and Other Respir Viruses

      Volume: 12244 Issue: 4 Pages: 1-8

    • DOI

      10.1111/irv.12244

    • NAID

      120006986547

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel high-throughput method for molecular serotyping and serotype-specific quantification of Streptococcus pneumoniae using a nanofluidic real-time PCR system.2014

    • Author(s)
      Dhoubhadel BG, Yasunami M, Yoshida LM, Thi HA, Thi TH, Thi TA, Watanabe K, Suzuki M, Morimoto K, Dang DA, Ariyoshi K.
    • Journal Title

      J Med Microbiol.

      Volume: 63 Issue: 4 Pages: 528-539

    • DOI

      10.1099/jmm.0.071464-0

    • NAID

      120006986506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nasopharyngeal bacterial interactions in children.2014

    • Author(s)
      Suzuki M, Dhoubhadel BG, Yoshida LM, Ariyoshi K.
    • Journal Title

      Emerg Infect Dis.

      Volume: 20 Issue: 2 Pages: 323-324

    • DOI

      10.3201/eid2002.121724

    • NAID

      120006986756

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The incidence and aetiology of hospitalised community-acquired pneumonia among Vietnamese adults: a prospective surveillance in Central Vietnam.2013

    • Author(s)
      Takahashi K, Suzuki M, Minh le N, Anh NH, Huong LT, Son TV, Long PT, Ai NT, Tho le H, Morimoto K, Kilgore PE, Anh DD, Ariyoshi K, Yoshida LM.
    • Journal Title

      BMC Infect Dis.

      Volume: 13 Issue: 1 Pages: 296-296

    • DOI

      10.1186/1471-2334-13-296

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of radiologically-confirmed pneumonia and Haemophilus influenzae type b carriage before Haemophilus influenzae type b conjugate vaccine introduction in Central Vietnam.2013

    • Author(s)
      Yoshida LM, Nguyen HA, Watanabe K, Le MN, Nguyen AT, Vu HT, Yoshino H, Suzuki M, Takahashi K, Le T, Moriuch H, Kilgore PE, Edmond K, Mulholland K, Dang DA, Ariyoshi K.
    • Journal Title

      J Pediatr.

      Volume: 163

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections.2013

    • Author(s)
      Yoshida LM, Suzuki M, Nguyen HA, Le MN, Dinh Vu T, Yoshino H, Schmidt  WP, Nguyen TT, Le HT, Morimoto K, Moriuchi H, Dang DA, Ariyoshi K.
    • Journal Title

      Eur Respir J.

      Volume: 42 Issue: 2 Pages: 461-469

    • DOI

      10.1183/09031936.00101812

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Environment-dependent effect of ALDH2*2 on childhood respiratory infections was found in a birth cohort study in Vietnam (ALDH2バリアントアレルは環境要因に依存して乳幼児期呼吸器感染症リスクに寄与している)2017

    • Author(s)
      安波道郎、宮原麗子、吉田レイミント、中村仁美、高橋健介、Vu Dinh Thiem、Dang Duc Anh、Le Huu Tho、森内浩幸、有吉紅也
    • Organizer
      日本人類遺伝学会 第62回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reiko Miyahara, Lay Myint Yoshida, Duc Ahn Dang, Kensuke Takahashi, Hitomi Nakamura, Dinh Thiem Vu, Huu Tho Le, Hiroyuki Moriuchi, Sharon E Cox, Koya Ariyoshi, Michio Yasunami2016

    • Author(s)
      Association of SNPs of TLR pathway regulating innate immune responses with pediatric respiratory infectious diseases in Vietnamese.
    • Organizer
      ICHG2016 [The 13th International Congress of Human Genetics]
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New association of HLA class II and non-responsiveness to hepatitis B vaccine was identified by a birth-cohort study in Vietnam2014

    • Author(s)
      Michio Yasunami
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Nara, Japan
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] What are we learning about hepatitis virus infection from the Nha Trang birth cohort study in Vietnam?2014

    • Author(s)
      Michio Yasunami.
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections - 2014.
    • Place of Presentation
      Sendai International Center ,Sendai, Japan
    • Year and Date
      2014-01-20 – 2014-01-22
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Nha Trang Birth Cohort Study --- a prospective study for the identification of risk factors for childhood infection/infectious diseases.2014

    • Author(s)
      Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Dinh Thiem, Trinh Xuan Mai, Bui Trong Chien, Dang Duc Anh, Le Huu Tho, Masami Miyakawa, Hiroyuki Moriuchi, Koya Ariyoshi.
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections - 2014.
    • Place of Presentation
      Sendai International Center ,Sendai, Japan
    • Year and Date
      2014-01-20 – 2014-01-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] A birth cohort study revealed that the susceptibility to acute lower respiratory infection was associated with TLR10-TLR1-TLR6 polymorphisms.2013

    • Author(s)
      Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Trinh Xuan Mai, Bui Trong Chien, Vu Dinh Thiem, Le Huu Tho, Dang Duc Anh, Koya Ariyoshi.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉(千葉市)
    • Year and Date
      2013-12-11 – 2013-12-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cell type-specific, type I interferon-induced expression of APOBEC3G in HIV-exposed seronegatives.2013

    • Author(s)
      Michio Yasunami, Nuanjun Wichukchinda, Akiko Takaki, Archawin Rojanawiwat, Panita Pathipvanich, Pathom Sawanpanyalert, Koya Ariyoshi.
    • Organizer
      The 11th International Congress on AIDS in Asia and the Pacific.
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2013-11-18 – 2013-11-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nha Trang Birth Cohort Study: a population-based study for the identification of phenotype expression of genetic risk factors for childhood infectious diseases in Vietnam. The2013

    • Author(s)
      Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Dinh Thiem, Trinh Xuan Mai, Bui Trong Chien, Dang Duc Anh, Le Huu Tho, Koya Ariyoshi.
    • Organizer
      American Society of Human Genetics 63rd Annual Meeting.
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-10-22 – 2013-10-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] ベトナム人の小児肺炎における肺炎球菌の鼻腔定着率、菌量および血清型分布について2013

    • Author(s)
      Dhoubhadel Bhim Gopal、YOSHIDA LAY MYINT、ANH NGUYEN HIEN、MINH LE NHAT、THO LE HOO、YASUNAMI MICHIO、SUZUKI MOTOI
    • Organizer
      第54回日本熱帯医学会大会
    • Place of Presentation
      長崎ブリックホール、長崎(長崎市)
    • Year and Date
      2013-10-03 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] ニャチャン出生コホート研究‐前向き研究による小児呼吸器感染の遺伝的危険因子同定2013

    • Author(s)
      安波 道郎、宮原 麗子、吉田 レイミント、中村 仁美、高橋 健介、VU DINH THIEM、TRINH XUAN MAI、DANG DUC ANH、LE HUU THO、有吉 紅也
    • Organizer
      第54回日本熱帯医学会大会
    • Place of Presentation
      長崎ブリックホール、長崎(長崎市)
    • Year and Date
      2013-10-03 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新生児B 型肝炎ワクチン応答に及ぼすHLA の効果2013

    • Author(s)
      安波 道郎、宮原 麗子、中村 仁美、吉田 レイミント、高橋 健介、ヴ・ ディン・ティエム、レ・ フー・トー、ダン・ ドゥク・アーイン、森内 浩幸、有吉 紅也.
    • Organizer
      第22回日本組織適合性学会大会
    • Place of Presentation
      コラッセふくしま、福島(福島市)
    • Year and Date
      2013-09-14 – 2013-09-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遺伝子発現を用いた呼吸器感染症発症リスクの検討2013

    • Author(s)
      宮原 麗子,安波 道郎 ,吉田 レイミント ,高橋 健介,ダン ドゥクアイン,有吉 紅也
    • Organizer
      第110回日本内科学会講演会
    • Place of Presentation
      東京国際フォーラム、東京(千代田区)
    • Year and Date
      2013-04-11 – 2013-04-13
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺炎球菌血清型迅速分子診断法2013

    • Inventor(s)
      有吉紅也、安波道郎、吉田レイミント、ビム・グッパル・ドバデル
    • Industrial Property Rights Holder
      長崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-090703
    • Filing Date
      2013-04-23
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2022-02-22  

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